Publications by authors named "Maryam Ahmadi"

110 Publications

Desulfurization of liquid fuels using aluminum modified mesoporous adsorbent: towards experimental and kinetic investigations.

Sci Rep 2021 Apr 23;11(1):8848. Epub 2021 Apr 23.

Department of Chemical Engineering, Faculty of Engineering, Golestan University, Aliabad Katoul, Iran.

In this study, a modified mesoporous adsorbent (MSU-S) impregnated by aluminum was used to remove the aromatic sulfur compounds from n-decane as the model fuel. Physical and chemical properties of as-synthesized adsorbent were investigated by XRD (X-Ray Diffraction), SEM (Scanning Electron Microscopy), FTIR (Fourier Transform Infrared spectroscopy) and BET (Brunauer-Emmett-Teller) method. Adsorptive desulfurization of model fuel was studied through batch and continues processes under mild temperature and normal atmospheric pressure. The equilibrium adsorption was modeled by Langmuir, Temkin, and Freundlich and the kinetics of adsorption was studied through first, second and intraparticle diffusion models. It was figured out that Temkin and the pseudo-second-order model were best fitting the adsorption equilibrium and describing the kinetics, respectively.
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http://dx.doi.org/10.1038/s41598-021-88439-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065138PMC
April 2021

Subvisible Particles in Solutions of Remicade in Intravenous Saline Activate Immune System Pathways in In Vitro Human Cell Systems.

J Pharm Sci 2021 Apr 14. Epub 2021 Apr 14.

Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, 80045. Electronic address:

Among patients that receive Remicade® therapy, more than 20% have adverse infusion related reactions and approximately 50% have immunogenic responses. Upon characterization of initial Remicade®-IV solution we observed a high concentration of subvisible particles that could inadvertently be delivered to patients. This solution was processed through the IV infusion system, mimicking the typical clinical administration setup - either with or without an in-line filter connected to the IV line. The samples generated thereafter were tested using various in vitro assays for activation of the innate immune system via cytokine release in whole blood and in peripheral blood mononuclear cell (PBMC) cultures, and activation of the Toll like receptors (TLRs). Activation of the adaptive immune system was evaluated by monitoring upregulation of surface receptors on dendritic cells (DCs) and CD4+ T cell proliferation in response to IV solution of Remicade®. Our results indicate that subvisible particles in Remicade®-saline solution have a significant role in activation of the immune system but there are extrinsic factors potentially contributed by the in-line filters or other process parameters that also contribute to immune system activation.
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http://dx.doi.org/10.1016/j.xphs.2021.04.005DOI Listing
April 2021

Quality and cost analysis of a wastewater treatment plant using GPS-X and CapdetWorks simulation programs.

J Environ Manage 2021 Apr 2;284:111993. Epub 2021 Feb 2.

Department of Chemical Engineering, Babol Noshirvani University of Technology (BNUT), Babol, Iran. Electronic address:

Wastewater management is a significant challenge, especially for arid and semiarid countries due to the water scarcity crisis. Considering human health, environmental regulations, wastewater treatment plant expenses, and water reusability, this study aims to assist in designing an efficient and economical WWTP. Technical and economic simulation and modeling are important for designing, constructing, and predicting the requirements of wastewater treatment plant designs. Simulation of a project before its implementation, in the first place, reduces additional costs, and from another point of view, a project is examined and researched from different aspects. In this study, three wastewater treatment plants based on conventional activated sludge, contact stabilization, and step aeration were simulated and evaluated technically and economically using the Zargandeh treatment plant data in Tehran. In three scenarios, GPS-X software investigated the effect of raw wastewater variations between their minimum and maximum intervals on effluent quality, and because the range of inlet effluent was different, more precise results were obtained. Then, the economic costs of the project, including implementation, maintenance, and also energy use, were calculated by Capdetwork software, and contact stabilization was found to be more cost-effective.
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http://dx.doi.org/10.1016/j.jenvman.2021.111993DOI Listing
April 2021

HIV-1 Accessory Proteins: Which one is Potentially Effective in Diagnosis and Vaccine Development?

Protein Pept Lett 2020 Dec 31. Epub 2020 Dec 31.

Department of Hepatitis, AIDS and Blood borne diseases, Pasteur Institute of Iran, Tehran,. Iran.

Background: The combination antiretroviral therapy (cART) could increase the number of circulating naive CD4 T lymphocytes, but was not able to eradicate human immunodeficiency virus-1 (HIV-1) infection.

Objective: Thus, induction of strong immune responses is important for control of HIV-1 infection. Furthermore, a simple and perfect serological method is required to detect virus in untreated-, treated- and drug resistant- HIV-1 infected individuals.

Methods: This study was conducted to assess and compare immunogenic properties of Nef, Vif, Vpr and Vpu accessory proteins as an antigen candidate in mice and their diagnostic importance in human as a biomarker.

Results: Our data showed that in mice, all heterologous prime/ boost regimens were more potent than homologous prime/ boost regimens in eliciting Th1 response and Granzyme B secretion as CTL activity. Moreover, the Nef, Vpu and Vif proteins could significantly increase Th1 immune response. In contrast, the Vpr protein could considerably induce Th2 immune response. On the other hand, among four accessory proteins, HIV-1 Vpu could significantly detect treated group from untreated group as a possible biomarker in human.

Conclusion: Generally, among accessory proteins, Nef, Vpu and Vif antigens were potentially more suitable vaccine antigen candidates than Vpr antigen. Human antibodies against all these proteins were higher in HIV-1 different groups than healthy group. Among them, Vpu was known as a potent antigen in diagnosis of treated from untreated individuals. The potency of accessory proteins as an antigen candidate in an animal model and a human cohort study are underway.
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http://dx.doi.org/10.2174/0929866528999201231213610DOI Listing
December 2020

The effect of air pollution on drivers' safety performance.

Environ Sci Pollut Res Int 2021 Apr 26;28(13):15768-15781. Epub 2020 Nov 26.

Department of Civil and Environmental Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.

Numerous studies have determined the adverse effects of air pollution on the health, welfare, and comfort of humans. More recently, the effects of air pollution on cognitive performance of humans are also focused. However, as a group in direct exposure to air pollution, drivers are rarely studied. The present study aims to evaluate the effect of air pollution on the performance of drivers. Their performance is evaluated by observing the number of recorded accidents. The effect of pollutant concentration (primarily PM) on the number of accidents is investigated in a case study in Tehran. The temperature inversion phenomenon is used as an instrumental variable in a two-stage least squares method. The results indicate that temperature inversion had a significant positive correlation with the concentration of pollutants. Considering temperature inversion as an instrumental variable for these pollutants, it is observed that 1 μg/m increase in concentration of PM, increased the number of accidents approximately by 4% in 1 day, for the range of parameters studied. No significant relationship was observed regarding the effect of NO and CO on accidents during the study period.
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http://dx.doi.org/10.1007/s11356-020-11687-yDOI Listing
April 2021

The Impact of Mobile Health on Cancer Screening: A Systematic Review.

Cancer Inform 2020 13;19:1176935120954191. Epub 2020 Oct 13.

School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Mobile health is an emerging technology around the world that can be effective in cancer screening. This study aimed to examine the effectiveness of mobile health applications on cancer screening.

Methods: We conducted a systematic literature review of studies related to the use of mobile health applications in cancer screening. We also conducted a comprehensive search of articles on cancer screening related to the use of mobile health applications in journals published between January 1, 2008, and January 31, 2019, using 5 databases: IEEE, Scopus, Web of Science, Science Direct and PubMed.

Results: A total of 23 articles met the inclusion criteria and were included in the present review. All studies have identified positive effects of applications on cancer screening and clinical health outcomes. Furthermore, more than half of mobile applications had multiple functions such as providing information, planning and education. Moreover, most of the studies, which examined the satisfaction of patients and quality improvement, showed healthcare application users have significantly higher satisfaction of living and it leads to improving quality.

Conclusion: This study found that the use of mobile health applications has a positive impact on health-related behaviours and outcomes. Application users were more satisfied with applying mobile health applications to manage their health condition in comparison with users who received conventional care.
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http://dx.doi.org/10.1177/1176935120954191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573752PMC
October 2020

Influences for Gender Disparity in Academic Family Medicine in North American Medical Schools.

Cureus 2020 May 30;12(5):e8368. Epub 2020 May 30.

Radiology, Vancouver General Hospital, Vancouver, CAN.

Background Women physicians continue to comprise the minority of leadership roles in Academic Family Medicine (AFM) faculty across North American medical schools. Our study quantified the current state of gender disparity by analyzing academic position, leadership ranking, and research productivity. Methods We generated a database for 6,746 AFM faculty members. Gender and academic profiles were obtained for 2,892 academic ranks and 1,706 leadership roles by searching faculty listings enlisted in Fellowship and Residency Electronic Interactive Database (FREIDA) and Canadian Resident Matching Service (CaRMS). To measure research productivity, we obtained bibliometric data: h-index, citations, and tenure from 2,383 faculty members using Elsevier's SCOPUS archives. Data analysis and h-index were formulated using Stata version 14.2 (StataCorp LP, College Station, TX). Results Our results indicated that women hold 46.11% (3,110/6,746) of faculty positions. The proportional composition decreased with increasing academic ranking (49.84% assistant, 46.78% associate, and 41.5% full professor). The same decreasing trend was demonstrated with leadership rank (57.14% minor leadership, 47.65% second-in-command, and 36.61 first-in-command). Compared to their gender counterparts, women in AFM demonstrated lower publication productivity as measured by citation number (p=0.04) and years of study (p=0.008). The final prediction equation model after multivariable analyses included gender, publications, citations, country of graduation, and years of active research (p<0.05). Conclusions The composition of academic family medicine faculty members included in this study demonstrated gender disparity. Inclusivity initiatives and policies to tackle the issue of female retention, promotion, and recruitment need to be further explored.
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http://dx.doi.org/10.7759/cureus.8368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326302PMC
May 2020

Carbohydrate Intake, Glycemic Index, and Glycemic Load and the Risk of Breast Cancer among Iranian Women.

Nutr Cancer 2021 9;73(5):785-793. Epub 2020 Jun 9.

Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Limited studies have conducted on the association between carbohydrate intake, glycemic index (GI), glycemic load (GL), and BC risk among Middle Eastern women. Our objective was to examine whether intake of carbohydrates, GI and GL would lead to more risk of BC among Iranian women. In this case-control study, 136 women with histologically confirmed BC and 272 control women were recruited. Dietary intake was assessed using a validated 168-item food frequency questionnaire (FFQ) from which GI and GL were estimated. We calculated Odds ratios (OR) using logistic regression. The multivariate OR for the highest . the lowest quartile was 2.49 (95% CI 1.28-4.82; trend = 0.005) for GI with a significant trend. OR for GI and GL among postmenopausal women were 4.45 (95% CI 1.59-12.47; trend = 0.002) and 4.15 (95% CI 0.87-19.67; trend = 0.03), respectively. OR for GI among women with reduced vegetable intake was 13.55 (95% CI 3.90-46.99; trend <0.001). Our data suggest that high GI and GL play an important role in the risk of BC particularly among postmenopausal woman.
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http://dx.doi.org/10.1080/01635581.2020.1776886DOI Listing
June 2020

Common data elements of breast cancer for research databases: A systematic review.

J Family Med Prim Care 2020 Mar 26;9(3):1296-1301. Epub 2020 Mar 26.

Assistant Professor, Radiation Oncology, Oncophathology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Common Data Elements (CDEs) are data-metadata descriptors used to collect research study data. CDEs facilitate the collection, processing, and sharing of breast cancer data. This study intended to explore the CDEs of breast cancer for research databases and primary care systems.

Methods: This study was conducted using systematic search and review. This systematic literature review covered PubMed, Scopus, Science Direct, SID, ISC, Web of Science, and Google Scholar search engine. It included studies in English language with accessible full-text from the beginning of 2007 to September 2019.

Results: Reviewing 25 studies revealed that 52 percent of studies were carried out in the US and most studies were conducted between 2013 and 2015. The most domains for using CDEs were: Pathology Report and Registry. The CDEs of breast cancer for research databases were categorized into three categories namely clinical, research, and non-clinical and indicate the importance of these data elements. Most of the studies focused on creating and deploying clinical CDEs as physical examination, clinical history and pathology data.

Conclusion: The integration of biomedical and clinical data relevant to breast cancer enhances the power of research variable analysis and statistical analysis, thereby facilitating improved knowledge of effective therapeutic interventions. Also CDEs used to collect, store, and retrieve patient data in various health setting such as primary care and research databases.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_931_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266190PMC
March 2020

A Novel Sulfonyl-Based Small Molecule Exhibiting Anti-cancer Properties.

Front Pharmacol 2020 12;11:237. Epub 2020 Mar 12.

Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.

Phenotypic screening is an ideal strategy for the discovery of novel bioactive molecules. Using a customized high-throughput screening (HTS) assay employing primary T lymphocytes, we screened a small library of 4,398 compounds with unknown biological function/target to identify compounds eliciting immunomodulatory properties and discovered a sulfonyl-containing hit, we named InhiTinib. This compound inhibited interferon (IFN)-gamma production and proliferation of primary CD3 T cells without inducing cell death. In contrast, InhiTinib triggered apoptosis in several murine and human cancer cell lines. Besides, the compound was well tolerated by immunocompetent mice, triggered tumor regression in animals with pre-established EL4 T-cell lymphomas, and prolonged the overall survival of mice harboring advanced tumors. Altogether, our data demonstrate the anti-cancer properties of InhiTinib, which can henceforth bridge to wider-scale biochemical and clinical tests following further in-depth pharmacodynamic studies.
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http://dx.doi.org/10.3389/fphar.2020.00237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081885PMC
March 2020

Denoising improves visualization of evoked potentials with limited number of trials.

Authors:
Maryam Ahmadi

J Clin Neurosci 2020 May 27;75:213-217. Epub 2020 Mar 27.

Center for Systems Neuroscience, University of Leicester, Leicester, UK. Electronic address:

Ensemble averaging is typically used to enhance the signal to noise ratio (SNR) of event related potentials (ERPs). This approach has the disadvantage of extending the recording time. We present an alternative approach to achieve SNRs similar to the ones obtained with ensemble averaging but with fewer trials. Single trial ERPs were denoised by using a wavelet denoising technique. With simulated ERPs we compared the performance obtained with the standard and denoised averages by quantifying the root-mean-square-error (RMSE) between ensemble averages obtained with and without denoising. Denoising decreased the RMSE, giving similar values to the ones obtained with the standard averages but with less than half the number of trials. RMSEs were comparable for larger number of trials, thus showing that denoising did not introduce spurious distortions to the ERPs. Wavelet denoising proved to be an efficient technique to improve evoked potential SNRs. It is useful in clinical settings, where recordings may be constrained by the limited capability to obtain a sufficient number of trials.
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http://dx.doi.org/10.1016/j.jocn.2020.03.039DOI Listing
May 2020

Main Elements of National Model of Electronic Prescription System from Physicians' Point of View: A Case Study in a Developing Country.

Iran J Pharm Res 2019 ;18(4):2204-2215

Department of Health Information Management and Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Identifying the factors and components of an electronic prescription system is of utmost importance in effective designing and implementation of this system. In this regard, the current study was conducted to determine the main factors affecting the national model of electronic prescription from the physicians' point of view. This is a cross-sectional, descriptive-analytical research carried out in 2015. Based on the census sampling method, 104 members of the board of directors of the Iranian general practitioners' associations, general practitioners' alumni association of Iran, and physicians owner of a website or weblog were selected as samples for this study. Data were collected using a valid and reliable questionnaire. After analyzing the data with SPSS software (v.16), a model was proposed using a regression algorithm. The findings indicated that accessing the current medication data and medication history of patients during prescription, and also creating the electronic patient medication record (ePMR) are the most important selective components for physicians with frequency percent of 92.1%. Moreover, from the physicians' viewpoint, the method of "transmission of prescriptions to the central national database and retrieving prescriptions information from the selected pharmacy of the patient" had the highest priority (weight coefficient) in the model of the national electronic prescription system. Therefore, the Iranian prescription system is required to be developed based on the centralized architecture and national electronic prescription database.
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http://dx.doi.org/10.22037/ijpr.2019.1100801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059044PMC
January 2019

Development and use of a clinical decision support system for the diagnosis of social anxiety disorder.

Comput Methods Programs Biomed 2020 Jul 24;190:105354. Epub 2020 Jan 24.

School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.

Background: Mental disorders, according to the definition of World Health Organization, consist of a wide range of signs, which are generally specified by a combination of unusual thoughts, feelings, behavior, and relationships with others. Social anxiety disorder (SAD) is one of the most prevalent mental disorders, described as permanent and severe fear or feeling of embarrassment in social situations. Considering the imprecise nature of SAD symptoms, the main objective of this study was to generate an intelligent decision support system for SAD diagnosis, using Adaptive neuro-fuzzy inference system (ANFIS) technique and to conduct an evaluation method, using sensitivity, specificity and accuracy metrics.

Method: In this study, a real-world dataset with the sample size of 214 was selected and used to generate the model. The method comprised a multi-stage procedure named preprocessing, classification, and evaluation. The preprocessing stage, itself, consists of three steps called normalization, feature selection, and anomaly detection, using the Self-Organizing Map (SOM) clustering method. The ANFIS technique with 5-fold cross-validation was used for the classification of social anxiety disorder.

Results And Conclusion: The preprocessed dataset with seven input features were used to train the ANFIS model. The hybrid optimization learning algorithm and 41 epochs were used as optimal learning parameters. The accuracy, sensitivity, and specificity metrics were reported 98.67%, 97.14%, and 100%, respectively. The results revealed that the proposed model was quite appropriate for SAD diagnosis and in line with findings of other studies. Further research study addressing the design of a decision support system for diagnosing the severity of SAD is recommended.
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http://dx.doi.org/10.1016/j.cmpb.2020.105354DOI Listing
July 2020

Comparative Evaluation of Efficacy of Green Tea Mouth Rinse and Green Tea Gel on the Salivary and Colony Count in 12-18-year-old Teenagers: A Randomized Clinical Trial.

Contemp Clin Dent 2019 Jan-Mar;10(1):81-85

Department of Pediatric Dentistry, Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Aims: Green tea is an antibacterial agent with no significant side effect. This feature makes green tea safe for children to use. The purpose of this study was to compare the effectiveness of green tea gel and mouth rinse on salivary level of and of teenagers aged 12-18 years.

Subjects And Methods: In this randomized controlled clinical trial study, 30 children aged 12-18 years were included in the study according to the inclusion criteria and were randomly divided into two groups. Participants in mouth rinse group were asked to rinse their mouth with 0.5% green tea mouthwash twice a day for 2 weeks. In the gel group, participants were requested to brush their teeth with 0.5% green tea gel twice a day for 2 weeks. After 4 weeks of washout period, mouthwash group applied the gel and the gel group rinsed the mouthwash for 2 weeks and with the same instruction as mentioned. Colony count of and was determined before and after intervention and data were analyzed using test.

Results: According to the independent test, there was no significant difference in the salivary levels of S. mutans before and after intervention regarding age and gender ( = 0.33). Results from paired -test showed significant decrease in the mean count of and colonies in both groups before and after intervention ( < 0.001).

Conclusions: Green tea gel and mouthwash contribute to a significant reduction of salivary levels of and colonies, with a greater effect of mouthwash than the green tea gel, which was not statistically significant.
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http://dx.doi.org/10.4103/ccd.ccd_368_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974996PMC
February 2020

Vagal sensory neurons drive mucous cell metaplasia.

J Allergy Clin Immunol 2020 06 16;145(6):1693-1696.e4. Epub 2020 Jan 16.

FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, Mass; Department of Neurobiology, Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.01.003DOI Listing
June 2020

Pressure Pain Threshold in Subjects With Piriformis Syndrome: Test-Retest, Intrarater, and Interrater Reliability, and Minimal Detectible Changes.

Arch Phys Med Rehabil 2020 05 7;101(5):781-788. Epub 2019 Dec 7.

Rehabilitation Research Center, Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

Objective: This study aimed to assess the test-retest, intrarater, and interrater reliability of using the pressure pain threshold (PPT) in healthy and affected piriformis muscles and to estimate its absolute reliability. As a secondary objective, the degree of tenderness of the affected piriformis muscles was compared with healthy piriformis muscles.

Study Design: This study used a comparative and reliability-based design.

Setting: Rehabilitation clinic.

Participants: Patients (N=30) with unilateral piriformis muscle syndrome (30 affected and 30 healthy piriformis muscles) were recruited, and the PPT of both the healthy and affected piriformis muscles was recorded using digital algometry. Measurements of PPT were done by 2 raters (rater 1 and 2), which were selected at random order. Rater 1 repeated the PPT measurements 24-72 hours after initial assessment.

Interventions: Not applicable.

Main Outcome Measure: PPT.

Results: Excellent intrarater intraclass correlation coefficient (ICC) values were observed for the PPT of the affected piriformis (ICC: 0.86-0.96) and the healthy piriformis (ICC: 0.88-0.96) in the same session. The PPT measurements using digital algometry showed good-to-excellent interrater reliability (ICC: 0.64-0.92) and test-retest reliability (ICC: 0.72-0.95) in both the healthy and affected piriformis muscles. The findings revealed a significant decrease in the PPT of the affected piriformis muscle in comparison to the healthy piriformis muscle (mean difference 12.76; 95% confidence interval, 15.69-9.82; P<.001).

Conclusions: Digital algometry is a reliable tool for measuring piriformis PPT, regardless of the testing session and the rater. Patients with unilateral piriformis muscle syndrome have increased tenderness and decreased PPT in the affected piriformis muscle in comparison to the healthy piriformis muscle.
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http://dx.doi.org/10.1016/j.apmr.2019.10.194DOI Listing
May 2020

Sub-obstacles related to long distance and lack of easy access to outpatient cardiac rehabilitation services.

ARYA Atheroscler 2019 May;15(3):152-153

Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

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http://dx.doi.org/10.22122/arya.v15i3.1959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698082PMC
May 2019

Ultrasound-guided dry needling decreases pain in patients with piriformis syndrome.

Muscle Nerve 2019 11 27;60(5):558-565. Epub 2019 Aug 27.

Rehabilitation Research Center, Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Piriformis muscle syndrome (PMS) is a disorder that can lead to symptoms of buttock pain and limited hip-joint mobility, and may have an impact on quality of life.

Methods: Thirty-two patients with PMS were randomized to the treatment group, which included three sessions of ultrasound-guided dry needling (DN) of the piriformis muscle (n = 16), or a waitlist control group (n = 16). The primary outcome was pain intensity measured on the visual analog scale recorded at baseline and then at 72 hours and 1 week after treatment.

Results: At 1-week follow-up, pain intensity was significantly less in the DN group than in the waitlist control group (-2.16 [-1.01 to -3.32], P = .007) by an amount consistent with clinically meaningful improvement.

Discussion: The findings suggest that DN resulted in clinically meaningful short-term improvement in pain intensity of patients with PMS.
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http://dx.doi.org/10.1002/mus.26671DOI Listing
November 2019

Designing Data Elements and Minimum Data Set (MDS) for Creating the Registry of Patients with Gestational Diabetes Mellitus.

J Med Life 2019 Apr-Jun;12(2):160-167

Department of Health Information Management, School of Management and Medical Information Sciences, University of Medical Sciences, Tehran, Iran.

The prevalence of gestational diabetes mellitus (GDM) is increasing in Iran. Collection of patients' data is commonly conducted through using medical records. However, for providing a structured reporting based on the information needs, a minimum data set is a fast, inexpensive, and suitable method. For exchanging high-quality data between different healthcare centers and health monitoring organization, the data are required to be uniformly collected and registered. The present study aims at designing an MDS for creating the registry of GDM. The present study is an applied one, conducted in two stages, with a qualitative Delphi method in 2018. In the first stage of the study, it was attempted to extract the data elements of mothers with GDM, through reviewing the related studies and collecting these patients' data from the medical records. Then, based on the results of the first stage, a questionnaire including demographic, clinical, and pharmaceutical data was distributed among 20 individuals including gynecologists, pharmacists, nurses, and midwives. The validity of the questionnaire was examined by a team of experts and its reliability was examined by using Cronbach's alpha. Data analysis was conducted using descriptive statistics (frequency, percentage, and mean) and excel. An MDS of gestational diabetes mellitus was developed. This MDS divided into three categories: administrative, clinical, and pharmaceutical with 4, 18, and 2 sections and 35, 199, and 12 data elements, respectively. Determining the minimum data sets of GDM will be an effective step toward integrating and improving data management of patients with GDM. Moreover, it will be possible to store and retrieve the data related to these patients.
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http://dx.doi.org/10.25122/jml-2019-0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685309PMC
October 2019

Does working memory improvement benefit from sleep in older adults?

Neurobiol Sleep Circadian Rhythms 2019 Jan 18;6:53-61. Epub 2019 Jan 18.

Department of Cognitive Science, University of California Irvine, CA, USA.

Working Memory (WM), is an important factor influencing many higher-order cognitive functions that decline with age. Repetitive training appears to increase WM, yet the mechanisms underlying this improvement are not understood. Sleep has been shown to benefit long-term memory formation and may also play a role in WM enhancement in young adults. However, considering age-related decline in sleep, it is uninvestigated whether sleep will facilitate WM in older adults. In the present work, we investigated the impact of a nap, quiet wakefulness (QW) and active wakefulness (AW) on within-day training on the Operation Span (OSPAN) task in older adults. Improvement in WM was found following a nap and QW, but not active wake. Furthermore, better WM was associated with shared electrophysiological features, including slow oscillation (SO, 0.5-1 Hz) power in both the nap and QW, and greater coupling between SO and sigma (12-15 Hz) in the nap. In summary, our data suggest that WM improvement in older adults occurs opportunistically during offline periods that afford enhancement in slow oscillation power, and that further benefits may come with cross-frequency coupling of neural oscillations during sleep.
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http://dx.doi.org/10.1016/j.nbscr.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586603PMC
January 2019

Development a national minimum data set (MDS) of the information management system for disability in Iran.

Disabil Health J 2019 10 28;12(4):641-648. Epub 2019 May 28.

Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Health Information Management, Health Information Technology Department, Paramedical School, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address:

Background: Disability management and policymaking require complete and valid data on disability.

Objective: Development of a minimum data set (MDS) of the information management system for disability in Iran.

Methods: This descriptive, cross-sectional study was performed in 2017. Data were collected from the documents of persons with disabilities data bank of the State Welfare Organization of Iran available at "payment.behzisti.net", and data elements of the Ministry of Health and Medical Education (MOHME) resources, in addition to the Internet and library. A checklist was used for data collection. The Delphi technique was applied to reach a consensus about the data elements using a questionnaire. The content validity and reliability of the questionnaire were assessed by experts' opinions and the test-retest method, respectively.

Results: An MDS of disability was developed including administrative and clinical categories with 130 and 345 data elements, respectively. Two hundred and thirty eight data elements were mandatory elements (administrative: 60, clinical: 178) and the rest were optional elements.

Conclusions: An MDS can be a starting point for standardizing the disability data. A minimum data set has the potential to standardize the data and overcome the problem of low-quality disability data in Iran through providing consistent, complete and uniform data elements. Thus, the use of this MDS is useful in determination of the level of disability and its benefits, and in policy-making and effective planning for providing persons with disabilities with more efficient and cost-effective services.
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http://dx.doi.org/10.1016/j.dhjo.2019.05.008DOI Listing
October 2019

Designing a communication protocol for acquired immunodeficiency syndrome information exchange.

J Educ Health Promot 2019 14;8:99. Epub 2019 May 14.

Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Interoperability will provide similar understanding on the meaning of communicated messages to intelligent systems and their users. This feature is essential for controlling and managing contagious diseases which threaten public health, such as acquired immunodeficiency syndrome (AIDS). The aim of this study was also designing communication protocols for normalizing the content and structure of intelligent messages in order to optimize the interoperability.

Materials And Methods: This study used a checklist to extract information content compatible with minimum data set (MDS) of AIDS. After coding information content through selected classification and nomenclature systems, the reliability and validity of codes were evaluated by external agreement method. The MindMaple software was used for mapping the information content to Systematized Nomenclature of Medicine-Clinical Terminology (SNOMED-CT) integrated codes. Finally, the Clinical Document Architecture (CDA) format was used for standard structuring of information content.

Results: The information content standard format, compatible selected classification, or nomenclature system and their codes were determined for all information contents. Their corresponding codes in SNOMED-CT were structured in the form of CDA body and title.

Conclusion: The complex and multidimensional nature of AIDS requires the participation of multidisciplinary teams from different organizations, complex analyzes, multidimensional and complex information modeling, and maximum interoperability. In this study, the use of CDA structure along with SNOMED-CT codes is completely compatible with optimal interoperability needs for AIDS control and management.
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http://dx.doi.org/10.4103/jehp.jehp_2_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532363PMC
May 2019

A preliminary study investigating time perception in adolescents with posttraumatic stress disorder and major depressive disorder.

Psychol Trauma 2019 Sep 27;11(6):671-676. Epub 2019 May 27.

School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University.

Objective: The aim of the current study was to conduct a preliminary investigation into time perception in adolescents with posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and healthy controls.

Method: Iranian adolescents with PTSD (n = 15) or MDD (n = 15) and healthy, non-trauma-exposed control participants (n = 15) completed 3 measures of time perception: a verbal time estimation task, a production task, and a reproduction task.

Results: The PTSD group was found to have significantly poorer overall time perception accuracy compared to the control group (d = 1.38). Group differences were dependent on the type of time perception task; the groups did not differ significantly on the time reproduction task but did differ significantly on the verbal time estimation task and production task. The PTSD group had significantly poorer time estimate accuracy (i.e., underestimates) on the verbal estimation task than did the MDD group (d = 1.10), and the control group performed at the intermediate level. The PTSD and MDD groups did not differ significantly on the production task, but both clinical groups had significantly poorer performance than did the control group (ds> .76). Finally, working memory mediated the relationship between group and time perception accuracy (95% confidence interval [2.10, 38.69]).

Conclusions: These findings highlight the need for further research examining time perception in PTSD. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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http://dx.doi.org/10.1037/tra0000471DOI Listing
September 2019

Assessment priorities in cerebral palsy using ICF core set by Iranian occupational therapists.

Can J Occup Ther 2019 Oct 2;86(4):289-298. Epub 2019 May 2.

Background.: International Classification of Functioning, Disability and Health (ICF) core set for cerebral palsy allows for the description of the levels of functioning in cerebral palsy. It is not exactly clear which of these levels is more important for evaluation from the perspective of occupational therapists in Iran. By identifying these priorities, we can establish a better plan for intervention.

Purpose.: This study defines assessment priorities in children with cerebral palsy (<6 years).

Method.: Sixty-two Iranian occupational therapists studied the priorities of assessment based on the Iranian ICF core set. The therapists were asked to rate the code categories from 1 to 3. The results are presented as mean values.

Findings.: Occupational therapists first focus on body functions assessment, then activities/participation, and ultimately, environmental factors.

Implications.: Occupational therapists in Iran have a bottom-up approach toward clients with cerebral palsy. It may be necessary to revise the educational curriculum, prepare a training course, and provide more supervision for practising occupational therapists.
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http://dx.doi.org/10.1177/0008417419833400DOI Listing
October 2019

Identifying and validating requirements of telemental health services for Iranian veterans.

J Family Med Prim Care 2019 Mar;8(3):1216-1221

Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran.

Background: The ability of timely access to mental health care is very important for combat veterans that are facing many barriers such as living in rural and remote areas and the lack of integration. Telemental health services improve the veterans' health situation by providing mental health care from a distance. We aimed to identify the telemental health service requirements for Iranian veterans and validate them from the perspective of the statistical population.

Methods: This descriptive cross-sectional study was conducted in 2018. In the first phase, a review was conducted in relevant databases, such as PubMed, Scopus, Ovid, Ebsco, and Web of Science. In the second phase, veterans, mental health providers, and telemedicine experts were consulted to validating of the identified telemental health service requirements by a researcher-made questionnaire. Analysis of collecting data was done using SPSS software.

Results: By full-text reviewing of 15 related articles, the identified elements were justified in 2 main categories and 24 subcategories including telemental health services (17 items) and telemental health requirements (7 items). According to the findings, the highest score was related to "save health-care costs" (4.47) and "reduce transportation-related problems" (4.47). Moreover, the "feasible alternative to face-to-face care" (2.22) obtained the lowest score from the perspective of the statistical population.

Conclusion: Due to the importance of accessibility and patient-based mental health services, more studies are needed to investigate the point of views of patients and specialists to better understand the concerns and barriers to the implementation and use of telemental health services.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_324_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482756PMC
March 2019

Experimental, kinetic, and thermodynamic studies of adsorptive desulfurization and denitrogenation of model fuels using novel mesoporous materials.

J Hazard Mater 2019 07 8;374:129-139. Epub 2019 Apr 8.

Chemical Engineering Department, Amirkabir University of Technology, Mahshahr Campus, Mahshahr,Iran. Electronic address:

The kinetics, equilibrium and thermodynamics studies of adsorptive desulfurization and denitrogenation to eliminate the refractory sulfur and nitrogen compounds like BT, DBT, quinoline and carbazole of model fuel by mesoporous material (MSU-S) and cobalt modified mesoporous material (CoO-MSU-S) adsorbents were carried out. The adsorption performance, capacity and selectivity of the adsorbent toward sulfur and nitrogen compounds were examined. Equilibrium and kinetics experiments confirmed that Co impregnation would enhance the adsorption capacity of MSU-S. The results demonstrated that CoO-MSU-S led to a considerable improvement in the adsorption performance. The adsorption amounts reached 18.41, 21.20, 39.65 and 24.60 mg.g for BT, DBT, quinoline and carbazole, respectively. The Langmuir isotherm model showed good fittings with the experimental equilibrium data for benzothiophene, dibenzothiophene and carbazole, and the data for quinoline was expressed well by the Freundlich for CoO-MSU-S adsorbent. Negative Gibbs free energy showed that all sulfur and nitrogen compounds were adsorbed spontaneously. The experimental data revealed that the pseudo-second-order model can describe the kinetics of adsorption of compounds on the adsorbent. The data obtained from the breakthrough curves indicated that DBT < BT < carbazole < quinoline order for the selectivity of modified adsorbent towards the adsorbates.
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http://dx.doi.org/10.1016/j.jhazmat.2019.04.029DOI Listing
July 2019

Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients.

Curr Mol Med 2019 ;19(5):357-363

Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Asthma is a chronic and complex inflammatory disease of the respiratory tract. Also, multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Against this background, IL-33 and IL1RL1 play a critical role in autoimmune and inflammatory disorders. Here, we explored the IL-33 serum level and two potential genetic variants in the IL33 gene and its receptor in Iranian asthma and MS patients.

Methods: This study consisted of asthma (n=140) and MS patients (n=140), and healthy subjects (n=72). Genotyping was carried out in two genetic polymorphisms, rs1342326 variant of IL-33 and rs10204137SNP variant of IL-33 receptor genes, using High- Resolution Melt Real- Time PCR based method. The level of serum IL-33 was also measured using enzyme-linked immunosorbent assay method.

Results: The level of IL33 was significantly higher in asthma and MS patients compared to the control group (P< 0.001- P<0.001).The frequency distribution of the genotype in rs1342326 variant of IL-33 gene in patients with asthma, MS and healthy subjects was not significantly different (P>0.05). The frequency distribution of the genotype in rs10204137 variant of IL-33 gene in MS patients and healthy subjects was significantly different (p = 0.013).

Conclusion: Our findings demonstrated that asthma and MS patients had a higher level of IL-33, and IL-33 receptor genetic polymorphism was associated with MS. Further studies in a larger multicenter setting are needed to explore the value of this marker as a risk stratification biomarker.
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http://dx.doi.org/10.2174/1566524019666190405120137DOI Listing
July 2020

Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy.

Front Neurosci 2019 31;13:25. Epub 2019 Jan 31.

Département de Pharmacologie et Physiologie, Faculté de Médecine, Université de Montréal, Montréal, QC, Canada.

Diabetes is a common condition characterized by persistent hyperglycemia. High blood sugar primarily affects cells that have a limited capacity to regulate their glucose intake. These cells include capillary endothelial cells in the retina, mesangial cells in the renal glomerulus, Schwann cells, and neurons of the peripheral and central nervous systems. As a result, hyperglycemia leads to largely intractable complications such as retinopathy, nephropathy, hypertension, and neuropathy. Diabetic pain neuropathy is a complex and multifactorial disease that has been associated with poor glycemic control, longer diabetes duration, hypertension, advanced age, smoking status, hypoinsulinemia, and dyslipidemia. While many of the driving factors involved in diabetic pain are still being investigated, they can be broadly classified as either neuron -intrinsic or -extrinsic. In neurons, hyperglycemia impairs the polyol pathway, leading to an overproduction of reactive oxygen species and reactive nitrogen species, an enhanced formation of advanced glycation end products, and a disruption in Na/K ATPase pump function. In terms of the extrinsic pathway, hyperglycemia leads to the generation of both overactive microglia and microangiopathy. The former incites a feed-forward inflammatory loop that hypersensitizes nociceptor neurons, as observed at the onset of diabetic pain neuropathy. The latter reduces neurons' access to oxygen, glucose and nutrients, prompting reductions in nociceptor terminal expression and losses in sensation, as observed in the later stages of diabetic pain neuropathy. Overall, microglia can be seen as potent and long-lasting amplifiers of nociceptor neuron activity, and may therefore constitute a potential therapeutic target in the treatment of diabetic pain neuropathy.
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http://dx.doi.org/10.3389/fnins.2019.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365454PMC
January 2019

Newborn screening data management: proposing a framework for Iran.

J Innov Health Inform 2018 Dec 31;25(4):221-229. Epub 2018 Dec 31.

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Introduction: Different countries use a variety of methods to manage the newborn screening data. In this study, we aimed to compare the experiences of the selected countries to propose a framework for managing the newborn screening data in Iran.

Methods: In this comparative study, data were collected using electronic databases and the official website of the Department of Health in America, England and Australia. Data related to the process of newborn screening in Iran were collected using an open-ended questionnaire and reviewing the published documents.

Results: In this study, a framework for newborn screening data management was proposed which consisted of six main areas, namely; objectives, involved organisations, data elements, data collection processes, data classification systems and the methods of controlling data quality.

Conclusion: The framework suggested in this study can help to re-organise the process of newborn screening with more focus on data management. These data can be used in conducting research and setting strategies for improving the quality of child health in the country.
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http://dx.doi.org/10.14236/jhi.v25i4.985DOI Listing
December 2018

Standardization of Health Terminology Systems and the Roles of Responsible Organizations.

Iran J Public Health 2018 Oct;47(10):1613-1614

Dept. of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277718PMC
October 2018