Publications by authors named "Mary Carrington"

100Publications

Computationally Optimized SARS-CoV-2 MHC Class I and II Vaccine Formulations Predicted to Target Human Haplotype Distributions.

Cell Syst 2020 08 27;11(2):131-144.e6. Epub 2020 Jul 27.

MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA; MIT Electrical Engineering and Computer Science, Cambridge, MA, USA; MIT Biological Engineering, Cambridge, MA, USA. Electronic address:

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August 2020

Predicting the Immunogenicity of T cell epitopes: From HIV to SARS-CoV-2.

bioRxiv 2020 May 15. Epub 2020 May 15.

Ragon Insitute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA.

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May 2020

Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing.

Front Immunol 2019 10;10:3034. Epub 2020 Jan 10.

Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.

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November 2020

The Interaction of LILRB2 with HLA-B Is Associated with Psoriasis Susceptibility.

J Invest Dermatol 2020 06 24;140(6):1292-1295.e3. Epub 2019 Dec 24.

Department of Dermatology, University of California San Francisco, San Francisco, California, USA. Electronic address:

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June 2020

Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors.

Sci Signal 2019 12 17;12(612). Epub 2019 Dec 17.

Manchester Collaborative Centre for Inflammation Research, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK.

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December 2019

HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation.

Mol Biol Evol 2020 03;37(3):639-650

Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.

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March 2020

Natural Killer Cells Offer Differential Protection From Leukemia in Chinese Southern Han.

Front Immunol 2019 16;10:1646. Epub 2019 Jul 16.

Division of Biomedical Informatics and Personalized Medicine, Department of Microbiology and Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

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October 2020

Relationship between human leukocyte antigen alleles and risk of Kaposi's sarcoma in Cameroon.

Genes Immun 2019 11 20;20(8):684-689. Epub 2019 May 20.

Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA.

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November 2019

Topological perspective on HIV escape.

Science 2019 05;364(6439):438-439

Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

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May 2019

HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control.

Proc Natl Acad Sci U S A 2019 01 2;116(3):944-949. Epub 2019 Jan 2.

Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, 24306 Plön, Germany;

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January 2019

HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes.

Cancer Res 2018 07 7;78(14):4086-4096. Epub 2018 May 7.

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.

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July 2018

Identification of an elaborate NK-specific system regulating HLA-C expression.

PLoS Genet 2018 01 12;14(1):e1007163. Epub 2018 Jan 12.

Basic Science Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America.

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January 2018

Characterization of Specific Cells Using MHC Class II Tetramers Reveals Phenotypic Differences Related to HIV Infection and Tuberculosis Disease.

J Immunol 2017 Aug 9. Epub 2017 Aug 9.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, 7925 Cape Town, South Africa;

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August 2017

Host genetic variation and HIV disease: from mapping to mechanism.

Immunogenetics 2017 08 10;69(8-9):489-498. Epub 2017 Jul 10.

Cancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

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August 2017

Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection.

AIDS 2017 09;31(14):1935-1943

aAIDS Clinical Center, National Center for Global Health and Medicine, Tokyo bCenter for AIDS Research, Kumamoto University, Kumamoto, Japan cFaculty of Health Sciences, Simon Fraser University, Burnaby dBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada eDepartment of Paediatrics, University of Oxford, Oxford, UK fCentre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico gInfectious Diseases Clinic, Roosevelt Hospital, Guatemala City, Guatemala hNational Hospital of Tropical Diseases, Dong Da District, Hanoi, Vietnam iHIV National Laboratory, Honduran Ministry of Health jHospital Escuela Universitario, Tegucigalpa, Honduras kGorgas Memorial Institute for Health Studies, Panama City, Panama lHospital Metropolitano Vivian Pellas, Managua, Nicaragua mMinistry of Health, Belmopan, Belize nUniversity of California San Francisco, San Francisco, California oCancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland pRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA qMurdoch University, Perth, Australia rVanderbilt University, Nashville, Tennessee, USA sDepartment of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

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September 2017

Sequence and Phylogenetic Analysis of the Untranslated Promoter Regions for Class I Genes.

J Immunol 2017 03 1;198(6):2320-2329. Epub 2017 Feb 1.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702;

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March 2017

HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region.

Am J Hum Genet 2016 Dec 3;99(6):1353-1358. Epub 2016 Nov 3.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address:

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December 2016

Killer cell immunoglobulin-like receptors are associated with common variable immune deficiency pathogenesis.

J Allergy Clin Immunol 2016 11 21;138(5):1495-1498. Epub 2016 Sep 21.

Department of Microbiology, the University of Alabama at Birmingham, Birmingham, Ala; Department of Medicine, the University of Alabama at Birmingham, Birmingham, Ala. Electronic address:

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November 2016

HIV-1 Vpu Mediates HLA-C Downregulation.

Cell Host Microbe 2016 May;19(5):686-95

Cancer and Inflammation Program, Leidos Biomedical Research, Frederick National Laboratory, Frederick, MD 21702, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139-3583, USA. Electronic address:

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May 2016

Unique human immune signature of Ebola virus disease in Guinea.

Nature 2016 May;533(7601):100-4

Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany.

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May 2016

A vision of KIR variation at super resolution.

Immunology 2016 Jul 5;148(3):249-52. Epub 2016 Apr 5.

Clinical and Experimental Sciences, University of Southampton, Southampton, UK.

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July 2016

HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses.

J Virol 2015 Dec 9;90(5):2208-20. Epub 2015 Dec 9.

Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital and Harvard Medical School, Cambridge, Massachusetts, USA Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, USA

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December 2015

HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults.

J Infect Dis 2016 Apr 9;213(8):1248-52. Epub 2015 Dec 9.

Nuffield Department of Medicine Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford.

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April 2016

Selective downregulation of HLA-C and HLA-E in childhood acute lymphoblastic leukaemia.

Br J Haematol 2016 08 3;174(3):477-80. Epub 2015 Nov 3.

Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University, Düsseldorf, Germany.

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August 2016

Risk of Classic Kaposi Sarcoma With Combinations of Killer Immunoglobulin-Like Receptor and Human Leukocyte Antigen Loci: A Population-Based Case-control Study.

J Infect Dis 2016 Feb 12;213(3):432-8. Epub 2015 Aug 12.

Cancer and Inflammation Program, Laboratory of Experimental Immunology Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.

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February 2016

High HLA-DP Expression and Graft-versus-Host Disease.

N Engl J Med 2015 Aug;373(7):599-609

From the Division of Clinical Research, Fred Hutchinson Cancer Research Center (E.W.P., M.M., T.G., P.S.), and the Department of Medicine, University of Washington School of Medicine (E.W.P.) - both in Seattle; Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratories for Cancer Research, Frederick, MD (C.O., M.C.); Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston (M.C.); Center for International Blood and Marrow Transplant Research, Minneapolis (M.D.H., S.R.S.); and Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee (M.M.H., T.W.).

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August 2015

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat.

J Virol 2015 Oct 29;89(20):10176-89. Epub 2015 Jul 29.

Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA Harvard Medical School, Boston, Massachusetts, USA Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA Infectious Disease Division, Brigham and Women's Hospital, Boston, Massachusetts, USA

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October 2015

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.

PLoS Pathog 2015 Jun 15;11(6):e1004954. Epub 2015 Jun 15.

Department of Paediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Department of Paediatric Infectious Diseases, Great Ormond St Hospital for Children, London, United Kingdom.

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June 2015

The impact of host genetic variation on infection with HIV-1.

Nat Immunol 2015 Jun;16(6):577-83

1] Cancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA. [2] The Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.

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June 2015

Epigenetic regulation of differential HLA-A allelic expression levels.

Hum Mol Genet 2015 Aug 1;24(15):4268-75. Epub 2015 May 1.

Cancer Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research Incorporated, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA and Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA

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August 2015

WEST NILE VIRUS ANTIBODY DECAY RATE IN FREE-RANGING BIRDS.

J Wildl Dis 2015 Jul 28;51(3):601-8. Epub 2015 Apr 28.

10  Department of Entomology, Texas A&M University, 401 Joe Routt Boulevard, College Station, Texas 77843, USA.

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July 2015

Relative expression levels of the HLA class-I proteins in normal and HIV-infected cells.

J Immunol 2015 Apr 9;194(8):3594-600. Epub 2015 Mar 9.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, MD 21702; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139

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April 2015

Host genetic and viral determinants of HIV-1 RNA set point among HIV-1 seroconverters from sub-saharan Africa.

J Virol 2015 Feb 3;89(4):2104-11. Epub 2014 Dec 3.

Department of Global Health, University of Washington, Seattle, Washington, USA Department of Medicine, University of Washington, Seattle, Washington, USA Department of Pediatrics, University of Washington, Seattle, Washington, USA

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February 2015

Association between CTL Precursor Frequency to HLA-C Mismatches and HLA-C Antigen Cell Surface Expression.

Front Immunol 2014 27;5:547. Epub 2014 Oct 27.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center , Leiden , Netherlands ; Europdonor Foundation , Leiden , Netherlands.

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November 2014

HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation.

Blood 2014 Dec 16;124(26):3996-4003. Epub 2014 Oct 16.

Cancer and Inflammation Program, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD; and Ragon Institute of the Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA.

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December 2014

Relationship of HIV reservoir characteristics with immune status and viral rebound kinetics in an HIV therapeutic vaccine study.

AIDS 2014 Nov;28(18):2649-57

aBrigham and Women's Hospital, Harvard Med School bHarvard School of Public Health, Boston, Massachusetts cCancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland dRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts eMonogram Biosciences fUniversity of California, San Diego, La Jolla, California gCase Western Reserve University, Cleveland, Ohio, USA.

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November 2014

HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes.

J Virol 2014 Nov 27;88(22):12937-48. Epub 2014 Aug 27.

Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA Howard Hughes Medical Institute, Chevy Chase, Maryland, USA

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November 2014

On stand by: host genetics of HIV control.

AIDS 2013 Nov;27(18):2831-9

aCancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland bRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA cSchool of Life Sciences, École Polytechnique Fédérale de Lausanne dInstitute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland eProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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November 2013

Human Leukocyte Antigen Class I and II Alleles and Cervical Adenocarcinoma.

Front Oncol 2014 19;4:119. Epub 2014 Jun 19.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center , Seattle, WA , USA ; Department of Epidemiology, University of Washington , Seattle, WA , USA.

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July 2014

Distinct assembly profiles of HLA-B molecules.

J Immunol 2014 Jun 30;192(11):4967-76. Epub 2014 Apr 30.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;

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June 2014

Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA-C*03:04 and modulate primary natural killer cell function.

AIDS 2014 Jun;28(10):1399-408

aRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA bExperimental Immunology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands cDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston dDivision of Microbiology, New England Primate Research Center, Southborough, Massachusetts, USA eIrsicaixa AIDS Research Institute - HIVACAT, Autonomous University of Barcelona, Badalona and Institució Catalana de Recerca i Estudis Avancats (ICREA), Barcelona, Spain fCancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, Maryland gDepartment of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA hLaboratory for Translational Immunology, University Medical Center Utrecht, Utrecht iCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands jHeinrich-Pette-Institut, Leibniz Institute for Experimental Virology, Hamburg, Germany. *Nienke H. van Teijlingen and Angelique Hölzemer have contributed equally to the writing of the manuscript.

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June 2014

Maternal KIR in combination with paternal HLA-C2 regulate human birth weight.

J Immunol 2014 Jun 28;192(11):5069-73. Epub 2014 Apr 28.

Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 1QP, United Kingdom;

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June 2014

HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.

J Infect Dis 2014 Oct 8;210(7):1047-51. Epub 2014 Apr 8.

Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Maryland Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.

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October 2014

Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV.

PLoS Pathog 2014 Mar 27;10(3):e1004008. Epub 2014 Mar 27.

Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.

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March 2014

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.

PLoS Genet 2013 Nov 21;9(11):e1003926. Epub 2013 Nov 21.

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts, United States of America ; Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Harvard Medical School, Boston, Massachusetts, United States of America ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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November 2013

Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease.

Proc Natl Acad Sci U S A 2013 Dec 18;110(51):20705-10. Epub 2013 Nov 18.

Cancer and Inflammation Program, Laboratory of Experimental Immunology and Basic Research Program, Center for Cancer Research Genetics Core, Science Applications International Corporation-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.

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December 2013

Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair.

Immunogenetics 2014 Jan 6;66(1):1-8. Epub 2013 Oct 6.

Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.

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January 2014

Response to Comment on "Influence of HLA-C expression level on HIV control".

Science 2013 Sep;341(6151):1175

Cancer and Inflammation Program, Laboratory of Experimental Immunology, Science Applications International Corporation Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

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September 2013