Mason Breitzig - Washington University in St. Louis

Mason Breitzig

Washington University in St. Louis

St. Louis, MO | United States

Mason Breitzig - Washington University in St. Louis

Mason Breitzig

Introduction

Primary Affiliation: Washington University in St. Louis - St. Louis, MO , United States

Publications

15Publications

382Reads

217Profile Views

16PubMed Central Citations

Remission of fibrosis: rage to the rescue.

J Cell Commun Signal 2019 Mar 15;13(1):119-120. Epub 2018 Sep 15.

Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612, USA.

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http://link.springer.com/10.1007/s12079-018-0474-2
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http://dx.doi.org/10.1007/s12079-018-0474-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381376PMC
March 2019
8 Reads

Therapeutic effects of the rhSOD2-Hirudin fusion protein on bleomycin-induced pulmonary fibrosis in mice.

Eur J Pharmacol 2019 Mar 1. Epub 2019 Mar 1.

Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, MDC 19, Tampa, FL 33612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2019.03.001DOI Listing
March 2019
2.532 Impact Factor

miR-330-3p promotes lung cancer cells invasion, migration, and metastasis by directly targeting hSOD2b.

Biotechnol Appl Biochem 2019 Jan 15;66(1):21-32. Epub 2018 Oct 15.

Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou, People's Republic of China.

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http://dx.doi.org/10.1002/bab.1691DOI Listing
January 2019
10 Reads
1.362 Impact Factor

Thyroid hormone: a resurgent treatment for an emergent concern.

Am J Physiol Lung Cell Mol Physiol 2018 Dec 27;315(6):L945-L950. Epub 2018 Sep 27.

Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida , Tampa, Florida.

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http://dx.doi.org/10.1152/ajplung.00336.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337010PMC
December 2018
107 Reads
4.080 Impact Factor

The novel truncated isoform of human manganese superoxide dismutase has a differential role in promoting metastasis of lung cancer cells.

Cell Biol Int 2018 Aug 8;42(8):1030-1040. Epub 2018 May 8.

Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou, 510632, China.

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http://dx.doi.org/10.1002/cbin.10972DOI Listing
August 2018
45 Reads
1.933 Impact Factor

A mitochondrial delicacy: dynamin-related protein 1 and mitochondrial dynamics.

Am J Physiol Cell Physiol 2018 Jul 18;315(1):C80-C90. Epub 2018 Apr 18.

Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida , Tampa, Florida.

The constant physiological flux of mitochondrial fission and fusion is inextricably tied to the maintenance of cellular bioenergetics and the fluidity of mitochondrial networks. Yet, the intricacies of this dynamic duo remain unclear in diseases that encompass mitochondrial dysregulation. Particularly, the role of the GTPase fission protein dynamin-related protein 1 (Drp1) is of profound interest. Studies have identified that Drp1 participates in complex signaling pathways, suggesting that the function of mitochondria in pathophysiology may extend far beyond energetics alone. Research indicates that, in stressed conditions, Drp1 translocation to the mitochondria leads to elevated fragmentation and mitophagy; however, despite this, there is limited knowledge about the mechanistic regulation of Drp1 in disease conditions. This review highlights literature about fission, fusion, and, more importantly, discusses Drp1 in cardiac, neural, carcinogenic, renal, and pulmonary diseases. The therapeutic desirability for further research into its contribution to diseases that involve mitochondrial dysregulation is also discussed.

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http://dx.doi.org/10.1152/ajpcell.00042.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087727PMC
July 2018
142 Reads
1 Citation
3.780 Impact Factor

Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice.

Am J Physiol Lung Cell Mol Physiol 2018 05 1;314(5):L860-L870. Epub 2018 Feb 1.

Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida , Tampa, Florida.

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http://dx.doi.org/10.1152/ajplung.00365.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008128PMC
May 2018
4 Reads
4.080 Impact Factor

Epigenetics of Mucus Hypersecretion in Chronic Respiratory Diseases.

Am J Respir Cell Mol Biol 2018 03;58(3):299-309

Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida.

Asthma, chronic obstructive pulmonary disease, and cystic fibrosis are three chronic pulmonary diseases that affect an estimated 420 million individuals across the globe. A key factor contributing to each of these conditions is mucus hypersecretion. Although management of these diseases is vastly studied, researchers have only begun to scratch the surface of the mechanisms contributing to mucus hypersecretion. Epigenetic regulation of mucus hypersecretion, other than microRNA post-translational modification, is even more scarcely researched. Detailed study of epigenetic mechanisms, such as DNA methylation and histone modification, could not only help to better the understanding of these respiratory conditions but also reveal new treatments for them. Because mucus hypersecretion is such a complex event, there are innumerable genes involved in the process, which are beyond the scope of a single review. Therefore, the purpose of this review is to narrow the focus and summarize specific epigenetic research that has been conducted on a few aspects of mucus hypersecretion in asthma, chronic obstructive pulmonary disease, cystic fibrosis, and some cancers. Specifically, this review emphasizes the contribution of DNA methylation and histone modification of particular genes involved in mucus hypersecretion to identify possible targets for the development of future therapies for these conditions. Elucidating the role of epigenetics in these respiratory diseases may provide a breath of fresh air to millions of affected individuals around the world.

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http://dx.doi.org/10.1165/rcmb.2017-0072TRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854956PMC
March 2018
7 Reads
5 Citations
3.985 Impact Factor

Hedgehog: the key to maintaining adult lung repair and regeneration.

J Cell Commun Signal 2017 Mar 12;11(1):95-96. Epub 2016 Dec 12.

Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1007/s12079-016-0365-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362576PMC
March 2017
2 Reads

4-Hydroxy-2-nonenal: a critical target in oxidative stress?

Am J Physiol Cell Physiol 2016 Oct 6;311(4):C537-C543. Epub 2016 Jul 6.

Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida

In this perspective, we summarize and discuss critical advancements in the study of 4-hydroxy-2-nonenal (4-HNE) as it relates to diseases and clinical complications either caused or exacerbated by oxidative stress. Since its identification in 1980, 4-HNE has been extensively studied with an emphasis on its formation, its role in pathology, and its targets. As a reactive aldehyde, and a product of lipid peroxidation, studies corroborate its ability to disrupt signal transduction and protein activity, as well as induce inflammation and trigger cellular apoptosis in conditions of oxidative stress. Notably, we discuss the role of natural enzymes involved in the regulation of 4-HNE, and how they can be applied to its detoxification in various physiological conditions.

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http://dx.doi.org/10.1152/ajpcell.00101.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129750PMC
October 2016
3 Reads
10 Citations
3.780 Impact Factor

Global gene profiling of aging lungs in Atp8b1 mutant mice.

Aging (Albany NY) 2016 09;8(9):2232-2252

Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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http://dx.doi.org/10.18632/aging.101056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076460PMC
September 2016
14 Reads
6.432 Impact Factor

SOCS-1 rescues IL-1β-mediated suppression of epithelial sodium channel in mouse lung epithelial cells via ASK-1.

Oncotarget 2016 May;7(20):29081-91

Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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http://dx.doi.org/10.18632/oncotarget.8543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045379PMC
May 2016
6 Reads
6.360 Impact Factor

Top co-authors

Narasaiah Kolliputi
Narasaiah Kolliputi

Morsani College of Medicine

12
Richard F Lockey
Richard F Lockey

University of South Florida College of Medicine

9
Ramani Soundararajan
Ramani Soundararajan

Dalhousie University

6
Alexander Czachor
Alexander Czachor

Morsani College of Medicine

6
Jutaro Fukumoto
Jutaro Fukumoto

University of South Florida

5
Lakshmi Galam
Lakshmi Galam

University of South Florida

5
Feng Wang
Feng Wang

Peking University First Hospital

3
Richard Lockey
Richard Lockey

University of South Florida College of Medicine

3
Venkata Ramireddy Narala
Venkata Ramireddy Narala

Yogi Vemana University

3
Shuaiguang Li
Shuaiguang Li

Institute of Genomic Medicine

3