Martine Peeters

Martine Peeters

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Martine Peeters

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Challenges of scale-up to dolutegravir-based regimens in sub-Saharan Africa.

AIDS 2020 Apr;34(5):783-787

TransVIHMI, Institut de Recherche pour le Développement (IRD)/INSERM//University of Montpellier, Montpellier, France.

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http://dx.doi.org/10.1097/QAD.0000000000002470DOI Listing
April 2020

Identification of a Novel Simian Immunodeficiency Virus-Infected African Green Monkey () Confirms that Tantalus Monkeys in Cameroon Are Infected with a Mosaic SIVagm Lineage.

AIDS Res Hum Retroviruses 2020 Feb 30;36(2):167-170. Epub 2019 Oct 30.

Recherches Translationnelles sur le VIH et Maladies Infectieuses, Institut National de la Santé et de la Recherche Médicale 1175, Institut de Recherche pour le Développement, University of Montpellier, Montpellier, France.

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http://dx.doi.org/10.1089/AID.2019.0216DOI Listing
February 2020

Reply to Zhang et al.

J Infect Dis 2020 Feb 19. Epub 2020 Feb 19.

Recherches Translationelles sur le VIH et Maladies Infectieuses/Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement, and University of Montpellier, France.

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http://dx.doi.org/10.1093/infdis/jiaa041DOI Listing
February 2020

Dolutegravir-Based or Low-Dose Efavirenz-Based Regimen for the Treatment of HIV-1.

N Engl J Med 2019 08 24;381(9):816-826. Epub 2019 Jul 24.

University of Dshang, Dshang (C.K.), and Central Hospital of Yaoundé (C.K.), Military Hospital of Yaoundé (M.M.-E.), and Cité Verte Hospital (P.O.B.), Yaoundé — all in Cameroon; Recherches Translationnelles sur le VIH et les Maladies Infectieuses (TransVIHMI), University of Montpellier–L’Institut de recherche pour le développement (IRD)–INSERM (S.E.-D., S.L., M.P., E.D.), and University Hospital of Montpellier (E.D.), Montpellier, and Sesstim, Aix Marseille University–IRD–INSERM, Marseille (S.B.) — all in France; and Geneva University Hospitals, Geneva (A.C.).

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http://www.nejm.org/doi/10.1056/NEJMoa1904340
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http://dx.doi.org/10.1056/NEJMoa1904340DOI Listing
August 2019

Understanding Ebola virus and other zoonotic transmission risks through human-bat contacts: Exploratory study on knowledge, attitudes and practices in Southern Cameroon.

Zoonoses Public Health 2019 05 24;66(3):288-295. Epub 2019 Jan 24.

TransVIHMI, Institut de Recherche pour le Développement (IRD), University of Montpellier, INSERM, Montpellier, France.

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http://dx.doi.org/10.1111/zph.12563DOI Listing
May 2019

Prevalence of infection among asymptomatic and paucisymptomatic contact persons exposed to Ebola virus in Guinea: a retrospective, cross-sectional observational study.

Lancet Infect Dis 2019 Mar 11;19(3):308-316. Epub 2019 Feb 11.

Recherches translationnelles sur le VIH et les maladies infectieuses, Institut de Recherche pour le Développement, Institut National de la Santé et de la Recherche Médicale, Université de Montpellier, Montpellier, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14733099183064
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http://dx.doi.org/10.1016/S1473-3099(18)30649-2DOI Listing
March 2019

Noninvasive western lowland gorilla's health monitoring: A decade of simian immunodeficiency virus surveillance in southern Cameroon.

Ecol Evol 2018 Nov 25;8(22):10698-10710. Epub 2018 Oct 25.

TransVIHMI Institut de Recherche pour le Développement (IRD) Institut national de la santé et de la recherche médicale (INSERM) Université de Montpellier Montpellier France.

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http://dx.doi.org/10.1002/ece3.4478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262910PMC
November 2018

Serological Evidence of Ebola Virus Infection in Rural Guinea before the 2014 West African Epidemic Outbreak.

Am J Trop Med Hyg 2018 08 31;99(2):425-427. Epub 2018 May 31.

Institut de Recherche pour le Développement, IRD-UMI 233/INSERM U 1175, Montpellier University, Montpellier, France.

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http://dx.doi.org/10.4269/ajtmh.18-0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090347PMC
August 2018

Short Communication: Nucleoside Reverse Transcriptase Inhibitors with Reduced Predicted Activity Do Not Impair Second-Line Therapy with Lopinavir/Ritonavir or Darunavir/Ritonavir.

AIDS Res Hum Retroviruses 2018 06 23;34(6):477-480. Epub 2018 Apr 23.

1 Unité mixte Internationale Recherches Translationnelles sur le VIH et les Maladies Infectieuses (TransVIH-MI, UMI 233 IRD/U1175 Inserm), Institut de Recherche pour le Développement (IRD), Université de Montpellier , Montpellier, France .

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http://dx.doi.org/10.1089/AID.2017.0290DOI Listing
June 2018

The fourth HIV epidemic.

Lancet Infect Dis 2018 04 21;18(4):379-380. Epub 2018 Mar 21.

Unité Mixte Internationale de Recherche 233 de l'IRD TransVIHMI (IRD UMI 233-U 1175 INSERM-Université de Montpellier, Montpellier, France.

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http://dx.doi.org/10.1016/S1473-3099(18)30167-1DOI Listing
April 2018

Loss of CXCR6 coreceptor usage characterizes pathogenic lentiviruses.

PLoS Pathog 2018 04 16;14(4):e1007003. Epub 2018 Apr 16.

Departments of Medicine and Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919676PMC
April 2018

Comparison of different nucleic acid preparation methods to improve specific HIV-1 RNA isolation for viral load testing on dried blood spots.

J Virol Methods 2018 01 14;251:75-79. Epub 2017 Oct 14.

UMI233-TransVIHMI/INSERM U1175, Institut de Recherche pour le Développement (IRD) and University of Montpellier, Montpellier, France. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2017.10.014DOI Listing
January 2018

Reemergence of chloroquine-sensitive pfcrt K76 Plasmodium falciparum genotype in southeastern Cameroon.

Malar J 2017 03 27;16(1):130. Epub 2017 Mar 27.

UMR 216 Mère et Enfant Face aux Infections Tropicales, Institut de Recherche pour le Développement (IRD), 4, Avenue de l'Observatoire, 75270, Paris, France.

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http://dx.doi.org/10.1186/s12936-017-1783-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368939PMC
March 2017

Phylodynamics of the major HIV-1 CRF02_AG African lineages and its global dissemination.

Infect Genet Evol 2016 12 13;46:190-199. Epub 2016 May 13.

Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2016.05.017DOI Listing
December 2016

Genetic diversity and transmission networks of HIV-1 strains among men having sex with men (MSM) in Lomé, Togo.

Infect Genet Evol 2016 12 25;46:279-285. Epub 2016 May 25.

Laboratoire de Biologie Moléculaire et Immunologie (BIOLIM/FSS/UL), Faculté des Sciences de la Santé, Université de Lomé, Togo. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2016.05.030DOI Listing
December 2016

Short Communication: High Viral Load and Multidrug Resistance Due to Late Switch to Second-Line Regimens Could Be a Major Obstacle to Reach the 90-90-90 UNAIDS Objectives in Sub-Saharan Africa.

AIDS Res Hum Retroviruses 2016 12 2;32(12):1159-1162. Epub 2016 Aug 2.

1 UMI233-TransVIHMI, Institut de Recherche pour le Développement (IRD), INSERM U1175, Université de Montpellier , Montpellier, France .

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http://dx.doi.org/10.1089/AID.2016.0010DOI Listing
December 2016

Primate immunodeficiency virus classification and nomenclature: Review.

Infect Genet Evol 2016 12 24;46:150-158. Epub 2016 Oct 24.

UMI233-TransVIHMI, Institut de Recherche pour le Développement (IRD), INSERM U1175, University of Montpellier, Montpellier, France; IBC, Computational Biology Institute, 34095 Montpellier, France.

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http://dx.doi.org/10.1016/j.meegid.2016.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136504PMC
December 2016

In-depth analysis of HIV-1 drug resistance mutations in HIV-infected individuals failing first-line regimens in West and Central Africa.

AIDS 2016 11;30(17):2577-2589

aUMI233, Institut de Recherche pour le Développement (IRD), INSERM U1175, Université de Montpellier bInstitut de Biologie Computationnelle (IBC), LIRMM - UMR 5506, Université de Montpellier - CNRS, Montpellier cUnité Bioinformatique Evolutive, C3BI USR 3756 Institut Pasteur - CNRS, Paris, France.

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http://dx.doi.org/10.1097/QAD.0000000000001233DOI Listing
November 2016

High Rates of Drug Resistance Among Newly Diagnosed HIV-infected Children in the National Prevention of Mother-to-child Transmission Program in Togo.

Pediatr Infect Dis J 2016 08;35(8):879-85

From the *Laboratoire de Biologie moléculaire et d'immunologie (BIOLIM/FSS/UL) and †Département des sciences fondamentales et biologiques, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo; ‡UMI 233, Institut de Recherche pour le Développement (IRD) and Université de Montpellier, Montpellier, France; §Département de Santé Publique, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo; ¶ISPED, Centre INSERM U897-Epidémiologie-Biostatistique and ‖Inserm U897, ISPED, Université de Bordeaux, Bordeaux, France; **Département de Pédiatrie, Faculté des Sciences de la Santé, Université de Lomé; and ††Programme National de Lutte contre le Sida et les IST/Togo (PNLS/IST/Togo), Lomé, Togo.

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http://dx.doi.org/10.1097/INF.0000000000001203DOI Listing
August 2016

Cospeciation of gut microbiota with hominids.

Science 2016 Jul;353(6297):380-2

Department of Integrative Biology, 2506 Speedway A5000, University of Texas at Austin, Austin, TX 78712, USA.

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http://dx.doi.org/10.1126/science.aaf3951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995445PMC
July 2016

Implementation and Operational Research: Programmatic Feasibility of Dried Blood Spots for the Virological Follow-up of Patients on Antiretroviral Treatment in Nord Kivu, Democratic Republic of the Congo.

J Acquir Immune Defic Syndr 2016 Jan;71(1):e9-15

*Alter-Santé Internationale & Développement, Montpellier, France;†Unité Mixte Internationale 233-Institut de la Recherche pour le Développement/Université de Montpellier, Montpellier cedex 05, France (WHO collaborative centre for HIV resistance);‡Ministère de la santé, Kinshasa Gombe and Goma, Democratic Republic of Congo;§International Union Against Tuberculosis and Lung Disease (The Union), Paris, France; and‖HERA, Health Research for Action, Laarstrat 43, Reet, Belgium.

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http://dx.doi.org/10.1097/QAI.0000000000000844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679362PMC
January 2016

HIV-1 group O infection in Cameroon from 2006 to 2013: Prevalence, genetic diversity, evolution and public health challenges.

Infect Genet Evol 2015 Dec 11;36:210-216. Epub 2015 Sep 11.

Unité Mixte International 233, Institut de Recherche pour le Développement, INSERM U1175, and University of Montpellier, Montpellier, France; Centre de Recherche sur les Maladies Emergentes et Réémergentes - CREMER, Laboratoire de Virologie IMPM-IRD, Yaoundé, Cameroon. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15671348150037
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http://dx.doi.org/10.1016/j.meegid.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680975PMC
December 2015

Alarming rates of virological failure and drug resistance in patients on long-term antiretroviral treatment in routine HIV clinics in Togo.

AIDS 2015 Nov;29(18):2527-30

aLaboratoire de Biologie Moléculaire et d'Immunologie (BIOLIM/FSS/UL) bDépartement des sciences fondamentales et biologiques, Faculté des Sciences de la Santé, Université de Lome[Combining Acute Accent], Lomé, Togo cUMI 233, Institut de Recherche pour le Développement (IRD)/INSERM U1175/Université de Montpellier, Montpellier, France dProgramme National de Lutte contre le Sida (PNLS), Lomé, Togo.

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http://dx.doi.org/10.1097/QAD.0000000000000906DOI Listing
November 2015

Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo.

AIDS Res Ther 2015 27;12:38. Epub 2015 Nov 27.

Laboratoire de Biologie Moléculaire et d'Immunologie (BIOLIM/FSS/UL), Université de Lomé, Lomé, Togo ; Département des sciences fondamentales et biologiques, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo ; 08 B.P. 8742, Lomé 08, Togo.

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http://dx.doi.org/10.1186/s12981-015-0082-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662816PMC
November 2015

Correction: Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis.

PLoS Med 2015 Jun 1;12(6):e1001845. Epub 2015 Jun 1.

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http://dx.doi.org/10.1371/journal.pmed.1001845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452696PMC
June 2015

Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.

PLoS Med 2015 Apr 7;12(4):e1001810. Epub 2015 Apr 7.

Department of Medicine, Stanford University, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1001810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388826PMC
April 2015

Origin of the HIV-1 group O epidemic in western lowland gorillas.

Proc Natl Acad Sci U S A 2015 Mar 2;112(11):E1343-52. Epub 2015 Mar 2.

Unité Mixte Internationale 233, Institut de Recherche pour le Développement, INSERM U1175, and University of Montpellier, 34394 Montpellier, France; Computational Biology Institute, 34095 Montpellier, France

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http://dx.doi.org/10.1073/pnas.1502022112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371950PMC
March 2015

Stability of the gorilla microbiome despite simian immunodeficiency virus infection.

Mol Ecol 2015 Feb 19;24(3):690-7. Epub 2015 Jan 19.

Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, 06511, USA.

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http://dx.doi.org/10.1111/mec.13057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302016PMC
February 2015

Wild gorillas as a potential reservoir of Leishmania major.

J Infect Dis 2015 Jan 7;211(2):267-73. Epub 2014 Jul 7.

Aix Marseille Université, URMITE, UM63, CNRS 7278, IRD 198, Inserm 1095, Marseille.

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http://dx.doi.org/10.1093/infdis/jiu380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342692PMC
January 2015

Origin and diversity of human retroviruses.

AIDS Rev 2014 Jan-Mar;16(1):23-34

UMI 233, Institut de Recherche pour le Développement (IRD) and University of Montpellier 1, Montpellier, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289907PMC
December 2014

Rapid changes in the gut microbiome during human evolution.

Proc Natl Acad Sci U S A 2014 Nov 3;111(46):16431-5. Epub 2014 Nov 3.

Department of Integrative Biology, University of Texas, Austin, TX 78712;

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http://dx.doi.org/10.1073/pnas.1419136111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246287PMC
November 2014

Gorilla gorilla gorilla gut: a potential reservoir of pathogenic bacteria as revealed using culturomics and molecular tools.

Sci Rep 2014 Nov 24;4:7174. Epub 2014 Nov 24.

Aix Marseille Université, URMITE, UM63, CNRS 7278, IRD 198, Inserm 1095, 13005 Marseille, France.

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http://dx.doi.org/10.1038/srep07174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241516PMC
November 2014

HIV epidemiology. The early spread and epidemic ignition of HIV-1 in human populations.

Science 2014 10 2;346(6205):56-61. Epub 2014 Oct 2.

KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1126/science.1256739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254776PMC
October 2014

Pathogenic eukaryotes in gut microbiota of western lowland gorillas as revealed by molecular survey.

Sci Rep 2014 Sep 18;4:6417. Epub 2014 Sep 18.

Aix-Marseille Université, URMITE, UM63, CNRS 7278, IRD 198, Inserm 1095, 13005 Marseille, France.

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http://dx.doi.org/10.1038/srep06417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166708PMC
September 2014

Challenges of antiretroviral treatment monitoring in rural and remote-access regions in Africa.

AIDS Res Hum Retroviruses 2014 Jul 14;30(7):623-5. Epub 2014 Apr 14.

1 Hôpital Saint-Louis , Service de Maladies Infectieuses et Tropicales, Paris, France .

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http://dx.doi.org/10.1089/AID.2014.0035DOI Listing
July 2014

Assessment of gastrointestinal parasites in wild chimpanzees (Pan troglodytes troglodytes) in southeast Cameroon.

Parasitol Res 2014 Jul 30;113(7):2541-50. Epub 2014 Apr 30.

UMI 233 "TransVIHMI" Institut de Recherche pour le Developpement (IRD) and University of Montpellier 1 (UM1), Montpellier, France,

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http://link.springer.com/10.1007/s00436-014-3904-y
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http://dx.doi.org/10.1007/s00436-014-3904-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245021PMC
July 2014

Co-circulation of enteroviruses between apes and humans.

J Gen Virol 2014 Feb 4;95(Pt 2):403-407. Epub 2013 Nov 4.

Centre for Immunology, Infection and Evolution, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1099/vir.0.059048-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093782PMC
February 2014

Dried blood spots for HIV-1 drug resistance genotyping in decentralized settings in Senegal.

J Med Virol 2014 Jan 1;86(1):45-51. Epub 2013 Oct 1.

Université Cheikh Anta Diop, Laboratoire de Bactériologie-Virologie CHU A. Le Dantec, Dakar, Sénégal.

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http://dx.doi.org/10.1002/jmv.23778DOI Listing
January 2014

High frequency of HIV-1 infections with multiple HIV-1 strains in men having sex with men (MSM) in Senegal.

Infect Genet Evol 2013 Dec 11;20:206-14. Epub 2013 Sep 11.

Laboratoire de Bactériologie-Virologie, Hôpital Le Dantec, Dakar, Senegal; UMI 233, TransVIHMI, Institut de Recherche pour le Développement (IRD), University of Montpellier1 (UM1), Montpellier, France.

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http://dx.doi.org/10.1016/j.meegid.2013.09.002DOI Listing
December 2013

Sympatric chimpanzees and gorillas harbor convergent gut microbial communities.

Genome Res 2013 Oct 26;23(10):1715-20. Epub 2013 Jun 26.

Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA;

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http://dx.doi.org/10.1101/gr.154773.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787267PMC
October 2013

HIV type 1 subtype C remains the predominant subtype in men having sex with men in Senegal.

AIDS Res Hum Retroviruses 2013 Sep 19;29(9):1265-72. Epub 2013 Jul 19.

Laboratoire of Bacteriology-Virology, Hôpital Aristide Le Dantec, Dakar, Senegal.

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http://dx.doi.org/10.1089/aid.2013.0140DOI Listing
September 2013

Evidence for continuing cross-species transmission of SIVsmm to humans: characterization of a new HIV-2 lineage in rural Côte d'Ivoire.

AIDS 2013 Sep;27(15):2488-91

aUMI 233, IRD and University of Montpellier 1, Montpellier, France bDepartment of Diagnostics, Teaching Hospital, University of Bouake, Côte d'Ivoire cProject group Epidemiology of Highly Pathogenic Microorganisms RKI, Berlin, Germany dDepartment of Microbiology and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/01.aids.0000432443.22684.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881176PMC
September 2013

The origin and molecular epidemiology of HIV.

Expert Rev Anti Infect Ther 2013 Sep 9;11(9):885-96. Epub 2013 Sep 9.

TransVIHMI, UMI 233, Institut de Recherche pour le Développement (IRD)-Université Montpellier 1, Montpellier, France.

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http://dx.doi.org/10.1586/14787210.2013.825443DOI Listing
September 2013

Nonhuman primate retroviruses from Cambodia: high simian foamy virus prevalence, identification of divergent STLV-1 strains and no evidence of SIV infection.

Infect Genet Evol 2013 Aug 21;18:325-34. Epub 2013 Apr 21.

UM1 233, Institut de Recherche pour le Développement-IRD and University of Montpellier 1, Montpellier, France.

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http://dx.doi.org/10.1016/j.meegid.2013.04.015DOI Listing
August 2013

HIV type-1 group O infection in Gabon: low prevalence rate but circulation of genetically diverse and drug-resistant HIV type-1 group O strains.

AIDS Res Hum Retroviruses 2013 Jul 8;29(7):1085-90. Epub 2013 Mar 8.

Laboratoire de Rétrovirologie, CIRMF (Centre International de Recherches Médicales de Franceville), Franceville, Gabon.

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http://dx.doi.org/10.1089/aid.2012.0375DOI Listing
July 2013

Origin and evolution of the human immunodeficiency virus: where is it coming from, where is it going?

Virologie (Montrouge) 2013 Jun;17(3):119-131

Université Paris-Descartes, Sorbonne Paris Cité, EA 3620, 75015 Paris, France, AP-HP, CHU Necker-Enfants Malades, laboratoire de virologie, 75015 Paris, France.

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http://dx.doi.org/10.1684/vir.2013.0498DOI Listing
June 2013

Searching for virus phylotypes.

Bioinformatics 2013 Mar 17;29(5):561-70. Epub 2013 Jan 17.

Institut de Biologie Computationnelle, LIRMM, UMR 5506 CNRS - Université Montpellier 2, Montpellier, France.

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http://dx.doi.org/10.1093/bioinformatics/btt010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582263PMC
March 2013