Publications by authors named "Masoumeh Masoumpour"

18 Publications

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J AAPOS 2021 Feb 20. Epub 2021 Feb 20.

Department of Ophthalmology Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1016/j.jaapos.2020.11.009DOI Listing
February 2021

Intraocular Pressure Changes after Water Drinking Test in Surgically Treated Primary Congenital Glaucoma.

J Ophthalmic Vis Res 2020 Jul-Sep;15(3):318-325. Epub 2020 Aug 6.

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To assess intraocular pressure (IOP) changes after the water drinking test (WDT) in patients with primary congenital glaucoma (PCG).

Methods: In this prospective interventional study, 20 eyes of 20 patients with PCG were included. All patients had undergone trabeculotomy. Six out of twenty eyes had received a glaucoma drainage device (GDD) implantation. IOP was measured using an air-puff tonometer at baseline, and 15, 30, 45, and 60 min after WDT. The repeated-measures analysis of variance test was used to compare the mean IOPs at different time points.

Results: The mean ( standard deviation) of participants' age was 9.9 2.7 years (range, 6 to 16 years), and 8 (40%) participants were male. The mean IOPs at baseline and 15, 30, 45, and 60 minutes after the WDT were 15.8 3.7, 18.6 3.4, 19.0 3.8, 17.9 3.8, and 16.9 3.5 mmHg, respectively ( 0.001). Pairwise comparisons revealed that the mean IOPs after 15 and 30 min were significantly greater than the baseline IOP ( 0.001 and = 0.002, respectively); however, the difference in mean IOPs after 45 and 60 min were not statistically significant from the baseline IOP. The averages of IOP peak and IOP fluctuation after the WDT were 20.0 3.5 and 4.2 2.9 mmHg, respectively. IOP fluctuation in those who underwent trabeculotomy alone was twice that of those with GDDs, but the difference was not statistically significant (5.0 vs 2.5 mmHg; = 0.08).

Conclusion: In patients with PCG, WDT induced significant IOP elevation 15 and 30 min after the test, which returned to pre-test values after 45 min.
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http://dx.doi.org/10.18502/jovr.v15i3.7450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431708PMC
August 2020

Comparing the trabecular outflow by the response to topical pilocarpine in patients with and without glaucoma filtering surgery.

Jpn J Ophthalmol 2020 Nov 18;64(6):591-596. Epub 2020 Aug 18.

Glaucoma Research Center, Wills Eye Hospital, Philadelphia, PA, USA.

Purpose: To compare the trabecular outflow by the response to topical pilocarpine administration in patients with and without prior glaucoma filtering surgery.

Study Design: Prospective, cross-sectional, randomized, double-blinded study.

Methods: Open-angle glaucoma (OAG) patients without any prior glaucoma surgery, and those with prior trabeculectomy or tube shunt surgery aged 18-90 years were included. Both groups were randomized into pilocarpine or artificial tears (ATs). Intraocular pressure (IOP) was measured before and 90 min after the instillation of eye drops.

Results: A total of 189 eyes of 189 patients were included: 92 eyes in the pilocarpine and 97 eyes in the ATs group. There was a mean ± standard deviation of - 0.81 ± 3.08 mmHg decrease in IOP with pilocarpine in those without prior surgery, significantly higher than the ATs group (0.55 ± 2.31 mmHg; p = 0.02). No significant change in IOP with pilocarpine was noted in the surgical group compared to the ATs group (p = 0.90). In the surgery group, greater IOP reduction was observed with pilocarpine in those who had undergone surgery within the last three years than those who had surgery three or more years prior (- 1.56 ± 2.64 versus 1.41 ± 2.77 mmHg; p = 0.001).

Conclusion: Less IOP reduction was observed with pilocarpine in patients who had filtering surgery more than three years previously compared to those with more recent surgery.
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http://dx.doi.org/10.1007/s10384-020-00764-xDOI Listing
November 2020

Distribution of intraocular pressure in healthy Iranian children: the Shiraz Pediatric Eye Study.

J AAPOS 2020 06 6;24(3):155.e1-155.e6. Epub 2020 Jun 6.

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To describe the mean and normal range of intraocular pressure (IOP) and its associations in healthy Iranian school children using the noncontact tonometer.

Methods: In this cross-sectional study as part of the Shiraz Pediatric Eye Study, a stratified random sampling was performed among elementary school children of Shiraz, Iran. Basic demographics and socioeconomic status of households, past medical history, drug history, and eye health history were collected for each eligible student. Children underwent complete ophthalmic examination. Axial length, corneal curvature, and anterior chamber depth were measured using the IOL-Master 500.

Results: Of 2,001 eligible children, 1,901 (95.0%; 3,802 eyes) with a mean age of 9.1 ± 1.6 years (standard deviation; range, 6-12 years) had reliable IOP. The mean spherical equivalent refraction was 0.5 ± 1.3 D for the right eye and 0.6 ± 1.2 D for the left eye. Mean IOP in the right eye was 15.1 ± 2.5 mm Hg (median, 15.0; range, 8.0-27.0 mm Hg); in the left eye, 15.2 ± 2.5 mm Hg (median, 15.0; range, 9.0-28.0 mm Hg). In multiple regression analyses, the mean IOP was significantly lower among asthmatic children compared to normal participants (P = 0.007). The measured IOP was significantly higher in myopic participants than hyperopic patients (P = 0.003).

Conclusions: This study provides a useful normative IOP database using the noncontact tonometer for healthy Iranian school children.
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http://dx.doi.org/10.1016/j.jaapos.2018.07.358DOI Listing
June 2020

Psychometric properties of the Glaucoma Quality of Life-15 questionnaire: Use of explanatory factor analysis.

J Curr Ophthalmol 2018 Sep 17;30(3):211-216. Epub 2018 Jan 17.

Glaucoma Research Center, Wills Eye Hospital, Philadelphia, PA, USA.

Purpose: The purposes of this study were to validate the Persian translation of the Glaucoma Quality of Life-15 (GQL-15) questionnaire, evaluate its psychometric properties, and identify new composite items and item numbers.

Methods: This cross-sectional study was conducted from August to November 2016, at the Glaucoma Clinic of the Ophthalmology Department at Shiraz University of Medical Sciences, Iran. One hundred ninety patients with glaucoma were enrolled. Habitual-corrected visual acuity (HCVA), intraocular pressure (IOP), slit-lamp biomicroscopy, fundus exam, and mean deviation (MD) of the visual field were recorded in the course of clinical examination by glaucoma professional. Psychometric properties, i.e. test-retest reliability, internal consistency, content validity, and construct validity were evaluated with factor analysis. Based on the Disc Damage Likelihood Scale (DDLS), patients were stratified to mild, moderate, and severe disc damage. The association between the GQL-15 scores and disease severity (mild, moderate and severe) were evaluated by the analysis of variance (ANOVA).

Results: Of 190 eligible glaucoma patients, reliable clinical data were available for 140 participants. Mean age [standard deviation (SD)] of the patients was 58.7 (13.3) years. Cronbach's α coefficient ranged from 0.74 to 0.91, and the correlation coefficient for total score was 0.53. The content validity ratio (CVR) was 0.91 based on evaluations in expert panel. Exploratory factor analysis (EFA) based on eigenvalue higher than one identified two factors after varimax rotation for the GQL-15 which explained 66.5% of the total variance. Discriminant validity analysis disclosed statistically significant differences in mean quality of life scores between levels of disease severity.

Conclusion: The Persian version of the GQL-15 is a reliable and valid questionnaire for use in glaucoma clinics as a complementary tool for evidence-based decision-making.
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http://dx.doi.org/10.1016/j.joco.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127367PMC
September 2018

The Shiraz Pediatric Eye Study; a Population Based Survey of School Age Children: Rationale, Design and Baseline Characteristics.

J Ophthalmic Vis Res 2018 Jul-Sep;13(3):293-300

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To describe the rationale, study design, methodology, and baseline characteristics of the Shiraz Pediatric Eye Study, a population-based survey of schoolchildren in Shiraz, Iran.

Methods: This population-based study included schoolchildren aged 6-12 years from all four educational districts of Shiraz who were recruited in years 2015-2016. Stratified random sampling was used to select 2400 participants from all districts. Data were recorded from a detailed interview and ocular evaluation of each eligible student. The eye examination comprised uncorrected and best corrected visual acuity measurement, refraction, external eye examination (including specific strabismus and lid evaluation tests), slit lamp biomicroscopy, intraocular pressure measurement, the Ishihara color vision test, and stereoacuity. Exophthalmometry, optical biometry, and optical coherence tomography were performed for a randomly selected subset of children. General characteristics and socioeconomic variables were also recorded to assess risk factors.

Results: From a total of 2400 selected students, 2001 (83.3%) participated in the study. The mean age of the students was 9.1 ± 1.6 years, and 59.7% were girls. Most children had at least one parent with a diploma or less than diploma (63.5%), and 2.2% had illiterate parents.

Conclusion: This study is expected to provide accurate estimates of the prevalence of visual impairments and their related determinants in Shiraz. In addition, it will identify children who should be targeted by blindness prevention programs.
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http://dx.doi.org/10.4103/jovr.jovr_246_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058549PMC
August 2018

Is Corneal Arcus Independently Associated With Incident Cardiovascular Disease in Asians?

Am J Ophthalmol 2018 04 9;188:184-185. Epub 2018 Feb 9.

Shiraz, Iran.

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http://dx.doi.org/10.1016/j.ajo.2017.12.027DOI Listing
April 2018

Results for Water-drinking Test, before and after Laser Iridotomy, in Primary Angle-closure Suspects.

Optom Vis Sci 2018 02;95(2):150-154

Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Significance: Intraocular pressure and ocular biometric changes were similar before and after laser iridotomy in response to the water-drinking test in a cohort of patients at risk of angle closure. The water-drinking test does not seem to be a good provocative test to determine which eyes would benefit from a laser iridotomy. Our data call into question the preoperative predictive value of this test.

Purpose: The aim of this study was to evaluate the effect of water-drinking test on intraocular pressure and ocular biometric parameters, before and after laser peripheral iridotomy, in patients with an occludable angle.

Methods: Twenty-seven patients, who met the inclusion criteria and had at least 180 degrees of iridotrabecular apposition, underwent a complete eye examination followed by the measurement of ocular biometric (using LenStar LS-900; Haag-Streit AG, Koeniz, Switzerland) and anterior chamber parameters (using Pentacam HR; Oculus Optikgerate GmbH, Wetzlar, Germany). All the measurements were repeated 30 minutes after the water-drinking test. Two weeks after laser peripheral iridotomy, all the measurements were repeated both before and after the water-drinking test.

Results: The mean ± SD of the age of the participants was 57 ± 9 years, and 23 (85.2%) were male. Intraocular pressure increased after the water-drinking test in both pre-laser peripheral iridotomy (17.0 vs. 19.3 mmHg, P < .001) and post-laser peripheral iridotomy (15.6 vs. 18.6 mmHg, P < .001) conditions. The thickness values of central cornea increased slightly after the water-drinking test in pre-laser peripheral iridotomy (535 vs. 538 μm, P = .001) compared with post-laser peripheral iridotomy (532 vs. 536 μm, P = .003). The water-drinking test had no significant effect on other biometric or anterior chamber parameters, before or after laser peripheral iridotomy.

Conclusions: The water-drinking test increased intraocular pressure, both before and after laser peripheral iridotomy. Laser peripheral iridotomy had no significant effect on the amount of intraocular pressure change after the water-drinking test. The water-drinking test has no effect on other biometric or anterior chamber parameters.
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http://dx.doi.org/10.1097/OPX.0000000000001167DOI Listing
February 2018

Water Drinking Test: Intraocular Pressure Changes after Tube Surgery and Trabeculectomy.

J Ophthalmic Vis Res 2017 Oct-Dec;12(4):390-396

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To study the effects of filtration surgeries (tube and trabeculectomy) on changes in intraocular pressure after a water-drinking test.

Methods: In this prospective, non-randomized, comparative clinical study, 30 patients who had tube surgery and 30 age- and sex-matched trabeculectomy patients underwent a water-drinking test. Only one eye of each patient was included. The baseline intraocular pressure was ≤21 mmHg in all enrolled eyes with or without adjunctive topical medications. After the water-drinking test, the intraocular pressure was measured and recorded at 15, 30, 45, and 60 minutes and the results were compared between the two groups.

Results: In both groups, intraocular pressure significantly increased from baseline at all measured time-points ( < 0.001). In the trabeculectomy group, the average intraocular pressure increased from 14.8 ± 2.9 to 18.8 ± 4.7 mmHg at 30 minutes, but decreased at 60 min (18.0 ± 5.2 mmHg). In the Tube group, intraocular pressure increased incrementally until the last measurement (14.2 ± 3.9, 18.8 ± 5.6, and 19.7 ± 6.0 mmHg at baseline, 30, and 60 minutes, respectively). The end-pressure difference (intraocular pressure at 60 minutes vs. baseline) was significantly greater in the tube group (5.6 ± 3.6 mmHg; 41% change) than in the trabeculectomy group (3.2 ± 4.7; 23% change; = 0.03).

Conclusion: Intraocular pressure significantly increased after the water-drinking test in both the groups. Intraocular pressure started to decline 30 minutes after the water-drinking test in the trabeculectomy group, while it continued to increase up to 60 minutes in the Tube group. This finding may have implications regarding the efficacy or safety of the procedures in advanced glaucoma patients.
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http://dx.doi.org/10.4103/jovr.jovr_204_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644405PMC
November 2017

Evaluation of topical bevacizumab as an adjunct to mitomycin C augmented trabeculectomy.

J Curr Ophthalmol 2017 Jun 27;29(2):85-91. Epub 2016 Dec 27.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To investigate the safety and synergistic effect of topical bevacizumab after trabeculectomy surgery with mitomycin C (MMC).

Methods: In this prospective, non-randomized, comparative interventional study, 40 eyes from 40 patients with uncontrolled open-angle glaucoma were studied after they underwent primary trabeculectomy with mitomycin C (0.02% for 2 min). Following the procedure topical bevacizumab (4 mg/mL) was used for 2 weeks 4 times daily in group A. Patients in group B received routine postoperative care. The outcome measures were the intraocular pressure (IOP), number of anti-glaucoma medications, complications, and bleb evaluation.

Results: Of the 32 eyes that had at least 6 months follow-up, 16 were treated with adjuvant topical bevacizumab. The mean preoperative IOP in group A improved from 26.7 ± 9.3 mmHg with 2.8 ± 1.3 anti-glaucoma medications to 10.5 ± 2.8 mmHg with 0.7 ± 1 anti-glaucoma medications at last follow-up ( < 0.001). The mean preoperative IOP in group B improved from 21.8 ± 6.6 mmHg with 3 ± 0.8 anti-glaucoma medications to 11.4 ± 3.6 mmHg with 0.8 ± 1.2 anti-glaucoma medications at last follow-up ( < 0.001). There was an overall reduction of 54.4% and 43.7% in the IOP in groups A and B, respectively ( = 0.18). The cystic type of bleb was less common in group A ( = 0.043). One patient in group A developed a streptococcal corneal ulcer 1.5 months after surgery.

Conclusion: Administration of topical bevacizumab 4 mg/ml for two weeks following trabeculectomy with mitomycin-C did not significantly affect the IOP trend, but significantly decreased the cystic bleb formation in short-term follow-up.
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http://dx.doi.org/10.1016/j.joco.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463009PMC
June 2017

Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children.

Ophthalmol Ther 2016 Dec 5;5(2):235-243. Epub 2016 Oct 5.

Department of Ophthalmology, Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: This study aimed to determine intraocular pressure (IOP) and central corneal thickness (CCT) measurements in healthy Persian children to find clinical reference values in this ethnicity. Additionally, we examined the possible relationship between these measurements.

Methods: This cross-sectional study included 262 eyes of 131 Persian primary school children between 6 and 13 years of age. All eyes were healthy and had no anterior or posterior segment abnormalities, corneal disease, or evidence of glaucoma. Specular microscopy was used to measure CCT and both noncontact tonometry (NCT) and Goldmann applanation tonometer (GAT) were used to measure IOP. Correlations between IOP measurements were also examined.

Results: Mean CCT was 513.47 ± 34.51 μm in the right eye (OD) and 513.93 ± 33.88 μm in the left eye (OS). The CCT was not significantly different between older (10-13 years) and younger (6-9 years) patients. Mean IOP measured with GAT was 13.86 ± 2.13 mmHg OD and 13.72 ± 2.04 mmHg OS and mean IOP measured with NCT was 15.26 ± 2.38 mmHg OD and 15.11 ± 2.18 mmHg OS. The IOP and CCT measured with GAT were weakly correlated (OD: r = 0.141, P = 0.114; OS: r = 0.236, P = 0.007). However, IOP and CCT measured with NCT (OD: r = 0.487, P = 0.000; OS: r = 0.456, P = 0.000) were moderately correlated. Our outcomes demonstrated that for 100 μm increase in CCT, IOP measured with GAT and NCT increased by 0.8 and 3.3 mmHg, respectively, in OD and by 1.4 and 2.9 mmHg in OS. Based on intraclass correlation coefficients, IOP measurements made with GAT and NCT were in fair agreement in OD and in good agreement in OS.

Conclusion: The IOP and CCT in healthy Persian school children (6-13 years old) were positively correlated. Our findings revealed that corneal thickness is thinner in Persian children than in most other racial groups.

Funding: This study has been funded by deputy dean in research of School of Medicine and deputy vice chancellor of Shiraz University of Medical Sciences, Shiraz, Iran.
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http://dx.doi.org/10.1007/s40123-016-0063-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125124PMC
December 2016

Glaucoma Surgery in Pregnancy: A Case Series and Literature Review.

Iran J Med Sci 2016 Sep;41(5):437-45

Glaucoma Service, Wills Eye Institute, Jefferson Medical College, Philadelphia, USA.

Glaucoma management in pregnant patients is a real challenge, especially when the glaucoma is not controlled with medications. We report the results of 6 incisional glaucoma surgeries for the management of medically uncontrolled glaucoma patients during pregnancy. This retrospective, case series was conducted on the 6 eyes of 3pregnant patients with uncontrolled glaucoma using maximum tolerable medications. Details of the glaucoma surgical management of these patients as well as their postoperative care and pregnancy and clinical outcomes on longitudinal follow-up are discussed. All 3 patients had juvenile open-angle glaucoma and were on various anti-glaucoma medications, including oral acetazolamide. The first case described underwent trabeculectomy without antimetabolites in both eyes because of uncontrolled intraocular pressure with topical medications. The surgery was done with topical lidocaine jelly and subconjunctival lidocaine during the second and third trimesters. The second patient had an Ahmed valve implantation in both eyes during the second and third trimesters because of uncontrolled IOP with topical medications and no response to selective laser trabeculoplasty. Surgery was done with topical tetracaine and subconjunctival and sub-Tenon's lidocaine. The third case had a Baerveldt valve implantation under general anesthesia in the second trimester. In selected pregnant glaucoma patients with medically uncontrolled intraocular pressure threatening vision, incisional surgery may lead to good outcomes for the patient with no risk for the fetus.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967489PMC
September 2016

Current and Future Techniques in Wound Healing Modulation after Glaucoma Filtering Surgeries.

Open Ophthalmol J 2016 29;10:68-85. Epub 2016 Feb 29.

Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA.

Filtering surgeries are frequently used for controlling intraocular pressure in glaucoma patients. The long-term success of operation is intimately influenced by the process of wound healing at the site of surgery. Indeed, if has not been anticipated and managed accordingly, filtering surgery in high-risk patients could end up in bleb failure. Several strategies have been developed so far to overcome excessive scarring after filtering surgery. The principal step involves meticulous tissue handling and modification of surgical technique, which can minimize the severity of wound healing response at the first place. However, this is usually insufficient, especially in those with high-risk criteria. Thus, several adjuvants have been tried to stifle the exuberant scarring after filtration surgery. Conventionally, corticosteroids and anti-fibrotic agents (including 5-fluorouracil and Mitomycin-C) have been used for over three decades with semi-acceptable outcomes. Blebs and bleb associated complications are catastrophic side effects of anti-fibrotic agents, which occasionally are encountered in a subset of patients. Therefore, research continues to find a safer, yet effective adjuvant for filtering surgery. Recent efforts have primarily focused on selective inhibition of growth factors that promote scarring during wound healing process. Currently, only anti-VEGF agents have gained widespread acceptance to be translated into routine clinical practice. Robust evidence for other agents is still lacking and future confirmative studies are warranted. In this review, we explain the importance of wound healing process during filtering surgery, and describe the conventional as well as potential future adjuvants for filtration surgeries.
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http://dx.doi.org/10.2174/1874364101610010068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780518PMC
March 2016

Changes in corneal endothelial cell profile measurements after deep anterior lamellar keratoplasty for keratoconus.

Cornea 2013 Jun;32(6):751-6

Department of Ophthalmology, Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: The primary objective was to evaluate whether postoperative alterations in corneal shape (as reflected by keratometry values) affect endothelial cell profile measurements after deep anterior lamellar keratoplasty (DALK) in a group of patients with keratoconus. Secondary objective was to describe the pattern of changes in corneal endothelial cell profile measurements during the first 3 years after DALK.

Methods: In this prospective interventional case series, we enrolled patients who had significant keratoconus and were scheduled for DALK (Melles technique). Cases with concomitant intraocular surgeries, intra-/postoperative complications, and poor quality of images were excluded.

Results: Two hundred one eyes and 45 eyes (of the original 201) were enrolled for evaluating the primary and the secondary objectives, respectively. At 3 months post DALK, the mean endothelial cell density (ECD) had significantly increased and the mean cell area had decreased compared with preoperative measurements (2721 vs. 2823 cells/mm2, P = 0.015; and 378 vs. 362 μm2, P = 0.005, respectively). Regression analysis revealed a weak but significant nonlinear association between changes in mean keratometry and ECD changes at 3 months (R2 = 0.039, P = 0.02). Standard deviation of mean cell area had significantly decreased at 12 months after DALK compared with measurements taken at 3 months after surgery (P = 0.023) and remained stable thereafter.

Conclusions: Apparent measurements of ECD may not show a decrease but instead even a slight increase in some cases after uncomplicated DALK (Melles technique) for keratoconus. This finding along with a later decrease in standard deviation of mean cell area suggests that notable postoperative changes in corneal biomechanical forces may affect endothelial cell profile measurements.
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http://dx.doi.org/10.1097/ICO.0b013e31826cbd44DOI Listing
June 2013

Clinical and epidemiologic characteristics of severe childhood ocular injuries in southern iran.

Middle East Afr J Ophthalmol 2011 Apr;18(2):136-40

Poostchi Ophthalmology Research Center, Shiraz School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To evaluate the clinical and epidemiological characteristics of children with ocular trauma.

Materials And Methods: We retrospectively reviewed the medical records of 278 children (aged 15 years or less) hospitalized with ocular injuries and treated as inpatients at a tertiary referral center in Shiraz, Iran, from 2005 to 2008. Nominal variables were evaluated with a Chi-square test. A P-value less than 0.05 indicated statistical significance.

Results: The cohort was comprised of 205 (74%) males, outnumbering females by a ratio of 2.81/1. The mean age was 7.6 ± 3.96 years. Rural residents comprised 125 (45%) of the cohort. Sharp objects caused ocular injury in 211 (76%) cases, and 207 (74%) cases had open-globe injuries. The lens was injured in 62 (30%) cases at initial examination and 89 (43%) patients according to ultrasound examination (P = 0.006). Twenty-eight cases (10%) developed post-traumatic endophthalmitis. Endophthalmitis was associated with needle injury [odd ratio (OR) = 19.25] and presence of intraocular foreign body (OR = 3.48). Visual acuity of patients with closed-globe injuries was 20/200 or better on both initial and final examinations. Visual acuity of patients with open-globe injuries were in the range of light perception to 20/200.

Conclusions: Trauma is an important cause of childhood ocular morbidity in southern Iran. Playing with sharp objects is an important cause of ocular trauma in children, and most injuries can be prevented by careful supervision.
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http://dx.doi.org/10.4103/0974-9233.80702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119282PMC
April 2011

Anatomical retinal reattachment after scleral buckling with and without retinopexy: a pilot study.

Acta Ophthalmol 2008 May;86(3):297-301

Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To compare the anatomical results of scleral buckling with and without retinopexy and to assess the effect of retinopexy on the scleral buckling outcome.

Methods: This randomized clinical trial was performed on 55 patients. Twenty-two eyes were treated with scleral buckling (segmental or encircling) with or without drainage of subretinal fluid without any type of retinopexy (group 1); 33 patients received transscleral retinal cryopexy around retinal break(s) in addition to the former procedure. The two groups were matched regarding age, sex, myopia, aphakia, stage of proliferative vitroretinopathy (PVR) and number, type and location of the break(s).

Results: In the non-retinopexy group, 19 patients (86%) had complete retinal reattachment and one patient had partial reattachment after 34-48 months of follow-up. One patient did not develop attachment because of missed break out of the buckle, and one had no attachment at all because of PVR. Overall success rate was 91% (20 of 22) in this group. In the retinal cryopexy group, 26 patients (79%) had complete retinal reattachment and two had partial reattachment during 35-56 months of follow-up. In two patients, no attachment was achieved because of missed break out of the buckle; three patients developed redetachment after 1 and 3 months because of PVR. Overall success rate was 85% (28 of 33). The anatomical results in these two groups were the same statistically.

Conclusion: With the permanent scleral buckling technique, retinal cryopexy adds no benefit to the success rate of anatomical retinal reattachment.
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http://dx.doi.org/10.1111/j.1600-0420.2007.01037.xDOI Listing
May 2008

Chiari type capital I, Ukrainian malformation associated with morning glory disc anomaly.

J Neuroophthalmol 2006 Dec;26(4):279-81

Department of Ophthalmology, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Morning glory disc anomaly (MGDA) is a congenital malformation of the optic disc that has been reported in association with midline craniofacial defects such as basal encephalocele, hypertelorism, cleft lip and palate, and agenesis of the corpus callosum. We describe a 44 year-old woman with MGDA and Chiari type capital I, Ukrainian malformation, an association not previously reported.
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http://dx.doi.org/10.1097/01.wno.0000249325.57604.34DOI Listing
December 2006