Publications by authors named "Maryam Ali Al-Nesf"

10 Publications

  • Page 1 of 1

Primary immunodeficiency and the microbiome.

Curr Opin Pediatr 2021 Dec;33(6):633-638

Anti-Doping Laboratory Qatar, Doha, Qatar.

Purpose Of Review: The current understanding of the relationship of the microbiota to clinical manifestation in patients with primary immunodeficiency, specifically the inflammatory processes caused by or that result in microbial dysbiosis, and their potential therapeutic options in primary immunodeficiency diseases (PID), is the basis of this review.

Recent Findings: PIDs are heterogeneous diseases with variable presentations, genetic backgrounds, complications, and severity. The immune-mediators may be extrinsic, such as therapeutic regimens that patients are on, including immunoglobin, biologics, antibiotics and diet, or intrinsic, like cytokines, microRNA and microbiome. The microbiome in PID, in particular, appears to play a crucial role in helping the host's immune system maintain hemostatic control in the intestine. Many of the clinical manifestations and complications of PID may be attributed to inflammatory and immune dysregulatory processes connected to the imbalances of the diet-microbiota-host-immunity axis, as shown by data pointing to the loss of microbial diversity, dysbiosis, in PID.

Summary: The gut microbiome is a promising area of study in PID. Although the connection of the microbiome to humoral immunodeficiency is evident, the possibility of utilizing the association of humoral and cellular immunodeficiency and the microbiome for therapeutic benefit is still under investigation.
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http://dx.doi.org/10.1097/MOP.0000000000001067DOI Listing
December 2021

In vitro Interleukin-7 treatment partially rescues MAIT cell dysfunction caused by SARS-CoV-2 infection.

Sci Rep 2021 07 8;11(1):14090. Epub 2021 Jul 8.

Department of Human Genetics, Research Branch, Sidra Medicine, 26999, Doha, Qatar.

MAIT cells have been shown to be activated upon several viral infections in a TCR-independent manner by responding to inflammatory cytokines secreted by antigen-presenting cells. Recently, a few studies have shown a similar activation of MAIT cells in response to severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. In this study, we investigate the effect of SARS-CoV-2 infection on the frequency and phenotype of MAIT cells by flow cytometry, and we test in vitro stimulation conditions on the capacity to enhance or rescue the antiviral function of MAIT cells from patients with coronavirus disease 2019 (COVID-19). Our study, in agreement with recently published studies, confirmed the decline in MAIT cell frequency of hospitalized donors in comparison to healthy donors. MAIT cells of COVID-19 patients also had lower expression levels of TNF-alpha, perforin and granzyme B upon stimulation with IL-12 + IL-18. 24 h' incubation with IL-7 successfully restored perforin expression levels in COVID-19 patients. Combined, our findings support the growing evidence that SARS-CoV-2 is dysregulating MAIT cells and that IL-7 treatment might improve their function, rendering them more effective in protecting the body against the virus.
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http://dx.doi.org/10.1038/s41598-021-93536-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266862PMC
July 2021

Etiology and outcome of hemoptysis in Qatar, a high-resource country with a large expatriate population: A retrospective study.

Qatar Med J 2019 15;2019(1). Epub 2019 Jul 15.

Department of Medicine, Hamad Medical Corporation, Doha, Qatar, P.O. Box 3050.

Hemoptysis is an alarming symptom in clinical practice. We reviewed ten years of experience with hemoptysis in a tertiary hospital in Qatar to identify hemoptysis etiologies, patient characteristics, and associated factors. Hemoptysis was defined based on severity as mild ( < 50 ml or streaks of blood), moderate (50-150 ml) and massive (>150 ml) in the 24 hours before admission. Hemodynamically unstable is considered when systolic BP  < 100 mmHg,tachycardia with HR>110/min, tachypnea with RR>22/min, or SpO2  < 92% on room air. A total of 102 patients (41 females and 61 males) with 133 episodes of hemoptysis were identified in this study. Among the hemoptysis patients with co-morbidities, 19 patients had hypertension, 17 patients had cardiovascular disease, and 66 patients with other co-morbidities. COPD patients had a significant (p  <  0.02) association with hemoptysis. Chest X-ray was used in most patients and other modalities like CT scan and bronchoscopies were used less frequently. Pneumonia (12.8%), bronchiectasis (11.8%) and cardiovascular disorders (11.8%) are the primary causes of hemoptysis. Malignancy was less frequent (7.8%), and bronchogenic carcinoma was uncommon (2%). There were 24 (23.5 %) no identified causes of hemoptysis. The overall mortality was 9.8% in this study. Population demographics played a significant role in the severity of hemoptysis and prognosis. Most patients had benign etiologies, lower severity of hemoptysis and good prognosis. Differences in the etiology, initial severity, and prognosis of patients with hemoptysis were found significantly different when compared with those reported in previous studies.
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http://dx.doi.org/10.5339/qmj.2019.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626967PMC
July 2019

A Novel Mutation in a Qatari Patient With Hyper-IgE Syndrome.

Front Pediatr 2019 24;7:130. Epub 2019 Apr 24.

Section of Immunology, Allergy and Rheumatology, Department of Pediatrics, Center for Human Immunobiology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States.

Autosomal dominant hyper-IgE syndrome caused by mutations in the transcription factor STAT3 (AD-HIES) is characterized by a collection of immunologic and non-immune features including eczema, recurrent infections, elevated IgE levels, and connective tissue anomalies. We report the case of a Qatari child with a history of recurrent staphylococcal skin infections since infancy, who was found to have a novel, mutation in STAT3 (c.1934T>A, p.L645Q). The absence of mucocutaneous candidiasis and undetectable IgE levels until the age of 7 years prolonged the time to molecular confirmation of the cause for the patient's immune deficiency. STAT3 p.L645Q was found to have decreased transcriptional capacity. The patient also had low levels of Th17 cells and STAT3 phosphorylation was impaired in patient-derived cells. Nearly 100 unique mutations in STAT3 have been reported in association with AD-HIES.
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http://dx.doi.org/10.3389/fped.2019.00130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491627PMC
April 2019

Anaphylaxis triggers in a large tertiary care hospital in Qatar: a retrospective study.

World Allergy Organ J 2018 4;11(1):20. Epub 2018 Sep 4.

1Biomedical Science Department, College of Health Science, Qatar University, P.O. Box 2713, Doha, Qatar.

Background: Anaphylaxis is a serious allergic disease that may lead to death if not immediately recognized and treated. Triggers of anaphylaxis including food, drugs, and insect stings can vary widely. The incidence of anaphylaxis seems to be affected by age, sex, atopy, and geographic location. This study aims to examine the common triggers of anaphylaxis in Qatar.

Methods: A total of 1068 electronic medical records were audited using power chart system: 446 from the medical coding system of anaphylaxis and 622 from the epinephrine auto-injectors (EAIs) dispensed during January 2012-December 2017.

Results: Of 1068 patients, 574 (53.5%) had anaphylaxis; male to female ratio was 1.2, and 300 patients (77.9%) were less than 10 years old. The common triggers were food ( = 316, 55.0%), insect stings ( = 161, 28.0%), and drugs ( = 103, 17.9%). Common anaphylaxis food triggers were nuts ( = 173, 30.1%), eggs ( = 89, 15.5%), and seafood ( = 72, 12.5%), and common anaphylaxis medication triggers were antibiotics ( = 49, 8.5%) and nonsteroidal anti-inflammatory drugs ( = 30, 5.2%). Interestingly, 135 anaphylactic patients (23.5%) were due to black ant stings. The anaphylaxis triggers varied significantly between children and adults. Among children (less than 10 years), three quarters of the events were triggered by food (223, 74.3%) while among adults (20-55 years), insect stings ( = 59, 43.0%) and drugs ( = 44, 32.0%) were dominant.

Discussion: This is the first national study stratifying anaphylaxis triggers among different age groups in Qatar. This study will serve as a guide for clinical practice in allergy clinics in Qatar and will help to assess future trends of anaphylaxis in Qatar.
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http://dx.doi.org/10.1186/s40413-018-0200-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122634PMC
September 2018

Renal allograft tuberculosis with infected lymphocele transmitted from the donor.

Saudi J Kidney Dis Transpl 2014 Mar;25(2):370-5

Department of Medicine, Hamad General Hospital, Doha, Qatar.

Transmission of tuberculosis (TB) from a donor through renal transplantation is a rare incident. We are reporting a 53-year-old Qatari woman diagnosed with renal allograft TB infection. The disease was confirmed by isolation of Mycobacterium tuberculosis from fluid from the lymphocele and demonstration of caseating granuloma in graft biopsy with acid-fast bacilli seen on Ziehl-Neelsen staining. The diagnosis was made quite early post-transplantation. The presence of the granuloma, which is unusual with patients on intensive immunosuppressant medications, suggests that transmission of the infection occurred from the donor rather than from the activation of latent infection. In reviewing the literature, we found ten case reports of TB in transplanted kidney with transmission of TB infection from the donor. The presence of TB in lymphocele in association with the infected transplant by TB, to the best of our knowledge, was reported only once in the literature. Our case had unfavorable outcome and ended by renal allograft nephrectomy and hemodialysis. We are presenting this case of TB infection of renal allograft and lymphocele diagnosed early post-transplantation transmitted from the donor and pertinent review from the literature.
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http://dx.doi.org/10.4103/1319-2442.128549DOI Listing
March 2014

Two cases of food-dependent exercise-induced anaphylaxis with different culprit foods.

Ann Thorac Med 2014 Jan;9(1):42-4

Department of Medicine, Hamad General Hospital, Doha, Qatar.

Food-dependent exercise-induced anaphylaxis (FDEIA) is one of the severe allergic reactions in which symptoms develop only if exercise takes place within a few hours of eating a specific food. It is important to consider FDEIA in cases of unexplained anaphylaxis as reactions can occur several hours after ingesting the culprit food(s). We herein report the first two cases of FDEIA in the Middle East. The first one is induced by wheat, while the other by peanut. The pathophysiology, predisposing factors, diagnosis, and treatment of FDEIA are also summarized here.
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http://dx.doi.org/10.4103/1817-1737.124443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912687PMC
January 2014

Complex regional pain syndrome type I following tetanus toxoid injection.

J Clin Rheumatol 2014 Jan;20(1):49-50

From the Divisions of Pulmonary and Rheumatology, Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.1097/RHU.0000000000000061DOI Listing
January 2014

Primary Cutaneous Vasculitis Masquerading as Drug Induced following Aspirin Desensitization.

Case Rep Med 2013 24;2013:745714. Epub 2013 Nov 24.

Division of Respiratory, Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.

Aspirin-exacerbated respiratory disease (AERD) is a well-known clinical condition. Aspirin desensitization followed by daily aspirin therapy is the treatment of choice. We report a challenging case of primary cutaneous vasculitis following aspirin desensitization in a patient with AERD. The vasculitis was likely suppressed with higher dose systemic steroid use to control asthma. Aspirin desensitization led to improved asthma control and steroid reduction, which led to manifestation of prior suppressed cutaneous vasculitis. In our case, there was no evidence of systemic involvement and the patient had a favorable outcome with appropriate therapy.
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http://dx.doi.org/10.1155/2013/745714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857825PMC
December 2013
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