Publications by authors named "Masoud Vedadi"

100Publications

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.

Open Biol 2020 06 24;10(6):200041. Epub 2020 Jun 24.

Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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http://dx.doi.org/10.1098/rsob.200041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333892PMC
June 2020

Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.

J Med Chem 2020 05 14;63(10):5477-5487. Epub 2020 May 14.

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.0c00406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286362PMC
May 2020

Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro.

Cell Discov 2019 24;5:63. Epub 2019 Dec 24.

1Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX USA.

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http://dx.doi.org/10.1038/s41421-019-0136-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928010PMC
December 2019

Chemical probes for protein arginine methyltransferases.

Methods 2020 03 3;175:30-43. Epub 2019 Dec 3.

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2019.11.017DOI Listing
March 2020

Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain.

J Med Chem 2019 11 12;62(22):10144-10155. Epub 2019 Nov 12.

Structural Genomics Consortium, University of Toronto, MaRS Centre , South Tower, 101 College St., Suite 700 , Toronto , Ontario M5G 1L7 , Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00988DOI Listing
November 2019

Identification and characterization of the first fragment hits for SETDB1 Tudor domain.

Bioorg Med Chem 2019 09 12;27(17):3866-3878. Epub 2019 Jul 12.

Structural Genomics Consortium, University of Toronto, Toronto, Canada; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.07.020DOI Listing
September 2019

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).

J Med Chem 2019 10 24;62(20):8996-9007. Epub 2019 Jul 24.

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00522DOI Listing
October 2019

Discovery of selective activators of PRC2 mutant EED-I363M.

Sci Rep 2019 04 25;9(1):6524. Epub 2019 Apr 25.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.

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http://dx.doi.org/10.1038/s41598-019-43005-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484020PMC
April 2019

Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.

Nat Chem Biol 2019 08;15(8):846

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNCEshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/s41589-019-0242-5DOI Listing
August 2019

Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).

J Med Chem 2018 02 31;61(4):1541-1551. Epub 2018 Jan 31.

Center for Chemical Biology and Drug Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823789PMC
February 2018

Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.

Bioorg Med Chem 2017 08 19;25(16):4414-4423. Epub 2017 Jun 19.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562403PMC
August 2017

Molecular basis for the methylation specificity of ATXR5 for histone H3.

Nucleic Acids Res 2017 Jun;45(11):6375-6387

Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.

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http://dx.doi.org/10.1093/nar/gkx224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499861PMC
June 2017

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

ACS Comb Sci 2017 03 22;19(3):161-172. Epub 2017 Feb 22.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/acscombsci.6b00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376495PMC
March 2017

Targeting human SET1/MLL family of proteins.

Protein Sci 2017 04 6;26(4):662-676. Epub 2017 Mar 6.

Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7.

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http://dx.doi.org/10.1002/pro.3129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368065PMC
April 2017

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.

J Med Chem 2017 03 14;60(5):1876-1891. Epub 2017 Feb 14.

Department of Pharmacological Sciences and Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352984PMC
March 2017

Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.

J Med Chem 2016 11 2;59(21):9881-9889. Epub 2016 Nov 2.

Department of Pharmacological Sciences and Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148670PMC
November 2016

Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.

ACS Infect Dis 2016 09 3;2(9):627-641. Epub 2016 Aug 3.

Department of Biochemistry and Molecular Biology, Tulane School of Medicine , New Orleans, Louisiana 70112, United States.

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http://dx.doi.org/10.1021/acsinfecdis.6b00090DOI Listing
September 2016

A Suite of Biochemical Assays for Screening RNA Methyltransferase BCDIN3D.

SLAS Discov 2017 01 27;22(1):32-39. Epub 2016 Sep 27.

1 Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1087057116666276DOI Listing
January 2017

New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.

Bioorg Med Chem Lett 2016 09 21;26(18):4518-4522. Epub 2016 Jul 21.

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.07.041DOI Listing
September 2016

Structural basis of arginine asymmetrical dimethylation by PRMT6.

Biochem J 2016 10 1;473(19):3049-63. Epub 2016 Aug 1.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5J 1L7, Canada Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1042/BCJ20160537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5280038PMC
October 2016

Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.

J Med Chem 2016 08 11;59(16):7617-33. Epub 2016 Aug 11.

Departments of Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, Room 16-20B, Box 1677, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003625PMC
August 2016

Global Profiling of Acetyltransferase Feedback Regulation.

J Am Chem Soc 2016 05 17;138(20):6388-91. Epub 2016 May 17.

Chemical Biology Laboratory, National Cancer Institute , Frederick, Maryland 21702, United States.

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http://dx.doi.org/10.1021/jacs.6b03036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320254PMC
May 2016

PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase.

J Biol Chem 2016 Jun 29;291(26):13509-19. Epub 2016 Apr 29.

From the Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, the Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

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http://dx.doi.org/10.1074/jbc.M116.721472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919437PMC
June 2016

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.

Nat Chem Biol 2016 Mar 25;12(3):180-7. Epub 2016 Jan 25.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nchembio.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755828PMC
March 2016

A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5.

J Biomol Screen 2016 Mar 23;21(3):290-7. Epub 2015 Dec 23.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1177/1087057115623264DOI Listing
March 2016

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

ACS Chem Biol 2016 Mar 8;11(3):772-781. Epub 2015 Dec 8.

Departments of Structural and Chemical Biology, Oncological Sciences, and Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acschembio.5b00839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798913PMC
March 2016

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

Cancer Res 2015 Dec 15;75(23):5143-54. Epub 2015 Oct 15.

Children's Cancer Institute Australia, Randwick, Sydney, New South Wales, Australia. School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Randwick, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0423DOI Listing
December 2015

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.

Nature 2015 Sep 2;525(7568):206-11. Epub 2015 Sep 2.

Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature15251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568559PMC
September 2015

Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells.

Clin Epigenetics 2015 21;7:84. Epub 2015 Aug 21.

Department of Surgery and Cancer, Ovarian Cancer Action Research Centre, Imperial College London, Hammersmith Hospital Campus, London, W12 ONN UK ; Section of Molecular Pathology, Institute of Cancer Research, Sutton, SM2 5NG UK.

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http://dx.doi.org/10.1186/s13148-015-0118-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545913PMC
August 2015

Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2.

Biochim Biophys Acta 2015 Sep 19;1850(9):1842-8. Epub 2015 May 19.

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2015.05.013DOI Listing
September 2015

Discovery of a Dual PRMT5-PRMT7 Inhibitor.

ACS Med Chem Lett 2015 Apr 2;6(4):408-12. Epub 2015 Mar 2.

Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada ; The Department of Pharmacology and Toxicology, University of Toronto , Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1021/ml500467hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394339PMC
April 2015

Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.

Medchemcomm 2014 Dec 11;5(12):1821-1828. Epub 2014 Sep 11.

Department of Chemistry , Imperial College London , London SW7 2AZ , UK . Email: m. ; ; Tel: +44 (0)2075945815.

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http://xlink.rsc.org/?DOI=C4MD00274A
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http://dx.doi.org/10.1039/c4md00274aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349132PMC
December 2014

Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.

J Med Chem 2014 Aug 25;57(15):6822-33. Epub 2014 Jul 25.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, ‡Department of Pharmacology, School of Medicine, §Lineberger Comprehensive Cancer Center, and ∥Department of Biochemistry and Biophysics, UNC Macromolecular Interactions Facility, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/jm500871sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136711PMC
August 2014

A scintillation proximity assay for histone demethylases.

Anal Biochem 2014 Oct 8;463:54-60. Epub 2014 Jul 8.

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2014.06.023DOI Listing
October 2014

Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.

Nat Commun 2014 May 23;5:3952. Epub 2014 May 23.

1] Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan 430079, PR China [2] Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario, Canada M5G 1L7 [3] Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1038/ncomms4952DOI Listing
May 2014

A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro.

J Biomol Screen 2014 Jul 4;19(6):928-35. Epub 2014 Mar 4.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1177/1087057114525854DOI Listing
July 2014

A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a.

ChemMedChem 2014 Mar 17;9(3):549-53. Epub 2014 Jan 17.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/cmdc.201300450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005005PMC
March 2014

Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.

PLoS One 2013 19;8(12):e83737. Epub 2013 Dec 19.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada ; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083737PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868588PMC
October 2014

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

J Med Chem 2013 Nov 31;56(21):8931-42. Epub 2013 Oct 31.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, ‡National Institute of Mental Health Psychoactive Drug Screening Program, §Department of Pharmacology, School of Medicine, and ∥Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/jm401480rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880643PMC
November 2013

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

ACS Chem Biol 2013 24;8(6):1324-34. Epub 2013 Apr 24.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, §Department of Biochemistry and Biophysics, School of Medicine, ∥Department of Pharmacology, School of Medicine, ⊥National Institute of Mental Health Psychoactive Drug Screening Program, and ¶Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/cb400133jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773059PMC
August 2014

Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.

J Med Chem 2013 Mar 27;56(5):2110-24. Epub 2013 Feb 27.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/jm3018332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319713PMC
March 2013

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.

Bioorg Med Chem 2013 Apr 30;21(7):1787-1794. Epub 2013 Jan 30.

Structural Genomics Consortium, University of Toronto; 101 College Street, MaRS Centre, South tower, Toronto, Ontario, M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.bmc.2013.01.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780262PMC
April 2013

Strategy to target the substrate binding site of SET domain protein methyltransferases.

J Chem Inf Model 2013 Mar 1;53(3):681-91. Epub 2013 Mar 1.

Structural Genomics Consortium, University of Toronto , MaRS Centre, South Tower, seventh floor, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.

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http://dx.doi.org/10.1021/ci300596xDOI Listing
March 2013

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.

Sci Signal 2012 May 29;5(226):ra39. Epub 2012 May 29.

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1126/scisignal.2002979DOI Listing
May 2012

Thermal denaturation assays in chemical biology.

Assay Drug Dev Technol 2012 Apr 8;10(2):128-36. Epub 2011 Nov 8.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.

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http://www.liebertpub.com/doi/10.1089/adt.2011.0390
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http://dx.doi.org/10.1089/adt.2011.0390DOI Listing
April 2012

Fluorescence-based methods for screening writers and readers of histone methyl marks.

J Biomol Screen 2012 Jan 4;17(1):71-84. Epub 2011 Oct 4.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.

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http://journals.sagepub.com/doi/10.1177/1087057111422256
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http://dx.doi.org/10.1177/1087057111422256DOI Listing
January 2012

Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

J Med Chem 2011 Sep 5;54(17):6139-50. Epub 2011 Aug 5.

Center for Integrative Chemical Biology and Drug Discovery, Division of Medicinal Chemistry and Natural Products, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1021/jm200903zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171737PMC
September 2011