Mary M Machulda

Mary M Machulda

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Mary M Machulda

Mary M Machulda

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Longitudinal association between phosphatidylcholines, neuroimaging measures of Alzheimer's disease pathophysiology, and cognition in the Mayo Clinic Study of Aging.

Neurobiol Aging 2019 Mar 18;79:43-49. Epub 2019 Mar 18.

Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA; Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.03.005DOI Listing
March 2019

The influence of β-amyloid on [F]AV-1451 in semantic variant of primary progressive aphasia.

Neurology 2019 Feb 11;92(7):e710-e722. Epub 2019 Jan 11.

From the Departments of Radiology (J.L.W., C.G.S., I.S., M.L.S., C.R.J., V.J.L.), Health Science Research (Biostatistics) (P.R.M., S.D.W.), Neurology (Speech Pathology) (J.R.D., H.M.C., R.L.U.), Psychiatry and Psychology (M.M.M.), Neurology (Behavioral Neurology) (H.B., J.G.-R., D.T.J., B.F.B., D.S.K., R.C.P., K.A.J.), and Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (N.E.-T.), Mayo Clinic, Jacksonville, FL.

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http://dx.doi.org/10.1212/WNL.0000000000006913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382367PMC
February 2019

Prominent auditory deficits in primary progressive aphasia: A case study.

Cortex 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00109452193004
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http://dx.doi.org/10.1016/j.cortex.2019.01.021DOI Listing
February 2019

Quantitative assessment of grammar in amyloid-negative logopenic aphasia.

Brain Lang 2018 11 8;186:26-31. Epub 2018 Sep 8.

Department of Neurology (Division of Behavioral Neurology and Movement Disorders), Mayo Clinic, Rochester, MN, United States.

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http://dx.doi.org/10.1016/j.bandl.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299833PMC
November 2018

The Cross-Sectional and Longitudinal Associations Between IL-6, IL-10, and TNFα and Cognitive Outcomes in the Mayo Clinic Study of Aging.

J Gerontol A Biol Sci Med Sci 2018 Sep 25. Epub 2018 Sep 25.

Department of Health Sciences Research, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1093/gerona/gly217DOI Listing
September 2018

Non-right handed primary progressive apraxia of speech.

J Neurol Sci 2018 07 7;390:246-254. Epub 2018 May 7.

Department of Neurology (Behavioral Neurology), Mayo Clinic, Rochester, MN 55905, USA; Department of Neurology (Movement Disorders), Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986290PMC
July 2018

Joint associations of β-amyloidosis and cortical thickness with cognition.

Neurobiol Aging 2018 05 2;65:121-131. Epub 2018 Feb 2.

Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic and Foundation, Rochester, MN, USA; Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871603PMC
May 2018

Molecular neuroimaging in primary progressive aphasia with predominant agraphia.

Neurocase 2018 Apr 23;24(2):121-123. Epub 2018 Mar 23.

a Department of Neurology , Mayo Clinic , Rochester , MN , USA.

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http://dx.doi.org/10.1080/13554794.2018.1454963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101047PMC
April 2018

Tau-negative amnestic dementia masquerading as Alzheimer disease dementia.

Neurology 2018 Mar 7;90(11):e940-e946. Epub 2018 Feb 7.

From the Departments of Neurology (H.B., W.G.M., J.G.-R., R.C.P., B.F.B., D.S.K., D.T.J.), Psychiatry and Psychology (M.M.M.), Radiology (S.A.P., H.J.W., M.L.S., C.R.J., D.T.J.), Pathology (J.E.P.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M.), Mayo Clinic, Jacksonville, FL.

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http://dx.doi.org/10.1212/WNL.0000000000005124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858947PMC
March 2018

Sex differences in cerebrovascular pathologies on FLAIR in cognitively unimpaired elderly.

Neurology 2018 Feb 17;90(6):e466-e473. Epub 2018 Jan 17.

From the Departments of Radiology (F.F., K.K., G.M.P., C.R.J., P.V.), Health Sciences Research (S.D.W., S.A.P., R.O.R., M.M. Mielke), Neurology (J.G.-R., D.S.K., R.O.R., M.M. Mielke, R.C.P.), and Psychology (M.M. Machulda), Mayo Clinic Rochester; and School of Medicine (F.F.), University of Minnesota, Minneapolis.

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http://dx.doi.org/10.1212/WNL.0000000000004913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818016PMC
February 2018

Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech.

Cortex 2018 02 2;99:358-374. Epub 2018 Jan 2.

Department of Neurology, Division of Behavioral Neurology, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Division of Movement Disorders, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.cortex.2017.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800944PMC
February 2018

Novel GRN mutation presenting as an aphasic dementia and evolving into corticobasal syndrome.

Neurol Genet 2017 Dec 11;3(6):e201. Epub 2017 Dec 11.

Department of Neurology (H.B., R.C.P., D.S.K., B.F.B.), Department of Clinical Genomic and Neurology (R.H.G.), Department of Psychiatry and Psychology (M.A.M., J.A.F.), Department of Nuclear Medicine (V.J.W.), Department of Radiology (C.R.J.), and Alzheimer's Disease Research Center (C.M.D., D.J.G.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (N.A.F., R.R.), Mayo Clinic, Jacksonville, FL.

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http://dx.doi.org/10.1212/NXG.0000000000000201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733247PMC
December 2017

Weighting and standardization of frequencies to determine prevalence of AD imaging biomarkers.

Neurology 2017 Nov 13;89(20):2039-2048. Epub 2017 Oct 13.

From the Divisions of Epidemiology (R.O.R., M.V., M.M. Mielke, R.C.P.) and Biomedical Statistics and Informatics (J.A.S., J.A.A., W.K.K.), Department of Health Sciences Research, Department of Neurology (R.O.R., D.S.K., M.M. Mielke, J.G.-R., R.C.P.), Department of Psychiatry and Psychology (M.M. Machulda), and Department of Radiology (P.V., V.L., C.R.J.), Mayo Clinic, Rochester, MN; and Departments of Psychiatry and Psychology and Neurology (Y.E.G.), Mayo Clinic, Scottsdale, AZ.

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http://dx.doi.org/10.1212/WNL.0000000000004652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711507PMC
November 2017

Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech.

Neurology 2017 Nov 1;89(22):2271-2279. Epub 2017 Nov 1.

From the Department of Radiology (J.L.W., A.J.S., M.L.S., C.R.J.), Department of Health Sciences Research (Biostatistics) (S.D.W.), Department of Neurology (Speech Pathology) (J.R.D., H.M.C., E.A.S.), Department of Psychiatry & Psychology (Neuropsychology) (M.M.M.), Department of Information Technology (M.L.S.), and Department of Neurology (Behavioral Neurology and Movement Disorders) (K.A.J.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000004685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705252PMC
November 2017

H-MRS metabolites and rate of β-amyloid accumulation on serial PET in clinically normal adults.

Neurology 2017 Sep 25;89(13):1391-1399. Epub 2017 Aug 25.

From the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000004421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649764PMC
September 2017

Neurocognition in individuals with incidentally-identified meningioma.

J Neurooncol 2017 Aug 25;134(1):125-132. Epub 2017 May 25.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1007/s11060-017-2495-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544551PMC
August 2017

Tracking the development of agrammatic aphasia: A tensor-based morphometry study.

Cortex 2017 05 30;90:138-148. Epub 2016 Sep 30.

Department of Neurology (Behavioral Neurology), Mayo Clinic, Rochester, MN, USA; Department of Neurology (Movement Disorders), Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.cortex.2016.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374055PMC
May 2017

Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness.

Alzheimers Dement 2017 02 25;13(2):168-177. Epub 2016 Jul 25.

Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.06.2359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259552PMC
February 2017

Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort.

Alzheimers Dement 2016 Dec 18;12(12):1226-1234. Epub 2016 Jul 18.

Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148697PMC
December 2016

Evolution of neurodegeneration-imaging biomarkers from clinically normal to dementia in the Alzheimer disease spectrum.

Neurobiol Aging 2016 10 16;46:32-42. Epub 2016 Jun 16.

Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA; Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic and Foundation, Rochester, MN, USA; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018437PMC
October 2016

Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementia.

Neurology 2016 Aug 15;87(7):691-8. Epub 2016 Jul 15.

From the Departments of Neurology (D.S.K., P.V., M.M. Mielke, R.O.R., B.F.B., D.T.J., R.C.P.) and Radiology (C.R.J., V.J.L., K.K., J.L.G., M.L.S., D.T.J.), Mayo Clinic Alzheimer's Disease Research Center (D.S.K., C.R.J., B.F.B., D.T.J., R.C.P.), Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (H.J.W., S.D.W.), Division of Epidemiology, Department of Health Sciences Research (M.M. Mielke, R.O.R., R.C.P.), and Department of Psychiatry, Division of Psychology (M.M. Machulda), Mayo Clinic and Foundation, Rochester, MN.

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http://www.neurology.org/content/87/7/691.full.pdf
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http://dx.doi.org/10.1212/WNL.0000000000002979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999168PMC
August 2016

Multimorbidity and neuroimaging biomarkers among cognitively normal persons.

Neurology 2016 05 13;86(22):2077-84. Epub 2016 Apr 13.

From the Departments of Health Sciences Research (M.V., J.A.A., M.M. Mielke, Y.E.G., W.K.K., R.C.P., R.O.R.) and Neurology (M.M. Mielke, Y.E.G., R.E.A., D.S.K., R.C.P., R.O.R.), Mayo Clinic, Rochester, MN; Departments of Psychiatry and Psychology and Neurology (Y.E.G.), Mayo Clinic, Scottsdale, AZ; Mayo Clinic Graduate School of Medicine (R.E.A.), Rochester, MN; and Departments of Psychiatry and Psychology (M.M. Machulda) and Radiology (V.J.L., C.R.J.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000002624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891208PMC
May 2016

Decline in Weight and Incident Mild Cognitive Impairment: Mayo Clinic Study of Aging.

JAMA Neurol 2016 04;73(4):439-46

Department of Neurology, Mayo Clinic, Rochester, Minnesota3Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1001/jamaneurol.2015.4756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828256PMC
April 2016

Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort.

Alzheimers Dement 2016 Mar 19;12(3):281-91. Epub 2015 Nov 19.

Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.jalz.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850495PMC
March 2016

Role of β-Amyloidosis and Neurodegeneration in Subsequent Imaging Changes in Mild Cognitive Impairment.

JAMA Neurol 2015 Dec;72(12):1475-83

Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota2Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic and Foundation, Rochester, Minnesota5Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic and F.

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http://dx.doi.org/10.1001/jamaneurol.2015.2323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735877PMC
December 2015

Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging.

Neurology 2015 Nov 9;85(19):1712-21. Epub 2015 Oct 9.

From the Department of Neurology, Mayo Alzheimer's Disease Research Center (D.S.K., B.F.B., R.C.P., R.O.R., W.A.R.), Division of Epidemiology, Department of Health Sciences Research (R.O.R., M.M. Mielke, W.A.R., R.C.P.), Division of Biostatistics and Bioinformatics, Department of Health Sciences Research (V.S.P., J.A., R.H.C.), and Department of Psychiatry and Psychology, Division of Neurocognitive Disorders (R.J.I., M.M. Machulda, J.F.), College of Medicine, Mayo Clinic, Rochester, MN; and Departments of Neurology (A.B., S.D., R.A., S.A., P.A.W., S.S.) and Biostatistics (A.B.), Boston University Schools of Medicine and Public Health, MA.

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http://dx.doi.org/10.1212/WNL.0000000000002100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653114PMC
November 2015

Neuropsychiatric symptoms in primary progressive aphasia and apraxia of speech.

Dement Geriatr Cogn Disord 2015 21;39(3-4):228-38. Epub 2015 Jan 21.

Department of Neurology, Mayo Clinic, Rochester, Minn., USA.

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http://dx.doi.org/10.1159/000369062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464666PMC
August 2015

Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech.

Cortex 2015 Aug 27;69:220-36. Epub 2015 May 27.

Department of Neurology (Behavioural Neurology), Mayo Clinic, Rochester, MN, USA; Department of Neurology (Movement Disorders), Mayo Clinic, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cortex.2015.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522343PMC
August 2015

Neuropsychological Profiles Differ among the Three Variants of Primary Progressive Aphasia.

J Int Neuropsychol Soc 2015 Jul 11;21(6):429-35. Epub 2015 Jun 11.

4Department of Neurology (Behavioral Neurology),Mayo Clinic,Rochester,Minnesota.

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http://dx.doi.org/10.1017/S1355617715000399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261353PMC
July 2015

Clinical, FDG and amyloid PET imaging in posterior cortical atrophy.

J Neurol 2015 Jun 11;262(6):1483-92. Epub 2015 Apr 11.

Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.

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http://dx.doi.org/10.1007/s00415-015-7732-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469094PMC
June 2015

Risk and protective factors for cognitive impairment in persons aged 85 years and older.

Neurology 2015 May 8;84(18):1854-61. Epub 2015 Apr 8.

From the Divisions of Epidemiology (R.O.R., M.M. Mielke, Y.E.G., R.C.P.) and Biomedical Statistics and Informatics (R.H.C.), Department of Health Sciences Research, the Department of Neurology (R.O.R., B.F.B., D.S.K., R.C.P.), and the Department of Psychiatry and Psychology (M.M. Machulda), Mayo Clinic, Rochester, MN; and the Departments of Psychiatry and Psychology and Neurology (Y.E.G.), Mayo Clinic, Scottsdale, AZ.

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http://dx.doi.org/10.1212/WNL.0000000000001537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433468PMC
May 2015

Neuropsychiatric symptoms, APOE ε4, and the risk of incident dementia: a population-based study.

Neurology 2015 Mar 4;84(9):935-43. Epub 2015 Feb 4.

From Mayo Clinic Translational Neuroscience and Aging Program (A.P., J.K.-R., J.I.A., Y.E.G.), and Departments of Psychiatry & Psychology (Y.E.G.) and Neurology (Y.E.G.), Mayo Clinic, Scottsdale, AZ; Departments of Neurology (M.M.B., D.S.K., R.C.P.) and Psychiatry & Psychology (M.M. Machulda), Divisions of Epidemiology (R.O.R., M.M. Mielke, R.C.P., Y.E.G.) and Biomedical Statistics and Informatics (T.J.C., V.S.P.), Department of Health Sciences Research, Mayo Clinic, Rochester, MN; International Clinical Research Center (A.P., G.B.S., O.S., J.K.-R., Y.E.G.), Brno, Czech Republic; and Paracelsus Medical University (A.P.), Salzburg, Austria.

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http://dx.doi.org/10.1212/WNL.0000000000001307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351664PMC
March 2015

Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging.

Alzheimers Dement 2014 Nov 15;10(6):779-89. Epub 2014 Nov 15.

Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15525260140282
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http://dx.doi.org/10.1016/j.jalz.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273919PMC
November 2014