Masafumi Kitakaze

Masafumi Kitakaze

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Masafumi Kitakaze

Publications by authors named "Masafumi Kitakaze"

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Overexpression of Na-HCO cotransporter contributes to the exacerbation of cardiac remodeling in mice with myocardial infarction by increasing intracellular calcium overload.

Biochim Biophys Acta Mol Basis Dis 2020 Mar 26;1866(3):165623. Epub 2019 Nov 26.

Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.165623DOI Listing
March 2020

TRPV2 channel as a possible drug target for the treatment of heart failure.

Lab Invest 2020 Feb 19;100(2):207-217. Epub 2019 Dec 19.

Department of Clinical Research and Development, National Cerebral and Cardiovascular Center, Suita, Japan.

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http://dx.doi.org/10.1038/s41374-019-0349-zDOI Listing
February 2020

Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models.

Lab Invest 2020 Feb 2;100(2):324-337. Epub 2020 Jan 2.

Department of Clinical Research and Development, National Cerebral and Cardiovascular Center, Suita, Japan.

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http://dx.doi.org/10.1038/s41374-019-0363-1DOI Listing
February 2020

In vivo real-time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance.

FASEB J 2020 Feb 8;34(2):2041-2054. Epub 2020 Jan 8.

Department of Medical Biochemistry, Osaka University Graduate School of Medicine, Frontier Bioscience, Suita, Japan.

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http://dx.doi.org/10.1096/fj.201901686RDOI Listing
February 2020

Nitroglycerin Tolerance in Patients With ALDH2 Variant.

Circ J 2020 Feb 14. Epub 2020 Feb 14.

Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center.

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http://dx.doi.org/10.1253/circj.CJ-20-0049DOI Listing
February 2020

Lansoprazole alleviates pressure overload-induced cardiac hypertrophy and heart failure in mice by blocking the activation of β-catenin.

Cardiovasc Res 2020 Jan;116(1):101-113

Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China.

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http://dx.doi.org/10.1093/cvr/cvz016DOI Listing
January 2020

Heart rate determines the beneficial effects of beta-blockers on cardiovascular outcomes in patients with heart failure and atrial fibrillation.

Hypertens Res 2019 Nov 18;42(11):1716-1725. Epub 2019 Jun 18.

Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Osaka, Japan.

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http://dx.doi.org/10.1038/s41440-019-0289-4DOI Listing
November 2019

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.

N Engl J Med 2019 11 19;381(21):1995-2008. Epub 2019 Sep 19.

From the BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.V.M., M.C.P., K.F.D., P.S.J.); the Cardiovascular Division (S.D.S., A.S.D.) and the TIMI Study Group, Brigham and Women's Hospital and Harvard Medical School (M.S.S.) - all in Boston; Section of Endocrinology, Yale University School of Medicine, New Haven, CT (S.E.I.); Rigshospitalet Copenhagen University Hospital (L.K.) and the Department of Cardiology, Gentofte University Hospital (M. Schou), Copenhagen; the Department of Medicine, Saarland University Hospital, Homburg-Saar, Germany (M.B.); Saint Luke's Mid America Heart Institute, University of Missouri, Kansas City (M.N.K.); National University of Cordoba, Cordoba (F.A.M.), and the Division of Cardiology, Instituto Cardiovascular de Buenos Aires, Buenos Aires (M.D.) - both in Argentina; Wroclaw Medical University, Wroclaw (P.P.), and the Department of Cardiology, Medical University of Lodz, Lodz (J.D.) - both in Poland; the Department of Cardiology, University of Minnesota, Minneapolis (I.S.A.); 2nd Department of Internal Medicine, Cardiovascular Medicine, General Teaching Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic (J.B.); the Division of Cardiology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan (C.-E.C.); the Department of Cardiology, Medanta, Gurgaon, India (V.K.C.); the Department of Cardiology, University Medical Center and University of Groningen, Groningen, the Netherlands (R.A.B.); the 5th Department of Internal Medicine, Comenius University in Bratislava, Bratislava, Slovakia (A.D.); the Department of Cardiology, Shanghai Institute of Cardiovascular Disease and Zhongshan Hospital Fudan University, Shanghai, China (J.G.); Cumming School of Medicine and Libin Cardiovascular Institute, University of Calgary, Calgary, AB (J.G.H.), the Department of Cardiology, Montreal Heart Institute, Montreal (E.O.), and the Division of Cardiac Surgery, St. Michael's Hospital, University of Toronto, Toronto (S.V.) - all in Canada; Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); the Cardiovascular Division of Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan (M.K.); the Department of Molecular and Clinical Medicine and Cardiology, Sahlgrenska Academy (C.E.A.L.), and AstraZeneca (O.B., M. Sjöstrand, A.M.L.), Gothenburg, and the Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University (C.H.), Uppsala - all in Sweden; the Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Instituto do Coracao, Hospital das Clinicas da Faculdade de Medicina, Universidade de São Paolo, São Paolo (J.C.N.); the Department of Internal Medicine, Tan Tao University, Tan Duc, Vietnam (P.N.V.); the Department of Myocardial Disease and Heart Failure, National Medical Research Center of Cardiology, Moscow (S.T.); and the Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison (D.L.D.).

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http://dx.doi.org/10.1056/NEJMoa1911303DOI Listing
November 2019

Endogenously released adenosine causes pulmonary vasodilation during the acute phase of pulmonary embolization in dogs.

Int J Cardiol Heart Vasc 2019 Sep 10;24:100396. Epub 2019 Jul 10.

Department of Clinical Research and Development, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, Japan.

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http://dx.doi.org/10.1016/j.ijcha.2019.100396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620623PMC
September 2019

A dipeptidyl peptidase-IV inhibitor improves diastolic dysfunction in Dahl salt-sensitive rats.

J Mol Cell Cardiol 2019 Apr 14;129:257-265. Epub 2019 Mar 14.

Clinical Research and Development, National Cerebral and Cardiovascular Center, Osaka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.03.009DOI Listing
April 2019

Dysfunction of microtubules induces cardiac dysfunction.

EBioMedicine 2018 11 16;37:3-4. Epub 2018 Oct 16.

Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Centre, 5-7-1 Fujishirodai, Suita 565-8565, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286635PMC
November 2018

PARALLEL-HF - A Paradigm Shift for Heart Failure Treatment in Japan?

Circ J 2018 09 13;82(10):2479-2480. Epub 2018 Sep 13.

Department of Clinical Research and Development, National Cerebral and Cardiovascular Research Center.

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http://dx.doi.org/10.1253/circj.CJ-18-0939DOI Listing
September 2018

Elucidation of the Strongest Predictors of Cardiovascular Events in Patients with Heart Failure.

EBioMedicine 2018 Jul 20;33:185-195. Epub 2018 Jun 20.

Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Centre, 5-7-1 Fujishirodai, Suita, Osaka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085496PMC
July 2018

Prevention of Periprocedural Myocardial Injury During Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease.

Circ J 2018 06 17;82(7):1746-1748. Epub 2018 May 17.

Department of Clinical Research and Development, National Cerebral and Cardiovascular Center.

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https://www.jstage.jst.go.jp/article/circj/82/7/82_CJ-18-049
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http://dx.doi.org/10.1253/circj.CJ-18-0499DOI Listing
June 2018

Olmesartan attenuates pressure-overload- or post-infarction-induced cardiac remodeling in mice.

Oncotarget 2018 May 23;9(37):24601-24618. Epub 2017 Dec 23.

State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

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http://dx.doi.org/10.18632/oncotarget.23628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973849PMC
May 2018

Cutting Edge Science and Medicine of Adenosine in Patients With Heart Failure.

Circ J 2018 04 4;82(5):1247-1248. Epub 2018 Apr 4.

Department of Clinical Research and Development, National Cerebral and Cardiovascular Center.

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http://dx.doi.org/10.1253/circj.CJ-18-0327DOI Listing
April 2018

The Impact of Bronchodilator Therapy on Systolic Heart Failure with Concomitant Mild to Moderate COPD.

Diseases 2017 Dec 28;6(1). Epub 2017 Dec 28.

Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi Kamicho, Itabashi, Tokyo 173-8610, Japan.

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http://dx.doi.org/10.3390/diseases6010004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871950PMC
December 2017

Reply to 'Use of serum fibroblast growth factor 23 vs. plasma B-type natriuretic peptide levels in assessing the pathophysiology of patients with heart failure'.

Hypertens Res 2017 10 27;40(10):900-901. Epub 2017 Apr 27.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

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http://dx.doi.org/10.1038/hr.2017.59DOI Listing
October 2017

Pathophysiology of cardiorenal syndrome in patients with heart failure: potential therapeutic targets.

Am J Physiol Heart Circ Physiol 2017 Oct 21;313(4):H715-H721. Epub 2017 Jul 21.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan; and.

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http://dx.doi.org/10.1152/ajpheart.00215.2017DOI Listing
October 2017

Does the pathophysiology of heart failure prime the incidence of cancer?

Hypertens Res 2017 Sep 6;40(9):831-836. Epub 2017 Apr 6.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

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http://dx.doi.org/10.1038/hr.2017.45DOI Listing
September 2017

Radiation-induced HFpEF model as a potential tool for the exploration of novel therapeutic targets.

Am J Physiol Heart Circ Physiol 2017 08 16;313(2):H323-H325. Epub 2017 Jun 16.

Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita 565-8565, Japan.

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http://dx.doi.org/10.1152/ajpheart.00307.2017DOI Listing
August 2017

Translational Study of Hydrogen Gas Inhalation as Adjuncts to Reperfusion Therapy for Acute Myocardial Infarction.

Circ J 2017 Jun 1;81(7):936-937. Epub 2017 Jun 1.

Department of Clinical Research and Development, National Cerebral and Cardiovascular Center.

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http://dx.doi.org/10.1253/circj.CJ-17-0520DOI Listing
June 2017

Risk stratification based on nutritional screening on admission: Three-year clinical outcomes in hospitalized patients with acute heart failure syndrome.

J Cardiol 2016 11 7;68(5):392-398. Epub 2016 Jun 7.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan; Division of Advanced Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1016/j.jjcc.2016.05.004DOI Listing
November 2016

FGF23 promotes myocardial fibrosis in mice through activation of β-catenin.

Oncotarget 2016 Oct;7(40):64649-64664

State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.11623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323105PMC
October 2016

Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux.

Clin Sci (Lond) 2016 09 23;130(18):1641-53. Epub 2016 Jun 23.

Sino-Japan Collaborative Laboratory for Heart Failure Translating Medicine, Department of Cardiology, Zhujiang Hospital of Southern Medical University, No. 253, Middle Gongye Avenue, 510282 Guangzhou, China

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http://dx.doi.org/10.1042/CS20160082DOI Listing
September 2016

Acute hyperglycemia suppresses left ventricular diastolic function and inhibits autophagic flux in mice under prohypertrophic stimulation.

Cardiovasc Diabetol 2016 Sep 22;15(1):136. Epub 2016 Sep 22.

State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou avenue north, Guangzhou, 510515, China.

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http://dx.doi.org/10.1186/s12933-016-0452-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034479PMC
September 2016

Histone Deacetylase Inhibitor Phenylbutyrate Exaggerates Heart Failure in Pressure Overloaded Mice independently of HDAC inhibition.

Sci Rep 2016 Sep 26;6:34036. Epub 2016 Sep 26.

Cardiovascular Division of the Department of Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036044PMC
http://dx.doi.org/10.1038/srep34036DOI Listing
September 2016

Recent progress and next challenges in the treatment of symptomatic heart failure in Japan.

Circ J 2015 2;79(11):2322-3. Epub 2015 Oct 2.

Department of Medial Biochemistry, Osaka University Graduate School of Medicine.

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http://dx.doi.org/10.1253/circj.CJ-15-1014DOI Listing
August 2016

Glycemic Variability Predicts Rapid Progression of Non-Culprit Lesions in Patients With Acute Coronary Syndrome.

Circ J 2015 2;79(10):2114-5. Epub 2015 Sep 2.

Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine.

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http://dx.doi.org/10.1253/circj.CJ-15-0919DOI Listing
July 2016

Different Implications of Functional Tricuspid Regurgitation Between Heart Failure (HF) With Reduced Ejection Fraction (EF) and HF With Preserved EF.

Circ J 2015 29;79(7):1448-9. Epub 2015 May 29.

Department of Medial Biochemistry, Osaka University Graduate School of Medicine.

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http://dx.doi.org/10.1253/circj.CJ-15-0560DOI Listing
April 2016

Clinical Evidence of the Role of Histamine in Heart Failure.

J Am Coll Cardiol 2016 04;67(13):1553-1555

Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.01.046DOI Listing
April 2016

Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac Dysfunction.

Circ Res 2016 Mar 1;118(5):798-809. Epub 2016 Feb 1.

From the Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan (H.Y.F., S.S., T.M., K.O., M.Y., S.T., R.A., Y.A., Y.S., T.M.); Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Y.L.); Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto, Japan (H.A.); Department of Clinical Research and Development, National Cerebral and Cardiovascular Center, Osaka, Japan (M.A., M.K.); and Department of Biomedical Engineering, University of Virginia, Charlottesville (B.A.F.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307604DOI Listing
March 2016

Impact of onset time of acute kidney injury on outcomes in patients with acute decompensated heart failure.

Heart Vessels 2016 Jan 24;31(1):60-5. Epub 2014 Aug 24.

Department of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.

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http://dx.doi.org/10.1007/s00380-014-0572-xDOI Listing
January 2016

Targeting lysosomal Ca2+ to reduce reperfusion injury.

Cardiovasc Res 2015 Dec 23;108(3):321-3. Epub 2015 Oct 23.

Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita 565-8565, Japan

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http://dx.doi.org/10.1093/cvr/cvv242DOI Listing
December 2015

Impact of Either GLP-1 Agonists or DPP-4 Inhibitors on Pathophysiology of Heart Failure.

Int Heart J 2015 24;56(4):372-6. Epub 2015 Jun 24.

Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center.

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http://dx.doi.org/10.1536/ihj.15-028DOI Listing
September 2015

Ablation of C/EBP homologous protein increases the acute phase mortality and doesn't attenuate cardiac remodeling in mice with myocardial infarction.

Biochem Biophys Res Commun 2015 Aug 23;464(1):201-7. Epub 2015 Jun 23.

State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.06.117DOI Listing
August 2015

Trends in Characteristics of CVD in Asia and Japan: The Importance of Epidemiological Studies and Beyond.

J Am Coll Cardiol 2015 Jul;66(2):196-8

Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.05.035DOI Listing
July 2015

Data Mining as a Powerful Tool for Creating Novel Drugs in Cardiovascular Medicine: The Importance of a "Back-and-Forth Loop" Between Clinical Data and Basic Research.

Cardiovasc Drugs Ther 2015 Jun;29(3):309-15

Department of Cardiovascular Medicine and Development, National Cerebral and Cardiovascular Center, 5-7-1, Fujishirodai, Suita, 565-8565, Japan,

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http://link.springer.com/10.1007/s10557-015-6602-9
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http://dx.doi.org/10.1007/s10557-015-6602-9DOI Listing
June 2015

Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9.

Circulation 2015 Apr 27;131(17):1506-17; discussion 1517. Epub 2015 Mar 27.

From Sate Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China (X.W., B.W., J.Z., Z.Z., W.X., S.C., X.H., D.X., J.B., M.K., Y.L.); and Cardiovascular Division of the Department of Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan (M.A., M.K.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.114.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.013789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415966PMC
April 2015

Plasma B-type natriuretic peptide is a useful tool for assessing coronary heart disease risk in a Japanese general population.

Hypertens Res 2015 Jan 14;38(1):74-9. Epub 2014 Aug 14.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

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http://www.nature.com/articles/hr2014123
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http://dx.doi.org/10.1038/hr.2014.123DOI Listing
January 2015

Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis.

Chem Biol Interact 2015 Jan 6;225:90-8. Epub 2014 Nov 6.

Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People's Republic of China, School of Medicine, Jinan University, Guangzhou 510632, China.

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http://dx.doi.org/10.1016/j.cbi.2014.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684183PMC
January 2015

Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.

Nat Commun 2015 Jan 30;6:6137. Epub 2015 Jan 30.

1] Department of Medical Biochemistry, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan [2] Japan Science and Technology Agency-Core Research for Evolutional Science and Technology (CREST), Kawaguchi 332-0012, Japan.

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http://dx.doi.org/10.1038/ncomms7137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317497PMC
January 2015

Pathophysiological impact of serum fibroblast growth factor 23 in patients with nonischemic cardiac disease and early chronic kidney disease.

Am J Physiol Heart Circ Physiol 2014 Nov 12;307(10):H1504-11. Epub 2014 Sep 12.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan; Department of Clinical Research and Development, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

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http://dx.doi.org/10.1152/ajpheart.00331.2014DOI Listing
November 2014

Using basic and clinical research in cardiology to achieve personalized medicine: is it a maze or math?

J Am Coll Cardiol 2014 Sep;64(9):946-8

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2014.07.018DOI Listing
September 2014

Extensive late gadolinium enhancement on cardiovascular magnetic resonance predicts adverse outcomes and lack of improvement in LV function after steroid therapy in cardiac sarcoidosis.

Heart 2014 Aug 14;100(15):1165-72. Epub 2014 May 14.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan Department of Clinical Research and Development, National Cerebral and Cardiovascular Center, Osaka, Japan.

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http://dx.doi.org/10.1136/heartjnl-2013-305187DOI Listing
August 2014

Perioperative landiolol administration reduces atrial fibrillation after cardiac surgery: A meta-analysis of randomized controlled trials.

Adv Ther 2014 Apr 23;31(4):440-50. Epub 2014 Apr 23.

Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, 113-8603, Japan,

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http://dx.doi.org/10.1007/s12325-014-0116-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003343PMC
April 2014