Masato Hasegawa

Masato Hasegawa

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Masato Hasegawa

Masato Hasegawa

Publications by authors named "Masato Hasegawa"

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Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.

Mov Disord 2020 02 23;35(2):256-267. Epub 2019 Oct 23.

Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1002/mds.27887DOI Listing
February 2020

Human NPCs can degrade α-syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly through TNT-like structures.

Neurobiol Dis 2019 12 5;132:104609. Epub 2019 Sep 5.

Unité de Traffic Membranaire et Pathogénèse, Institut Pasteur, 28 Rue du Dr. Roux, Paris 75015, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104609DOI Listing
December 2019

The Wnt/Ca pathway is involved in interneuronal communication mediated by tunneling nanotubes.

EMBO J 2019 12 18;38(23):e101230. Epub 2019 Oct 18.

Unité de Trafic Membranaire et Pathogénèse, Département de Biologie Cellulaire et de l'Infection, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.15252/embj.2018101230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885744PMC
December 2019

Tau progression in single severe frontal traumatic brain injury in human brains.

J Neurol Sci 2019 Dec 9;407:116495. Epub 2019 Oct 9.

Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jns.2019.116495DOI Listing
December 2019

Prion-like properties of assembled TDP-43.

Curr Opin Neurobiol 2019 Dec 17;61:23-28. Epub 2019 Dec 17.

Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.

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http://dx.doi.org/10.1016/j.conb.2019.11.018DOI Listing
December 2019

The basis of clinicopathological heterogeneity in TDP-43 proteinopathy.

Acta Neuropathol 2019 11 26;138(5):751-770. Epub 2019 Sep 26.

Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.

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http://dx.doi.org/10.1007/s00401-019-02077-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800885PMC
November 2019

[Prion-like Propagation of Pathological α-Synuclein in Vivo].

Yakugaku Zasshi 2019 ;139(7):1007-1013

Dementia Research Project, Tokyo Metropolitan Institute of Medical Science.

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http://dx.doi.org/10.1248/yakushi.18-00165-4DOI Listing
September 2019

[Prion-like Propagation Model of Tau].

Yakugaku Zasshi 2019 ;139(7):1021-1025

Dementia Research Project, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science.

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http://dx.doi.org/10.1248/yakushi.18-00165-6DOI Listing
September 2019

Phosphorylated and aggregated TDP-43 with seeding properties are induced upon mutant Huntingtin (mHtt) polyglutamine expression in human cellular models.

Cell Mol Life Sci 2019 Jul 12;76(13):2615-2632. Epub 2019 Mar 12.

Institut NeuroMyoGène, CNRS UMR5310, INSERM U1217, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon I, 8 Avenue Rockefeller, 69373, Lyon Cedex 08, France.

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http://link.springer.com/10.1007/s00018-019-03059-8
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http://dx.doi.org/10.1007/s00018-019-03059-8DOI Listing
July 2019

Tau isoform expression and phosphorylation in marmoset brains.

J Biol Chem 2019 07 5;294(30):11433-11444. Epub 2019 Jun 5.

Laboratory of Molecular Neuroscience, Faculty of Sciences, Tokyo Metropolitan University, Minami-osawa, Hachioji, Tokyo 192-0397, Japan

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http://dx.doi.org/10.1074/jbc.RA119.008415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663862PMC
July 2019

Prion-like propagation of α-synuclein in neurodegenerative diseases.

Prog Mol Biol Transl Sci 2019 31;168:323-348. Epub 2019 Jul 31.

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2019.07.005DOI Listing
July 2019

Effect of L-DOPA/Benserazide on Propagation of Pathological α-Synuclein.

Front Neurosci 2019 14;13:595. Epub 2019 Jun 14.

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.3389/fnins.2019.00595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587610PMC
June 2019

Structure of NFT: Biochemical Approach.

Authors:
Masato Hasegawa

Adv Exp Med Biol 2019 ;1184:23-34

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.1007/978-981-32-9358-8_2DOI Listing
January 2019

The effect of truncation on prion-like properties of α-synuclein.

J Biol Chem 2018 09 20;293(36):13910-13920. Epub 2018 Jul 20.

From the Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan and

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.001862
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http://dx.doi.org/10.1074/jbc.RA118.001862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130941PMC
September 2018

Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting with catatonic syndrome.

Neuropathology 2018 Jun 7;38(3):281-287. Epub 2017 Nov 7.

Department of Psychiatry, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1111/neup.12442DOI Listing
June 2018

Pathological and immunoblot analysis of phosphorylated TDP-43 in sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration.

Neuropathology 2018 Apr 14;38(2):171-178. Epub 2017 Sep 14.

Department of Neurology and Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital & Institute of Gerontology, Tokyo, Japan.

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http://dx.doi.org/10.1111/neup.12430DOI Listing
April 2018

Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.

Acta Neuropathol Commun 2018 04 18;6(1):29. Epub 2018 Apr 18.

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.

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http://dx.doi.org/10.1186/s40478-018-0532-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907316PMC
April 2018

TDP-43 Prions.

Cold Spring Harb Perspect Med 2018 03 1;8(3). Epub 2018 Mar 1.

Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan 156-8506.

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http://dx.doi.org/10.1101/cshperspect.a024463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830907PMC
March 2018

Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice.

Exp Anim 2018 Feb 25;67(1):63-70. Epub 2017 Aug 25.

Dementia research project, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1538/expanim.17-0060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814315PMC
February 2018

Molecular mechanisms of the co-deposition of multiple pathological proteins in neurodegenerative diseases.

Neuropathology 2018 Feb 25;38(1):64-71. Epub 2017 Sep 25.

Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.1111/neup.12427DOI Listing
February 2018

Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.

J Biol Chem 2018 02 1;293(5):1781-1793. Epub 2017 Dec 1.

From the Department of Biological Sciences, Tokyo Metropolitan University, Minami-osawa, Hachioji, Tokyo 192-0397,

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http://dx.doi.org/10.1074/jbc.M117.798918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798307PMC
February 2018

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease.

Front Neurosci 2018 30;12:25. Epub 2018 Jan 30.

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.3389/fnins.2018.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797629PMC
January 2018

Pick's disease with neuronal four-repeat tau accumulation in the basal ganglia, brain stem nuclei and cerebellum.

Neuropathology 2017 Dec 9;37(6):544-559. Epub 2017 Jul 9.

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

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http://dx.doi.org/10.1111/neup.12394DOI Listing
December 2017

Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.

Sci Rep 2017 10 23;7(1):13847. Epub 2017 Oct 23.

Department of Molecular Neurobiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, 305-8575, Japan.

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http://dx.doi.org/10.1038/s41598-017-14185-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653861PMC
October 2017

Following the fate of endocytosed fibrils.

J Biol Chem 2017 08;292(32):13498-13499

From the Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1074/jbc.H117.780296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555208PMC
August 2017

Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held.

J Neurosci 2017 06 2;37(25):6043-6052. Epub 2017 Jun 2.

Cellular and Molecular Synaptic Function Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan,

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0179-1
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http://dx.doi.org/10.1523/JNEUROSCI.0179-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596501PMC
June 2017

Laparoscopic-endoscopic cooperative surgery for a duodenal neuroendocrine tumor: A case report.

Asian J Endosc Surg 2017 May 17;10(2):183-186. Epub 2017 Jan 17.

Department of Comprehensive Surgery, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.1111/ases.12356DOI Listing
May 2017

Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.

Pharmacol Ther 2017 Apr 1;172:22-33. Epub 2016 Dec 1.

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1016/j.pharmthera.2016.11.010DOI Listing
April 2017

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

Hum Mol Genet 2017 03;26(5):969-988

Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

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http://dx.doi.org/10.1093/hmg/ddx011DOI Listing
March 2017

Propagation of pathological α-synuclein in marmoset brain.

Acta Neuropathol Commun 2017 Feb 2;5(1):12. Epub 2017 Feb 2.

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.

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http://dx.doi.org/10.1186/s40478-017-0413-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289012PMC
February 2017

[The Prion-like Mechanism in Neurodegenerative Diseases-Current Studies and Future Prospects].

Brain Nerve 2016 Oct;68(10):1197-1204

Department of Dementia and Higher Brain Function, Tokyo Metropolitan, Institute of Medical Science.

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http://dx.doi.org/10.11477/mf.1416200573DOI Listing
October 2016

The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.

J Biol Chem 2016 09 5;291(36):18675-88. Epub 2016 Jul 5.

From the Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan and

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http://dx.doi.org/10.1074/jbc.M116.734707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009244PMC
September 2016

α-Synuclein: Experimental Pathology.

Cold Spring Harb Perspect Med 2016 Sep 1;6(9). Epub 2016 Sep 1.

Department of Neuropathology and Cell Biology, Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1101/cshperspect.a024273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008066PMC
September 2016

Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants.

Sci Rep 2016 09 19;6:33479. Epub 2016 Sep 19.

Laboratory of Molecular Neuroscience, Department of Biological Sciences, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan.

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http://dx.doi.org/10.1038/srep33479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027580PMC
September 2016

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.

Sci Rep 2016 08 4;6:30891. Epub 2016 Aug 4.

Department of Biomedical Sciences, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1038/srep30891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973277PMC
August 2016

The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease.

Brain Pathol 2016 07 9;26(4):488-505. Epub 2015 Nov 9.

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

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http://dx.doi.org/10.1111/bpa.12319DOI Listing
July 2016

α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly.

J Biol Chem 2016 07 19;291(29):15046-56. Epub 2016 May 19.

From the Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506,

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http://dx.doi.org/10.1074/jbc.M116.736355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946922PMC
July 2016

TDP-43 in the hypoglossal nucleus identifies amyotrophic lateral sclerosis in behavioral variant frontotemporal dementia.

J Neurol Sci 2016 Jul 4;366:197-201. Epub 2016 May 4.

Neuroscience Research Australia, Sydney, Australia; School of Medical Sciences, University of New South Wales, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2016.05.005DOI Listing
July 2016

Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43.

Prion 2016 07;10(4):283-9

a Dementia Research Project, Tokyo Metropolitan Institute of Medical Science , Tokyo , Japan.

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http://dx.doi.org/10.1080/19336896.2016.1207033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082967PMC
July 2016

An autopsied case of unclassifiable sporadic four-repeat tauopathy presenting with parkinsonism and speech disturbances.

Neuropathology 2016 Jun 27;36(3):295-304. Epub 2015 Nov 27.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

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http://dx.doi.org/10.1111/neup.12274DOI Listing
June 2016

Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils.

J Biol Chem 2016 Apr 17;291(17):8896-907. Epub 2016 Feb 17.

From the Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506 and

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http://dx.doi.org/10.1074/jbc.M115.713552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861459PMC
April 2016

Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.

Hum Mol Genet 2016 Apr 28;25(7):1420-33. Epub 2016 Jan 28.

Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan

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http://dx.doi.org/10.1093/hmg/ddw024DOI Listing
April 2016

Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation.

Authors:
Masato Hasegawa

Biomolecules 2016 Apr 28;6(2). Epub 2016 Apr 28.

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science; Setagaya-ku 156-8506, Japan.

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http://dx.doi.org/10.3390/biom6020024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919919PMC
April 2016

Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.

Sci Rep 2016 Mar 16;6:23281. Epub 2016 Mar 16.

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1038/srep23281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793195PMC
March 2016

[The proceeding of drug development based on the propagation of tau protein].

Nihon Rinsho 2016 Mar;74(3):432-7

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March 2016

Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy.

Acta Neuropathol Commun 2016 Mar 31;4:33. Epub 2016 Mar 31.

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford, M6 8HD, UK.

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http://dx.doi.org/10.1186/s40478-016-0301-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818389PMC
March 2016

The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method.

Am J Pathol 2016 Feb 11;186(2):398-409. Epub 2015 Dec 11.

Department of Biological Sciences, Laboratory of Molecular Neuroscience, Tokyo Metropolitan University, Hachioji, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.10.009DOI Listing
February 2016

The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties.

Hum Mol Genet 2015 Nov 15;24(22):6403-16. Epub 2015 Sep 15.

Department of Diagnosis, Prevention and Treatment of Dementia, Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 116-0013, Japan and.

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http://hmg.oxfordjournals.org/content/early/2015/09/22/hmg.d
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv351DOI Listing
November 2015

An autopsy case of familial amyotrophic lateral sclerosis with a TARDBP Q343R mutation.

Neuropathology 2015 Oct 12;35(5):462-8. Epub 2015 Jun 12.

Department of Internal Medicine, Geriatrics Research Institute and Hospital, Maebashi, Japan.

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http://dx.doi.org/10.1111/neup.12209DOI Listing
October 2015

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.

Acta Neuropathol 2015 Jun 14;129(6):895-907. Epub 2015 Apr 14.

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, 156-8506, Japan.

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http://dx.doi.org/10.1007/s00401-015-1415-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436700PMC
June 2015

Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.

J Neuropathol Exp Neurol 2015 Feb;74(2):158-65

From the Dementia Research Project (MH, TA, HA), Department of Neuropathology and Cell Biology (MM-S, MH), and Histology Center (HK), Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo; Department of Neuropsychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki (TA); and Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo (TM, MN), Japan.

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http://dx.doi.org/10.1097/NEN.0000000000000158DOI Listing
February 2015

Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.

J Neurol 2014 Nov 11;261(11):2209-17. Epub 2014 Sep 11.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan,

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http://dx.doi.org/10.1007/s00415-014-7491-8DOI Listing
November 2014

Pathological alpha-synuclein propagates through neural networks.

Acta Neuropathol Commun 2014 Aug 6;2:88. Epub 2014 Aug 6.

Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku 156-0057, Tokyo, Japan.

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http://dx.doi.org/10.1186/s40478-014-0088-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147188PMC
August 2014

A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease.

Sci Rep 2013 ;3:2540

Division of Biomedical and Life Sciences, Faculty of Health and Medicine, University of Lancaster, Lancaster, LA1 4AY, UK.

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http://dx.doi.org/10.1038/srep02540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756331PMC
June 2014

Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.

Acta Neuropathol Commun 2014 Jun 20;2:70. Epub 2014 Jun 20.

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford M6 8HD, UK.

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http://dx.doi.org/10.1186/2051-5960-2-70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229740PMC
June 2014

Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.

Int J Neurosci 2014 May 31;124(5):344-9. Epub 2013 Oct 31.

1Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science , Tokyo , Japan.

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http://dx.doi.org/10.3109/00207454.2013.848440DOI Listing
May 2014

[Intracellular seeded aggregation of TDP-43].

Rinsho Shinkeigaku 2012 ;52(11):1056-8

Tokyo Metropolitan Institute of Medical Science.

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http://dx.doi.org/10.5692/clinicalneurol.52.1056DOI Listing
April 2014

[Prion-like protein propagation in neurodegenerative diseases].

Rinsho Shinkeigaku 2012 ;52(11):1325-6

Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science.

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http://dx.doi.org/10.5692/clinicalneurol.52.1325DOI Listing
April 2014

Tau accumulation in the nucleus accumbens in tangle-predominant dementia.

Acta Neuropathol Commun 2014 Apr 8;2:40. Epub 2014 Apr 8.

Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

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http://actaneurocomms.biomedcentral.com/articles/10.1186/205
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http://dx.doi.org/10.1186/2051-5960-2-40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023632PMC
April 2014

Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-2.

Neurosci Lett 2014 Mar 31;563:112-7. Epub 2014 Jan 31.

Department of Biological Sciences, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2014.01.046DOI Listing
March 2014

3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease.

Acta Neuropathol 2014 Feb 9;127(2):303-5. Epub 2013 Nov 9.

Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, 156-8506, Japan,

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http://dx.doi.org/10.1007/s00401-013-1191-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895182PMC
February 2014

[Neuropathology of TDP-43 proteinopathy].

Brain Nerve 2013 Dec;65(12):1477-89

Tokyo Metropolitan Institute of Medical Science, Dementia Research Project.

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December 2013

Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.

Acta Neuropathol Commun 2013 Oct 14;1:68. Epub 2013 Oct 14.

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford M6 8HD, UK.

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http://dx.doi.org/10.1186/2051-5960-1-68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893586PMC
October 2013

Prion-like properties of pathological TDP-43 aggregates from diseased brains.

Cell Rep 2013 Jul 3;4(1):124-34. Epub 2013 Jul 3.

Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1016/j.celrep.2013.06.007DOI Listing
July 2013

Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice.

PLoS One 2012 20;7(12):e52389. Epub 2012 Dec 20.

Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052389PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527507PMC
June 2013

Prion-like spreading of pathological α-synuclein in brain.

Brain 2013 Apr 6;136(Pt 4):1128-38. Epub 2013 Mar 6.

Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1093/brain/awt037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613715PMC
April 2013

Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites.

J Biol Chem 2013 Mar 28;288(11):7968-77. Epub 2013 Jan 28.

Laboratory of Molecular Neuroscience, Department of Biological Sciences, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan.

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http://dx.doi.org/10.1074/jbc.M112.433326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597833PMC
March 2013

Molecular analysis and biochemical classification of TDP-43 proteinopathy.

Brain 2012 Nov 3;135(Pt 11):3380-91. Epub 2012 Oct 3.

Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1093/brain/aws230DOI Listing
November 2012