Publications by authors named "Mary Pat Beavers"

17Publications

Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors.

Comb Chem High Throughput Screen 2010 May;13(4):337-51

Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA.

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May 2010

Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.

Proc Natl Acad Sci U S A 2009 Jan 13;106(3):719-24. Epub 2009 Jan 13.

Department of Pharmacology, University of Pennsylvania, 1009 Stellar Chance Laboratories, 36th and Hamilton Walk, Philadelphia, PA 19104, USA.

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January 2009

Molecular docking of cathepsin L inhibitors in the binding site of papain.

J Chem Inf Model 2008 Jul 4;48(7):1464-72. Epub 2008 Jul 4.

Penn Center for Molecular Discovery, Institute for Medicine and Engineering, and Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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July 2008

Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.

Bioorg Med Chem Lett 2008 Jun 1;18(12):3646-51. Epub 2008 May 1.

Penn Center for Molecular Discovery, University of Pennsylvania, 1024 Vagelos Research Laboratories, Philadelphia, PA 19104-6383, USA.

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June 2008

The total synthesis of roquefortine C and a rationale for the thermodynamic stability of isoroquefortine C over roquefortine C.

J Am Chem Soc 2008 May 16;130(19):6281-7. Epub 2008 Apr 16.

Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.

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May 2008

Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays.

Bioorg Med Chem Lett 2007 Sep 5;17(17):4761-6. Epub 2007 Jul 5.

Penn Center for Molecular Discovery, University of Pennsylvania, 1024 Vagelos Research Laboratories, Philadelphia, PA 19104-6383, USA.

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September 2007

Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening.

J Med Chem 2007 Feb;50(3):462-71

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Health Science Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, Minnesota 55455, USA.

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February 2007

Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2.

Bioorg Med Chem Lett 2006 Mar 27;16(6):1696-701. Epub 2005 Dec 27.

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA.

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March 2006

Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1.

Bioorg Med Chem Lett 2005 Dec 28;15(23):5202-6. Epub 2005 Sep 28.

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA.

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December 2005

Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors.

Bioorg Med Chem Lett 2005 Nov;15(21):4790-3

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA.

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November 2005

Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.

J Med Chem 2004 Sep;47(20):4799-801

Johnson & Johnson Pharmaceutical Research and Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, USA.

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September 2004

Structure-based combinatorial library design: methodologies and applications.

J Mol Graph Model 2002 Jun;20(6):463-8

Computer Assisted Drug Discovery, R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

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June 2002