Publications by authors named "Masahiro Aoki"

46Publications

Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells.

Oncogene 2021 Jan 12;40(2):408-420. Epub 2020 Nov 12.

Division of Pathophysiology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan.

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January 2021

[Basic Science of Cancer Cachexia].

Gan To Kagaku Ryoho 2019 Dec;46(12):1818-1822

Division of Pathophysiology, Aichi Cancer Center Research Institute.

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December 2019

Stromal iodothyronine deiodinase 2 (DIO2) promotes the growth of intestinal tumors in Apc mutant mice.

Cancer Sci 2019 Aug 7;110(8):2520-2528. Epub 2019 Jul 7.

Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Japan.

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August 2019

TAZ activation by Hippo pathway dysregulation induces cytokine gene expression and promotes mesothelial cell transformation.

Oncogene 2019 03 6;38(11):1966-1978. Epub 2018 Nov 6.

Division of Cancer Biology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, Japan.

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March 2019

Clinical and in vitro studies of the correlation between MGMT and the effect of streptozocin in pancreatic NET.

Cancer Chemother Pharmacol 2019 01 11;83(1):43-52. Epub 2018 Oct 11.

Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.

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January 2019

HNRNPLL stabilizes mRNA for DNA replication proteins and promotes cell cycle progression in colorectal cancer cells.

Cancer Sci 2018 Aug 16;109(8):2458-2468. Epub 2018 Jul 16.

Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Japan.

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August 2018

Differences in Urinary Renal Failure Biomarkers in Cancer Patients Initially Treated with Cisplatin.

Anticancer Res 2017 09;37(9):5235-5239

Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi, Japan.

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September 2017

Oncogenic Roles of the PI3K/AKT/mTOR Axis.

Curr Top Microbiol Immunol 2017;407:153-189

Division of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan.

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June 2019

ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR Inhibitor.

Mol Cancer Ther 2015 Dec 5;14(12):2831-9. Epub 2015 Oct 5.

Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.

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December 2015

Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Δ716) mice involves stromal COX-2.

Cancer Sci 2015 Jun 1;106(6):692-9. Epub 2015 May 1.

Division of Molecular Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan.

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June 2015

Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1.

Mol Cancer Ther 2015 Mar 14;14(3):704-12. Epub 2015 Jan 14.

Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.

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March 2015

Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition.

Proc Natl Acad Sci U S A 2012 May 30;109(20):7776-81. Epub 2012 Apr 30.

Division of Molecular Pathology, Aichi Cancer Center, Chikusa-ku, Nagoya, Aichi 464-8681, Japan.

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May 2012

Induction of 6-sulfated glycans with cell adhesion activity via T-bet and GATA-3 in human helper T cells.

Biochim Biophys Acta 2012 Jul 14;1820(7):841-8. Epub 2012 Mar 14.

Division of Molecular Pathology, Aichi Cancer Center, Nagoya, Aichi 464-8681, Japan.

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July 2012

Rehabilitation and long-term course of nontraumatic myelopathy associated with surfing.

Am J Phys Med Rehabil 2013 Sep;92(9):828-32

Department of Rehabilitation Medicine, Sapporo Medical University School of Medicine, Hokkaido, Japan.

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September 2013

High-throughput profiling of microbial extracts.

J Nat Prod 2011 May 15;74(5):983-8. Epub 2011 Apr 15.

Discovery Science & Technology Department, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530 Japan.

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May 2011

JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Δ716) mice.

Gastroenterology 2011 May 12;140(5):1556-63.e6. Epub 2011 Feb 12.

Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida-Konoé-Cho, Sakyo-Ku, Kyoto, Japan.

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May 2011

Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1.

Cancer Res 2011 Jan 11;71(2):593-602. Epub 2011 Jan 11.

Department of Pharmacology, Graduate School of Medicine, Kyoto University, and Laboratory of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.

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January 2011

LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain.

J Biol Chem 2010 Jun 16;285(24):18283-90. Epub 2010 Apr 16.

Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

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June 2010

CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium.

Gastroenterology 2010 Feb 10;138(2):627-35. Epub 2009 Nov 10.

Department of Pharmacology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan.

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February 2010

The role of mTORC1 pathway in intestinal tumorigenesis.

Cell Cycle 2009 Nov 28;8(22):3684-7. Epub 2009 Nov 28.

Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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November 2009

Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice.

Cancer Sci 2009 Nov 9;100(11):2046-53. Epub 2009 Jul 9.

Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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November 2009

Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.

Gastroenterology 2009 Aug 7;137(2):629-38. Epub 2009 May 7.

Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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August 2009

Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas.

Lab Invest 2009 Jan 10;89(1):98-105. Epub 2008 Nov 10.

Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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January 2009

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.

Proc Natl Acad Sci U S A 2008 Sep 3;105(36):13544-9. Epub 2008 Sep 3.

Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida-Konoé-cho, Sakyo-ku, Kyoto 606-8501, Japan.

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September 2008

Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling.

J Biol Chem 2007 Aug 15;282(32):23532-40. Epub 2007 Jun 15.

Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

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August 2007

Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.

Nat Chem Biol 2005 Nov 16;1(6):333-7. Epub 2005 Oct 16.

Kamakura Research Laboratories, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.

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November 2005

Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins.

Cell Cycle 2005 Jul 3;4(7):908-13. Epub 2005 Jul 3.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

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July 2005

Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins.

Proc Natl Acad Sci U S A 2004 Sep 1;101(37):13613-7. Epub 2004 Sep 1.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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September 2004

Oncogenic transformation by beta-catenin: deletion analysis and characterization of selected target genes.

Oncogene 2002 Oct;21(46):6983-91

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, CA 92037, USA.

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October 2002