Marzena Pazgier, PhD - Uniformed Services University of the Health Sciences - Associate Professor

Marzena Pazgier

PhD

Uniformed Services University of the Health Sciences

Associate Professor

Bethesda, MD | United States

Main Specialties: Biotechnology, Chemistry

Additional Specialties: Structural Biology

Marzena Pazgier, PhD - Uniformed Services University of the Health Sciences - Associate Professor

Marzena Pazgier

PhD

Introduction

Primary Affiliation: Uniformed Services University of the Health Sciences - Bethesda, MD , United States

Specialties:

Additional Specialties:

Research Interests:

Publications

59Publications

1263Reads

145Profile Views

999PubMed Central Citations

From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses.

MAbs 2019 May/Jun;11(4):709-724. Epub 2019 Apr 2.

a Division of Vaccine Research , Institute of Human Virology of University of Maryland School of Medicine , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/19420862.2019.1589852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601566PMC
January 2020
1 Read
4.558 Impact Factor

The HIV-1 Antisense Protein ASP Is a Transmembrane Protein of the Cell Surface and an Integral Protein of the Viral Envelope.

J Virol 2019 Nov 15;93(21). Epub 2019 Oct 15.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/JVI.00574-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803264PMC
November 2019
5 Reads
4.439 Impact Factor

Concurrent Exposure of Neutralizing and Non-neutralizing Epitopes on a Single HIV-1 Envelope Structure.

Front Immunol 2019 5;10:1512. Epub 2019 Jul 5.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628914PMC
July 2019
2 Reads

CD4- and Time-Dependent Susceptibility of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.

J Virol 2019 05 1;93(10). Epub 2019 May 1.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia

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http://dx.doi.org/10.1128/JVI.01901-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498039PMC
May 2019
13 Reads
4.439 Impact Factor

Systematic mutational analysis of human neutrophil α-defensin HNP4.

Biochim Biophys Acta Biomembr 2019 04 15;1861(4):835-844. Epub 2019 Jan 15.

Institute of Human Virology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, USA.

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http://dx.doi.org/10.1016/j.bbamem.2019.01.007DOI Listing
April 2019
20 Reads
3.836 Impact Factor

Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.

Chem Sci 2019 Feb 30;10(5):1522-1530. Epub 2018 Nov 30.

Institute of Human Virology and Department of Biochemistry and Molecular Biology , University of Maryland , School of Medicine , Baltimore , MD , USA . Email: ; Email:

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http://dx.doi.org/10.1039/c8sc03275kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357863PMC
February 2019
18 Reads
9.211 Impact Factor

Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity.

Viruses 2019 01 16;11(1). Epub 2019 Jan 16.

Infectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.3390/v11010069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357199PMC
January 2019
1 Read
3.279 Impact Factor

Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses.

Cell 2018 06 3;173(7):1783-1795.e14. Epub 2018 May 3.

Divisions of Vaccine Research and Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/j.cell.2018.03.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003858PMC
June 2018
6 Reads
3 Citations
32.242 Impact Factor

Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.

Immunity 2018 06 29;48(6):1233-1244.e6. Epub 2018 May 29.

Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China; Center for Translational Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China; Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051418PMC
June 2018
22 Reads
21.561 Impact Factor

Human β-defensin 4 - defensin without the "twist".

Postepy Biochem 2016;62(3):349-361

Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute, Frederick MD 21702, USA.

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December 2017
26 Reads
1 Citation

Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region.

Structure 2017 11 19;25(11):1719-1731.e4. Epub 2017 Oct 19.

Division of Vaccine Research, Institute of Human Virology, Baltimore, MD, USA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677539PMC
November 2017
21 Reads
3 Citations
5.620 Impact Factor

Beyond Viral Neutralization.

AIDS Res Hum Retroviruses 2017 08 16;33(8):760-764. Epub 2017 Feb 16.

10 Centre de Recherche du CHUM, Université de Montréal , Quebec, Canada .

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http://dx.doi.org/10.1089/AID.2016.0299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695748PMC
August 2017
4 Reads
7 Citations
2.330 Impact Factor

Survivors Remorse: antibody-mediated protection against HIV-1.

Immunol Rev 2017 01;275(1):271-284

Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/imr.12510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642910PMC
January 2017
17 Reads
11 Citations
10.120 Impact Factor

Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240.

Sci Rep 2016 11 9;6:36685. Epub 2016 Nov 9.

Division of Vaccine Research of Institute of Human Virology, the University of Maryland School of Medicine, Baltimore, USA.

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http://dx.doi.org/10.1038/srep36685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101508PMC
November 2016
15 Reads
6 Citations
5.080 Impact Factor

Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.

EBioMedicine 2016 Oct 9;12:208-218. Epub 2016 Sep 9.

Centre de Recherche du CHUM, QC H2X 0A9, Canada; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC H2X 0A9, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078604PMC
October 2016
72 Reads
17 Citations

A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.

J Virol 2016 10 12;90(19):8395-409. Epub 2016 Sep 12.

Centre de Recherche du CHUM, Université de Montréal, Montreal, Quebec, Canada Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.1128/JVI.01068-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021418PMC
October 2016
16 Reads
8 Citations
4.440 Impact Factor

Role of HIV-1 Envelope Glycoproteins Conformation and Accessory Proteins on ADCC Responses.

Curr HIV Res 2016 ;14(1):9-23

Centre de recherche du CHUM (CRCHUM), 900 St-Denis street, Tour Viger, R09.420, Montreal, Quebec, H2X 0A9, Canada.

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http://dx.doi.org/10.2174/1570162x13666150827093449DOI Listing
August 2016
20 Reads
19 Citations
2.135 Impact Factor

Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.

Structure 2016 05 31;24(5):697-709. Epub 2016 Mar 31.

Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856543PMC
May 2016
30 Reads
13 Citations
5.620 Impact Factor

Full Length Single Chain Fc Protein (FLSC IgG1) as a Potent Antiviral Therapy Candidate: Implications for In Vivo Studies.

AIDS Res Hum Retroviruses 2016 Feb 22;32(2):178-86. Epub 2015 Jun 22.

1 Institute of Human Virology, University of Maryland School of Medicine , Baltimore, Maryland.

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http://dx.doi.org/10.1089/AID.2015.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761833PMC
February 2016
26 Reads
2.330 Impact Factor

A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies.

J Virol 2016 02 4;90(4):2127-34. Epub 2015 Dec 4.

Centre de Recherche du CHUM, Montreal, QC, Canada Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada

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http://authors.library.caltech.edu/62954/2/J.%20Virol.-2016-
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http://jvi.asm.org/lookup/doi/10.1128/JVI.02779-15
Publisher Site
http://dx.doi.org/10.1128/JVI.02779-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733974PMC
February 2016
9 Reads
22 Citations
4.440 Impact Factor

Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1.

J Virol 2015 Sep 17;89(17):8840-54. Epub 2015 Jun 17.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/JVI.01232-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524080PMC
September 2015
70 Reads
13 Citations
4.440 Impact Factor

Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1.

Viruses 2015 Sep 18;7(9):5115-32. Epub 2015 Sep 18.

Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.3390/v7092856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584300PMC
September 2015
6 Reads
17 Citations
3.280 Impact Factor

CD4 mimetics sensitize HIV-1-infected cells to ADCC.

Proc Natl Acad Sci U S A 2015 May 4;112(20):E2687-94. Epub 2015 May 4.

Centre de Recherche du Centre hospitalier de l'Université de Montréal and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada H2X 0A9; Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada H3A 2B4;

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http://dx.doi.org/10.1073/pnas.1506755112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443331PMC
May 2015
83 Reads
47 Citations
9.810 Impact Factor

Design of a potent antibiotic peptide based on the active region of human defensin 5.

J Med Chem 2015 Apr 20;58(7):3083-93. Epub 2015 Mar 20.

†State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.

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http://dx.doi.org/10.1021/jm501824aDOI Listing
April 2015
24 Reads
8 Citations
5.450 Impact Factor

Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection.

J Virol 2014 Nov 27;88(21):12895-906. Epub 2014 Aug 27.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/JVI.02194-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248932PMC
November 2014
78 Reads
43 Citations
4.440 Impact Factor

Single, double and quadruple alanine substitutions at oligomeric interfaces identify hydrophobicity as the key determinant of human neutrophil alpha defensin HNP1 function.

PLoS One 2013 13;8(11):e78937. Epub 2013 Nov 13.

Translational Medicine Center, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China ; Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078937PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827289PMC
September 2014
11 Reads
8 Citations
3.234 Impact Factor

Epitope target structures of Fc-mediated effector function during HIV-1 acquisition.

Curr Opin HIV AIDS 2014 May;9(3):263-70

aDivision of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine bDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/COH.0000000000000055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104495PMC
May 2014
30 Reads
16 Citations
4.680 Impact Factor

Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses.

Curr HIV Res 2013 Jul;11(5):378-87

Department of Surgery, Duke University Medical Center, P.O. Box 2926, Durham, NC 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878369PMC
http://dx.doi.org/10.2174/1570162x113116660059DOI Listing
July 2013
13 Reads
40 Citations
2.135 Impact Factor

Structural and functional analysis of the pro-domain of human cathelicidin, LL-37.

Biochemistry 2013 Mar 21;52(9):1547-58. Epub 2013 Feb 21.

Institute of Human Virology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1021/bi301008rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634326PMC
March 2013
23 Reads
7 Citations
3.020 Impact Factor

Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding.

Proc Natl Acad Sci U S A 2013 Jan 13;110(1):E69-78. Epub 2012 Dec 13.

Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1073/pnas.1217609110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538257PMC
January 2013
13 Reads
69 Citations
9.810 Impact Factor

An ultrahigh affinity d-peptide antagonist Of MDM2.

J Med Chem 2012 Jul 22;55(13):6237-41. Epub 2012 Jun 22.

Institute of Human Virology & Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1021/jm3005465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426300PMC
July 2012
54 Reads
18 Citations
5.450 Impact Factor

Invariant gly residue is important for α-defensin folding, dimerization, and function: a case study of the human neutrophil α-defensin HNP1.

J Biol Chem 2012 Jun 11;287(23):18900-12. Epub 2012 Apr 11.

The 1st Affiliated Hospital, Xi'an Jiaotong University School of Medicine, China.

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http://dx.doi.org/10.1074/jbc.M112.355255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365925PMC
June 2012
38 Reads
12 Citations
4.573 Impact Factor

Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.

J Biol Chem 2012 Jun 9;287(26):21615-27. Epub 2012 May 9.

Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1074/jbc.M112.367995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381126PMC
June 2012
28 Reads
25 Citations
4.573 Impact Factor

Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide.

J Biol Chem 2012 Mar 23;287(12):8944-53. Epub 2012 Jan 23.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1074/jbc.M111.332205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308808PMC
March 2012
8 Reads
22 Citations
4.573 Impact Factor

D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.

Proc Natl Acad Sci U S A 2010 Aug 26;107(32):14321-6. Epub 2010 Jul 26.

Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1073/pnas.1008930107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922601PMC
August 2010
41 Reads
50 Citations
9.810 Impact Factor

Limitations of peptide retro-inverso isomerization in molecular mimicry.

J Biol Chem 2010 Jun 9;285(25):19572-81. Epub 2010 Apr 9.

School of Pharmacy, Fudan University, Shanghai 201203, China.

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http://dx.doi.org/10.1074/jbc.M110.116814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885236PMC
June 2010
9 Reads
14 Citations
4.573 Impact Factor

Trp-26 imparts functional versatility to human alpha-defensin HNP1.

J Biol Chem 2010 May 10;285(21):16275-85. Epub 2010 Mar 10.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1074/jbc.M110.102749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871495PMC
May 2010
11 Reads
24 Citations
4.573 Impact Factor

A left-handed solution to peptide inhibition of the p53-MDM2 interaction.

Angew Chem Int Ed Engl 2010 May;49(21):3649-52

Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1002/anie.201000329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359147PMC
May 2010
5 Reads
20 Citations
11.261 Impact Factor

Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.

J Mol Biol 2010 Apr 10;398(2):200-13. Epub 2010 Mar 10.

Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/j.jmb.2010.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856455PMC
April 2010
38 Reads
39 Citations
4.333 Impact Factor

Apamin as a template for structure-based rational design of potent peptide activators of p53.

Angew Chem Int Ed Engl 2009 ;48(46):8712-5

Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1002/anie.200904550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845718PMC
February 2010
4 Reads
15 Citations
11.261 Impact Factor

Through the looking glass, mechanistic insights from enantiomeric human defensins.

J Biol Chem 2009 Oct 29;284(42):29180-92. Epub 2009 Jul 29.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1074/jbc.M109.018085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781462PMC
October 2009
38 Reads
41 Citations
4.573 Impact Factor

Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5.

FEBS Lett 2009 Aug 7;583(15):2507-12. Epub 2009 Jul 7.

University of Maryland Baltimore School of Medicine, Institute of Human Virology, Department of Biochemistry and Molecular Biology, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/j.febslet.2009.06.051DOI Listing
August 2009
4 Reads
22 Citations
3.170 Impact Factor

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.

Proc Natl Acad Sci U S A 2009 Mar 2;106(12):4665-70. Epub 2009 Mar 2.

Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1073/pnas.0900947106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660734PMC
March 2009
9 Reads
81 Citations
9.810 Impact Factor

Chemically synthesized human survivin does not inhibit caspase-3.

Protein Sci 2008 Sep 6;17(9):1624-9. Epub 2008 Jun 6.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1110/ps.036145.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525533PMC
September 2008
25 Reads
9 Citations
2.854 Impact Factor

The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability.

J Biol Chem 2008 Aug 22;283(31):21509-18. Epub 2008 May 22.

Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1074/jbc.M801851200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490794PMC
August 2008
17 Reads
29 Citations
4.573 Impact Factor

Human defensins: synthesis and structural properties.

Curr Pharm Des 2007 ;13(30):3096-118

Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.2174/138161207782110381DOI Listing
March 2008
24 Reads
19 Citations
3.452 Impact Factor

Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.

J Biol Chem 2007 Jul 23;282(27):19653-65. Epub 2007 Apr 23.

Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1074/jbc.M611003200DOI Listing
July 2007
14 Reads
39 Citations
4.573 Impact Factor

Studies of the biological properties of human beta-defensin 1.

J Biol Chem 2007 Jan 27;282(3):1819-29. Epub 2006 Oct 27.

Macromolecular Crystallography Laboratory, NCI, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1074/jbc.M607210200DOI Listing
January 2007
10 Reads
18 Citations
4.573 Impact Factor

Expression and purification of recombinant human alpha-defensins in Escherichia coli.

Protein Expr Purif 2006 Sep 20;49(1):1-8. Epub 2006 May 20.

Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.pep.2006.05.004DOI Listing
September 2006
6 Reads
9 Citations
1.700 Impact Factor

Structure of the isoaspartyl peptidase with L-asparaginase activity from Escherichia coli.

Acta Crystallogr D Biol Crystallogr 2004 Jun 21;60(Pt 6):1173-6. Epub 2004 May 21.

Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1107/S0907444904003403DOI Listing
June 2004
4 Reads
4 Citations
7.232 Impact Factor

A cold-adapted extracellular serine proteinase of the yeast Leucosporidium antarcticum.

Extremophiles 2003 Dec 4;7(6):435-42. Epub 2003 Jul 4.

Institute of Technical Biochemistry, Technical University of Łódź, ul. Stefanowskiego 4/10, 90-924 Łódź, Poland.

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http://dx.doi.org/10.1007/s00792-003-0340-9DOI Listing
December 2003
20 Reads
4 Citations
2.310 Impact Factor

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Wuyuan Lu
Wuyuan Lu

Institute of Human Virology

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William D Tolbert
William D Tolbert

Institute of Human Virology Departments of Biochemistry and Molecular Biology of University of Maryland School of Medicine

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George K Lewis
George K Lewis

Institute of Human Virology

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Weirong Yuan
Weirong Yuan

University of Maryland School of Medicine

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Neelakshi Gohain
Neelakshi Gohain

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Wei-yue Lu
Wei-yue Lu

Fudan University

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Anthony L DeVico
Anthony L DeVico

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Jacek Lubkowski
Jacek Lubkowski

the Center for Cancer Research

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Shilei Ding
Shilei Ding

University of Missouri

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