Martyna Szpakowska

Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.

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April 2020

Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21.

Authors:

Natasha A Moussouras Gertrud M Hjortø Francis C Peterson Martyna Szpakowska Andy Chevigné Mette M Rosenkilde Brian F Volkman Michael B Dwinell

Biochemistry 2020 04 26;59(13):1338-1350. Epub 2020 Mar 26.

From the Department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.

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April 2020

The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical relevance and therapy.

Authors:

Elin Sjöberg Max Meyrath Andy Chevigné Arne Östman Martin Augsten Martyna Szpakowska

Adv Cancer Res 2020 14;145:99-138. Epub 2020 Feb 14.

Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg. Electronic address:

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September 2020

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.

Authors:

Nathan Reynders Dayana Abboud Alessandra Baragli Muhammad Zaeem Noman Bernard Rogister Simone P Niclou Nikolaus Heveker Bassam Janji Julien Hanson Martyna Szpakowska Andy Chevigné

Cells 2019 06 18;8(6). Epub 2019 Jun 18.

Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), L-1526 Luxembourg, Luxembourg.

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June 2019

Driving Cytotoxic Natural Killer Cells into Melanoma: If CCL5 Plays the Music, Autophagy Calls the Shots.

Authors:

Malina Xiao Muhammad Zaeem Noman Ludovic Menard Andy Chevigne Martyna Szpakowska Manon Bosseler Markus Ollert Guy Berchem Bassam Janji

Crit Rev Oncog 2018 ;23(5-6):321-332

Laboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.

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August 2019

Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration.

Authors:

Estelle Willems Matthias Dedobbeleer Marina Digregorio Arnaud Lombard Nicolas Goffart Paul Noel Lumapat Jeremy Lambert Priscilla Van den Ackerveken Martyna Szpakowska Andy Chevigné Felix Scholtes Bernard Rogister

Oncogene 2019 01 6;38(1):73-87. Epub 2018 Aug 6.

Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Liège, Liège, Belgium.

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January 2019

Development of Mimokines, chemokine N terminus-based CXCR4 inhibitors optimized by phage display and rational design.

Authors:

Virginie Fievez Martyna Szpakowska Amor Mosbah Karthik Arumugam Julie Mathu Manuel Counson Nadia Beaupain Carole Seguin-Devaux Sabrina Deroo Michèle Baudy-Floc'h Andy Chevigné

J Leukoc Biol 2018 08 23;104(2):343-357. Epub 2018 Mar 23.

Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, Luxembourg Institute of Health (LIH), House of BioHealth, 4354 Esch-sur-Alzette, Luxembourg.

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August 2018

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.

Authors:

Martyna Szpakowska Max Meyrath Nathan Reynders Manuel Counson Julien Hanson Jan Steyaert Andy Chevigné

Biochem Pharmacol 2018 07 9;153:299-309. Epub 2018 Mar 9.

Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, Luxembourg Institute of Health (LIH), L-4354 Esch-sur-Alzette, Luxembourg. Electronic address:

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July 2018

Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.

Authors:

Martyna Szpakowska Amanda M Nevins Max Meyrath David Rhainds Thomas D'huys François Guité-Vinet Nadine Dupuis Pierre-Arnaud Gauthier Manuel Counson Andrew Kleist Geneviève St-Onge Julien Hanson Dominique Schols Brian F Volkman Nikolaus Heveker Andy Chevigné

Br J Pharmacol 2018 05 23;175(9):1419-1438. Epub 2018 Mar 23.

Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.

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May 2018

Profiling the Extended Cleavage Specificity of the House Dust Mite Protease Allergens Der p 1, Der p 3 and Der p 6 for the Prediction of New Cell Surface Protein Substrates.

Authors:

Alain Jacquet Vincenzo Campisi Martyna Szpakowska Marie-Eve Dumez Moreno Galleni Andy Chevigné

Int J Mol Sci 2017 Jun 27;18(7). Epub 2017 Jun 27.

Department of Infection and Immunity, Luxembourg Institute of Health (LIH), 29, rue Henri Koch, L-4354 Esch-sur-Alzette, Luxembourg.

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June 2017

The Lys-Asp-Tyr Triad within the Mite Allergen Der p 1 Propeptide Is a Critical Structural Element for the pH-Dependent Initiation of the Protease Maturation.

Authors:

Andy Chevigné Vincenzo Campizi Martyna Szpakowska David Bourry Marie-Eve Dumez José C Martins André Matagne Moreno Galleni Alain Jacquet

Int J Mol Sci 2017 May 20;18(5). Epub 2017 May 20.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

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May 2017

Activation of the Orphan G Protein-Coupled Receptor GPR27 by Surrogate Ligands Promotes -Arrestin 2 Recruitment.

Authors:

Nadine Dupuis Céline Laschet Delphine Franssen Martyna Szpakowska Julie Gilissen Pierre Geubelle Arvind Soni Anne-Simone Parent Bernard Pirotte Andy Chevigné Jean-Claude Twizere Julien Hanson

Mol Pharmacol 2017 06 17;91(6):595-608. Epub 2017 Mar 17.

Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases (N.D., C.L., J.G., P.G., A.S., J.H.), Laboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (N.D., B.P., J.H.), Neuroendocrinology Unit, GIGA-Neurosciences (D.F., A.-S.P.), Laboratory of Protein Signaling and Interactions, GIGA-Molecular Biology of Diseases (J.-C.T.), University of Liège, Liège, Belgium; and Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg (M.S., A.C.)

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June 2017