Publications by authors named "Maryam Hormozi"

16 Publications

  • Page 1 of 1

Effect of Selenium on Expression of Apoptosis-Related Genes in Cryomedia of Mice Ovary after Vitrification.

Biomed Res Int 2020 23;2020:5389731. Epub 2020 Sep 23.

Department of Anatomical Sciences, Lorestan University of Medical Sciences, Khorramabad, Iran.

Introduction: Freezing of ovarian tissue is used for preservation of fertility. The freezing-thawing process is accompanied by oxidative stress and induction of apoptosis. Apoptosis is a complex process that has been studied in animal models. The present study was aimed at investigating the effect of selenium on suppression of apoptosis during vitrification-thawing process of mice ovary via studying expression of apoptosis-related genes, and also, we aimed to design statistical models for the roles of single genes and gene-gene interactions in suppression of apoptosis.

Methods: A total of 10 right ovary samples from 10 mice were randomly divided into two groups of selenium treatment (at dose 5 g/ml sodium selenite, through adding to the media) and control group. Vitrification-thawing process was done according to the existed protocols. Real-time PCR was used for gene expression study. The apoptosis gene profile included , , , and . General linear model was applied to study single gene associations and gene-gene interactions.

Results: From the studied genes, showed a significant downregulation in the selenium group in comparison to the control group (∆∆CT = 1.96; = 0.013; relative expression (RE) = 0.28). showed a significant upregulation in the selenium group in comparison to the control group (∆∆CT = -2.49; < 0.001; RE = 3.49). No significant result was found for other genes. According to the multiple models, showed a protective single gene association (beta = -0.33; = 0.032), and ∗ interaction was significantly positive (beta = 0.19; = 0.036).

Conclusion: Addition of selenium to cryomedia of vitrification-thawing process could reduce the apoptosis induced by freezing-thawing stress in mice ovary via downregulation of and upregulation of at transcription level. Multivariable statistical models should be performed in future researches to study biological systems.
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http://dx.doi.org/10.1155/2020/5389731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530498PMC
September 2020

Effects of Hydroxytyrosol on Expression of Apoptotic Genes and Activity of Antioxidant Enzymes in LS180 Cells.

Cancer Manag Res 2020 27;12:7913-7919. Epub 2020 Aug 27.

Department of Community Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Purpose: Colorectal cancer is the third-most commonly occurring cancer in developed countries. Hydroxytyrosol is a potent antioxidant that has several activities, such as oxidative-stress control, inhibition of cell proliferation, and induction of apoptosis. In this study, the effect of hydroxytyrosol on the expression of genes effective in apoptosis - , , , , , and - and antioxidant-enzyme activity in LS180 cells of human colorectal cancer was investigated.

Methods: The human colorectal cancer cell line LS180 was treated with different concentrations of hydroxytyrosol for 24 hours. Expression of , , , , , and was investigated using real-time PCR. The activity of antioxidant and malondialdehyde enzymes was measured by calorimetric methods.

Results: Analysis of gene expression showed that hydroxytyrosol significantly increased the expression of and the BAX:BCL2 ratio in treatment groups compared to the control (<0.05). Also, hydroxytyrosol significantly reduced the expression of the gene (<0.05). Calorimetric analysis showed that hydroxytyrosol increased activity of the antioxidant enzymes catalase, superoxide dismutase, and glutathione peroxidase in treatment groups significantly more than the control group and reduced thiobarbituric acid-reactive substances on an oxidative stress index (<0.05).

Conclusion: Hydroxytyrosol may induce apoptosis in colorectal cancer cells by increasing the expression of gene and increasing the : ratio. Also, hydroxytyrosol may increase the activity of antioxidant enzymes and reduce the proliferation of LS180 cells by changing the antioxidant-defense system in cancer cells.
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http://dx.doi.org/10.2147/CMAR.S253591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468519PMC
August 2020

Comparison of thyroid disease prevalence in patients with celiac disease and controls.

Gastroenterol Hepatol Bed Bench 2020 ;13(1):44-49

Department of Pathology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Aim: This study aimed to investigate the prevalence of thyroid disease (TD) in untreated CD patients and to evaluate the effect of gender and age on its prevalence.

Background: Celiac disease (CD) is a form of intestinal malabsorption syndrome which is closely related to endocrine disorders, especially autoimmune thyroid disease and diabetes The prevalence of TD is possibly high among patients with CD which necessitates the need for screening for TD among them.

Methods: This comparative cross-sectional study was conducted on 288 consecutive untreated patients with CD (mean age, 27.9±14) and 250 controls (mean age, 29.01±13.15) referred for endoscopy in a hospital located in Iran. Thyroid function was evaluated by measuring T3, T4, and TSH levels using ELISA technique, and testing anti-thyroperoxidase (anti-TPO) antibodies through electrochemiluminescence method. Data analysis was conducted in SPSS v.22 software using descriptive statistics and chi-squared test.

Results: Thyroid disease prevalence was 4-fold higher in patients than in controls (13.6% vs. 3.2%, p<0.05). Hypothyroidism was diagnosed in 30 patients and 7 controls, while hyperthyroidism was observed in 9 patients and in one control. Chi-squared test results reported a significant difference in TD prevalence between patients and controls based on gender and age (p<0.05). In both groups, women were significantly more affected than men, and the TD prevalence was higher in younger patients compared to adults.

Conclusion: There was a strong association between thyroid dysfunction and CD. In this regard, it is necessary to screen patients for TD.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069534PMC
January 2020

Oncogenesis and Tumor Inhibition by MicroRNAs and its Potential Therapeutic Applications: A Systematic Review.

Microrna 2020 ;9(3):198-215

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

MicroRNAs appear as small molecule modifiers, which improve many new findings and mechanical illustrations for critically important biological phenomena and pathologic events. The best-characterized non-coding RNA family consists of about 2600 human microRNAs. Rich evidence has revealed their crucial importance in maintaining normal development, differentiation, growth control, aging, modulation of cell survival or apoptosis, as well as migration and metastasis as microRNAs dysregulation leads to cancer incidence and progression. By far, microRNAs have recently emerged as attractive targets for therapeutic intervention. The rationale for developing microRNA therapeutics is based on the premise that aberrantly expressed microRNAs play a significant role in the emergence of a variety of human diseases ranging from cardiovascular defects to cancer, and that repairing these microRNA deficiencies by either antagonizing or restoring microRNA function may yield a therapeutic benefit. Although microRNA antagonists are conceptually similar to other inhibitory therapies, improving the performance of microRNAs by microRNA replacement or inhibition that is a less well- described attitude. In this assay, we have condensed the last global knowledge and concepts regarding the involvement of microRNAs in cancer emergence, which has been achieved from the previous studies, consisting of the regulation of key cancer-related pathways, such as cell cycle control and the DNA damage response and the disruption of profile expression in human cancer. Here, we have reviewed the special characteristics of microRNA replacement and inhibition therapies and discussed explorations linked with the delivery of microRNA mimics in turmeric cells. Besides, the achievement of biomarkers based on microRNAs in clinics is considered as novel non-invasive biomarkers in diagnostic and prognostic assessments.
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http://dx.doi.org/10.2174/2211536608666191104103834DOI Listing
January 2020

stimulate proliferation of mouse embryonic fibroblasts via expression of growth factors TGFβ1 and bFGF.

Inflamm Regen 2019 20;39. Epub 2019 Apr 20.

5Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.

Background: TGF-β has an important role in the process of wound healing and scar formation. The aim of this study is to determine the effects of ethanolic and methanolic extracts of on the expression of TGFβ1 and bFGF in the mouse embryonic fibroblast cells (MEFs).

Methods: extract was purchased and different substances defined with gas chromatography and mass spectrometry. MEFs were prepared and after incubating for 15 min, cell viability analyzed. TGF β 1 and bFGF gene expression was evaluated by real-time PCR. TGFβ1 and bFGF protein expression analyzed by ELISA. The statistical analysis of data was done by using SPSS software. Differences were considered significant at ( < 0.05).

Results: The results of the MTT test showed that the concentrations of 5 μg/ml and10 μg/ml were more suitable for cell proliferation. There was an increase in TGF β 1 gene expression in the MEFs. Expression of TGF β 1 gene remains the same after 24 h. Gene expression of bFGF showed a similar pattern with β expression for both solvents. Analysis of TGFβ1 protein expression showed an increase in TGFβ1 gene expression in the MEFs. Protein expression of bFGF in the MEFs increased at different concentrations at 12 and 24 h after treatment ( < 0.05 and  < 0.01 respectively).

Conclusion: stimulates proliferation of MEFs. Calendula via increased expression of growth factors (TGFβ1 and bFGF) at the first 12 h and a decrease of these factors at 24 h after treatment may ameliorate function of the MEFs in the during wound healing.
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http://dx.doi.org/10.1186/s41232-019-0097-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475102PMC
April 2019

Achillea biebersteinni Afan may inhibit scar formation: In vitro study.

Mol Genet Genomic Med 2019 05 9;7(5):e640. Epub 2019 Apr 9.

Department of Community Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background: One of the major problems in wound healing is scar formation; however, there are few ways to prevent or treat it. Different species of Achillea are used to treat wounds in folk medicine from the past but there are few studies on the effect of it on wound healing and inhibition of scar formation. The aim of this study was to investigate the effect of Achillea biebersteinii Afan hydroethanolic extract on the expression of TGFβ1 and bFGF as effective growth factors of wound healing in mouse embryonic fibroblast cells.

Methods: Mouse embryonic fibroblast cells were exposed to different concentrations of Achillea extract at two different time (12 and 24 hr); the expression of TGFβ1 and bFGF was performed by real-time-PCR and ELISA at the level of gene and protein.

Results: It was observed that the plant extract at 5 and 10 µg/ml downregulated the expression of TGFβ1 and upregulated the expression of bFGF at the level of gene and protein.

Conclusion: The results showed that the pattern of changes in the expression of TGFβ1 and bFGF by Achillea biebersteinni Afan extract may inhibit scar formation.
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http://dx.doi.org/10.1002/mgg3.640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503027PMC
May 2019

Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):891-895

c Department of Community Medicine , Lorestan University of Medical Sciences , Khorramabad , Iran.

Astaxanthin, a Xanthophyll carotenoid, has strong antioxidant properties. Some studies have shown the effectiveness of this compound on the prevention and treatment of cancer. Therefore, the aim of this study was to evaluate the effects of astaxanthin on induction of apoptosis and antioxidant activity in the LS-180 cell line. In this experimental study, after the treatment of LS-180 50, 100 and 150 μm of Astaxanthin for 24 h, the expression levels of Bax, Bcl2 and Caspase3 genes were investigated by Real-time PCR. Also, the level of malondialdehyde, as an indicator of oxidative stress and activity of anti-superoxide dismutase enzymes, catalase and glutathione peroxidase was investigated by colorimetric methods. The results showed that astaxanthin increases the expression of Bax and Caspase3 genes and decreases that of Bcl2, thereby, inducing apoptosis and inhibiting growth and proliferation of the cells. Additionally, reduction in the levels of malondialdehyde was evident with a significant elevation in antioxidant activity mediated by the action of superoxide dismutase, catalase and glutathione peroxidase. These results suggest that astaxanthin has the potency to induce apoptosis in LS-180 cells by increasing the expression of apoptotic genes and activity of antioxidant enzymes. Thus, astaxanthin has potential in the prevention and treatment of cancer.
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http://dx.doi.org/10.1080/21691401.2019.1580286DOI Listing
December 2019

Can parents' educational level and occupation affect perceived parental support and metabolic control in adolescents with type 1 diabetes?

J Educ Health Promot 2019 29;8:11. Epub 2019 Jan 29.

Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background/aim: Parents have an important role to play in supporting adolescents with type 1 diabetes mellitus (T1DM). Their education and occupation are important factors for the management of this disease. This study aimed to investigate the parental support that Iranian adolescents with T1DM experience and to examine the effect of parents' education and occupation on adolescents' perceived the parental support and metabolic control.

Methods: This is a cross-sectional survey. The participants were 98 adolescents (aged 11-18 years) with T1DM referred to Endocrinology Clinics of Shahid Rahimi and Shahid Madani hospitals in Khorramabad, Iran, in 2016. For evaluating the adolescents' perceptions of parental support, the family version of Diabetes Social Support Questionnaire was employed. It measures in five diabetic care areas (insulin administration, blood testing, meal planning, exercise, and emotional support). Data were analyzed in SPSS version 22 software using descriptive statistics and inferential tests including Pearson correlation test, ANOVA, and independent -test.

Results: The parents' educational level had a significant relationship with adolescents' perceived parental support and hemoglobin A1c (HbA1c) level ( < 0.05). Occupation of father had no significant influence on his supportive behavior and HbA1c level in adolescents, but mother's occupation significantly influenced them ( < 0.05). In adolescents with higher perceived parental support, the mean HbA1c was lower.

Conclusions: Parents with higher educational level can improve the metabolic control and provide better meal planning in adolescents with T1DM.
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http://dx.doi.org/10.4103/jehp.jehp_215_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378813PMC
January 2019

Effects of coenzyme Q10 supplementation on oxidative stress and antioxidant enzyme activity in glazers with occupational cadmium exposure: A randomized, double-blind, placebo-controlled crossover clinical trial.

Toxicol Ind Health 2019 Jan 19;35(1):32-42. Epub 2018 Nov 19.

5 Department of Community Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Trial Registration:: Iranian Registry of Clinical Trials Registration Number: IRCT2016061228407N1 ( www.who.int/ictrp/network/irct/en/ ).
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http://dx.doi.org/10.1177/0748233718809256DOI Listing
January 2019

The biochemical effects of occupational exposure to lead and cadmium on markers of oxidative stress and antioxidant enzymes activity in the blood of glazers in tile industry.

Toxicol Ind Health 2018 Jul 18;34(7):459-467. Epub 2018 Apr 18.

4 Department of Community Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

The aim of the present study was to evaluate the effects of occupational exposure to lead (Pb) and cadmium (Cd) on markers of oxidative stress in glazers in tile industries. Total antioxidant capacity (TAC), malondialdehyde (MDA), and the activity of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were determined in the blood of 80 subjects, including 40 glazers and 40 nonexposed subjects. Mean levels of blood Cd (8.90 ± 2.80 µg/L) and blood Pb (62.90 ± 38.10 µg/L) of glazers showed a significant increase compared with the control group. In the serum of glazers, the level of MDA was significantly higher and the level of TAC was significantly lower than the control group. We have noted a disturbance in the levels of antioxidants by a significant increase in the CAT activity and a significant decrease in the activities of SOD and GPx in the serum of glazers compared with the controls. Correlation analysis demonstrated that the serum MDA level and CAT activity were positively associated with the blood levels of Pb and Cd. Also, GPx and SOD were negatively correlated with blood Cd levels. The study clearly indicated that co-exposure to Cd and Pb can induce oxidative stress in glazers, resulting in increased lipid peroxidation and altered antioxidant enzymes.
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http://dx.doi.org/10.1177/0748233718769526DOI Listing
July 2018

The risk of hearing loss associated with occupational exposure to organic solvents mixture with and without concurrent noise exposure: A systematic review and meta-analysis.

Int J Occup Med Environ Health 2017 Jun 23;30(4):521-535. Epub 2017 May 23.

Shiraz University of Medical Sciences, Shiraz, Iran (Department of Health and Nutrition School Library).

This study is a meta-analysis of the previous epidemiological studies which investigated the quantitative estimates of the association between independent or combined exposure to noise and mixed organic solvents and hearing loss until October 2014. Overall, 15 studies with information on 7530 individuals (6% female) were included. Having assessed - by puretone audiometry - the adjusted odds ratio estimates for the association between solvents mixture exposure and the risk of developing hearing loss stood at 2.05 (95% confidence interval (CI): 1.44-2.9). Similarly, for subjects who were concurrently exposed to noise and solvents mixture, an OR of 2.95 (95% CI: 2.1-4.17) was obtained. There was some evidence of heterogeneity within each of the 2 exposure groups (p heterogeneity < 0.001). This heterogeneity was not explained by differences in strength of effect between duration of exposure, the number of solvent and exposure index in subgroups of solvents mixture exposure. Based on the available data, our analysis has provided the evidence of increased risk of developing hearing loss for workers exposed to organic solvents even at quite low concentration. Moreover, if such exposure is accompanied by noise, it will exacerbate the extent of hearing loss. Int J Occup Med Environ Health 2017;30(4):521-535.
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http://dx.doi.org/10.13075/ijomeh.1896.01024DOI Listing
June 2017

The effect of aloe vera on the expression of wound healing factors (TGFβ1 and bFGF) in mouse embryonic fibroblast cell: In vitro study.

Biomed Pharmacother 2017 Apr 24;88:610-616. Epub 2017 Feb 24.

Department of Anatomical Sciences, Lorestan University of Medical Science, Khorramabad, Iran. Electronic address:

Background: Aloe vera (A.v) have been used traditionally for topical treatment of wounds and burns in different countries for centuries, but the mechanism of this effect is not well understood. Various growth factors are implicated in the process of wound healing. Among the different growth factors involved in the process, TGFβ1 and bFGF are the most importantly expressed in fibroblast cells. The aim of this study was to evaluate the effect of A.v on the expression of angiogenesis growth factors in mouse embryonic fibroblast cells.

Methods: We exposed mouse embryonic fibroblast cells to different concentrations of A.v (50, 100 and 150μg/ml) at two different time of 12 and 24h. Fibroblast cell without A.v treatment serves as the control. The expression of TGFβ1and bFGF was measured by real time-polymerase chain reaction (real-time-PCR) and enzyme-linked immunosorbent assay (ELISA) at the level of gene and protein.

Results: We observed that A.v gel at first up-regulated the expression of TGFβ1 and bFGF, but, these genes were later repressed after a particular time.

Conclusion: Our results demonstrated that A.v was dose-dependent and time-dependent on the expression of bFGF and TGFβ1 in fibroblast cell in vitro. This mechanism can be employed in the prospective treatment of physical lesion.
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http://dx.doi.org/10.1016/j.biopha.2017.01.095DOI Listing
April 2017

The effect of Setarud (IMOD(TM)) on angiogenesis in transplanted human ovarian tissue to nude mice.

Iran J Reprod Med 2015 Oct;13(10):605-14

Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.

Background: One of the promising methods in fertility preservation among women with cancer is cryopreservation of ovarian cortex but there are many drawbacks such as apoptosis and considerable reduction of follicular density in the transplanted ovary. One solution to reduce ischemic damage is enhancing angiogenesis after transplantation of ovarian cortex tissue.

Objective: The aim of this study was to investigate the effect of Setarud, on angiogenesis in transplanted human ovarian tissue.

Materials And Methods: In this case control study, twenty four nude mice were implanted subcutaneously, with human ovarian tissues, from four women. The mice were randomly divided into two groups (n=12): the experimental group was treated with Setarud, while control group received only vehicle. Each group was divided into three subgroups (n=4) based on the graft recovery days post transplantation (PT). The transplanted fragments were removed on days 2, 7, and 30 PT and the expression of Angiopoietin-1, Angiopoietin-2, and Vascular endothelial growth factor at both gene and protein levels and vascular density were studied in the grafted ovarian tissues.

Results: On the 2(nd) and 7(th) day PT, the level of Angiopoietin-1 gene expression in case group was significantly lower than that in control group, while the opposite results were obtained for Angiopoietin-2 and Vascular endothelial growth factor. These results were also confirmed at the protein level. The density of vessels in Setarud group elevated significantly on day 7 PT compared to pre-treatment state.

Conclusion: Our results showed that administration of Setarud may stimulates angiogenesis in transplanted human ovarian tissues, although further researches are needed before a clear judgment is made.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668347PMC
October 2015

Implementation of internet training on posture reform of computer users in iran.

Acta Inform Med 2014 Dec 19;22(6):379-84. Epub 2014 Dec 19.

Department of Hygiene Education and Health Promotion, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

Background And Purpose: Musculoskeletal disorders are of common problems among computer (PC) users. Training of posture reform plays a significant role in the prevention of the emergence, progression and complications of these diseases. The present research was performed to study the effect of the Internet training on the posture reform of the Internet users working in two Iranian universities including Sistan and Baluchestan University and Islamic Azad University of Zahedan in 2014.

Materials And Method: This study was a quasi-experimental intervention with control group and conducted in two Iranian universities including Sistan and Baluchestan University and Islamic Azad University of Zahedan. The study was done on 160 PC users in the two groups of intervention (80 people) and control (80 people). Training PowerPoint was sent to the intervention group through the Internet and a post test was given to them after 45 days. Statistical software of SPSS 19 and statistical tests of Kolmogrov, t-test, Fisher Exact test, and correlation coefficient were used for data analysis.

Results: After the training, the mean scores of knowledge, attitude, performance and self-efficacy in the intervention group were 24.21 ± 1.34, 38.36 ± 2.89, 7.59 ± 1.16, and 45.06 ± 4.11, respectively (P <0.001). The mean scores of knowledge in the intervention group 5.45±2.81 and in the control group 1.20 ± 1.07 showed a significant change. Mean scores of attitude in the intervention group 3.60 ± 3.59 and in the control group 0.48± 1.03 showed a significant change as well. Mean scores of self-efficacy in the intervention group 14.83 ± 4.67 and in the control group 0.88 ± 1.93 indicated a significant change and mean scores of performance in the intervention group 5.28 ± 1.24 and in the control group 0.62 ± 0.73 indicated a significant change (P <0.001).

Discussion: The results of the study showed that training through the Internet had a significant impact on the posture reform of the PC users. According to the findings observed, there was a significant relationship between the scores of self-efficacy-performance after training. Therefore, based on the findings of the study, it is suggested that Internet training to increase self-efficacy approach in the successive periods can be effective to reform the postures of PC users.
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http://dx.doi.org/10.5455/aim.2014.22.379-384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315643PMC
December 2014

Amelioration of lipid peroxidation in vivo and in vitro by Satureja khozestanica essential oil in alloxan-induced diabetic rats.

J Diabetes Metab Disord 2014 13;13(1):119. Epub 2014 Dec 13.

Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khoram Abad, Iran.

Background: We examined possible protective effect of Satureja khozestanica essential oil (SKE) on in vivo and in vitro lipid peroxidation in alloxan-induced Type 1 diabetic rats.

Methods: Thirty Sprage-dawley male rats were divided into three groups randomly; group one as control, group two diabetic untreatment, and group three treatments with SKE by 500 ppm in drinking water, respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, animals were anaesthetized, livers and kidneys were then removed immediately and used fresh or kept frozen until their lipid peroxidation analysis. Lipid peroxidation was determined by measurement of thiobarbituric acid reactive substances (TBARS). Blood samples were also collected before killing to measure the levels of fasting blood suger (FBS) and lipid peroxidation.

Results: SKE significantly inhibited the levels of FBS, TBARS serum and kidney content in treated group compared with the diabetic untreated group. Also the levels of malonedialdehyde liver content unaltered in treated group. SKE significantly inhibited LDL oxidation in vitro.

Conclusions: The findings showed that SKE exerts beneficial effects on the lipid peroxidation in alloxan-induced Type 1 diabetic rats.
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http://dx.doi.org/10.1186/s40200-014-0119-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280039PMC
December 2014

5'-(N-ethylcarboxamido) adenosine improves angiogenesis in transplanted human ovarian tissue.

Fertil Steril 2011 Jun;95(8):2560-3.e1-5

Biochemistry Department, Tehran University of Medical Sciences, Tehran, Iran.

To investigate the effect of 5'-(N-ethylcarboxamido) adenosine (NECA), an adenosine agonist, on triggering angiogenesis in transplanted human ovarian tissue, the expression of angiopoietin-1 (Ang1), Ang2, vascular endothelial growth factor 121 (VEGF-121) and VEGF-189 at both gene and protein levels as well as the density of vasculature were studied in tissue fragments grafted to NECA-treated and control groups of nude mice. The results showed that NECA treatment triggered down-regulation of Ang1, induced VEGF-189 expression, and stimulated neovascularization, highlighting the beneficial effect of NECA on the process of angiogenesis.
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http://dx.doi.org/10.1016/j.fertnstert.2011.05.041DOI Listing
June 2011