Publications by authors named "Massimiliano Mazzone"

100Publications

Neutrophilic HGF-MET signaling exacerbates intestinal inflammation.

J Crohns Colitis 2020 Jun 17. Epub 2020 Jun 17.

Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/ecco-jcc/jjaa121DOI Listing
June 2020

Editorial: Macrophage Metabolism and Immune Responses.

Front Immunol 2020 29;11:1078. Epub 2020 May 29.

Inflammation and Macrophage Plasticity Lab, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.

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http://dx.doi.org/10.3389/fimmu.2020.01078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272707PMC
May 2020

B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?

Circ Res 2020 Aug 12;127(6):707-723. Epub 2020 Jun 12.

From the Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology (CCB), VIB, Leuven, Belgium (M.E., W.C., R.M.-P., R.A.-R., S.W., D.P., G.D.C., M.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.316071DOI Listing
August 2020

Pro-tumorigenic functions of macrophages at the primary, invasive and metastatic tumor site.

Cancer Immunol Immunother 2020 Sep 4;69(9):1673-1697. Epub 2020 Jun 4.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Dr Qarib St, Keshavarz Blvd, 14194, Tehran, Iran.

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http://dx.doi.org/10.1007/s00262-020-02616-6DOI Listing
September 2020

Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?

Front Oncol 2020 30;10:646. Epub 2020 Apr 30.

Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology (CCB), VIB, Leuven, Belgium.

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http://dx.doi.org/10.3389/fonc.2020.00646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203474PMC
April 2020

PoEMs edit breast cancer outcome.

Aging (Albany NY) 2020 02 26;12(5):4045-4047. Epub 2020 Feb 26.

Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven B3000, Belgium.

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http://dx.doi.org/10.18632/aging.102870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093187PMC
February 2020

Impact of Immunometabolism on Cancer Metastasis: A Focus on T Cells and Macrophages.

Cold Spring Harb Perspect Med 2020 Sep 1;10(9). Epub 2020 Sep 1.

Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven B3000, Belgium.

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http://dx.doi.org/10.1101/cshperspect.a037044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461771PMC
September 2020

Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer.

Cell Metab 2019 11 22;30(5):917-936.e10. Epub 2019 Aug 22.

Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven B3000, Belgium; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven B3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.07.015DOI Listing
November 2019

Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy.

Physiol Rev 2020 01 15;100(1):1-102. Epub 2019 Aug 15.

Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven, Belgium; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium; Institute of Anatomy, University of Zurich, Zurich, Switzerland; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; and Ludwig Cancer Research Institute, Epalinges, Switzerland.

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http://dx.doi.org/10.1152/physrev.00018.2019DOI Listing
January 2020

Blood Vessel Proximity Shapes Cancer Cell Metabolism.

Cell Metab 2019 07;30(1):16-18

Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven B3000, Belgium; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven B3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.06.011DOI Listing
July 2019

Tumor-associated macrophages: a short compendium.

Cell Mol Life Sci 2019 Apr 12;76(8):1447-1458. Epub 2019 Feb 12.

Lab of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, 3000, Leuven, Belgium.

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http://link.springer.com/10.1007/s00018-018-2997-3
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http://dx.doi.org/10.1007/s00018-018-2997-3DOI Listing
April 2019

Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis.

Annu Rev Physiol 2019 02;81:535-560

VIB-Center for Cancer Biology and Department of Oncology, KU Leuven, Leuven B-3000 Belgium; email:

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https://www.annualreviews.org/doi/10.1146/annurev-physiol-02
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http://dx.doi.org/10.1146/annurev-physiol-020518-114721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589442PMC
February 2019

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.

Cell Metab 2018 12 23;28(6):881-894.e13. Epub 2018 Aug 23.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 51006, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.07.016DOI Listing
December 2018

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Cell Metab 2018 12 23;28(6):866-880.e15. Epub 2018 Aug 23.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183046
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http://dx.doi.org/10.1016/j.cmet.2018.07.019DOI Listing
December 2018

Neutrophils enhance early Trypanosoma brucei infection onset.

Sci Rep 2018 07 25;8(1):11203. Epub 2018 Jul 25.

Unit of Veterinary Protozoology, Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp (ITM), Antwerp, Belgium.

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http://dx.doi.org/10.1038/s41598-018-29527-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060092PMC
July 2018

The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer.

Semin Cancer Biol 2018 10 20;52(Pt 2):107-116. Epub 2018 Jun 20.

VIB-Center for Cancer Biology, and KU Leuven, Department of Oncology, 3000 Leuven, Belgium; Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548870PMC
October 2018

Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis.

Oncotarget 2017 Nov 3;8(55):93688-93703. Epub 2017 Oct 3.

Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, CSIC-Universidad de Sevilla-Universidad Pablo de Olavide, Sevilla, Spain.

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http://dx.doi.org/10.18632/oncotarget.21458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706828PMC
November 2017

Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis.

Cell Rep 2017 Dec;21(10):2842-2854

Lab of Tumor Inflammation and Angiogenesis, Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Lab of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732321PMC
December 2017

Metabolism and TAM functions-it takes two to tango.

FEBS J 2018 02 8;285(4):700-716. Epub 2017 Nov 8.

Hematology Unit, National Cancer Research Center, Istituto Tumori 'Giovanni Paolo II', Bari, Italy.

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http://dx.doi.org/10.1111/febs.14295DOI Listing
February 2018

Is There Merit for MET-Targeted Therapies in Gastroesophageal Cancer?

JAMA Oncol 2018 01;4(1):131-132

Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, Catholic University Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1001/jamaoncol.2017.2725DOI Listing
January 2018

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.

Cell Rep 2017 08;20(7):1654-1666

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy; Hematology Unit, National Cancer Research Center, Istituto Tumori "Giovanni Paolo II," 70124 Bari, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575233PMC
August 2017

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming.

Nat Immunol 2017 Sep 17;18(9):985-994. Epub 2017 Jul 17.

Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland.

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http://dx.doi.org/10.1038/ni.3796DOI Listing
September 2017

PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner.

Cell Rep 2017 03;18(12):2836-2844

Laboratory of Tumor Inflammation and Angiogenesis, Vesalius Research Center, VIB, 3000 Leuven, Belgium; Laboratory of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378984PMC
March 2017

The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.

Cell Rep 2017 02;18(7):1699-1712

Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, 3000 Leuven, Belgium; Laboratory of Tumor Inflammation and Angiogenesis, Department of Oncology, Center for Cancer Biology, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.01.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318657PMC
February 2017

SLC25A26 overexpression impairs cell function via mtDNA hypermethylation and rewiring of methyl metabolism.

FEBS J 2017 03 21;284(6):967-984. Epub 2017 Feb 21.

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari 'Aldo Moro', Italy.

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http://dx.doi.org/10.1111/febs.14028DOI Listing
March 2017

Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells.

Antioxid Redox Signal 2017 03 2;26(8):351-363. Epub 2016 Nov 2.

1 Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari , Bari, Italy .

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http://dx.doi.org/10.1089/ars.2016.6715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346956PMC
March 2017

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis.

Cell Metab 2016 11 20;24(5):701-715. Epub 2016 Oct 20.

Lab of Tumor Inflammation and Angiogenesis, VIB, 3000 Leuven, Belgium; Lab of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.008DOI Listing
November 2016

The impact of hypoxia on tumor-associated macrophages.

J Clin Invest 2016 10 2;126(10):3672-3679. Epub 2016 Aug 2.

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http://dx.doi.org/10.1172/JCI84427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096805PMC
October 2016

Vessel Normalization in the Spot-LIGHT of Cancer Treatment.

Trends Mol Med 2016 Feb 7;22(2):85-87. Epub 2016 Jan 7.

Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, B3000 Leuven, Belgium; Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, KU Leuven, B3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2015.12.009DOI Listing
February 2016

Sixty shades of oxygen-an attractive opportunity for cancer immunotherapy.

Ann Transl Med 2015 Aug;3(13):187

1 Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven B3000, Belgium ; 2 Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, KU Leuven, Leuven B3000, Belgium.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2015.07.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543336PMC
August 2015

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

EMBO Mol Med 2015 Oct;7(10):1350-65

Lab of Molecular Oncology and Angiogenesis, Department of Oncology, KU Leuven, Leuven, Belgium Lab of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium

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http://dx.doi.org/10.15252/emmm.201505492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604688PMC
October 2015

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.

Cell Rep 2015 Aug 30;12(6):992-1005. Epub 2015 Jul 30.

Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.07.010DOI Listing
August 2015

MET is required for the recruitment of anti-tumoural neutrophils.

Nature 2015 Jun 18;522(7556):349-53. Epub 2015 May 18.

1] Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven B3000, Belgium [2] Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, KU Leuven, Leuven B3000, Belgium.

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http://dx.doi.org/10.1038/nature14407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594765PMC
June 2015

Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency.

Glia 2015 Sep 2;63(9):1606-20. Epub 2015 Apr 2.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven-University of Leuven, Cell Metabolism, Leuven, Belgium.

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http://dx.doi.org/10.1002/glia.22831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572738PMC
September 2015

Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival.

FASEB J 2015 Jul 2;29(7):2814-27. Epub 2015 Apr 2.

*Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, United Kingdom; Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium; Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, Katholieke Universiteit (KU) Leuven, Belgium; and Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, Greece

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http://dx.doi.org/10.1096/fj.14-252379DOI Listing
July 2015

Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer.

Gut 2016 06 26;65(6):990-1000. Epub 2015 Mar 26.

Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium Laboratory of Molecular Oncology and Angiogenesis, Department of Oncology, Vesalius Research Center, KU Leuven, Leuven, Belgium.

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http://gut.bmj.com/content/early/2015/03/26/gutjnl-2014-3089
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http://gut.bmj.com/cgi/doi/10.1136/gutjnl-2014-308988
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http://dx.doi.org/10.1136/gutjnl-2014-308988DOI Listing
June 2016

Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.

Nat Commun 2015 Feb 27;6:6385. Epub 2015 Feb 27.

1] Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172, 59045 Lille, France [2] University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114), 59045 Lille, France.

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http://dx.doi.org/10.1038/ncomms7385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351556PMC
February 2015

Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia.

FASEB J 2015 Mar 20;29(3):960-72. Epub 2014 Nov 20.

*Laboratory of Atherothrombosis, Division of Cardiovascular Sciences, and Cell Therapy Area, Division of Cancer, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain; Department of Vascular Surgery, Complejo Hopitalario de Navarra, Pamplona, Spain; Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium; Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, KU Leuven, Leuven, Belgium; and Small Animal Imaging Research Unit, CIMA and Clínica Universidad de Navarra, Pamplona, Spain

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http://dx.doi.org/10.1096/fj.14-259689DOI Listing
March 2015

Altering the intratumoral localization of macrophages to inhibit cancer progression.

Oncoimmunology 2014 Jan 14;3(1):e27872. Epub 2014 Feb 14.

Laboratory of Molecular Oncology and Angiogenesis; Vesalius Research Center; VIB; Leuven, Belgium ; Laboratory of Molecular Oncology and Angiogenesis; Vesalius Research Center; Department of Oncology; K.U. Leuven; Leuven, Belgium.

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http://dx.doi.org/10.4161/onci.27872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008455PMC
January 2014

Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A.

PLoS Biol 2014 Mar 11;12(3):e1001808. Epub 2014 Mar 11.

INSERM, Jean-Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Lille, France; UDSL, School of Medicine, Place de Verdun, Lille, France; Institut de Médecine Prédictive et de Recherche Thérapeutique, IFR114, Lille, France.

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http://dx.doi.org/10.1371/journal.pbio.1001808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949669PMC
March 2014

Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.

Cancer Cell 2013 Dec;24(6):695-709

Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, 3000 Leuven, Belgium; Laboratory of Molecular Oncology and Angiogenesis, Department of Oncology, Vesalius Research Center, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108130049
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http://dx.doi.org/10.1016/j.ccr.2013.11.007DOI Listing
December 2013

Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.

Cancer Res 2014 Jan 12;74(1):24-30. Epub 2013 Nov 12.

Authors' Affiliations: Laboratory of Myeloid Cell Immunology, VIB; Laboratory of Cellular and Molecular Immunology; Cell Differentiation Unit, Diabetes Research Centre, Vrije Universiteit Brussel; Biomedical Magnetic Resonance Unit, U.C. Louvain, Brussels; Laboratory of Molecular Oncology and Angiogenesis; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB; and Experimental Medicine and Endocrinology, Department of Experimental Medicine, K.U. Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1196DOI Listing
January 2014

The "cord of life" serving antiangiogenic therapy.

Blood 2013 May;121(21):4254-5

VIB-KU Leuven, Belgium.

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http://dx.doi.org/10.1182/blood-2013-03-489898DOI Listing
May 2013

Renal CD133(+)/CD73(+) progenitors produce erythropoietin under hypoxia and prolyl hydroxylase inhibition.

J Am Soc Nephrol 2013 Jul 9;24(8):1234-41. Epub 2013 May 9.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1681/ASN.2012080772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736703PMC
July 2013

miR-511-3p modulates genetic programs of tumor-associated macrophages.

Cell Rep 2012 Feb 9;1(2):141-54. Epub 2012 Feb 9.

Angiogenesis and Tumor Targeting Unit, and HSR-TIGET, Division of Regenerative Medicine, San Raffaele Institute, 20132-Milan, Italy.

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http://dx.doi.org/10.1016/j.celrep.2011.12.005DOI Listing
February 2012

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.

J Immunol 2012 Aug 11;189(4):1955-65. Epub 2012 Jul 11.

Department of General and Transplantation Surgery, University of Heidelberg, Heidelberg, D-69120 Germany.

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http://dx.doi.org/10.4049/jimmunol.1103471DOI Listing
August 2012

Overcoming resistance to antiangiogenic therapies.

Oncologist 2012 6;17(8):1039-50. Epub 2012 Jul 6.

Digestive Oncology Unit, University Hospital Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium.

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http://dx.doi.org/10.1634/theoncologist.2012-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425522PMC
April 2013

Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform.

EMBO Mol Med 2012 Mar 13;4(3):234-50. Epub 2012 Jan 13.

Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, Candiolo, Italy.

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http://dx.doi.org/10.1002/emmm.201100205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376853PMC
March 2012

Semaphorin signals on the road of endothelial tip cells.

Dev Cell 2011 Aug;21(2):189-90

Institute for Cancer Research, Laboratory of Cell Biology, University of Torino Medical School, 10060 Candiolo, Italy.

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http://dx.doi.org/10.1016/j.devcel.2011.07.017DOI Listing
August 2011

Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?

Nat Rev Clin Oncol 2011 May 31;8(7):393-404. Epub 2011 May 31.

Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, KU Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/nrclinonc.2011.83DOI Listing
May 2011

Growing tumor vessels: more than one way to skin a cat - implications for angiogenesis targeted cancer therapies.

Mol Aspects Med 2011 Apr 22;32(2):71-87. Epub 2011 Apr 22.

Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.mam.2011.04.001DOI Listing
April 2011

Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation.

Cancer Res 2010 Aug 3;70(16):6537-47. Epub 2010 Aug 3.

Laboratory of Experimental Medicine and Endocrinology, Vesalius Research Center, KU Leuven, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4092DOI Listing
August 2010

Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way.

Nat Rev Clin Oncol 2009 Jun;6(6):315-26

Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium.

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http://dx.doi.org/10.1038/nrclinonc.2009.64DOI Listing
June 2009

Role and therapeutic potential of VEGF in the nervous system.

Physiol Rev 2009 Apr;89(2):607-48

The Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium.

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http://dx.doi.org/10.1152/physrev.00031.2008DOI Listing
April 2009

Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited.

Cancer Cell 2009 Mar;15(3):167-70

Vesalius Research Center, VIB, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ccr.2009.02.007DOI Listing
March 2009

Regulation of angiogenesis by oxygen and metabolism.

Dev Cell 2009 Feb;16(2):167-79

Vesalius Research Center, Leuven, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S153458070900031
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http://dx.doi.org/10.1016/j.devcel.2009.01.003DOI Listing
February 2009