Massimiliano Bonafe

Massimiliano Bonafe

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Massimiliano Bonafe

Massimiliano Bonafe

Publications by authors named "Massimiliano Bonafe"

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88Publications

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Androgen receptor in breast cancer: A wolf in sheep's clothing? A lesson from prostate cancer.

Semin Cancer Biol 2019 Apr 16. Epub 2019 Apr 16.

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.04.002DOI Listing
April 2019

The telomere world and aging: Analytical challenges and future perspectives.

Ageing Res Rev 2019 Mar 4;50:27-42. Epub 2019 Jan 4.

Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2019.01.004DOI Listing
March 2019

Anticancer drug discovery using multicellular tumor spheroid models.

Expert Opin Drug Discov 2019 Mar 28;14(3):289-301. Epub 2019 Jan 28.

a Biosciences Laboratory , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.

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http://dx.doi.org/10.1080/17460441.2019.1570129DOI Listing
March 2019

Aberrant Metabolism in Hepatocellular Carcinoma Provides Diagnostic and Therapeutic Opportunities.

Oxid Med Cell Longev 2018 4;2018:7512159. Epub 2018 Nov 4.

Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.

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http://dx.doi.org/10.1155/2018/7512159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247426PMC
January 2019

Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging.

Semin Immunol 2018 12 15;40:6-16. Epub 2018 Sep 15.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna Italy; Bioscience Laboratory, Istituto Romagnolo per lo Studio e la Cura dei tumori IRST, IRCCS, Meldola, Forlì, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2018.08.003DOI Listing
December 2018

Inflammaging 2018: An update and a model.

Semin Immunol 2018 12 2;40:1-5. Epub 2018 Nov 2.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy; Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.

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http://dx.doi.org/10.1016/j.smim.2018.10.008DOI Listing
December 2018

Anti-senescence compounds: A potential nutraceutical approach to healthy aging.

Ageing Res Rev 2018 Sep 6;46:14-31. Epub 2018 May 6.

Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, INRCA-IRCCS National Institute, Ancona, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15681637183001
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http://dx.doi.org/10.1016/j.arr.2018.05.001DOI Listing
September 2018

Liquid biopsy in the diagnosis of HPV DNA in breast lesions.

Future Microbiol 2018 02 4;13:187-194. Epub 2017 Oct 4.

Department of Experimental, Diagnostic & Specialty Medicine, Alma Mater Studiorum, University of Bologna, 40138, Bologna, Italy.

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http://dx.doi.org/10.2217/fmb-2017-0145DOI Listing
February 2018

Exosome-based immunomodulation during aging: A nano-perspective on inflamm-aging.

Mech Ageing Dev 2017 12 1;168:44-53. Epub 2017 Mar 1.

August Pi i Sunyer Biomedical Research Institute (IDIBAPS) and Centre of Biomedical Investigation on Diabetes and Associated Metabolic Disorders Network (CIBERDEM), 08036 Barcelona, Spain; Center of Clinical Pathology and Innovative Therapy, National Institute INRCA-IRCCS, Ancona, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2017.02.008DOI Listing
December 2017

Senescence associated macrophages and "macroph-aging": are they pieces of the same puzzle?

Aging (Albany NY) 2016 12;8(12):3159-3160

IRCCS, Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy.

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http://dx.doi.org/10.18632/aging.101133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270660PMC
December 2016

Endothelial Cell Senescence and Inflammaging: MicroRNAs as Biomarkers and Innovative Therapeutic Tools.

Curr Drug Targets 2016 ;17(4):388-97

Department of Clinical and Molecular Sciences (DISCLIMO), Università Politecnica delle Marche, Ancona, Via Tronto 10/A - 60020 Ancona, Italy.

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http://dx.doi.org/10.2174/1389450116666150804105659DOI Listing
October 2016

Carbonic Anhydrase 9 mRNA/microRNA34a Interplay in Hypoxic Human Mammospheres.

J Cell Physiol 2016 Jul 30;231(7):1534-41. Epub 2015 Nov 30.

Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi University Hospital, Bologna, Italy.

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http://dx.doi.org/10.1002/jcp.25245DOI Listing
July 2016

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging.

Oncotarget 2015 Nov;6(34):35509-21

Department of Experimental, Diagnostic and Specialty Medicine, DIMES, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.18632/oncotarget.5899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742121PMC
November 2015

High-throughput genotyping of high-risk Human Papillomavirus by MALDI-TOF Mass Spectrometry-based method.

New Microbiol 2015 Apr 29;38(2):211-23. Epub 2015 Apr 29.

Center for Applied Biomedical Research - CRBA, University Hospital S.Orsola-Malpighi, Via Massarenti 9, 40138, Bologna, Italy.

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April 2015

Interleukin-6 and pro inflammatory status in the breast tumor microenvironment.

World J Surg Oncol 2015 Mar 28;13:129. Epub 2015 Mar 28.

Struttura Complessa di Chirurgia Generale e Specialità Chirurgiche Azienda Ospedaliera 'Santa Maria', University of Perugia Azienda Ospedaliera Terni, Viale Tristano di Joannuccio, 105100, Terni, Italy.

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http://www.wjso.com/content/13/1/129
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http://dx.doi.org/10.1186/s12957-015-0529-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397867PMC
March 2015

Circulating microRNAs in aging.

Oncotarget 2015 Jan;6(3):1340-1

Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, and Center of Clinical Pathology and Innovative Therapy, INRCA-IRCCS National Institute, Ancona, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359295PMC
http://dx.doi.org/10.18632/oncotarget.3175DOI Listing
January 2015

PPARγ and RXR ligands disrupt the inflammatory cross-talk in the hypoxic breast cancer stem cells niche.

J Cell Physiol 2014 Nov;229(11):1595-606

Department of Biological, Geological and Environmental Sciences, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1002/jcp.24601DOI Listing
November 2014

Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia.

PLoS One 2013 15;8(11):e80742. Epub 2013 Nov 15.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy ; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080742PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829939PMC
August 2014

Lamins are rapamycin targets that impact human longevity: a study in centenarians.

J Cell Sci 2014 Jan 23;127(Pt 1):147-57. Epub 2013 Oct 23.

National Research Council of Italy, Institute of Molecular Genetics, Unit of Bologna IOR, 40136 Bologna, Italy.

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http://dx.doi.org/10.1242/jcs.133983DOI Listing
January 2014

Slug/β-catenin-dependent proinflammatory phenotype in hypoxic breast cancer stem cells.

Am J Pathol 2013 Nov 12;183(5):1688-1697. Epub 2013 Sep 12.

Department of Experimental, Diagnostic and Specialty Medicine, St. Orsola-Malpighi University Hospital, Bologna, Italy; Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.07.020DOI Listing
November 2013

Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people.

Bioessays 2012 Jan 16;34(1):40-9. Epub 2011 Nov 16.

Department of Experimental Pathology, University of Bologna, Italy.

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http://doi.wiley.com/10.1002/bies.201100104
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http://dx.doi.org/10.1002/bies.201100104DOI Listing
January 2012

Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells.

Mol Cancer 2010 Nov 23;9:300. Epub 2010 Nov 23.

Center for Applied Biomedical Research (CRBA), St, Orsola-Malpighi University Hospital, via Massarenti 9, 40138 Bologna, Italy.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-9-300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002335PMC
November 2010

Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity.

Mol Cell Endocrinol 2009 Feb 5;299(1):118-23. Epub 2008 Nov 5.

Center for Applied Biomedical Research, (CRBA), St. Orsola-Malpighi University Hospital, Italy.

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http://dx.doi.org/10.1016/j.mce.2008.10.038DOI Listing
February 2009

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland.

J Clin Invest 2007 Dec;117(12):3988-4002

Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, Department of Pharmacology and Toxicology, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1172/JCI32533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096439PMC
December 2007

daf-16 protects the nematode Caenorhabditis elegans during food deprivation.

J Gerontol A Biol Sci Med Sci 2006 May;61(5):444-60

Institute for Behavioral Genetics, Box 447, University of Colorado, Boulder, CO 80309, USA.

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http://dx.doi.org/10.1093/gerona/61.5.444DOI Listing
May 2006

Tumor necrosis factor-alpha gene -308G>A polymorphism is associated with ST-elevation myocardial infarction and with high plasma levels of biochemical ischemia markers.

Coron Artery Dis 2005 Dec;16(8):489-93

Center of Molecular Biology, Department of Cardiology-CCU and Center of Statistics, Italian National Research Centers on Aging (I.N.R.C.A.), Ancona, Italy.

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December 2005

The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients.

Int J Cardiol 2005 Sep;103(3):266-71

Department of Cardiology, Center of Molecular Biology, Center of Statistics and Diabetologic Unit, Italian National Research Centers on Aging (INRCA), Via della Montagnola, 81, 60121 Ancona, Italy.

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http://dx.doi.org/10.1016/j.ijcard.2004.08.064DOI Listing
September 2005

Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity.

Exp Gerontol 2004 Jul;39(7):1095-100

Department of Geriatric Medicine and Metabolic Diseases, VI Divisione di Medicina Interna, II University of Naples, Piazza Miraglia 2, I-80138, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S053155650400139
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http://dx.doi.org/10.1016/j.exger.2004.03.034DOI Listing
July 2004

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans.

Am J Physiol Endocrinol Metab 2003 Nov;285(5):E1064-71

Department of Geriatric Medicine and Metabolic Diseases, University of Naples, 80138 Naples, Italy.

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http://ajpendo.physiology.org/content/ajpendo/285/5/E1064.fu
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http://ajpendo.physiology.org/lookup/doi/10.1152/ajpendo.002
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http://dx.doi.org/10.1152/ajpendo.00296.2003DOI Listing
November 2003

Immunoproteasomes and immunosenescence.

Ageing Res Rev 2003 Oct;2(4):419-32

Department of Experimental Pathology, University of Bologna, Via San Giacomo, 12, Bologna IT-40126, Italy.

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October 2003

Is chronic inflammation a determinant of blood pressure in the elderly?

Am J Hypertens 2003 Jul;16(7):537-43

Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Naples, Italy.

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http://dx.doi.org/10.1016/s0895-7061(03)00861-6DOI Listing
July 2003

p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes.

Biochem Biophys Res Commun 2002 Dec;299(4):539-41

Department of Experimental Pathology, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1016/s0006-291x(02)02691-8DOI Listing
December 2002

The -174 C/G locus affects in vitro/in vivo IL-6 production during aging.

Exp Gerontol 2002 Jan-Mar;37(2-3):309-14

Direzione Scientifica Italian National Research Centers on Aging (INRCA), Via S. Margherita, n.5, 60121 Ancona, Italy.

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http://dx.doi.org/10.1016/s0531-5565(01)00197-8DOI Listing
April 2002

Allele frequencies of +874T-->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians.

Exp Gerontol 2002 Jan-Mar;37(2-3):315-9

Laboratorio di Immunopatologia, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Corso Tukory 211, 90134 Palermo, Italy.

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http://dx.doi.org/10.1016/s0531-5565(01)00198-xDOI Listing
April 2002

LL-paraoxonase genotype is associated with a more severe degree of homeostasis model assessment IR in healthy subjects.

J Clin Endocrinol Metab 2002 Jan;87(1):222-5

Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, I-80138 Naples, Italy.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jce
Publisher Site
http://dx.doi.org/10.1210/jcem.87.1.8183DOI Listing
January 2002