Publications by authors named "Mascha Binder"

78 Publications

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.

Authors:
Yu Zhao Christoph Kilian Jan-Eric Turner Lidia Bosurgi Kevin Roedl Patricia Bartsch Ann-Christin Gnirck Filippo Cortesi Christoph Schultheiß Malte Hellmig Leon U B Enk Fabian Hausmann Alina Borchers Milagros N Wong Hans-Joachim Paust Francesco Siracusa Nicola Scheibel Marissa Herrmann Elisa Rosati Petra Bacher Dominik Kylies Dominik Jarczak Marc Lütgehetmann Susanne Pfefferle Stefan Steurer Julian Schulze Zur-Wiesch Victor G Puelles Jan-Peter Sperhake Marylyn M Addo Ansgar W Lohse Mascha Binder Samuel Huber Tobias B Huber Stefan Kluge Stefan Bonn Ulf Panzer Nicola Gagliani Christian F Krebs

Sci Immunol 2021 02;6(56)

III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Germany.

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February 2021

Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome.

Authors:
Rebecca A Porritt Lisa Paschold Magali Noval Rivas Mary Hongying Cheng Lael M Yonker Harsha Chandnani Merrick Lopez Donjete Simnica Christoph Schultheiß Chintda Santiskulvong Jennifer Van Eyk Alessio Fasano Ivet Bahar Mascha Binder Moshe Arditi

bioRxiv 2020 Nov 9. Epub 2020 Nov 9.

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November 2020

SARS-CoV-2-specific antibody rearrangements in prepandemic immune repertoires of risk cohorts and patients with COVID-19.

Authors:
Lisa Paschold Donjete Simnica Edith Willscher Maria Jgt Vehreschild Jochen Dutzmann Daniel G Sedding Christoph Schultheiß Mascha Binder

J Clin Invest 2021 01;131(1)

Department of Internal Medicine IV, Oncology/Hematology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

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January 2021

Targeting the Mutational Landscape of Bystander Cells: Drug-Promoted Blood Cancer From High-Prevalence Pre-neoplasias in Patients on BRAF Inhibitors.

Authors:
Donjete Simnica Harald Ittrich Carsten Bockemeyer Alexander Stein Mascha Binder

Front Oncol 2020 11;10:540030. Epub 2020 Sep 11.

Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

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September 2020

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation.

Authors:
Mary Hongying Cheng She Zhang Rebecca A Porritt Magali Noval Rivas Lisa Paschold Edith Willscher Mascha Binder Moshe Arditi Ivet Bahar

Proc Natl Acad Sci U S A 2020 10 28;117(41):25254-25262. Epub 2020 Sep 28.

Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213;

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October 2020

Phase III study of nivolumab alone or combined with ipilimumab as immunotherapy versus standard of care in resectable head and neck squamous cell carcinoma.

Authors:
Henrike B Zech Nikolaus Moeckelmann Arne Boettcher Adrian Muenscher Mascha Binder Eik Vettorazzi Carsten Bokemeyer Philippe Schafhausen Christian S Betz Chia-Jung Busch

Future Oncol 2020 Dec 9;16(36):3035-3043. Epub 2020 Sep 9.

Department of Otorhinolaryngology & Head & Neck Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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December 2020

SLAMF receptors negatively regulate B cell receptor signaling in chronic lymphocytic leukemia via recruitment of prohibitin-2.

Authors:
Lisa von Wenserski Christoph Schultheiß Sarah Bolz Simon Schliffke Donjete Simnica Edith Willscher Helwe Gerull Gerrit Wolters-Eisfeld Kristoffer Riecken Boris Fehse Marcus Altfeld Peter Nollau Mascha Binder

Leukemia 2020 Aug 21. Epub 2020 Aug 21.

Department of Internal Medicine IV Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany.

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August 2020

Next-Generation Immunosequencing Reveals Pathological T-Cell Architecture in Autoimmune Hepatitis.

Authors:
Christoph Schultheiß Donjete Simnica Edith Willscher Anna Oberle Lorenzo Fanchi Nicola Bonzanni Nils H Wildner Julian Schulze Zur Wiesch Christina Weiler-Normann Ansgar W Lohse Mascha Binder

Hepatology 2020 Jul 21. Epub 2020 Jul 21.

Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

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July 2020

Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease.

Authors:
Christoph Schultheiß Lisa Paschold Donjete Simnica Malte Mohme Edith Willscher Lisa von Wenserski Rebekka Scholz Imke Wieters Christine Dahlke Eva Tolosa Daniel G Sedding Sandra Ciesek Marylyn Addo Mascha Binder

Immunity 2020 08 30;53(2):442-455.e4. Epub 2020 Jun 30.

Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, 06120 Halle (Saale), Germany. Electronic address:

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August 2020

Impact of bone marrow involvement on outcome in relapsed and refractory transplant eligible diffuse large B-cell lymphoma and transformed indolent lymphoma.

Authors:
Denis Terziev Marcus Bauer Lisa Paschold Claudia Wickenhauser Andreas Wienke Mascha Binder Lutz P Müller Thomas Weber

PLoS One 2020 8;15(7):e0235786. Epub 2020 Jul 8.

Department of Internal Medicine IV, Haematology and Oncology, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany.

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September 2020

A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy.

Authors:
Maxi Wass Stefanie Göllner Birgit Besenbeck Richard F Schlenk Petra Mundmann Joachim R Göthert Richard Noppeney Christoph Schliemann Jan-Henrik Mikesch Georg Lenz Martin Dugas Martin Wermke Christoph Röllig Martin Bornhäuser Hubert Serve Uwe Platzbecker Kathrin I Foerster Jürgen Burhenne Walter E Haefeli Lutz P Müller Mascha Binder Caroline Pabst Carsten Müller-Tidow

Leukemia 2020 Jun 19. Epub 2020 Jun 19.

Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.

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June 2020

Ipilimumab or FOLFOX with Nivolumab and Trastuzumab in previously untreated HER2-positive locally advanced or metastatic EsophagoGastric Adenocarcinoma - the randomized phase 2 INTEGA trial (AIO STO 0217).

Authors:
Joseph Tintelnot Eray Goekkurt Mascha Binder Peter Thuss-Patience Sylvie Lorenzen Jorge Riera Knorrenschild Albrecht Kretzschmar Thomas Ettrich Udo Lindig Lutz Jacobasch Daniel Pink Salah-Eddin Al-Batran Axel Hinke Susanna Hegewisch-Becker Sven Nilsson Carsten Bokemeyer Alexander Stein

BMC Cancer 2020 Jun 1;20(1):503. Epub 2020 Jun 1.

Department of Internal Medicine II (Oncology Center), University Medical Center Hamburg-Eppendorf, Hubertus Wald Tumorzentrum/UCCH, Martinistr. 52, 20246, Hamburg, Germany.

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June 2020

Nanobody-based CD38-specific heavy chain antibodies induce killing of multiple myeloma and other hematological malignancies.

Authors:
Levin Schriewer Kerstin Schütze Katharina Petry Julia Hambach William Fumey Julia Koenigsdorf Natalie Baum Stephan Menzel Björn Rissiek Kristoffer Riecken Boris Fehse Jana Larissa Röckendorf Joanna Schmid Birte Albrecht Hans Pinnschmidt Francis Ayuk Nicolaus Kröger Mascha Binder Gunter Schuch Timon Hansen Friedrich Haag Gerhard Adam Friedrich Koch-Nolte Peter Bannas

Theranostics 2020 3;10(6):2645-2658. Epub 2020 Feb 3.

Department of Diagnostic and Interventional Radiology and Nuclear medicine, University Medical Center, Hamburg-Eppendorf, Germany.

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February 2020

Clinical presentation and diagnosis of adult patients with non-Hodgkin lymphoma in Sub-Saharan Africa.

Authors:
Nikolaus C S Mezger Jana Feuchtner Mirko Griesel Lucia Hämmerl Tobias P Seraphin Annelle Zietsman Jean-Félix Péko Fisihatsion Tadesse Nathan G Buziba Henry Wabinga Mary Nyanchama Margaret Z Borok Mamadou Kéita Guy N'da Cesaltina F Lorenzoni Marie-Thérèse Akele-Akpo Cornelia Gottschick Mascha Binder Jörg Mezger Ahmedin Jemal Donald M Parkin Claudia Wickenhauser Eva J Kantelhardt

Br J Haematol 2020 07 17;190(2):209-221. Epub 2020 Mar 17.

Institute of Medical Epidemiology, Biometrics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

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July 2020

Cancer Cells Expressing Oncogenic Rat Sarcoma Show Drug-Addiction Toward Epidermal Growth Factor Receptor Antibodies Mediated by Sustained MAPK Signaling.

Authors:
Joseph Tintelnot Sina Metz Marie Trentmann Anna Oberle Lisa von Wenserski Christoph Schultheiß Friederike Braig Malte Kriegs Boris Fehse Kristoffer Riecken Carsten Bokemeyer Alexander Stein Mascha Binder

Front Oncol 2019 21;9:1559. Epub 2020 Jan 21.

Department of Oncology and Hematology, BMT With Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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January 2020

Local Intracerebral Immunomodulation Using Interleukin-Expressing Mesenchymal Stem Cells in Glioblastoma.

Authors:
Malte Mohme Cecile L Maire Ulf Geumann Simon Schliffke Lasse Dührsen Krystian Fita Nuray Akyüz Mascha Binder Manfred Westphal Christine Guenther Katrin Lamszus Felix G Hermann Nils Ole Schmidt

Clin Cancer Res 2020 06 27;26(11):2626-2639. Epub 2020 Jan 27.

Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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June 2020

T cell receptor next-generation sequencing reveals cancer-associated repertoire metrics and reconstitution after chemotherapy in patients with hematological and solid tumors.

Authors:
Donjete Simnica Nuray Akyüz Simon Schliffke Malte Mohme Lisa V Wenserski Thorben Mährle Lorenzo F Fanchi Katrin Lamszus Mascha Binder

Oncoimmunology 2019;8(11):e1644110. Epub 2019 Jul 25.

Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

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July 2019

High Aldehyde Dehydrogenase Levels Are Detectable in the Serum of Patients with Lung Cancer and May Be Exploited as Screening Biomarkers.

Authors:
Alessandra Rossi Minna Voigtlaender Hans Klose Hartmut Schlüter Gerhard Schön Sonja Loges Moreno Paolini Carsten Bokemeyer Martin Reck Giulio Tarro Mascha Binder

J Oncol 2019 22;2019:8970645. Epub 2019 Aug 22.

Department of Oncology, Hematology and Bone Marrow Tansplantation with Section Pneumology, Hubertus University Medical Center Hamburg-Eppendorf, Hubertus Wald Tumorzentrum (University Cancer Center Hamburg), University Medical Center Hamburg, 25 Martinistrasse Str., Hamburg, Germany.

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August 2019

High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias.

Authors:
Donjete Simnica Simon Schliffke Christoph Schultheiß Nicola Bonzanni Lorenzo F Fanchi Nuray Akyüz Barbara Gösch Christian Casar Benjamin Thiele Janina Schlüter Ansgar W Lohse Mascha Binder

Front Immunol 2019 21;10:1897. Epub 2019 Aug 21.

Department of Internal Medicine IV, Oncology and Hematology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

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October 2020

[Monoclonal Gammopathy Of Unknown Significance - A Common Incidental Finding - What is to be thought of? What has to be done?]

Authors:
Aneta Schieferdecker Mascha Binder Katja Weisel Carsten Bokemeyer

Dtsch Med Wochenschr 2019 07 16;144(14):982-989. Epub 2019 Jul 16.

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July 2019

The burden of hepatitis E among patients with haematological malignancies: A retrospective European cohort study.

Authors:
Johann von Felden Laurent Alric Sven Pischke Celia Aitken Stefan Schlabe Ulrich Spengler Maria Teresa Giordani Paul Schnitzler Dominik Bettinger Robert Thimme Alienor Xhaard Mascha Binder Francis Ayuk Ansgar W Lohse Jan J Cornelissen Robert A de Man Vincent Mallet

J Hepatol 2019 09 18;71(3):465-472. Epub 2019 May 18.

Hepatology Service, Assistance Publique - Hôpitaux de Paris, Hôpital Cochin, Université Paris Descartes, Paris, France; Institut National de la Santé et de la Recherche Médicale unité 1223, Institut Pasteur, Paris, France. Electronic address:

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September 2019

Fulminant blast crisis with de novo 11q23 rearrangement in a Philadelphia-positive CML patient undergoing treatment with dasatinib.

Authors:
Snjezana Janjetovic Anne Marie Asemissen Frank Dicker Mascha Binder Judith Dierlamm Carsten Bokemeyer Philippe Schafhausen

Tumori 2019 Dec 1;105(6):NP8-NP11. Epub 2019 Apr 1.

Department of Oncology and Hematology, BMT with Section of Pneumology, Hubertus Wad Tumorzentrum, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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December 2019

T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model.

Authors:
Simon Schliffke Antonella Carambia Nuray Akyüz Benjamin Thiele Johannes Herkel Mascha Binder

J Neuroimmunol 2019 07 23;332:49-56. Epub 2019 Mar 23.

Department of Oncology and Hematology, BMT with Section Pneumology, Hubertus Wald Tumorzentrum / UCCH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Haematology and Oncology, University Hospital Halle (Saale), Halle (Saale), Germany. Electronic address:

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July 2019

Nanobody Targeting of Epidermal Growth Factor Receptor (EGFR) Ectodomain Variants Overcomes Resistance to Therapeutic EGFR Antibodies.

Authors:
Joseph Tintelnot Natalie Baum Christoph Schultheiß Friederike Braig Marie Trentmann Johannes Finter William Fumey Peter Bannas Boris Fehse Kristoffer Riecken Kerstin Schuetze Carsten Bokemeyer Thies Rösner Thomas Valerius Matthias Peipp Friedrich Koch-Nolte Mascha Binder

Mol Cancer Ther 2019 04 1;18(4):823-833. Epub 2019 Mar 1.

Department of Oncology and Hematology, BMT with section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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April 2019

Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane.

Authors:
Maria Angela Gomes de Castro Hanna Wildhagen Shama Sograte-Idrissi Christoffer Hitzing Mascha Binder Martin Trepel Niklas Engels Felipe Opazo

Nat Commun 2019 02 18;10(1):820. Epub 2019 Feb 18.

Institute of Neuro- and Sensory Physiology, University Medical Center Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.

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February 2019

Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T-cell clusters as a response pattern to lenalidomide.

Authors:
Thorben Mährle Nuray Akyüz Pim Fuchs Nicola Bonzanni Donjete Simnica Ulrich Germing Anne Marie Asemissen Johann Christoph Jann Florian Nolte Wolf-Karsten Hofmann Daniel Nowak Mascha Binder

Haematologica 2019 07 17;104(7):1355-1364. Epub 2019 Jan 17.

Department of Oncology and Hematology, BMT with Pneumology section, Hubertus Wald Tumorzentrum / UCCH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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July 2019

European Myeloma Network recommendations on tools for the diagnosis and monitoring of multiple myeloma: what to use and when.

Authors:
Jo Caers Laurent Garderet K Martin Kortüm Michael E O'Dwyer Niels W C J van de Donk Mascha Binder Sandra Maria Dold Francesca Gay Jill Corre Yves Beguin Heinz Ludwig Alessandra Larocca Christoph Driessen Meletios A Dimopoulos Mario Boccadoro Martin Gramatzki Sonja Zweegman Hermann Einsele Michele Cavo Hartmut Goldschmidt Pieter Sonneveld Michel Delforge Holger W Auner Evangelos Terpos Monika Engelhardt

Haematologica 2018 11 31;103(11):1772-1784. Epub 2018 Aug 31.

Department of Medicine I, Hematology, Oncology & Stem Cell Transplantation, Medical Center, Faculty of Medicine, University of Freiburg, Germany.

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November 2018

A significant proportion of patients with primary central nervous system lymphoma harbor clonal bone marrow B-cells.

Authors:
Anna Brandt Jakob Matschke Wilfried Fehrle Lisa von Wenserski Carsten Bokemeyer Gerald Illerhaus Mascha Binder

Leuk Lymphoma 2019 02 22;60(2):334-340. Epub 2018 Jul 22.

a Department of Oncology, Hematology and Bone Marrow Transplantation with section Pneumology , University Medical Center Hamburg-Eppendorf , Hamburg , Germany.

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February 2019

Dynamic changes of the normal B lymphocyte repertoire in CLL in response to ibrutinib or FCR chemo-immunotherapy.

Authors:
Simon Schliffke Mariela Sivina Ekaterina Kim Lisa von Wenserski Benjamin Thiele Nuray Akyüz Clemens Falker-Gieske Donjete Statovci Anna Oberle Toni Thenhausen Artus Krohn-Grimberghe Carsten Bokemeyer Nitin Jain Zeev Estrov Alessandra Ferrajoli William Wierda Michael Keating Jan A Burger Mascha Binder

Oncoimmunology 2018;7(4):e1417720. Epub 2018 Jan 15.

Department of Oncology and Hematology, BMT with section Pneumology, Hubertus Wald Tumorzentrum / UCCH, University Medical Center Hamburg-Eppendorf, Martinistraße, Hamburg, Germany.

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January 2018

The phosphotyrosine phosphatase SHP2 promotes anergy in chronic lymphocytic leukemia.

Authors:
Simon Schliffke Sophia Buhs Sarah Bolz Helwe Gerull Lisa von Wenserski Kristoffer Riecken Boris Fehse Peter Nollau Mascha Binder

Blood 2018 04 23;131(15):1755-1758. Epub 2018 Feb 23.

Department of Oncology and Hematology, Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg.

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April 2018