Mary C Dinauer

Mary C Dinauer

UNVERIFIED PROFILE

Are you Mary C Dinauer?   Register this Author

Register author
Mary C Dinauer

Mary C Dinauer

Publications by authors named "Mary C Dinauer"

Are you Mary C Dinauer?   Register this Author

100Publications

1328Reads

46Profile Views

Neutrophil swarming delays the growth of clusters of pathogenic fungi.

Nat Commun 2020 Apr 27;11(1):2031. Epub 2020 Apr 27.

BioMEMS Resource Center, Massachusetts General Hospital, Boston, MA, 02129, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-15834-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184738PMC
April 2020

Insights into the NOX NADPH Oxidases Using Heterologous Whole Cell Assays.

Authors:
Mary C Dinauer

Methods Mol Biol 2019 ;1982:139-151

Department of Pediatrics, Washington University in St. Louis School of Medicine , St. Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9424-3_9DOI Listing
January 2020

Neutrophil Defects and Diagnosis Disorders of Neutrophil Function: An Overview.

Authors:
Mary C Dinauer

Methods Mol Biol 2020 ;2087:11-29

Department of Pediatrics (Hematology/Oncology), St. Louis Children's Hospital, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-0716-0154-9_2DOI Listing
January 2020

Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption.

BMB Rep 2019 Nov;52(11):659-664

Laboratory for Leukocyte Signaling Research, Department of Pharmacology, Inha University School of Medicine, Incheon 22212, Korea.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889896PMC
November 2019

Inflammatory consequences of inherited disorders affecting neutrophil function.

Authors:
Mary C Dinauer

Blood 2019 05 21;133(20):2130-2139. Epub 2019 Mar 21.

Department of Pediatrics and Department of Pathology & Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2018-11-844563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524563PMC
May 2019

Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment.

Mol Ther 2018 05 10;26(5):1181-1197. Epub 2018 Mar 10.

Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993968PMC
May 2018

Laurence Alan Boxer, M.D. (1940-2017).

Authors:
Mary C Dinauer

J Leukoc Biol 2017 05;101(5):1075

Departments of Pediatrics and Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.1LT0217-060DOI Listing
May 2017

PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo.

J Leukoc Biol 2017 02 19;101(2):449-457. Epub 2016 Aug 19.

Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; and

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1189/jlb.3AB0316-139R
Publisher Site
http://dx.doi.org/10.1189/jlb.3AB0316-139RDOI Listing
February 2017

Primary immune deficiencies with defects in neutrophil function.

Authors:
Mary C Dinauer

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):43-50

Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO.

View Article

Download full-text PDF

Source
http://www.asheducationbook.org/cgi/doi/10.1182/asheducation
Publisher Site
http://dx.doi.org/10.1182/asheducation-2016.1.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142438PMC
December 2016

Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts.

Immunology 2015 Dec 29;146(4):595-606. Epub 2015 Sep 29.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imm.12530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693894PMC
December 2015

NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis.

Blood 2015 Dec 6;126(25):2724-33. Epub 2015 Oct 6.

Department of Pediatrics and Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-05-644773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683333PMC
December 2015

Disorders of neutrophil function: an overview.

Authors:
Mary C Dinauer

Methods Mol Biol 2014 ;1124:501-15

Departments of Pediatrics (Hematology/Oncology) and Pathology & Immunology, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-62703-845-4_30DOI Listing
October 2014

Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67.

J Clin Cell Immunol 2014 Jun;5(3)

Departments of Pediatrics (Hematology/Oncology), Microbiology/Immunology, and Medical and Molecular Genetics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414043PMC
June 2014

Cupric yersiniabactin is a virulence-associated superoxide dismutase mimic.

ACS Chem Biol 2014 Feb 11;9(2):551-61. Epub 2013 Dec 11.

Center for Women's Infectious Diseases Research, ‡Division of Infectious Diseases, §Department of Internal Medicine, ∥Department of Chemistry, ⊥Department of Pediatrics, and #Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, Missouri 63110, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb400658kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934373PMC
February 2014

Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis.

Traffic 2013 Nov 16;14(11):1118-31. Epub 2013 Sep 16.

Department of Cell Physiology and Metabolism, University of Geneva, 1 rue Michel-Servet, CH-1211, Geneva 4, Switzerland.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/tra.12115
Publisher Site
http://dx.doi.org/10.1111/tra.12115DOI Listing
November 2013

An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD.

Blood 2013 Apr 20;121(17):3473-83. Epub 2013 Feb 20.

Department of Pediatrics, Herman B Wells Center for Pediatric Research, Riley Hospital for Children, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/content/early/2013/02/20/blood-2
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-10-46
Publisher Site
http://dx.doi.org/10.1182/blood-2012-10-461913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637016PMC
April 2013

Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558.

J Leukoc Biol 2012 Oct 20;92(4):869-82. Epub 2012 Jul 20.

Herman B Wells Center for Pediatric Research, Department of Pediatrics (Hematology/Oncology), James Whitcomb Riley Hospital for Children and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.0512244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441311PMC
October 2012

Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells.

J Immunol 2012 Oct 14;189(8):3800-4. Epub 2012 Sep 14.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://www.jimmunol.org/content/189/8/3800.full.pdf
Web Search
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1103080
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1103080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466399PMC
October 2012

Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.

Proc Natl Acad Sci U S A 2011 Dec 21;108(49):19617-22. Epub 2011 Nov 21.

Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH 45435, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/content/108/49/19617.full.pdf
Web Search
http://www.pnas.org/cgi/doi/10.1073/pnas.1114692108
Publisher Site
http://dx.doi.org/10.1073/pnas.1114692108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241757PMC
December 2011

The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis.

Mol Cell Biol 2011 Jun 28;31(11):2227-40. Epub 2011 Mar 28.

Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA.

View Article

Download full-text PDF

Source
http://mcb.asm.org/content/31/11/2227.full.pdf
Web Search
http://mcb.asm.org/cgi/doi/10.1128/MCB.01348-10
Publisher Site
http://dx.doi.org/10.1128/MCB.01348-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133238PMC
June 2011

Interferon-γ production by neutrophils during bacterial pneumonia in mice.

Am J Respir Crit Care Med 2011 May 17;183(10):1391-401. Epub 2010 Dec 17.

Center for Airways Disease, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599-7248, USA.

View Article

Download full-text PDF

Source
http://www.atsjournals.org/doi/abs/10.1164/rccm.201004-0592O
Publisher Site
http://dx.doi.org/10.1164/rccm.201004-0592OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114063PMC
May 2011

Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.

J Biol Chem 2011 May 4;286(18):16308-20. Epub 2011 Mar 4.

Department of Biochemistry and Molecular Biology, Wright State University School Medicine, Dayton, Ohio 45435, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.206672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091237PMC
May 2011

Gene therapy of chronic granulomatous disease: the engraftment dilemma.

Mol Ther 2011 Jan 2;19(1):28-35. Epub 2010 Nov 2.

Institute for Biomedical Research, Georg-Speyer-Haus, Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2010.232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017455PMC
January 2011

Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice.

Blood 2010 Dec 2;116(24):5419-22. Epub 2010 Sep 2.

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-07-295949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012550PMC
December 2010

p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.

J Biol Chem 2010 Nov 5;285(45):35169-79. Epub 2010 Sep 5.

From the Department of Pediatrics (Hematology/Oncology), Herman B Wells Center for Pediatric Research, Riley Hospital for Children, and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.164475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966130PMC
November 2010

Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells.

Cell Signal 2010 May 13;22(5):770-82. Epub 2010 Jan 13.

Department of Pharmacology, University of Illinois, Chicago, 60612, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2010.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282168PMC
May 2010

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.

J Clin Invest 2010 Mar 15;120(3):859-70. Epub 2010 Feb 15.

Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI41443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827964PMC
March 2010

Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding.

J Biol Chem 2010 Jan 30;285(5):2959-67. Epub 2009 Nov 30.

From the Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157 and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.030643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823407PMC
January 2010

Chronic granulomatous disease and other disorders of phagocyte function.

Authors:
Mary C Dinauer

Hematology Am Soc Hematol Educ Program 2005 :89-95

Wells Center for Ped. Research, Indiana School of Medicine, 1044 W. Walnut St., R4 402C, Indianapolis, IN 46202-5225, USA.

View Article

Download full-text PDF

Source
http://www.asheducationbook.org/cgi/doi/10.1182/asheducation
Publisher Site
http://dx.doi.org/10.1182/asheducation-2005.1.89DOI Listing
November 2009

Activation of antibacterial autophagy by NADPH oxidases.

Proc Natl Acad Sci U S A 2009 Apr 1;106(15):6226-31. Epub 2009 Apr 1.

Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0811045106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664152PMC
April 2009

A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis.

Mol Biol Cell 2009 Mar 7;20(5):1520-32. Epub 2009 Jan 7.

Department of Pediatrics (Hematology/Oncology), Herman B Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.e08-06-0620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649267PMC
March 2009

Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth.

Am J Physiol Heart Circ Physiol 2009 Mar 16;296(3):H877-86. Epub 2009 Jan 16.

Department of Cellular and Integrative Physiology, Indiana Univ. School of Medicine, 1001 W. 10th St., WD OPW 425 E, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpheart.00772.2008
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00772.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660231PMC
March 2009

Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes.

J Immunol 2009 Feb;182(4):2325-39

Herman B. Wells Center for Pediatric Research, Department of Pediatrics (Hematology/Oncology), James Whitcomb Riley Hospital for Children, Department of Microbiology and Immunology, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0803476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666390PMC
February 2009

Mutational analysis reveals distinct features of the Nox4-p22 phox complex.

J Biol Chem 2008 Dec 10;283(50):35273-82. Epub 2008 Oct 10.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M804200200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596391PMC
December 2008

Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome.

Blood 2008 Nov 18;112(9):3867-77. Epub 2008 Aug 18.

Herman B Wells Center for Pediatric Research, Department of Pediatrics (Hematology/Oncology), Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-11-12
Publisher Site
http://dx.doi.org/10.1182/blood-2007-11-126029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572805PMC
November 2008

The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts.

Am J Pathol 2008 Aug 26;173(2):507-17. Epub 2008 Jun 26.

Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S000294401061626
Publisher Site
http://dx.doi.org/10.2353/ajpath.2008.071059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475787PMC
August 2008

Disorders of neutrophil function: an overview.

Authors:
Mary C Dinauer

Methods Mol Biol 2007 ;412:489-504

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-467-4_30DOI Listing
June 2008

Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury.

Am J Physiol Lung Cell Mol Physiol 2008 Feb 9;294(2):L178-86. Epub 2007 Nov 9.

Department of Pharmacology, University of Illinois College of Medicine, 835 South Wolcott Ave., Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00263.2007DOI Listing
February 2008

Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production.

J Biol Chem 2007 Oct 13;282(41):30273-84. Epub 2007 Aug 13.

Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M704416200
Publisher Site
http://dx.doi.org/10.1074/jbc.M704416200DOI Listing
October 2007

Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice.

Mol Cell Biol 2007 Aug 25;27(15):5275-85. Epub 2007 May 25.

Department of Microbiology and Immunology and The Walther Oncology Center, 950 W. Walnut St. R2 302, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.01967-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952080PMC
August 2007

Granulocyte colony-stimulating factor prior to nonmyeloablative irradiation decreases murine host hematopoietic stem cell function and increases engraftment of donor marrow cells.

Stem Cells 2007 Jun 8;25(6):1578-85. Epub 2007 Mar 8.

Cancer Research Institute R4 402C, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1634/stemcells.2006-0808
Publisher Site
http://dx.doi.org/10.1634/stemcells.2006-0808DOI Listing
June 2007

The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.

Mol Cell Biol 2007 Jan 23;27(1):312-23. Epub 2006 Oct 23.

Cancer Research Institute, 1044 W. Walnut Street, R4 402C, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://mcb.asm.org/cgi/doi/10.1128/MCB.00985-06
Publisher Site
http://dx.doi.org/10.1128/MCB.00985-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800642PMC
January 2007

Rac2 concentrations in umbilical cord neutrophils.

Biol Neonate 2006 30;90(3):156-9. Epub 2006 Mar 30.

Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000092451DOI Listing
October 2006

Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity.

J Biol Chem 2006 Oct 8;281(41):30336-46. Epub 2006 Aug 8.

Herman B. Wells Center for Pediatric Research, Department of Pediatrics (Hematology/Oncology), Microbiology/Immunology, and Medical and Molecular Genetics, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M607191200DOI Listing
October 2006

The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase A2 regulation.

J Leukoc Biol 2006 Sep 14;80(3):630-9. Epub 2006 Jul 14.

Infectious Diseases Laboratory, Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.1105684DOI Listing
September 2006

The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.

J Exp Med 2006 Aug 31;203(8):1915-25. Epub 2006 Jul 31.

Department of Pediatrics (Hematology/Oncology), Herman B Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://www.jem.org/lookup/doi/10.1084/jem.20052085
Publisher Site
http://dx.doi.org/10.1084/jem.20052085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118377PMC
August 2006

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases.

Cell Signal 2006 Jan 31;18(1):69-82. Epub 2005 May 31.

Department of Immunology IMM28, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S089865680500073
Publisher Site
http://dx.doi.org/10.1016/j.cellsig.2005.03.023DOI Listing
January 2006

p40phox: the last NADPH oxidase subunit.

Blood Cells Mol Dis 2005 Sep-Oct;35(2):291-302

Grupo de Inmunodeficiencias Primarias, Corporación Biogénesis and Facultad de Medicina, Universidad de Antioquia, Medellín, Antioquia, Colombia.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S107997960500105
Publisher Site
http://dx.doi.org/10.1016/j.bcmd.2005.06.010DOI Listing
January 2006

Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid.

J Leukoc Biol 2006 Jan 7;79(1):223-34. Epub 2005 Nov 7.

Herman B. Wells Center for Pediatric Research, Department of Pediatrics (Hematology/Oncology), James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1189/jlb.0705371
Publisher Site
http://dx.doi.org/10.1189/jlb.0705371DOI Listing
January 2006

p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils.

Blood 2005 Dec 11;106(12):3962-9. Epub 2005 Aug 11.

Department of Immunology IMM28, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2005-03-0859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895105PMC
December 2005

Gene correction reduces cutaneous inflammation and granuloma formation in murine X-linked chronic granulomatous disease.

J Invest Dermatol 2005 Oct;125(4):705-10

Department of Pediatrics (Hematology/Oncology), Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S0022202X1532459
Publisher Site
http://dx.doi.org/10.1111/j.0022-202X.2005.23908.xDOI Listing
October 2005

Newly diagnosed chronic granulomatous disease in a 53-year-old woman with Crohn disease.

Ann Allergy Asthma Immunol 2005 Aug;95(2):204-9

Department of Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202-5289, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1081-1206(10)61212-4DOI Listing
August 2005

Stable long-term gene correction with low-dose radiation conditioning in murine X-linked chronic granulomatous disease.

Blood Cells Mol Dis 2004 Nov-Dec;33(3):365-71

Herman B. Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S107997960400138
Publisher Site
http://dx.doi.org/10.1016/j.bcmd.2004.06.007DOI Listing
April 2005

Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain.

J Biol Chem 2005 Jan 25;280(2):953-64. Epub 2004 Oct 25.

Herman B Wells Center for Pediatric Research, the Department of Pediatrics (Hematology/Oncology), James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M408820200DOI Listing
January 2005

Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells.

J Immunol 2004 Dec;173(12):7462-70

Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.173.12.7462DOI Listing
December 2004

A murine model of antimetabolite-based, submyeloablative conditioning for bone marrow transplantation: biologic insights and potential applications.

Exp Hematol 2004 Dec;32(12):1255-64

Herman B Wells Center for Pediatric Research and Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind., USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2004.08.007DOI Listing
December 2004

Mitochondrial transmembrane potential is diminished in phorbol myristate acetate-stimulated peritoneal resident macrophages isolated from wild-type mice, but not in those from gp91-phox-deficient mice.

Histochem Cell Biol 2004 Oct 9;122(4):323-32. Epub 2004 Jul 9.

Department of Anatomy and Cell Biology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-5305 Kochi, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00418-004-0674-0DOI Listing
October 2004

In vivo role of myeloperoxidase for the host defense.

Jpn J Infect Dis 2004 Oct;57(5):S15

Kihara Institute for Biological Research, Yokohama City University, Yokohama, Japan.

View Article

Download full-text PDF

Source
October 2004

Gene therapy for chronic granulomatous disease.

Expert Opin Biol Ther 2004 Sep;4(9):1423-34

Herman B Wells Center for Pediatric Research and Depatment of Padiatrics (Hematology/Oncology), James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.1517/14712598.4.9.142
Publisher Site
http://dx.doi.org/10.1517/14712598.4.9.1423DOI Listing
September 2004

[Expression and activity of polymorphisms in the 67-kDa protein of the NADPH oxidase system].

Biomedica 2004 Sep;24(3):262-72

Grupo de Inmunodeficiencias Primarias, Corporación Biogénesis, Universidad de Antioquia, Medellín, Antioquia, Colombia.

View Article

Download full-text PDF

Source
September 2004

Rac2 is critical for neutrophil primary granule exocytosis.

Blood 2004 Aug 8;104(3):832-9. Epub 2004 Apr 8.

Pulmonary Research Group and the Canadian Institutes of Health Research Group on Molecular and Cell Biology of Lipids, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-07-2624DOI Listing
August 2004

Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species.

J Biol Chem 2004 Jul 3;279(27):28136-42. Epub 2004 May 3.

Departments of Immunology and Cell Biology, Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M313891200DOI Listing
July 2004

Gene therapy for chronic granulomatous disease.

Acta Haematol 2003 ;110(2-3):86-92

Herman B Wells Center for Pediatric Research and Department of Pediatrics (Hematology/Oncology), James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000072457DOI Listing
November 2003

The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions.

J Immunol 2003 Oct;171(8):4425-30

Herman B. Wells Center for Pediatric Research, Department of Pediatrics (Hematology/Oncology), James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.171.8.4425DOI Listing
October 2003

Long-term high-level reconstitution of NADPH oxidase activity in murine X-linked chronic granulomatous disease using a bicistronic vector expressing gp91phox and a Delta LNGFR cell surface marker.

Hum Gene Ther 2003 May;14(7):651-66

Herman B. Wells Center for Pediatric Research, Department of Pediatrics (Hematology/Oncology), James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/104303403321618164DOI Listing
May 2003

Regulation of neutrophil function by Rac GTPases.

Authors:
Mary C Dinauer

Curr Opin Hematol 2003 Jan;10(1):8-15

Department of Pediatrics, Herman B. Wells Center for Pediatric Research, James Whitcomb Riley Hospitals for Children, Indiana University School of Medicine, Indianapolis 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00062752-200301000-00003DOI Listing
January 2003

Retroviral-mediated gene transfer and nonmyeloablative conditioning: studies in a murine X-linked chronic granulomatous disease model.

J Pediatr Hematol Oncol 2002 Dec;24(9):787-90

Department of Pediatrics (Hematology/Oncology), Indiana University School of Medicine, 1044 W. Walnut Street, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00043426-200212000-00026DOI Listing
December 2002

Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions.

J Immunol 2002 Nov;169(9):5043-51

Herman B Wells Center for Pediatric Research and Department of Pediatrics (Hematology/Oncology), Indiana University Medical School, Indianapolis 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.169.9.5043DOI Listing
November 2002

Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: effects of a retroviral-mediated gene transfer protocol and implications for gene therapy.

Exp Hematol 2002 Nov;30(11):1324-32

Herman B. Wells Center for Pediatric Research and Department of Pediatrics, Hematology/Oncology, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0301-472x(02)00927-xDOI Listing
November 2002

Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 function.

J Biol Chem 2002 Aug 31;277(33):30368-74. Epub 2002 May 31.

Department of Pediatrics (Hematology/Oncology), Herman B. Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202-5225, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M203993200DOI Listing
August 2002

Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans.

J Infect Dis 2002 Jun 16;185(12):1833-7. Epub 2002 May 16.

Kihara Institute for Biological Research, Yokohama City University, Maioka-cho 641-12, Totsuka, Yokohama 244-0813, Japan.

View Article

Download full-text PDF

Source
https://academic.oup.com/jid/article-lookup/doi/10.1086/3406
Publisher Site
http://dx.doi.org/10.1086/340635DOI Listing
June 2002