Publications by authors named "Martine F Roussel"

95Publications

Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.

Authors:
P Jake Slavish Liying Chi Mi-Kyung Yun Lyudmila Tsurkan Nancy E Martinez Barbara Jonchere Sergio C Chai Michele Connelly M Brett Waddell Sourav Das Geoffrey Neale Zhenmei Li William R Shadrick Rachelle R Olsen Kevin W Freeman Jonathan A Low Jeanine E Price Brandon M Young Nagakumar Bharatham Vincent A Boyd Jun Yang Richard E Lee Marie Morfouace Martine F Roussel Taosheng Chen Daniel Savic R Kiplin Guy Stephen W White Anang A Shelat Philip M Potter

Cancer Res 2020 Sep 10;80(17):3507-3518. Epub 2020 Jul 10.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-3934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483993PMC
September 2020

Patient-derived orthotopic xenografts of pediatric brain tumors: a St. Jude resource.

Authors:
Kyle S Smith Ke Xu Kimberly S Mercer Frederick Boop Paul Klimo Michael DeCupyere Jose Grenet Sarah Robinson Paige Dunphy Suzanne J Baker David W Ellison Thomas E Merchant Santhosh A Upadayaya Amar Gajjar Gang Wu Brent A Orr Giles W Robinson Paul A Northcott Martine F Roussel

Acta Neuropathol 2020 08 10;140(2):209-225. Epub 2020 Jun 10.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s00401-020-02171-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360541PMC
August 2020

An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.

Authors:
Juwina Wijaya BaoHan T Vo Jingjing Liu Beisi Xu Gang Wu Yao Wang Junmin Peng Jin Zhang Laura J Janke Brent A Orr Jiyang Yu Martine F Roussel John D Schuetz

Cancer Res 2020 04 16;80(7):1524-1537. Epub 2020 Jan 16.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-2054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416697PMC
April 2020

Preclinical Models of Craniospinal Irradiation for Medulloblastoma.

Authors:
Jennifer L Stripay Thomas E Merchant Martine F Roussel Christopher L Tinkle

Cancers (Basel) 2020 Jan 5;12(1). Epub 2020 Jan 5.

Departments of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.3390/cancers12010133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016884PMC
January 2020

CNS Penetration of Cyclophosphamide and Metabolites in Mice Bearing Group 3 Medulloblastoma and Non-Tumor Bearing Mice.

Authors:
Olivia Campagne Abigail Davis Bo Zhong Sreenath Nair Victoria Haberman Yogesh T Patel Laura Janke Martine F Roussel Clinton Stewart

J Pharm Pharm Sci 2019 ;22(1):612-629

Pharmaceutical Sciences Department, St. Jude Children's Research Hospital, Memphis TN..

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http://dx.doi.org/10.18433/jpps30608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413074PMC
August 2020

Modeling pediatric medulloblastoma.

Authors:
Martine F Roussel Jennifer L Stripay

Brain Pathol 2020 05 17;30(3):703-712. Epub 2019 Dec 17.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105.

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http://dx.doi.org/10.1111/bpa.12803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317774PMC
May 2020

CNS penetration and pharmacodynamics of the CHK1 inhibitor prexasertib in a mouse Group 3 medulloblastoma model.

Authors:
Olivia Campagne Abigail Davis Anil R Maharaj Bo Zhong Jennifer Stripay Dana Farmer Martine F Roussel Clinton F Stewart

Eur J Pharm Sci 2020 Jan 25;142:105106. Epub 2019 Oct 25.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 28105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.105106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925336PMC
January 2020

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.

Authors:
Liguo Zhang Xuelian He Xuezhao Liu Feng Zhang L Frank Huang Andrew S Potter Lingli Xu Wenhao Zhou Tao Zheng Zaili Luo Kalen P Berry Allison Pribnow Stephanie M Smith Christine Fuller Blaise V Jones Maryam Fouladi Rachid Drissi Zeng-Jie Yang W Clay Gustafson Marc Remke Scott L Pomeroy Emily J Girard James M Olson A Sorana Morrissy Maria C Vladoiu Jiao Zhang Weidong Tian Mei Xin Michael D Taylor S Steven Potter Martine F Roussel William A Weiss Q Richard Lu

Cancer Cell 2019 09 29;36(3):302-318.e7. Epub 2019 Aug 29.

Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760242PMC
September 2019

Women in cancer research.

Authors:
Christina A Mitchell Martine F Roussel Leonie Walsh Ashani T Weeraratna

Nat Rev Cancer 2019 10 15;19(10):547-552. Epub 2019 Aug 15.

Department of Biochemistry and Molecular Biology, John Hopkins School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41568-019-0176-yDOI Listing
October 2019

MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.

Authors:
Ida Annunziata Diantha van de Vlekkert Elmar Wolf David Finkelstein Geoffrey Neale Eda Machado Rosario Mosca Yvan Campos Heather Tillman Martine F Roussel Jason Andrew Weesner Leigh Ellen Fremuth Xiaohui Qiu Min-Joon Han Gerard C Grosveld Alessandra d'Azzo

Nat Commun 2019 08 9;10(1):3623. Epub 2019 Aug 9.

Department of Genetics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1038/s41467-019-11568-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689058PMC
August 2019

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.

Authors:
Jamie R Genthe Jaeki Min Dana M Farmer Anang A Shelat Jose A Grenet Wenwei Lin David Finkelstein Karen Vrijens Taosheng Chen R Kiplin Guy Wilson K Clements Martine F Roussel

ACS Chem Biol 2019 Jul 28;14(7):1673. Epub 2019 Jun 28.

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http://dx.doi.org/10.1021/acschembio.9b00488DOI Listing
July 2019

Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma.

Authors:
Jun Wang Diana M Merino Nicholas Light Brian L Murphy Yong-Dong Wang Xiaohui Guo Andrew P Hodges Lianne Q Chau Kun-Wei Liu Girish Dhall Shahab Asgharzadeh Erin N Kiehna Ryan J Shirey Kim D Janda Michael D Taylor David Malkin David W Ellison Scott R VandenBerg Charles G Eberhart Rosalie C Sears Martine F Roussel Richard J Gilbertson Robert J Wechsler-Reya

Cancer Res 2019 05 18;79(9):2208-2219. Epub 2019 Mar 18.

Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497574PMC
May 2019

A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.

Authors:
Jezabel Rodriguez-Blanco Bin Li Jun Long Chen Shen Fan Yang Darren Orton Sara Collins Noriyuki Kasahara Nagi G Ayad Heather J McCrea Martine F Roussel William A Weiss Anthony J Capobianco David J Robbins

Clin Cancer Res 2019 02 28;25(4):1379-1388. Epub 2018 Nov 28.

Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, University of Miami, Miller School of Medicine, Miami, Florida.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142219PMC
February 2019

Preclinical Modeling of Image-Guided Craniospinal Irradiation for Very-High-Risk Medulloblastoma.

Authors:
Stephanie M C Smith Brandon M Bianski Brent A Orr Gretchen Harknett Arzu Onar-Thomas Richard J Gilbertson Thomas E Merchant Martine F Roussel Christopher L Tinkle

Int J Radiat Oncol Biol Phys 2019 03 23;103(3):728-737. Epub 2018 Oct 23.

Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183389
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http://dx.doi.org/10.1016/j.ijrobp.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421074PMC
March 2019

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.

Authors:
Kristian W Pajtler Ji Wen Martin Sill Tong Lin Wilda Orisme Bo Tang Jens-Martin Hübner Vijay Ramaswamy Sujuan Jia James D Dalton Kelly Haupfear Hazel A Rogers Chandanamali Punchihewa Ryan Lee John Easton Gang Wu Timothy A Ritzmann Rebecca Chapman Lukas Chavez Fredrick A Boop Paul Klimo Noah D Sabin Robert Ogg Stephen C Mack Brian D Freibaum Hong Joo Kim Hendrik Witt David T W Jones Baohan Vo Amar Gajjar Stan Pounds Arzu Onar-Thomas Martine F Roussel Jinghui Zhang J Paul Taylor Thomas E Merchant Richard Grundy Ruth G Tatevossian Michael D Taylor Stefan M Pfister Andrey Korshunov Marcel Kool David W Ellison

Acta Neuropathol 2018 08 16;136(2):211-226. Epub 2018 Jun 16.

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s00401-018-1877-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105278PMC
August 2018

Mouse medulloblastoma driven by CRISPR activation of cellular Myc.

Authors:
BaoHan T Vo Jin Ah Kwon Chunliang Li David Finkelstein Beisi Xu Brent A Orr Charles J Sherr Martine F Roussel

Sci Rep 2018 06 7;8(1):8733. Epub 2018 Jun 7.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1038/s41598-018-24956-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992137PMC
June 2018

The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma.

Authors:
Debolina Ganguly Meiyun Fan Chuan He Yang Blazej Zbytek David Finkelstein Martine F Roussel Lawrence M Pfeffer

Oncotarget 2018 Apr 24;9(31):22095-22112. Epub 2018 Apr 24.

Department of Pathology and Laboratory Medicine, and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.18632/oncotarget.25188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955139PMC
April 2018

Development and validation of a sensitive LC MS/MS method for the measurement of the checkpoint kinase 1 inhibitor prexasertib and its application in a cerebral microdialysis study.

Authors:
Bo Zhong Anil Maharaj Abigail Davis Martine F Roussel Clinton F Stewart

J Pharm Biomed Anal 2018 Jul 17;156:97-103. Epub 2018 Apr 17.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984718PMC
July 2018

CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss.

Authors:
Tal Teitz Jie Fang Asli N Goktug Justine D Bonga Shiyong Diao Robert A Hazlitt Luigi Iconaru Marie Morfouace Duane Currier Yinmei Zhou Robyn A Umans Michael R Taylor Cheng Cheng Jaeki Min Burgess Freeman Junmin Peng Martine F Roussel Richard Kriwacki R Kiplin Guy Taosheng Chen Jian Zuo

J Exp Med 2018 04 7;215(4):1187-1203. Epub 2018 Mar 7.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN

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http://dx.doi.org/10.1084/jem.20172246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881471PMC
April 2018

A new genetically engineered mouse model of choroid plexus carcinoma.

Authors:
Salsabiel El Nagar Frederique Zindy Charlotte Moens Luc Martin Damien Plassard Martine F Roussel Thomas Lamonerie Nathalie Billon

Biochem Biophys Res Commun 2018 02 12;496(2):568-574. Epub 2018 Jan 12.

Université Côte d'Azur, CNRS, Inserm, iBV, Nice, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X173236
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http://dx.doi.org/10.1016/j.bbrc.2017.11.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880203PMC
February 2018

Establishing a Preclinical Multidisciplinary Board for Brain Tumors.

Authors:
Birgit V Nimmervoll Nidal Boulos Brandon Bianski Jason Dapper Michael DeCuypere Anang Shelat Sabrina Terranova Hope E Terhune Amar Gajjar Yogesh T Patel Burgess B Freeman Arzu Onar-Thomas Clinton F Stewart Martine F Roussel R Kipling Guy Thomas E Merchant Christopher Calabrese Karen D Wright Richard J Gilbertson

Clin Cancer Res 2018 04 4;24(7):1654-1666. Epub 2018 Jan 4.

Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Cambridge, England, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884708PMC
April 2018

Epigenetic Drivers in Pediatric Medulloblastoma.

Authors:
Martine F Roussel Jennifer L Stripay

Cerebellum 2018 02;17(1):28-36

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s12311-017-0899-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807456PMC
February 2018

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

Authors:
William R Shadrick Peter J Slavish Sergio C Chai Brett Waddell Michele Connelly Jonathan A Low Cynthia Tallant Brandon M Young Nagakumar Bharatham Stefan Knapp Vincent A Boyd Marie Morfouace Martine F Roussel Taosheng Chen Richard E Lee R Kiplin Guy Anang A Shelat Philip M Potter

Bioorg Med Chem 2018 01 4;26(1):25-36. Epub 2017 Nov 4.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.bmc.2017.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733700PMC
January 2018

mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.

Authors:
Chang-Chih Wu Shirui Hou Brent A Orr Bryan R Kuo Yong Ha Youn Taren Ong Fanny Roth Charles G Eberhart Giles W Robinson David J Solecki Makoto M Taketo Richard J Gilbertson Martine F Roussel Young-Goo Han

Dev Cell 2017 12 2;43(6):673-688.e5. Epub 2017 Nov 2.

Department of Developmental Neurobiology, Neurobiology and Brain Tumor Program, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736446PMC
December 2017

Exome sequencing analysis of murine medulloblastoma models identifies WDR11 as a potential tumor suppressor in Group 3 tumors.

Authors:
Lei Wei Brian L Murphy Gang Wu Matthew Parker John Easton Richard J Gilbertson Jinghui Zhang Martine F Roussel

Oncotarget 2017 Sep 27;8(39):64685-64697. Epub 2017 Jul 27.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.18632/oncotarget.19642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630286PMC
September 2017

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.

Authors:
Jamie R Genthe Jaeki Min Dana M Farmer Anang A Shelat Jose A Grenet Wenwei Lin David Finkelstein Karen Vrijens Taosheng Chen R Kiplin Guy Wilson K Clements Martine F Roussel

ACS Chem Biol 2017 09 29;12(9):2436-2447. Epub 2017 Aug 29.

Departments of Hematology, ‡Chemical Biology and Therapeutics, §Tumor Cell Biology, and ∥Computational Biology, St. Jude Children's Research Hospital , Memphis, Tennessee, United States.

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http://dx.doi.org/10.1021/acschembio.7b00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676454PMC
September 2017

Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.

Authors:
Yu Fukuda Yao Wang Shangli Lian John Lynch Shinjiro Nagai Bruce Fanshawe Ayten Kandilci Laura J Janke Geoffrey Neale Yiping Fan Brian P Sorrentino Martine F Roussel Gerard Grosveld John D Schuetz

JCI Insight 2017 Aug 3;2(15). Epub 2017 Aug 3.

Department of Pharmaceutical Sciences.

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http://dx.doi.org/10.1172/jci.insight.92409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543914PMC
August 2017

Targeting Metabolic Reprogramming by Influenza Infection for Therapeutic Intervention.

Authors:
Heather S Smallwood Susu Duan Marie Morfouace Svetlana Rezinciuc Barry L Shulkin Anang Shelat Erika E Zink Sandra Milasta Resha Bajracharya Ajayi J Oluwaseum Martine F Roussel Douglas R Green Ljiljana Pasa-Tolic Paul G Thomas

Cell Rep 2017 05;19(8):1640-1653

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599215PMC
May 2017

Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma.

Authors:
BaoHan T Vo Chunliang Li Marc A Morgan Ilan Theurillat David Finkelstein Shaela Wright Judith Hyle Stephanie M C Smith Yiping Fan Yong-Dong Wang Gang Wu Brent A Orr Paul A Northcott Ali Shilatifard Charles J Sherr Martine F Roussel

Cell Rep 2017 03;18(12):2907-2917

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173029
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http://dx.doi.org/10.1016/j.celrep.2017.02.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415387PMC
March 2017

Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.

Authors:
Shalini Singh Danielle Howell Niraj Trivedi Ketty Kessler Taren Ong Pedro Rosmaninho Alexandre Asf Raposo Giles Robinson Martine F Roussel Diogo S Castro David J Solecki

Elife 2016 05 14;5. Epub 2016 May 14.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, United States.

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http://dx.doi.org/10.7554/eLife.12717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891180PMC
May 2016

Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.

Authors:
Timothy N Phoenix Deanna M Patmore Scott Boop Nidal Boulos Megan O Jacus Yogesh T Patel Martine F Roussel David Finkelstein Liliana Goumnerova Sebastien Perreault Elizabeth Wadhwa Yoon-Jae Cho Clinton F Stewart Richard J Gilbertson

Cancer Cell 2016 Apr 31;29(4):508-522. Epub 2016 Mar 31.

Li Ka Shing Centre, CRUK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, England. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829447PMC
April 2016

The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.

Authors:
BaoHan T Vo Elmar Wolf Daisuke Kawauchi Anneli Gebhardt Jerold E Rehg David Finkelstein Susanne Walz Brian L Murphy Yong Ha Youn Young-Goo Han Martin Eilers Martine F Roussel

Cancer Cell 2016 Jan;29(1):5-16

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://www.cell.com/cancer-cell/pdf/S1535-6108(15)00467-5.pd
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http://www.cell.com/cms/attachment/2044676461/2056424844/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S153561081500467
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http://dx.doi.org/10.1016/j.ccell.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714043PMC
January 2016

Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors.

Authors:
Marie Morfouace Birgit Nimmervoll Nidal Boulos Yogesh T Patel Anang Shelat Burgess B Freeman Giles W Robinson Karen Wright Amar Gajjar Clinton F Stewart Richard J Gilbertson Martine F Roussel

J Neurooncol 2016 Jan 30;126(2):225-34. Epub 2015 Oct 30.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s11060-015-1965-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718940PMC
January 2016

TNF Counterbalances the Emergence of M2 Tumor Macrophages.

Authors:
Franz Kratochvill Geoffrey Neale Jessica M Haverkamp Lee-Ann Van de Velde Amber M Smith Daisuke Kawauchi Justina McEvoy Martine F Roussel Michael A Dyer Joseph E Qualls Peter J Murray

Cell Rep 2015 Sep 10;12(11):1902-14. Epub 2015 Sep 10.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581986PMC
September 2015

ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.

Authors:
Marie Morfouace Satish Cheepala Sadhana Jackson Yu Fukuda Yogesh T Patel Soghra Fatima Daisuke Kawauchi Anang A Shelat Clinton F Stewart Brian P Sorrentino John D Schuetz Martine F Roussel

Cancer Res 2015 Sep 21;75(18):3879-89. Epub 2015 Jul 21.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573843PMC
September 2015

Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation.

Authors:
Frederique Zindy Youngsoo Lee Daisuke Kawauchi Olivier Ayrault Leila Ben Merzoug Yang Li Peter J McKinnon Martine F Roussel

PLoS One 2015 19;10(6):e0129642. Epub 2015 Jun 19.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129642PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474721PMC
April 2016

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling.

Authors:
Marc Zuckermann Volker Hovestadt Christiane B Knobbe-Thomsen Marc Zapatka Paul A Northcott Kathrin Schramm Jelena Belic David T W Jones Barbara Tschida Branden Moriarity David Largaespada Martine F Roussel Andrey Korshunov Guido Reifenberger Stefan M Pfister Peter Lichter Daisuke Kawauchi Jan Gronych

Nat Commun 2015 Jun 11;6:7391. Epub 2015 Jun 11.

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/ncomms8391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467376PMC
June 2015

Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.

Authors:
Clara Penas Eve-Ellen Govek Yin Fang Vimal Ramachandran Mark Daniel Weiping Wang Marie E Maloof Ronald J Rahaim Mathieu Bibian Daisuke Kawauchi David Finkelstein Jeng-Liang Han Jun Long Bin Li David J Robbins Marcos Malumbres Martine F Roussel William R Roush Mary E Hatten Nagi G Ayad

Cell Rep 2015 Apr 2;11(2):249-60. Epub 2015 Apr 2.

Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401652PMC
April 2015

Generation of Atoh1-rtTA transgenic mice: a tool for inducible gene expression in hair cells of the inner ear.

Authors:
Brandon C Cox Jennifer A Dearman Joseph Brancheck Frederique Zindy Martine F Roussel Jian Zuo

Sci Rep 2014 Nov 3;4:6885. Epub 2014 Nov 3.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217099PMC
November 2014

Embryonic Expression and Function of the Ink4d Cyclin D-Dependent Kinase Inhibitor.

Authors:
Joanne R Doherty Lisa M Nilsson Emin Kuliyev Haiqing Zhu Rose Matthew John L Cleveland Paul E Mead Martine F Roussel

Cell Dev Biol 2014 Feb;3(1)

Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192657PMC
February 2014

Role of the miR-17∼92 cluster family in cerebellar and medulloblastoma development.

Authors:
Frederique Zindy Daisuke Kawauchi Youngsoo Lee Olivier Ayrault Leila Ben Merzoug Peter J McKinnon Andrea Ventura Martine F Roussel

Biol Open 2014 Jun 13;3(7):597-605. Epub 2014 Jun 13.

Department of Tumor Cell Biology, Danny Thomas Research Center, St Jude Children's Research Hospital, Memphis, TN 38105-3678, USA

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http://dx.doi.org/10.1242/bio.20146734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154296PMC
June 2014

Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma.

Authors:
Marie Morfouace Anang Shelat Megan Jacus Burgess B Freeman David Turner Sarah Robinson Frederique Zindy Yong-Dong Wang David Finkelstein Olivier Ayrault Laure Bihannic Stephanie Puget Xiao-Nan Li James M Olson Giles W Robinson R Kiplin Guy Clinton F Stewart Amar Gajjar Martine F Roussel

Cancer Cell 2014 Apr 27;25(4):516-29. Epub 2014 Mar 27.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994669PMC
April 2014

WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.

Authors:
Sandrine L Anne Eve-Ellen Govek Olivier Ayrault Jee Hae Kim Xiaodong Zhu David A Murphy Linda Van Aelst Martine F Roussel Mary E Hatten

PLoS One 2013 26;8(11):e81769. Epub 2013 Nov 26.

Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841149PMC
October 2014

Role of MYC in Medulloblastoma.

Authors:
Martine F Roussel Giles W Robinson

Cold Spring Harb Perspect Med 2013 Nov 1;3(11). Epub 2013 Nov 1.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808772PMC
November 2013

Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression.

Authors:
Brian L Murphy Susanna Obad Laure Bihannic Olivier Ayrault Frederique Zindy Sakari Kauppinen Martine F Roussel

Cancer Res 2013 Dec 21;73(23):7068-78. Epub 2013 Oct 21.

Authors' Affiliations: Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee; Santaris Pharma, Hørsholm; and Department of Haematology, Aalborg University Hospital, Copenhagen, Denmark.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857104PMC
December 2013

Miz1 is required to maintain autophagic flux.

Authors:
Elmar Wolf Anneli Gebhardt Daisuke Kawauchi Susanne Walz Björn von Eyss Nicole Wagner Christoph Renninger Georg Krohne Esther Asan Martine F Roussel Martin Eilers

Nat Commun 2013 ;4:2535

1] Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany [2].

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May 2014

Identification of small molecule activators of BMP signaling.

Authors:
Karen Vrijens Wenwei Lin Jimmy Cui Dana Farmer Jonathan Low Elodie Pronier Fu-Yue Zeng Anang A Shelat Kiplin Guy Michael R Taylor Taosheng Chen Martine F Roussel

PLoS One 2013 19;8(3):e59045. Epub 2013 Mar 19.

Departments of Tumor Cell Biology, Memphis, Tennessee, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602516PMC
September 2013

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:
Paul A Northcott David J H Shih John Peacock Livia Garzia A Sorana Morrissy Thomas Zichner Adrian M Stütz Andrey Korshunov Jüri Reimand Steven E Schumacher Rameen Beroukhim David W Ellison Christian R Marshall Anath C Lionel Stephen Mack Adrian Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M G Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Y B Chiu Andy Chu Eric Chuah Richard D Corbett Gemma R Hoad Shaun D Jackman Yisu Li Allan Lo Karen L Mungall Ka Ming Nip Jenny Q Qian Anthony G J Raymond Nina T Thiessen Richard J Varhol Inanc Birol Richard A Moore Andrew J Mungall Robert Holt Daisuke Kawauchi Martine F Roussel Marcel Kool David T W Jones Hendrick Witt Africa Fernandez-L Anna M Kenney Robert J Wechsler-Reya Peter Dirks Tzvi Aviv Wieslawa A Grajkowska Marta Perek-Polnik Christine C Haberler Olivier Delattre Stéphanie S Reynaud François F Doz Sarah S Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Wolfram Scheurlen Charles G Eberhart Michelle Fèvre-Montange Anne Jouvet Ian F Pollack Xing Fan Karin M Muraszko G Yancey Gillespie Concezio Di Rocco Luca Massimi Erna M C Michiels Nanne K Kloosterhof Pim J French Johan M Kros James M Olson Richard G Ellenbogen Karel Zitterbart Leos Kren Reid C Thompson Michael K Cooper Boleslaw Lach Roger E McLendon Darell D Bigner Adam Fontebasso Steffen Albrecht Nada Jabado Janet C Lindsey Simon Bailey Nalin Gupta William A Weiss László Bognár Almos Klekner Timothy E Van Meter Toshihiro Kumabe Teiji Tominaga Samer K Elbabaa Jeffrey R Leonard Joshua B Rubin Linda M Liau Erwin G Van Meir Maryam Fouladi Hideo Nakamura Giuseppe Cinalli Miklós Garami Peter Hauser Ali G Saad Achille Iolascon Shin Jung Carlos G Carlotti Rajeev Vibhakar Young Shin Ra Shenandoah Robinson Massimo Zollo Claudia C Faria Jennifer A Chan Michael L Levy Poul H B Sorensen Matthew Meyerson Scott L Pomeroy Yoon-Jae Cho Gary D Bader Uri Tabori Cynthia E Hawkins Eric Bouffet Stephen W Scherer James T Rutka David Malkin Steven C Clifford Steven J M Jones Jan O Korbel Stefan M Pfister Marco A Marra Michael D Taylor

Nature 2012 Aug;488(7409):49-56

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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August 2012

Novel mutations target distinct subgroups of medulloblastoma.

Authors:
Giles Robinson Matthew Parker Tanya A Kranenburg Charles Lu Xiang Chen Li Ding Timothy N Phoenix Erin Hedlund Lei Wei Xiaoyan Zhu Nader Chalhoub Suzanne J Baker Robert Huether Richard Kriwacki Natasha Curley Radhika Thiruvenkatam Jianmin Wang Gang Wu Michael Rusch Xin Hong Jared Becksfort Pankaj Gupta Jing Ma John Easton Bhavin Vadodaria Arzu Onar-Thomas Tong Lin Shaoyi Li Stanley Pounds Steven Paugh David Zhao Daisuke Kawauchi Martine F Roussel David Finkelstein David W Ellison Ching C Lau Eric Bouffet Tim Hassall Sridharan Gururangan Richard Cohn Robert S Fulton Lucinda L Fulton David J Dooling Kerri Ochoa Amar Gajjar Elaine R Mardis Richard K Wilson James R Downing Jinghui Zhang Richard J Gilbertson

Nature 2012 Aug;488(7409):43-8

St Jude Children's Research Hospital, Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412905PMC
August 2012

Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression.

Authors:
Zhiyong Liu Jennifer A Dearman Brandon C Cox Brandon J Walters Lingli Zhang Olivier Ayrault Frederique Zindy Lin Gan Martine F Roussel Jian Zuo

J Neurosci 2012 May;32(19):6600-10

Departments of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0818-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359704PMC
May 2012

A mouse model of the most aggressive subgroup of human medulloblastoma.

Authors:
Daisuke Kawauchi Giles Robinson Tamar Uziel Paul Gibson Jerold Rehg Cuilan Gao David Finkelstein Chunxu Qu Stanley Pounds David W Ellison Richard J Gilbertson Martine F Roussel

Cancer Cell 2012 Feb;21(2):168-80

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285412PMC
February 2012

Roles of p53 and p27(Kip1) in the regulation of neurogenesis in the murine adult subventricular zone.

Authors:
Sara Gil-Perotin Jeffery D Haines Jasbir Kaur Mireya Marin-Husstege Michael J Spinetta Kwi-Hye Kim Maria Duran-Moreno Timothy Schallert Frederique Zindy Martine F Roussel Jose M Garcia-Verdugo Patrizia Casaccia

Eur J Neurosci 2011 Oct 7;34(7):1040-52. Epub 2011 Sep 7.

Department of Comparative Neurobiology, CIBERNED, Valencia, Spain.

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http://dx.doi.org/10.1111/j.1460-9568.2011.07836.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214596PMC
October 2011

Medulloblastoma: advances and challenges.

Authors:
Martine F Roussel Giles Robinson

F1000 Biol Rep 2011 1;3. Epub 2011 Mar 1.

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http://dx.doi.org/10.3410/B3-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100785PMC
July 2011

Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21.

Authors:
Yuefeng Wang John C Fisher Rose Mathew Li Ou Steve Otieno Jack Sublet Limin Xiao Jianhan Chen Martine F Roussel Richard W Kriwacki

Nat Chem Biol 2011 Apr 27;7(4):214-21. Epub 2011 Feb 27.

Departments of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nchembio.536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124363PMC
April 2011

Development and cancer of the cerebellum.

Authors:
Mary E Hatten Martine F Roussel

Trends Neurosci 2011 Mar;34(3):134-42

Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.tins.2011.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051031PMC
March 2011

Cerebellum development and medulloblastoma.

Authors:
Martine F Roussel Mary E Hatten

Curr Top Dev Biol 2011 ;94:235-82

Department of Tumor Cell Biology and Genetics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213765PMC
April 2011

Subtypes of medulloblastoma have distinct developmental origins.

Authors:
Paul Gibson Yiai Tong Giles Robinson Margaret C Thompson D Spencer Currle Christopher Eden Tanya A Kranenburg Twala Hogg Helen Poppleton Julie Martin David Finkelstein Stanley Pounds Aaron Weiss Zoltan Patay Matthew Scoggins Robert Ogg Yanxin Pei Zeng-Jie Yang Sonja Brun Youngsoo Lee Frederique Zindy Janet C Lindsey Makoto M Taketo Frederick A Boop Robert A Sanford Amar Gajjar Steven C Clifford Martine F Roussel Peter J McKinnon David H Gutmann David W Ellison Robert Wechsler-Reya Richard J Gilbertson

Nature 2010 Dec 8;468(7327):1095-9. Epub 2010 Dec 8.

Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059767PMC
http://dx.doi.org/10.1038/nature09587DOI Listing
December 2010

E2f1-3 are critical for myeloid development.

Authors:
Prashant Trikha Nidhi Sharma Rene Opavsky Andres Reyes Clarissa Pena Michael C Ostrowski Martine F Roussel Gustavo Leone

J Biol Chem 2011 Feb 28;286(6):4783-95. Epub 2010 Nov 28.

College of Medicine and Public Health, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1074/jbc.M110.182733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039366PMC
February 2011

Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration.

Authors:
Fan Zhang Michael Tagen Stacy Throm Jeremy Mallari Laura Miller R Kiplin Guy Michael A Dyer Richard T Williams Martine F Roussel Katie Nemeth Fangyi Zhu Jiakun Zhang Min Lu John C Panetta Nidal Boulos Clinton F Stewart

Drug Metab Dispos 2011 Jan 14;39(1):15-21. Epub 2010 Oct 14.

Department of Pharmaceutical Sciences, Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1124/dmd.110.035915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014266PMC
January 2011

New concepts in organ site research on medulloblastoma: genetics and genomics.

Authors:
Martine F Roussel

Future Oncol 2010 Aug;6(8):1229-31

St Jude Children's Research Hospital, Department of Genetics & Tumor Cell Biology, Memphis, TN 38105, USA.

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http://dx.doi.org/10.2217/fon.10.86DOI Listing
August 2010

Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells.

Authors:
Olivier Ayrault Haotian Zhao Frederique Zindy Chunxu Qu Charles J Sherr Martine F Roussel

Cancer Res 2010 Jul 1;70(13):5618-27. Epub 2010 Jun 1.

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896438PMC
July 2010

Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma.

Authors:
Olivier Ayrault Michael D Godeny Christopher Dillon Frederique Zindy Patrick Fitzgerald Martine F Roussel Helen M Beere

Proc Natl Acad Sci U S A 2009 Oct 23;106(40):17037-42. Epub 2009 Sep 23.

Department of Genetics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.0902880106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761355PMC
October 2009

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.

Authors:
Danny T Huang Olivier Ayrault Harold W Hunt Asad M Taherbhoy David M Duda Daniel C Scott Laura A Borg Geoffrey Neale Peter J Murray Martine F Roussel Brenda A Schulman

Mol Cell 2009 Feb;33(4):483-95

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725360PMC
February 2009

The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.

Authors:
Tamar Uziel Fedor V Karginov Suqing Xie Joel S Parker Yong-Dong Wang Amar Gajjar Lin He David Ellison Richard J Gilbertson Gregory Hannon Martine F Roussel

Proc Natl Acad Sci U S A 2009 Feb 5;106(8):2812-7. Epub 2009 Feb 5.

Department of Genetics and Tumor Cell Biology, Saint Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.0809579106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636735PMC
February 2009

Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma.

Authors:
Olivier Ayrault Frederique Zindy Jerold Rehg Charles J Sherr Martine F Roussel

Mol Cancer Res 2009 Jan;7(1):33-40

Department of Genetics and Tumor Cell Biology, Mail Stop no. 350, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637533PMC
January 2009

Differential post-transcriptional regulation of two Ink4 proteins, p18 Ink4c and p19 Ink4d.

Authors:
Antoine Forget Olivier Ayrault Willem den Besten Mei-Ling Kuo Charles J Sherr Martine F Roussel

Cell Cycle 2008 Dec 13;7(23):3737-46. Epub 2008 Dec 13.

Department of Tumor Cell Biology and Genetics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628444PMC
http://dx.doi.org/10.4161/cc.7.23.7187DOI Listing
December 2008

Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.

Authors:
Judith Souphron M Brett Waddell Amir Paydar Zeynep Tokgöz-Gromley Martine F Roussel Brenda A Schulman

Biochemistry 2008 Aug 25;47(34):8961-9. Epub 2008 Jul 25.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/bi800604cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587436PMC
August 2008

Rethinking brain tumors: the fourth Mouse Models of Human Cancers Consortium nervous system tumors workshop.

Authors:
Karlyne M Reilly Joshua B Rubin Richard J Gilbertson Joel R Garbow Martine F Roussel David H Gutmann

Cancer Res 2008 Jul;68(14):5508-11

Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678167PMC
July 2008

Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development.

Authors:
Haotian Zhao Olivier Ayrault Frederique Zindy Jee-Hae Kim Martine F Roussel

Genes Dev 2008 Mar;22(6):722-7

Departments of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1101/gad.1636408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275424PMC
March 2008

N-myc coordinates retinal growth with eye size during mouse development.

Authors:
Rodrigo A P Martins Frederique Zindy Stacy Donovan Jiakun Zhang Stanley Pounds Alice Wey Paul S Knoepfler Robert N Eisenman Martine F Roussel Michael A Dyer

Genes Dev 2008 Jan;22(2):179-93

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1101/gad.1608008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192753PMC
January 2008

[TP53 and RB tumor suppressor pathways collaborate in retinoblastoma genesis].

Authors:
Olivier Ayrault Frédérique Zindy Martine F Roussel

Med Sci (Paris) 2007 Apr;23(4):356-8

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April 2007

Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors.

Authors:
Frederique Zindy Tamar Uziel Olivier Ayrault Christopher Calabrese Marc Valentine Jerold E Rehg Richard J Gilbertson Charles J Sherr Martine F Roussel

Cancer Res 2007 Mar;67(6):2676-84

Department of Genetics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3418DOI Listing
March 2007

p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis.

Authors:
Heidi Laine Angelika Doetzlhofer Johanna Mantela Jukka Ylikoski Marikki Laiho Martine F Roussel Neil Segil Ulla Pirvola

J Neurosci 2007 Feb;27(6):1434-44

Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.4956-06.2
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673588PMC
February 2007

N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development.

Authors:
Frederique Zindy Paul S Knoepfler Suqing Xie Charles J Sherr Robert N Eisenman Martine F Roussel

Proc Natl Acad Sci U S A 2006 Aug 24;103(31):11579-83. Epub 2006 Jul 24.

Department of Genetics and Tumor Cell Biology, Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.0604727103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518798PMC
August 2006

Statistical significance threshold criteria for analysis of microarray gene expression data.

Authors:
Cheng Cheng Stanley B Pounds James M Boyett Deqing Pei Mei-Ling Kuo Martine F Roussel

Stat Appl Genet Mol Biol 2004 19;3:Article36. Epub 2004 Dec 19.

Department of Biostatistics, St. Jude Children's Research Hospital.

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http://dx.doi.org/10.2202/1544-6115.1064DOI Listing
May 2006

Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia.

Authors:
Richard T Williams Martine F Roussel Charles J Sherr

Proc Natl Acad Sci U S A 2006 Apr 17;103(17):6688-93. Epub 2006 Apr 17.

Department of Hematology-Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.0602030103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440588PMC
April 2006

The CDK inhibitor p18Ink4c is a tumor suppressor in medulloblastoma.

Authors:
Tamar Uziel Frederique Zindy Charles J Sherr Martine F Roussel

Cell Cycle 2006 Feb 15;5(4):363-5. Epub 2006 Feb 15.

Department of Genetics & Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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February 2006

Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors.

Authors:
Sara Gil-Perotin Mireya Marin-Husstege Jiadong Li Mario Soriano-Navarro Frederique Zindy Martine F Roussel Jose-Manuel Garcia-Verdugo Patricia Casaccia-Bonnefil

J Neurosci 2006 Jan;26(4):1107-16

Department Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.3970-05.2
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674560PMC
January 2006

The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.

Authors:
Tamar Uziel Frederique Zindy Suqing Xie Youngsoo Lee Antoine Forget Susan Magdaleno Jerold E Rehg Christopher Calabrese David Solecki Charles G Eberhart Sarah E Sherr Sarah Plimmer Steven C Clifford Mary E Hatten Peter J McKinnon Richard J Gilbertson Tom Curran Charles J Sherr Martine F Roussel

Genes Dev 2005 Nov 31;19(22):2656-67. Epub 2005 Oct 31.

Department of Tumor Cell Biology and Genetics, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1101/gad.1368605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283959PMC
November 2005

Monoclonal antibodies to the mouse p19(Arf) tumor suppressor protein.

Authors:
David Bertwistle Frederique Zindy Charles J Sherr Martine F Roussel

Hybrid Hybridomics 2004 Oct;23(5):293-300

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1089/hyb.2004.23.293DOI Listing
October 2004

A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.

Authors:
Danny T Huang David W Miller Rose Mathew Robert Cassell James M Holton Martine F Roussel Brenda A Schulman

Nat Struct Mol Biol 2004 Oct 7;11(10):927-35. Epub 2004 Sep 7.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/nsmb826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862556PMC
October 2004

N-terminal polyubiquitination and degradation of the Arf tumor suppressor.

Authors:
Mei-Ling Kuo Willem den Besten David Bertwistle Martine F Roussel Charles J Sherr

Genes Dev 2004 Aug;18(15):1862-74

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1101/gad.1213904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517406PMC
August 2004

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture.

Authors:
Carolyn N Wrobel Jayanta Debnath Eva Lin Sean Beausoleil Martine F Roussel Joan S Brugge

J Cell Biol 2004 Apr;165(2):263-73

Dept. of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.200309102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172030PMC
April 2004

Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter.

Authors:
Tomoya Yokota Youichirou Matsuzaki Kazuhiro Miyazawa Frederique Zindy Martine F Roussel Toshiyuki Sakai

Oncogene 2004 Jul;23(31):5340-9

Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1038/sj.onc.1207689DOI Listing
July 2004

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo.

Authors:
Frederique Zindy Richard T Williams Troy A Baudino Jerold E Rehg Stephen X Skapek John L Cleveland Martine F Roussel Charles J Sherr

Proc Natl Acad Sci U S A 2003 Dec 9;100(26):15930-5. Epub 2003 Dec 9.

Departments of Genetics and Tumor Cell Biology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.2536808100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307670PMC
December 2003

A molecular fingerprint for medulloblastoma.

Authors:
Youngsoo Lee Heather L Miller Patricia Jensen Roberto Hernan Michele Connelly Cynthia Wetmore Frederique Zindy Martine F Roussel Tom Curran Richard J Gilbertson Peter J McKinnon

Cancer Res 2003 Sep;63(17):5428-37

Department of Genetics and Tumor Cell Biology, Saint Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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September 2003

Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice.

Authors:
Frederique Zindy Lisa M Nilsson Luc Nguyen Cecile Meunier Richard J Smeyne Jerold E Rehg Charles Eberhart Charles J Sherr Martine F Roussel

Cancer Res 2003 Sep;63(17):5420-7

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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September 2003

Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.

Authors:
Troy A Baudino Kirsteen H Maclean Jennifer Brennan Evan Parganas Chunying Yang Aaron Aslanian Jacqueline A Lees Charles J Sherr Martine F Roussel John L Cleveland

Mol Cell 2003 Apr;11(4):905-14

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00102-3DOI Listing
April 2003

Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d.

Authors:
Ping Chen Frederique Zindy Caroline Abdala Feng Liu Xiankui Li Martine F Roussel Neil Segil

Nat Cell Biol 2003 May;5(5):422-6

Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W. 3rd St., Fifth Floor, Los Angeles, CA 90057, USA.

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http://www.nature.com/articles/ncb976
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http://dx.doi.org/10.1038/ncb976DOI Listing
May 2003

Oncogenic potential of the c-FMS proto-oncogene (CSF-1 receptor).

Authors:
Martine F Roussel Charles J Sherr

Cell Cycle 2003 Jan-Feb;2(1):5-6

Dept. of Genetics and Tumor Cell Biology, Howard Hughes Medical Institute, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA

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http://www.tandfonline.com/doi/abs/10.4161/cc.2.1.295
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http://dx.doi.org/10.4161/cc.2.1.295DOI Listing
August 2003

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing.

Authors:
Masataka Sugimoto Mei-Ling Kuo Martine F Roussel Charles J Sherr

Mol Cell 2003 Feb;11(2):415-24

Howard Hughes Medical Institute, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.

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http://www.cell.com/molecular-cell/pdf/S1097-2765(03)00057-1
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http://dx.doi.org/10.1016/s1097-2765(03)00057-1DOI Listing
February 2003

Arf induces p53-dependent and -independent antiproliferative genes.

Authors:
Mei-Ling Kuo Eric J Duncavage Rose Mathew Willem den Besten Deqing Pei Deanna Naeve Tadashi Yamamoto Cheng Cheng Charles J Sherr Martine F Roussel

Cancer Res 2003 Mar;63(5):1046-53

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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March 2003

p53: regular or super?

Authors:
Martine F Roussel

Cancer Cell 2002 Dec;2(6):434-5

Department of Genetics and Tumor Cell Biology, Danny Thomas Research Tower, 5006C, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/s1535-6108(02)00216-7DOI Listing
December 2002

The cyclin-dependent kinase inhibitors p19(Ink4d) and p27(Kip1) are coexpressed in select retinal cells and act cooperatively to control cell cycle exit.

Authors:
Justine J Cunningham Edward M Levine Frederique Zindy Olga Goloubeva Martine F Roussel Richard J Smeyne

Mol Cell Neurosci 2002 Mar;19(3):359-74

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1006/mcne.2001.1090DOI Listing
March 2002

The RING domain of Mdm2 can inhibit cell proliferation.

Authors:
Jinjun Dang Mei-Ling Kuo Christine M Eischen Lilia Stepanova Charles J Sherr Martine F Roussel

Cancer Res 2002 Feb;62(4):1222-30

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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February 2002