Mary Jeanne Kreek

Mary Jeanne Kreek

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Mary Jeanne Kreek

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Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents alcohol relapse-like drinking in male and female mice.

Brain Res 2019 Dec 27;1724:146410. Epub 2019 Aug 27.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, NY, USA.

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http://dx.doi.org/10.1016/j.brainres.2019.146410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779526PMC
December 2019

Kappa Opioid Receptors and Mu Opioid Receptors as Combined Targets for Medication Development for Alcoholism.

Biol Psychiatry 2019 Dec;86(11):809-810

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.08.011DOI Listing
December 2019

Escalation of drug use in persons dually diagnosed with opioid and cocaine dependence: Gender comparison and dimensional predictors.

Drug Alcohol Depend 2019 Dec 22;205:107657. Epub 2019 Oct 22.

Laboratory of the Biology of Addictive Diseases, the Rockefeller University, New York NY, United States.

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http://dx.doi.org/10.1016/j.drugalcdep.2019.107657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893149PMC
December 2019

Sex and chronic stress differentially alter phosphorylated mu and delta opioid receptor levels in the rat hippocampus following oxycodone conditioned place preference.

Neurosci Lett 2019 Nov 24;713:134514. Epub 2019 Sep 24.

Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY, 10065, United States; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2019.134514DOI Listing
November 2019

A 3' UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction.

PLoS One 2019 5;14(11):e0224399. Epub 2019 Nov 5.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224399PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830932PMC
November 2019

Murine model of OPRM1 A118G alters oxycodone self-administration and locomotor activation, but not conditioned place preference.

Neuropharmacology 2019 Nov 25:107864. Epub 2019 Nov 25.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, 10065.

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http://dx.doi.org/10.1016/j.neuropharm.2019.107864DOI Listing
November 2019

Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses.

ACS Chem Neurosci 2019 Aug 31;10(8):3590-3600. Epub 2019 Jul 31.

Rockefeller University , 1230 York Avenue , New York , New York 10065 , United States.

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http://dx.doi.org/10.1021/acschemneuro.9b00195DOI Listing
August 2019

Impact of Pharmacological Manipulation of the -Opioid Receptor System on Self-grooming and Anhedonic-like Behaviors in Male Mice.

J Pharmacol Exp Ther 2019 Jul 11;370(1):1-8. Epub 2019 Apr 11.

Laboratory on the Biology of Addictive Diseases, the Rockefeller University, New York, New York (E.R.B., B.D.M., M.J.K.), and Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, Kansas (T.E.P.).

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http://dx.doi.org/10.1124/jpet.119.256354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538891PMC
July 2019

Sex Differences in Neuroplasticity- and Stress-Related Gene Expression and Protein Levels in the Rat Hippocampus Following Oxycodone Conditioned Place Preference.

Neuroscience 2019 07 7;410:274-292. Epub 2019 May 7.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, United States of America.

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http://dx.doi.org/10.1016/j.neuroscience.2019.04.047DOI Listing
July 2019

Combination of Clinically Utilized Kappa-Opioid Receptor Agonist Nalfurafine With Low-Dose Naltrexone Reduces Excessive Alcohol Drinking in Male and Female Mice.

Alcohol Clin Exp Res 2019 Jun 2;43(6):1077-1090. Epub 2019 May 2.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York.

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http://dx.doi.org/10.1111/acer.14033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551307PMC
June 2019

Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice.

Pharmacol Biochem Behav 2019 06 13;181:28-36. Epub 2019 Apr 13.

Laboratory of Addictive Diseases, Rockefeller University, New York, USA.

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http://dx.doi.org/10.1016/j.pbb.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545156PMC
June 2019

Chronic immobilization stress primes the hippocampal opioid system for oxycodone-associated learning in female but not male rats.

Synapse 2019 05 22;73(5):e22088. Epub 2019 Jan 22.

Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York.

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http://doi.wiley.com/10.1002/syn.22088
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http://dx.doi.org/10.1002/syn.22088DOI Listing
May 2019

VMAT2 gene () variants associated with a greater risk for developing opioid dependence.

Pharmacogenomics 2019 04 15;20(5):331-341. Epub 2019 Apr 15.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.2217/pgs-2018-0137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566135PMC
April 2019

Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction.

J Addict Med 2019 Nov/Dec;13(6):430-435

Dr Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Tel Aviv Sourasky Medical Center (EP, MA); Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel (EP); The Laboratory of the Biology of Addictive Diseases (OL, MR, MJK, MA); The Laboratory of Statistical Genetics, The Rockefeller University, New York, NY (JO); Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Las Vegas, NV (MA).

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http://dx.doi.org/10.1097/ADM.0000000000000515DOI Listing
March 2019

Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions.

Curr Top Behav Neurosci 2018 ;39:175-192

Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/7854_2016_9DOI Listing
January 2019

A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction.

PLoS One 2018 28;13(6):e0199951. Epub 2018 Jun 28.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199951PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023117PMC
December 2018

Chronic Oxycodone Self-administration Altered Reward-related Genes in the Ventral and Dorsal Striatum of C57BL/6J Mice: An RNA-seq Analysis.

Neuroscience 2018 11 29;393:333-349. Epub 2018 Jul 29.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, United States.

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http://dx.doi.org/10.1016/j.neuroscience.2018.07.032DOI Listing
November 2018

Sex Differences in the Rat Hippocampal Opioid System After Oxycodone Conditioned Place Preference.

Neuroscience 2018 11 11;393:236-257. Epub 2018 Oct 11.

Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY 10065, United States; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 1300 York Ave, New York, NY 10021, United States; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064522183066
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http://dx.doi.org/10.1016/j.neuroscience.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246823PMC
November 2018

Oprm1 A112G, a single nucleotide polymorphism, alters expression of stress-responsive genes in multiple brain regions in male and female mice.

Psychopharmacology (Berl) 2018 Sep 19;235(9):2703-2711. Epub 2018 Jul 19.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s00213-018-4965-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132675PMC
September 2018

Re-evaluation of the KMSK scales, rapid dimensional measures of self-exposure to specific drugs: Gender-specific features.

Drug Alcohol Depend 2018 09 21;190:179-187. Epub 2018 Jul 21.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

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http://dx.doi.org/10.1016/j.drugalcdep.2018.05.028DOI Listing
September 2018

Naltrexone and nalmefene attenuate cocaine place preference in male mice.

Neuropharmacology 2018 09 23;140:174-183. Epub 2018 Jul 23.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2018.07.025DOI Listing
September 2018

Involvement of Activated Brain Stress Responsive Systems in Excessive and "Relapse" Alcohol Drinking in Rodent Models: Implications for Therapeutics.

J Pharmacol Exp Ther 2018 07 18;366(1):9-20. Epub 2018 Apr 18.

Laboratory of Biology of Addictive Diseases, Rockefeller University, New York, New York.

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http://dx.doi.org/10.1124/jpet.117.245621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988024PMC
July 2018

Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice.

Neurosci Lett 2018 04 26;673:19-23. Epub 2018 Feb 26.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, NY, USA.

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http://dx.doi.org/10.1016/j.neulet.2018.02.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293468PMC
April 2018

Gender-specific association of functional 68 bp repeats with cannabis exposure in an African American cohort.

Neuropsychiatr Dis Treat 2018 16;14:1025-1034. Epub 2018 Apr 16.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.2147/NDT.S159954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909790PMC
April 2018

Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence.

Neuropsychopharmacology 2018 03 31;43(4):739-750. Epub 2017 Aug 31.

Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1038/npp.2017.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809790PMC
March 2018

Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin.

Pharmacogenomics 2018 03 21;19(4):333-341. Epub 2018 Feb 21.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10065, USA.

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http://dx.doi.org/10.2217/pgs-2017-0179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941712PMC
March 2018

Sex differences after chronic stress in the expression of opioid-, stress- and neuroplasticity-related genes in the rat hippocampus.

Neurobiol Stress 2018 Feb 11;8:33-41. Epub 2018 Jan 11.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, United States.

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http://dx.doi.org/10.1016/j.ynstr.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991341PMC
February 2018

V1b Receptor Antagonist SSR149415 and Naltrexone Synergistically Decrease Excessive Alcohol Drinking in Male and Female Mice.

Alcohol Clin Exp Res 2018 Jan 28;42(1):195-205. Epub 2017 Nov 28.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York.

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https://onlinelibrary.wiley.com/doi/pdf/10.1111/acer.13544
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http://doi.wiley.com/10.1111/acer.13544
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http://dx.doi.org/10.1111/acer.13544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750120PMC
January 2018

Dopamine gene variants in opioid addiction: comparison of dependent patients, nondependent users and healthy controls.

Pharmacogenomics 2018 Jan 6;19(2):95-104. Epub 2017 Dec 6.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA.

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http://dx.doi.org/10.2217/pgs-2017-0134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826863PMC
January 2018

Medications for substance use disorders (SUD): emerging approaches.

Expert Opin Emerg Drugs 2017 12 30;22(4):301-315. Epub 2017 Oct 30.

a Laboratory in the Biology of Addictive Diseases , The Rockefeller University , New York , NY , USA.

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http://dx.doi.org/10.1080/14728214.2017.1395855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276123PMC
December 2017

Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice.

Psychopharmacology (Berl) 2017 Oct 20;234(19):2955-2970. Epub 2017 Jul 20.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s00213-017-4691-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693682PMC
October 2017

The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment.

Pharmacogenomics 2017 Oct 4;18(15):1387-1391. Epub 2017 Oct 4.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, NY, 10065, USA.

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http://dx.doi.org/10.2217/pgs-2017-0092DOI Listing
October 2017

Can a rapid measure of self-exposure to drugs of abuse provide dimensional information on depression comorbidity?

Am J Addict 2017 Sep 27;26(6):632-639. Epub 2017 Jun 27.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York.

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http://dx.doi.org/10.1111/ajad.12578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573655PMC
September 2017

"Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats".

Psychopharmacology (Berl) 2017 Aug 27;234(15):2219-2231. Epub 2017 May 27.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue - Box 171, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s00213-017-4647-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591939PMC
August 2017

Alterations of expression of inflammation/immune-related genes in the dorsal and ventral striatum of adult C57BL/6J mice following chronic oxycodone self-administration: a RNA sequencing study.

Psychopharmacology (Berl) 2017 Aug 26;234(15):2259-2275. Epub 2017 Jun 26.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s00213-017-4657-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826641PMC
August 2017

Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury.

Cell Mol Gastroenterol Hepatol 2017 May 24;3(3):500-505. Epub 2017 Jan 24.

Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center at Dallas, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jcmgh.2017.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404026PMC
May 2017

Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence.

Drug Alcohol Depend 2016 Nov 5;168:164-169. Epub 2016 Sep 5.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.drugalcdep.2016.08.634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842569PMC
November 2016

Sex differences in responsiveness to the prescription opioid oxycodone in mice.

Pharmacol Biochem Behav 2016 09 15;148:99-105. Epub 2016 Jun 15.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, United States.

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http://dx.doi.org/10.1016/j.pbb.2016.06.006DOI Listing
September 2016

Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration.

Neuropharmacology 2016 06 9;105:639-650. Epub 2016 Jan 9.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2016.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894495PMC
June 2016

African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.

Pharmacogenomics 2016 06 7;17(9):995-1003. Epub 2016 Jun 7.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.2217/pgs-2016-0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996315PMC
June 2016

Methadone Medical Maintenance: An Early 21st-Century Perspective.

J Addict Dis 2015 ;34(2-3):226-37

a Laboratory of the Biology of Addictive Diseases, The Rockefeller University , New York , New York , USA.

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http://dx.doi.org/10.1080/10550887.2015.1059225DOI Listing
May 2016

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.

Authors:
Tae-Hwi Schwantes-An Juan Zhang Li-Shiun Chen Sarah M Hartz Robert C Culverhouse Xiangning Chen Hilary Coon Josef Frank Helen M Kamens Bettina Konte Leena Kovanen Antti Latvala Lisa N Legrand Brion S Maher Whitney E Melroy Elliot C Nelson Mark W Reid Jason D Robinson Pei-Hong Shen Bao-Zhu Yang Judy A Andrews Paul Aveyard Olga Beltcheva Sandra A Brown Dale S Cannon Sven Cichon Robin P Corley Norbert Dahmen Louisa Degenhardt Tatiana Foroud Wolfgang Gaebel Ina Giegling Stephen J Glatt Richard A Grucza Jill Hardin Annette M Hartmann Andrew C Heath Stefan Herms Colin A Hodgkinson Per Hoffmann Hyman Hops David Huizinga Marcus Ising Eric O Johnson Elaine Johnstone Radka P Kaneva Kenneth S Kendler Falk Kiefer Henry R Kranzler Ken S Krauter Orna Levran Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Nicholas G Martin Manuel Mattheisen Grant W Montgomery Bertram Müller-Myhsok Michael F Murphy Michael C Neale Momchil A Nikolov Denise Nishita Markus M Nöthen John Nurnberger Timo Partonen Michele L Pergadia Maureen Reynolds Monika Ridinger Richard J Rose Noora Rouvinen-Lagerström Norbert Scherbaum Christine Schmäl Michael Soyka Michael C Stallings Michael Steffens Jens Treutlein Ming Tsuang Tamara L Wall Norbert Wodarz Vadim Yuferov Peter Zill Andrew W Bergen Jingchun Chen Paul M Cinciripini Howard J Edenberg Marissa A Ehringer Robert E Ferrell Joel Gelernter David Goldman John K Hewitt Christian J Hopfer William G Iacono Jaakko Kaprio Mary Jeanne Kreek Ivo M Kremensky Pamela A F Madden Matt McGue Marcus R Munafò Robert A Philibert Marcella Rietschel Alec Roy Dan Rujescu Sirkku T Saarikoski Gary E Swan Alexandre A Todorov Michael M Vanyukov Robert B Weiss Laura J Bierut Nancy L Saccone

Behav Genet 2016 Mar 21;46(2):151-69. Epub 2015 Sep 21.

Department of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St. Louis, MO, 63110, USA.

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https://genepi.qimr.edu.au/contents/p/staff/Schwantes_An_Beh
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http://link.springer.com/10.1007/s10519-015-9737-3
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http://dx.doi.org/10.1007/s10519-015-9737-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752855PMC
March 2016

Involvement of Endocannabinoids in Alcohol "Binge" Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB1 Receptor Antagonists.

Alcohol Clin Exp Res 2016 Mar 9;40(3):467-73. Epub 2016 Feb 9.

Laboratory of the Biology of Addictive Diseases , The Rockefeller University, New York, New York.

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http://dx.doi.org/10.1111/acer.12989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962692PMC
March 2016

Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry.

Prog Neuropsychopharmacol Biol Psychiatry 2016 Jan 12;64:118-23. Epub 2015 Aug 12.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.pnpbp.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564302PMC
January 2016

Corrigendum: Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders.

Front Pharmacol 2015 30;6:285. Epub 2015 Nov 30.

Laboratory on the Biology of Addictive Diseases, The Rockefeller University New York, NY, USA.

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http://dx.doi.org/10.3389/fphar.2015.00285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663718PMC
December 2015

Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders.

Front Pharmacol 2015 8;6:190. Epub 2015 Sep 8.

Laboratory on the Biology of Addictive Diseases, The Rockefeller University , New York, NY, USA.

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http://dx.doi.org/10.3389/fphar.2015.00190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561799PMC
October 2015

Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans.

Ann Hum Genet 2015 May 27;79(3):188-98. Epub 2015 Feb 27.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA.

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http://doi.wiley.com/10.1111/ahg.12104
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http://dx.doi.org/10.1111/ahg.12104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399004PMC
May 2015

Mouse model of the OPRM1 (A118G) polymorphism: differential heroin self-administration behavior compared with wild-type mice.

Neuropsychopharmacology 2015 Mar 13;40(5):1091-100. Epub 2015 Mar 13.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1038/npp.2014.286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367451PMC
March 2015

A window of opportunity: maximizing the effectiveness of new HCV regimens in the United States with the expansion of the Affordable Care Act.

Am J Public Health 2015 Mar 20;105(3):457-63. Epub 2015 Jan 20.

Sean J. Haley is with the Department of Health and Nutrition Sciences, Brooklyn College and the City University of New York, School of Public Health, New York. Mary Jeanne Kreek is with the Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York.

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http://dx.doi.org/10.2105/AJPH.2014.302327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330831PMC
March 2015

Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in rats.

Physiol Behav 2015 Feb 9;139:127-35. Epub 2014 Nov 9.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.physbeh.2014.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275356PMC
February 2015

Effects of handling and vehicle injections on adrenocorticotropic and corticosterone concentrations in Sprague-Dawley compared with Lewis rats.

J Am Assoc Lab Anim Sci 2015 Jan;54(1):35-9

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311740PMC
January 2015

Alcohol: a stimulant activating brain stress responsive systems with persistent neuroadaptation.

Neuropharmacology 2014 Dec 12;87:51-8. Epub 2014 Jun 12.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2014.05.044DOI Listing
December 2014

Personality as a risk factor for illicit opioid use and a protective factor for illicit opioid dependence.

Drug Alcohol Depend 2014 Dec 14;145:101-5. Epub 2014 Oct 14.

Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands; Central Committee on the Treatment of Heroin Addicts (CCBH), Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.drugalcdep.2014.09.783DOI Listing
December 2014

Genetics of opiate addiction.

Curr Psychiatry Rep 2014 Nov;16(11):504

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s11920-014-0504-6DOI Listing
November 2014

Drug addiction and stress-response genetic variability: association study in African Americans.

Ann Hum Genet 2014 Jul 26;78(4):290-8. Epub 2014 Apr 26.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1111/ahg.12064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065216PMC
July 2014

Prospective study of QTc changes among former opiate addicts since admission to methadone maintenance treatment: benzodiazepine risk.

J Addict Med 2013 Nov-Dec;7(6):428-34

From the Dr Miriam and Sheldon G. Adelson Clinics for Drug Abuse Treatment and Research (EP, MA), Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Dr Miriam and Sheldon G. Adelson Clinics for Drug Abuse Treatment and Research (SL, MA), Las Vegas, NV; Laboratory of the Biology of Addictive Diseases (MJK, MA), The Rockefeller University, New York, NY.

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http://dx.doi.org/10.1097/ADM.0b013e3182a8a4f2DOI Listing
April 2014

Extended access oxycodone self-administration and neurotransmitter receptor gene expression in the dorsal striatum of adult C57BL/6 J mice.

Psychopharmacology (Berl) 2014 Apr 13;231(7):1277-87. Epub 2013 Nov 13.

Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, Box 171, New York, NY, 10065, USA,

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http://link.springer.com/10.1007/s00213-013-3306-3
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http://dx.doi.org/10.1007/s00213-013-3306-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954898PMC
April 2014

Methadone maintenance treatment experience in Macao--prospective follow-up for initial 4.5 years.

J Psychoactive Drugs 2013 Sep-Oct;45(4):313-21

Dr. Miriam & Sheldon G. Adelson Clinic for Drug Abuse, Treatment & Research, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

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http://dx.doi.org/10.1080/02791072.2013.825032DOI Listing
January 2014

Neurocognitive and neuroinflammatory correlates of PDYN and OPRK1 mRNA expression in the anterior cingulate in postmortem brain of HIV-infected subjects.

J Neuroinflammation 2014 Jan 9;11. Epub 2014 Jan 9.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1186/1742-2094-11-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896676PMC
January 2014

Genetic diversity and linkage disequilibrium in the chemokine receptor CCR2-CCR5 region among individuals and populations.

Cytokine 2013 Nov 5;64(2):571-6. Epub 2013 Sep 5.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2013.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806048PMC
November 2013

Effects of voluntary alcohol drinking on corticotropin-releasing factor and preprodynorphin mRNA levels in the central amygdala of Sardinian alcohol-preferring rats.

Neurosci Lett 2013 Oct 8;554:110-4. Epub 2013 Sep 8.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2013.08.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825761PMC
October 2013

Suppression of hypothalamic-pituitary-adrenal axis by acute heroin challenge in rats during acute and chronic withdrawal from chronic heroin administration.

Neurochem Res 2013 Sep 16;38(9):1850-60. Epub 2013 Jun 16.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/s11064-013-1091-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735680PMC
September 2013

Oxycodone-induced conditioned place preference and sensitization of locomotor activity in adolescent and adult mice.

Pharmacol Biochem Behav 2013 Sep 1;110:112-6. Epub 2013 Jul 1.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2013.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805792PMC
September 2013

CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.

Addict Biol 2013 Jul 25;18(4):709-16. Epub 2011 Jul 25.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1111/j.1369-1600.2011.00349.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735354PMC
July 2013

Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats.

Synapse 2013 Jun 26;67(6):358-61. Epub 2013 Feb 26.

Laboratory of the Biology of Addictive Diseases, the Rockefeller University, New York, New York 10065, USA.

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http://dx.doi.org/10.1002/syn.21638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756541PMC
June 2013

Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice.

Neuropharmacology 2013 Apr 16;67:259-66. Epub 2012 Nov 16.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2012.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616618PMC
April 2013

Expression of ephrin receptors and ligands in postmortem brains of HIV-infected subjects with and without cognitive impairment.

J Neuroimmune Pharmacol 2013 Mar 12;8(1):333-44. Epub 2013 Jan 12.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.

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http://link.springer.com/10.1007/s11481-012-9429-1
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http://dx.doi.org/10.1007/s11481-012-9429-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587720PMC
March 2013

Tolerance and sensitization to chronic escalating dose heroin following extended withdrawal in Fischer rats: possible role of mu-opioid receptors.

Psychopharmacology (Berl) 2013 Jan 25;225(1):127-40. Epub 2012 Jul 25.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/s00213-012-2801-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494815PMC
January 2013

κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.

Trends Neurosci 2012 Oct 16;35(10):587-96. Epub 2012 Jun 16.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.tins.2012.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685470PMC
October 2012

Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.

J Clin Invest 2012 Oct 1;122(10):3387-93. Epub 2012 Oct 1.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10065, USA.

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http://www.jci.org/articles/view/60390
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http://dx.doi.org/10.1172/JCI60390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534165PMC
October 2012

Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice.

Neuropharmacology 2012 Aug 4;63(2):322-9. Epub 2012 Apr 4.

The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10065, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002839081200120
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http://dx.doi.org/10.1016/j.neuropharm.2012.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979702PMC
August 2012

Former heroin addicts with or without a history of cocaine dependence are more impulsive than controls.

Drug Alcohol Depend 2012 Jul 20;124(1-2):113-20. Epub 2012 Jan 20.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.drugalcdep.2011.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372650PMC
July 2012

Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo.

J Pharmacol Exp Ther 2012 Jun 20;341(3):802-8. Epub 2012 Mar 20.

Laboratory on the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1124/jpet.112.193227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362888PMC
June 2012

Association of polymorphisms of the mu opioid receptor gene with the severity of HIV infection and response to HIV treatment.

J Infect Dis 2012 Jun 28;205(11):1745-56. Epub 2012 Mar 28.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1093/infdis/jis264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415853PMC
June 2012

Common and specific liability to addiction: approaches to association studies of opioid addiction.

Drug Alcohol Depend 2012 Jun 27;123 Suppl 1:S33-41. Epub 2012 Apr 27.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.drugalcdep.2012.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689423PMC
June 2012

The genetics of the opioid system and specific drug addictions.

Hum Genet 2012 Jun 1;131(6):823-42. Epub 2012 May 1.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/s00439-012-1172-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721349PMC
June 2012

Dose escalation and dose preference in extended-access heroin self-administration in Lewis and Fischer rats.

Psychopharmacology (Berl) 2012 Mar 6;220(1):163-72. Epub 2011 Sep 6.

The Rockefeller University, Laboratory of the Biology of Addictive Diseases, 1230 York Avenue, Box 171, New York, NY 10065, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359091PMC
http://dx.doi.org/10.1007/s00213-011-2464-4DOI Listing
March 2012

Measuring the incentive value of escalating doses of heroin in heroin-dependent Fischer rats during acute spontaneous withdrawal.

Psychopharmacology (Berl) 2012 Jan 7;219(1):59-72. Epub 2011 Jul 7.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/s00213-011-2380-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249530PMC
January 2012

Functions of arginine vasopressin and its receptors: importance of human molecular genetics studies in bidirectional translational research.

Biol Psychiatry 2011 Sep;70(6):502-3

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10065, USA.

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http://dx.doi.org/10.1016/j.biopsych.2011.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762586PMC
September 2011

Extreme marginalization: addiction and other mental health disorders, stigma, and imprisonment.

Ann N Y Acad Sci 2011 Aug;1231:65-72

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06152.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716375PMC
August 2011