Masahiro Kawahara

Masahiro Kawahara

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Masahiro Kawahara

Publications by authors named "Masahiro Kawahara"

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An epitope-directed antibody affinity maturation system utilizing mammalian cell survival as readout.

Biotechnol Bioeng 2019 Jul 29;116(7):1742-1751. Epub 2019 Mar 29.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1002/bit.26965DOI Listing
July 2019

Involvement of SAPK/JNK Signaling Pathway in Copper Enhanced Zinc-Induced Neuronal Cell Death.

Toxicol Sci 2019 May;169(1):293-302

Department of Bio-Analytical Chemistry, Faculty of Pharmacy, Musashino University, Nishitokyo-shi, Tokyo, Japan.

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https://academic.oup.com/toxsci/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/toxsci/kfz043DOI Listing
May 2019

Characterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease.

J Gastroenterol 2019 Feb 26;54(2):149-159. Epub 2018 Nov 26.

Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, 520-2192, Japan.

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http://dx.doi.org/10.1007/s00535-018-1530-7DOI Listing
February 2019

Astaxanthin, a xanthophyll carotenoid, prevents development of dextran sulphate sodium-induced murine colitis.

J Clin Biochem Nutr 2019 Jan 11;64(1):66-72. Epub 2018 Aug 11.

Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan.

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http://dx.doi.org/10.3164/jcbn.18-47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348411PMC
January 2019

Ameliorating effects of bortezomib, a proteasome inhibitor, on development of dextran sulfate sodium-induced murine colitis.

J Clin Biochem Nutr 2018 Nov 8;63(3):217-223. Epub 2018 Jun 8.

Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan.

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http://dx.doi.org/10.3164/jcbn.18-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252295PMC
November 2018

Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation.

Int J Mol Sci 2018 Aug 19;19(8). Epub 2018 Aug 19.

Department of Bio-Analytical Chemistry, Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishitokyo, Tokyo 202-8585, Japan.

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http://dx.doi.org/10.3390/ijms19082449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121660PMC
August 2018

Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.

ACS Synth Biol 2018 07 21;7(7):1709-1714. Epub 2018 Jun 21.

Department of Chemistry and Biotechnology, Graduate School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku , Tokyo 113-8656 , Japan.

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http://dx.doi.org/10.1021/acssynbio.8b00163DOI Listing
July 2018

Effect of fermented vegetable beverage containing in patients with mild to moderate ulcerative colitis.

Biomed Rep 2018 Jul 18;9(1):74-80. Epub 2018 May 18.

Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga 520-2192, Japan.

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http://dx.doi.org/10.3892/br.2018.1099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007040PMC
July 2018

Dissection of Signaling Events Downstream of the c-Mpl Receptor in Murine Hematopoietic Stem Cells Via Motif-Engineered Chimeric Receptors.

Stem Cell Rev 2018 02;14(1):101-109

Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1007/s12015-017-9768-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801400PMC
February 2018

Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease.

J Gastroenterol 2018 01 29;53(1):95-106. Epub 2017 Aug 29.

Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, 520-2192, Japan.

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http://dx.doi.org/10.1007/s00535-017-1384-4DOI Listing
January 2018

Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity.

Int J Pharm 2018 Jan 6;535(1-2):140-147. Epub 2017 Nov 6.

Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2017.11.012DOI Listing
January 2018

Pyruvic acid prevents Cu/Zn-induced neurotoxicity by suppressing mitochondrial injury.

Biochem Biophys Res Commun 2018 01 24;495(1):1335-1341. Epub 2017 Nov 24.

Department of Bio-Analytical Chemistry, Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.11.152DOI Listing
January 2018

Zinc, Carnosine, and Neurodegenerative Diseases.

Nutrients 2018 Jan 29;10(2). Epub 2018 Jan 29.

Department of Bio-Analytical Chemistry, Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan.

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http://dx.doi.org/10.3390/nu10020147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852723PMC
January 2018

Cell-Surface Expression Levels Are Important for Fine-Tuning the Performance of Receptor Tyrosine Kinase-Based Signalobodies.

Biotechnol J 2017 Dec 25;12(12). Epub 2017 Sep 25.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1002/biot.201700441DOI Listing
December 2017

Microfluidic preparation of anchored cell membrane sheets for in vitro analyses and manipulation of the cytoplasmic face.

Sci Rep 2017 11 2;7(1):14962. Epub 2017 Nov 2.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1038/s41598-017-14737-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668413PMC
November 2017

Expression of Interleukin-26 is upregulated in inflammatory bowel disease.

World J Gastroenterol 2017 Aug;23(30):5519-5529

Makoto Fujii, Atsushi Nishida, Hirotsugu Imaeda, Masashi Ohno, Kyohei Nishino, Shigeki Sakai, Osamu Inatomi, Shigeki Bamba, Masahiro Kawahara, Akira Andoh, Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan.

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http://dx.doi.org/10.3748/wjg.v23.i30.5519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558115PMC
August 2017

Engineering a growth sensor to select intracellular antibodies in the cytosol of mammalian cells.

J Biosci Bioeng 2017 Jul 17;124(1):125-132. Epub 2017 Mar 17.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jbiosc.2017.02.017DOI Listing
July 2017

A Chemically Inducible Helper Module for Detecting Protein-Protein Interactions with Tunable Sensitivity Based on KIPPIS.

Anal Chem 2017 05 13;89(9):4824-4830. Epub 2017 Apr 13.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://pubs.acs.org/doi/10.1021/acs.analchem.6b04063
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http://dx.doi.org/10.1021/acs.analchem.6b04063DOI Listing
May 2017

Central nervous system involvement of acute promyelocytic leukemia, three case reports.

Clin Case Rep 2017 05 29;5(5):645-653. Epub 2017 Mar 29.

Division of Gastroenterology and Hematology Department of Medicine Shiga University of Medical Science Otsu Japan.

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http://dx.doi.org/10.1002/ccr3.919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412762PMC
May 2017

Preventive Effects of Carnosine on Lipopolysaccharide-induced Lung Injury.

Sci Rep 2017 02 16;7:42813. Epub 2017 Feb 16.

Laboratory of Bio-Analytical Chemistry, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan.

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http://dx.doi.org/10.1038/srep42813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311717PMC
February 2017

Copper Enhances Zinc-Induced Neurotoxicity and the Endoplasmic Reticulum Stress Response in a Neuronal Model of Vascular Dementia.

Front Neurosci 2017 9;11:58. Epub 2017 Feb 9.

Department of Bio Analytical Chemistry, Musashino University Nishitokyo-shi, Japan.

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http://dx.doi.org/10.3389/fnins.2017.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299027PMC
February 2017

Differentiation signalobody: Demonstration of antigen-dependent osteoclast differentiation from a progenitor cell line.

J Biosci Bioeng 2016 Sep 12;122(3):357-63. Epub 2016 Mar 12.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1016/j.jbiosc.2016.02.010DOI Listing
September 2016

[Link between aluminum neurotoxicity and neurodegenerative disorders].

Nihon Rinsho 2016 Jul;74(7):1176-85

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July 2016

A Japanese family with X-linked sideroblastic anemia affecting females and manifesting as macrocytic anemia.

Int J Hematol 2016 Jun 10;103(6):713-7. Epub 2016 Feb 10.

Department of Hematology, Ijinkai Takeda General Hospital, 28-1 Moriminami-cho, Ishida, Fushimi-ku, Kyoto, 601-1495, Japan.

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http://dx.doi.org/10.1007/s12185-016-1949-7DOI Listing
June 2016

Ligand-inducible dimeric antibody for selecting antibodies against a membrane protein based on mammalian cell proliferation.

Biotechnol Bioeng 2016 May 26;113(5):1113-23. Epub 2015 Oct 26.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1002/bit.25858DOI Listing
May 2016

Growth signalobody selects functional intrabodies in the mammalian cytoplasm.

Biotechnol J 2016 Mar 14;11(4):565-73. Epub 2016 Jan 14.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/biot.201500364DOI Listing
March 2016

Quantification of horse plasma proteins altered by xylazine using the fluorogenic derivatization-liquid chromatography-tandem mass spectrometry.

J Equine Sci 2015 3;26(4):141-6. Epub 2016 Feb 3.

Laboratory of Proteomics Analysis, Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo 202-8585, Japan.

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http://dx.doi.org/10.1294/jes.26.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739145PMC
February 2016

An In Vitro System Comprising Immortalized Hypothalamic Neuronal Cells (GT1-7 Cells) for Evaluation of the Neuroendocrine Effects of Essential Oils.

Evid Based Complement Alternat Med 2015 21;2015:343942. Epub 2015 Oct 21.

Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, 1-1-20 Shin-machi, Nishitokyo-shi, Tokyo 202-8585, Japan.

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http://dx.doi.org/10.1155/2015/343942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631885PMC
November 2015

Selection of cDNA candidates that induce oligomerization of NLRP3 using a chimeric receptor approach.

J Biosci Bioeng 2015 Aug 29;120(2):223-30. Epub 2015 Jan 29.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jbiosc.2014.12.021DOI Listing
August 2015

Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia.

Metallomics 2015 Aug 7;7(8):1233-9. Epub 2015 Apr 7.

Laboratory of Bio-Analytical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan.

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http://dx.doi.org/10.1039/c5mt00049aDOI Listing
August 2015

Involvement of trace elements in the pathogenesis of prion diseases.

Curr Pharm Biotechnol 2014 ;15(11):1049-57

Department of Bio-Analytical Chemistry, Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan.

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July 2015

Domain structure of growth signalobodies critically affects the outcome of antibody library selection.

J Biochem 2015 Jun 22;157(6):497-506. Epub 2015 Jan 22.

Department of Bioengineering and Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan Department of Bioengineering and Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1093/jb/mvv008DOI Listing
June 2015

Crosstalk between metals and neurodegenerative diseases.

Nihon Eiseigaku Zasshi 2014 ;69(3):155-65

Department of Bio-Analytical Chemistry, Faculty of Pharmacy, Musashino University.

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May 2015

Antigen-responsive regulation of Cell motility and migration via the signalobodies based on c-Fms and c-Mpl.

Biotechnol Prog 2014 Mar-Apr;30(2):411-7. Epub 2014 Jan 13.

Dept. of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1002/btpr.1861DOI Listing
December 2014

Collagen surfaces modified with photo-cleavable polyethylene glycol-lipid support versatile single-cell arrays of both non-adherent and adherent cells.

Macromol Biosci 2014 Dec 5;14(12):1670-6. Epub 2014 Sep 5.

Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1002/mabi.201400312DOI Listing
December 2014

AAG8 promotes carcinogenesis by activating STAT3.

Cell Signal 2014 Sep 12;26(9):1863-9. Epub 2014 Apr 12.

Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.04.001DOI Listing
September 2014

Construction of unnatural heterodimeric receptors based on IL-2 and IL-6 receptor subunits.

Biotechnol Prog 2013 Nov-Dec;29(6):1512-8. Epub 2013 Aug 29.

Dept. of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1002/btpr.1785DOI Listing
August 2014

Detecting protein-protein interactions based on kinase-mediated growth induction of mammalian cells.

Sci Rep 2014 Aug 19;4:6127. Epub 2014 Aug 19.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1038/srep06127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137342PMC
August 2014

S-Fms signalobody enhances myeloid cell growth and migration.

Biotechnol J 2014 Jul 22;9(7):954-61. Epub 2014 Jan 22.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/biot.201300346DOI Listing
July 2014

A novel platform for antibody library selection in mammalian cells based on a growth signalobody.

Biotechnol Bioeng 2014 Jun 27;111(6):1170-9. Epub 2013 Dec 27.

Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1002/bit.25173DOI Listing
June 2014

Modeling tandem AAG8-MEK inhibition in melanoma cells.

Cancer Med 2014 Jun 14;3(3):710-8. Epub 2014 Mar 14.

Department of Bioengineering, Graduate School of Engineering, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/cam4.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101763PMC
June 2014

Co-occurrence of monoclonal gammopathy and myelodysplasia: a retrospective study of fourteen cases.

Int J Hematol 2014 Jun 1;99(6):721-5. Epub 2014 Apr 1.

The Center for Hematological Diseases, Takeda General Hospital, Fushimi, Kyoto, 601-1495, Japan,

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http://dx.doi.org/10.1007/s12185-014-1570-6DOI Listing
June 2014

Quantitative control of intracellular signaling activity through chimeric receptors incorporating multiple identical tyrosine motifs.

Biotechnol Bioeng 2014 May 27;111(5):948-55. Epub 2013 Nov 27.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1002/bit.25151DOI Listing
May 2014

Disruption of zinc homeostasis and the pathogenesis of senile dementia.

Metallomics 2014 Feb;6(2):209-19

Department of Bio-Analytical Chemistry, Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan.

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http://dx.doi.org/10.1039/c3mt00257hDOI Listing
February 2014

A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation.

Exp Hematol Oncol 2014 Feb 17;3(1). Epub 2014 Feb 17.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1186/2162-3619-3-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932988PMC
February 2014

Construction of antibody/insulin receptor chimera for growth induction of mammalian cells.

Cytotechnology 2013 Dec 25;65(6):945-53. Epub 2013 Apr 25.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Tokyo, Japan.

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http://dx.doi.org/10.1007/s10616-013-9571-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853637PMC
December 2013

Reconstitution of a cytokine receptor scaffold utilizing multiple different tyrosine motifs.

Biotechnol Bioeng 2013 Dec 28;110(12):3197-204. Epub 2013 Jun 28.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1002/bit.24973DOI Listing
December 2013

Cell fate conversion by conditionally switching the signal-transducing domain of signalobodies.

Biotechnol Bioeng 2013 Dec 9;110(12):3219-26. Epub 2013 Aug 9.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

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http://dx.doi.org/10.1002/bit.24985DOI Listing
December 2013

Top-down motif engineering of a cytokine receptor for directing ex vivo expansion of hematopoietic stem cells.

J Biotechnol 2013 Dec 23;168(4):659-65. Epub 2013 Sep 23.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1016/j.jbiotec.2013.09.012DOI Listing
December 2013

Interfractional change of high-risk CTV D90 during image-guided brachytherapy for uterine cervical cancer.

J Radiat Res 2013 Nov 3;54(6):1138-45. Epub 2013 Jun 3.

Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

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http://dx.doi.org/10.1093/jrr/rrt073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823790PMC
November 2013

The molecular mechanisms of zinc neurotoxicity and the pathogenesis of vascular type senile dementia.

Int J Mol Sci 2013 Nov 7;14(11):22067-81. Epub 2013 Nov 7.

Department of Bio Analytical Chemistry, Research Institute of Pharmaceutical Sciences, Musashino University, Nishitokyo-shi, Tokyo 202-8585, Japan.

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http://www.mdpi.com/1422-0067/14/11/22067
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http://dx.doi.org/10.3390/ijms141122067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856052PMC
November 2013

Death signalobody: inducing conditional cell death in response to a specific antigen.

Hum Gene Ther Methods 2013 Jun 21;24(3):141-50. Epub 2013 Apr 21.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1089/hgtb.2012.147DOI Listing
June 2013

D-histidine and L-histidine attenuate zinc-induced neuronal death in GT1-7 cells.

Metallomics 2013 May 18;5(5):453-60. Epub 2013 Mar 18.

Laboratory of Bio-Analytical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan.

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http://dx.doi.org/10.1039/c3mt20264jDOI Listing
May 2013

Analysis of cellular phenotype during in vitro immunization of murine splenocytes for generating antigen-specific immunoglobulin.

J Biosci Bioeng 2013 Mar 22;115(3):339-45. Epub 2012 Nov 22.

Innovative Antibody Engineering Laboratory, Advance Co. Ltd., 5-7 Kobunacho, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jbiosc.2012.10.008DOI Listing
March 2013

Use of FDG-PET in Radiation Treatment Planning for Thoracic Cancers.

Int J Mol Imaging 2012 14;2012:609545. Epub 2012 May 14.

Gunma University Heavy Ion Medical Center, Maebashi, Gunma 371-8511, Japan.

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http://dx.doi.org/10.1155/2012/609545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361167PMC
August 2012

Selective cleavage of ErbB4 by G-protein-coupled gonadotropin-releasing hormone receptor in cultured hypothalamic neurons.

J Cell Physiol 2012 Jun;227(6):2492-501

Department of Biochemistry, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

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http://dx.doi.org/10.1002/jcp.22988DOI Listing
June 2012

Activation of target signal transducers utilizing chimeric receptors with signaling-molecule binding motifs.

Biotechnol Bioeng 2012 Jun 7;109(6):1528-37. Epub 2012 Jan 7.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1002/bit.24421DOI Listing
June 2012

Growth control of genetically modified cells using an antibody/c-Kit chimera.

J Biosci Bioeng 2012 May 9;113(5):641-6. Epub 2012 Jan 9.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1016/j.jbiosc.2011.12.005DOI Listing
May 2012

Growth promotion of genetically modified hematopoietic progenitors using an antibody/c-Mpl chimera.

Cytokine 2011 Sep 22;55(3):402-8. Epub 2011 Jun 22.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1016/j.cyto.2011.05.024DOI Listing
September 2011

Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126.

Metallomics 2011 Jul 28;3(7):726-34. Epub 2011 Mar 28.

Department of Analytical Chemistry, School of Pharmaceutical Sciences Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka-shi, Miyazaki. Japan.

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http://dx.doi.org/10.1039/c1mt00015bDOI Listing
July 2011

Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein.

Int J Alzheimers Dis 2011 Apr 12;2011:304583. Epub 2011 Apr 12.

Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka-shi, Miyazaki 882-8508, Japan.

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http://dx.doi.org/10.4061/2011/304583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087492PMC
April 2011

Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses.

Int J Alzheimers Dis 2011 Mar 8;2011:276393. Epub 2011 Mar 8.

Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka-shi, Miyazaki 882-8508, Japan.

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http://dx.doi.org/10.4061/2011/276393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056430PMC
March 2011

Neurotoxicity of β-amyloid protein: oligomerization, channel formation, and calcium dyshomeostasis.

Curr Pharm Des 2010 ;16(25):2779-89

Department of Analytical Chemistry School of Pharmaceutical Sciences Kyushu University of Health and Welfare 1714-1 Yoshino-cho, Nobeoka-shi, Miyazaki 882-8508, Japan.

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February 2011

Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal diseases by reversed-phase high-performance liquid chromatography.

Chem Biodivers 2010 Jun;7(6):1371-9

School of Pharmaceutical Science, Kyushu University of Health and Welfare, Nobeoka 882-8508, Japan.

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http://dx.doi.org/10.1002/cbdv.200900330DOI Listing
June 2010

Selection and growth regulation of genetically modified cells with hapten-specific antibody/receptor tyrosine kinase chimera.

Biotechnol Prog 2009 Jul-Aug;25(4):1138-45

Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1002/btpr.185DOI Listing
December 2009

Analysis of the role of tripeptidyl peptidase II in MHC class I antigen presentation in vivo.

J Immunol 2009 Nov 19;183(10):6069-77. Epub 2009 Oct 19.

Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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http://dx.doi.org/10.4049/jimmunol.0803564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314709PMC
November 2009

The influence of domain structures on the signal transduction of chimeric receptors derived from the erythropoietin receptor.

J Biochem 2009 May 20;145(5):575-84. Epub 2009 Jan 20.

Department of Chemistry and Biotechnology, School of Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1093/jb/mvp013DOI Listing
May 2009

Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein.

Expert Rev Neurother 2009 May;9(5):681-93

Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka-shi, Miyazaki, Japan.

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http://dx.doi.org/10.1586/ern.09.28DOI Listing
May 2009

T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera.

Cytokine 2009 Apr 14;46(1):127-36. Epub 2009 Feb 14.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1016/j.cyto.2008.12.020DOI Listing
April 2009

Construction of a fluorescein-responsive chimeric receptor with strict ligand dependency.

Biotechnol Bioeng 2008 Dec;101(5):975-84

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1002/bit.21961DOI Listing
December 2008

Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73.

Blood 2008 Nov 18;112(9):3856-66. Epub 2008 Jun 18.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1182/blood-2007-09-111773DOI Listing
November 2008

Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera.

J Immunol Methods 2008 Aug 10;337(1):16-23. Epub 2008 Jun 10.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jim.2008.05.003DOI Listing
August 2008

[Conformational change, pore formation and neurotoxicity of amyloidogenic proteins].

Rinsho Byori 2008 Feb;56(2):130-6

Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Miyazaki.

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February 2008

Neurosteroids block the increase in intracellular calcium level induced by Alzheimer’s β-amyloid protein in long-term cultured rat hippocampal neurons.

Neuropsychiatr Dis Treat 2008 Feb;4(1):209-18

Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience 2-6 Musashidai, Fuchu-shi, Tokyo 183-8526, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515900PMC
http://dx.doi.org/10.2147/ndt.s2059DOI Listing
February 2008

Antigen-mediated migration of murine pro-B Ba/F3 cells via an antibody/receptor chimera.

J Biotechnol 2008 Jan 21;133(1):154-61. Epub 2007 Sep 21.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1016/j.jbiotec.2007.09.009DOI Listing
January 2008

Protective substances against zinc-induced neuronal death after ischemia: carnosine as a target for drug of vascular type of dementia.

Recent Pat CNS Drug Discov 2007 Jun;2(2):145-9

Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka-city, Miyazaki, 882-8508, Japan.

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June 2007

Growth control of hybridoma cells with an artificially induced EpoR-gp130 heterodimer.

Cytotechnology 2006 Nov 5;52(3):171-9. Epub 2006 Dec 5.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan,

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http://dx.doi.org/10.1007/s10616-006-9035-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449410PMC
November 2006