Martina U Muckenthaler

Martina U Muckenthaler

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Martina U Muckenthaler

Publications by authors named "Martina U Muckenthaler"

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The increase in hemoglobin concentration with altitude varies among human populations.

Ann N Y Acad Sci 2019 Aug 30;1450(1):204-220. Epub 2019 Jun 30.

Pediatric Hematology, Oncology and Immunology, University Hospital Heidelberg, Molecular Medicine Partnership Unit, University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research, Heidelberg, Germany.

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http://dx.doi.org/10.1111/nyas.14136DOI Listing
August 2019

Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma.

Sci Rep 2019 Aug 5;9(1):11326. Epub 2019 Aug 5.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41598-019-47833-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683135PMC
August 2019

Air-blood barrier thickening and alterations of alveolar epithelial type 2 cells in mouse lungs with disrupted hepcidin/ferroportin regulatory system.

Histochem Cell Biol 2019 Mar 3;151(3):217-228. Epub 2018 Oct 3.

Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00418-018-1737-yDOI Listing
March 2019

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.

Eur Heart J 2019 Mar 20. Epub 2019 Mar 20.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Otto Meyerhof Zentrum, Im Neuenheimer Feld 350, Heidelberg, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehz112DOI Listing
March 2019

miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma.

Sci Rep 2019 Feb 6;9(1):1518. Epub 2019 Feb 6.

Department of Pediatric Hematology, Oncology, and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41598-018-35947-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365501PMC
February 2019

Iron Homeostasis in the Lungs-A Balance between Health and Disease.

Pharmaceuticals (Basel) 2019 Jan 1;12(1). Epub 2019 Jan 1.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, 69120 Heidelberg, Germany.

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http://www.mdpi.com/1424-8247/12/1/5
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http://dx.doi.org/10.3390/ph12010005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469191PMC
January 2019

ALK3 undergoes ligand-independent homodimerization and BMP-induced heterodimerization with ALK2.

Free Radic Biol Med 2018 12 15;129:127-137. Epub 2018 Sep 15.

Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, University of Muenster, Muenster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.09.021DOI Listing
December 2018

IKZF1 Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.

J Clin Oncol 2018 04 2;36(12):1240-1249. Epub 2018 Mar 2.

Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School; Petra Dörge, German Center for Infection Research, Hannover; Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein; Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel; Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital; Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin; Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg; Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany; Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic; Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo; Maria Grazia Valsecchi, University of Milano-Bicocca, Monza; Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy; Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland; Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel; Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria; Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France; and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2017.74.3617DOI Listing
April 2018

Uncoupled iron homeostasis in type 2 diabetes mellitus.

J Mol Med (Berl) 2017 Dec 3;95(12):1387-1398. Epub 2017 Oct 3.

Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00109-017-1596-3
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http://dx.doi.org/10.1007/s00109-017-1596-3DOI Listing
December 2017

Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin.

J Mol Med (Berl) 2017 08 5;95(8):851-860. Epub 2017 Jun 5.

Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Im Neuenheimer Feld 350, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00109-017-1551-3DOI Listing
August 2017

Imatinib and spironolactone suppress hepcidin expression.

Haematologica 2017 07 6;102(7):1173-1184. Epub 2017 Apr 6.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg and Molecular Medicine Partnership Unit, Heidelberg, Germany

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http://dx.doi.org/10.3324/haematol.2016.162917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566021PMC
July 2017

No changes in heme synthesis in human Friedreich´s ataxia erythroid progenitor cells.

Gene 2017 Jul 12;621:5-11. Epub 2017 Apr 12.

Department of Medical Chemistry and Pathobiochemistry, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2017.04.014DOI Listing
July 2017

Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease.

EBioMedicine 2017 Jun 29;20:230-239. Epub 2017 Apr 29.

Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Im Neuenheimer Feld 350, D-69120 Heidelberg, Germany; Molecular Medicine Partnership Unit, D-69120 Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, D-69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.04.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478206PMC
June 2017

Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis.

Sci Rep 2017 06 22;7(1):4023. Epub 2017 Jun 22.

Department of Pediatric Hematology, Oncology and Immunology University of Heidelberg, Heidelberg University Clinic, INF 350, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41598-017-02898-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481338PMC
June 2017

Pathophysiological consequences and benefits of mutations: 20 years of research.

Haematologica 2017 05 9;102(5):809-817. Epub 2017 Mar 9.

Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany

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http://dx.doi.org/10.3324/haematol.2016.160432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477599PMC
May 2017

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.

Int J Mol Sci 2017 May 5;18(5). Epub 2017 May 5.

Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/ijms18050984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454897PMC
May 2017

Newborn screening for severe combined immunodeficiency using a novel and simplified method to measure T-cell excision circles (TREC).

Clin Immunol 2017 02 2;175:51-55. Epub 2016 Dec 2.

Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.11.016DOI Listing
February 2017

A Red Carpet for Iron Metabolism.

Cell 2017 01;168(3):344-361

Division of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cell.2016.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706455PMC
January 2017

Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.

Sci Rep 2016 Sep 30;6:34630. Epub 2016 Sep 30.

National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043349PMC
http://dx.doi.org/10.1038/srep34630DOI Listing
September 2016

Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes.

J Biol Chem 2016 Jun 27;291(25):13160-74. Epub 2016 Apr 27.

From the Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, 69117 Heidelberg, Germany, the Molecular Medicine Partnership Unit, 69120 Heidelberg, Germany, and

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http://dx.doi.org/10.1074/jbc.M115.691543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933231PMC
June 2016

Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of HFE as a negative regulator of CD8+ T-lymphocyte activation and differentiation in vivo.

PLoS One 2015 16;10(4):e0124246. Epub 2015 Apr 16.

I3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Basic and Clinical Research on Iron Biology, IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; Clinical Hematology, Santo António Hospital-Centro Hospitalar do Porto, Porto, Portugal; Molecular Immunology and Pathology, ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124246PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399836PMC
April 2016

miR-20a regulates expression of the iron exporter ferroportin in lung cancer.

J Mol Med (Berl) 2016 Mar 12;94(3):347-59. Epub 2015 Nov 12.

Department of Pediatric Hematology, Oncology, and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00109-015-1362-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803811PMC
March 2016

Mice with hepcidin-resistant ferroportin accumulate iron in the retina.

FASEB J 2016 Feb 27;30(2):813-23. Epub 2015 Oct 27.

*F. M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Ophthalmology and Optometry, Innsbruck Medical University, Innsbruck, Austria; Department of Psychiatry and Behavioral Sciences, and Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA; Department of Pediatric Hematology, Oncology, and Immunology, University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, Heidelberg, Germany; and European Molecular Biology Laboratory, Heidelberg, Germany

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http://dx.doi.org/10.1096/fj.15-276758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714557PMC
February 2016

Significant prevalence of sickle cell disease in Southwest Germany: results from a birth cohort study indicate the necessity for newborn screening.

Ann Hematol 2016 Feb 12;95(3):397-402. Epub 2015 Dec 12.

Department of Pediatric Oncology, Hematology, Oncology and Immunology, University of Heidelberg, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00277-015-2573-yDOI Listing
February 2016

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.

Blood 2016 Jan 16;127(4):473-86. Epub 2015 Dec 16.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, Heidelberg University & European Molecular Biology Laboratory, Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2015-08-663245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850229PMC
January 2016

Adaptation of iron requirement to hypoxic conditions at high altitude.

J Appl Physiol (1985) 2015 Dec 16;119(12):1432-40. Epub 2015 Jul 16.

Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Molecular Medicine Partnership Unit, University of Heidelberg, Translational Lung Research Center Heidelberg, and German Center for Lung Research, Heidelberg, Germany

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http://dx.doi.org/10.1152/japplphysiol.00248.2015DOI Listing
December 2015

Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver.

J Biol Chem 2015 Dec 2;290(52):30855-65. Epub 2015 Nov 2.

From the Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma 376-8515, Japan,

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http://dx.doi.org/10.1074/jbc.M115.694414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692214PMC
December 2015

Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E.

Physiol Rep 2015 Aug;3(8)

Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru

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http://dx.doi.org/10.14814/phy2.12475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562561PMC
August 2015

Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels.

Biometals 2015 Apr 31;28(2):293-306. Epub 2015 Jan 31.

Chair for Molecular Animal Breeding and Biotechnology, Department of Veterinary Sciences, and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany,

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http://dx.doi.org/10.1007/s10534-015-9824-1DOI Listing
April 2015

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.

Blood 2015 Apr 6;125(14):2265-75. Epub 2015 Feb 6.

Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2014-08-595256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383800PMC
April 2015

Aqueous humor ferritin in hereditary hyperferritinemia cataract syndrome.

Optom Vis Sci 2015 Apr;92(4 Suppl 1):S40-7

*MD †Dr rer nat ‡PhD Department of Ophthalmology and Optometry (ML, FS, AT, AK-E, CS, MH, GG, HAR), Department of Anatomy (FS), Department of Laboratory Medicine (HW), and First Department of Internal Medicine (MS, EA), Paracelsus Medical University, Salzburg, Austria; Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, Germany (MUM); and Molecular Medicine Partnership Unit, Heidelberg, Germany (MUM).

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http://dx.doi.org/10.1097/OPX.0000000000000544DOI Listing
April 2015

Increased hepcidin levels in high-altitude pulmonary edema.

J Appl Physiol (1985) 2015 Feb 18;118(3):292-8. Epub 2014 Dec 18.

Medical Clinic VII, Sports Medicine, University Hospital Heidelberg, Germany;

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http://dx.doi.org/10.1152/japplphysiol.00940.2014DOI Listing
February 2015

miRNAs affect the expression of innate and adaptive immunity proteins in celiac disease.

Am J Gastroenterol 2014 Oct 29;109(10):1662-74. Epub 2014 Jul 29.

1] Department of Health Sciences, School of Medicine, University of Milano-Bicocca, Monza, Italy [2] International Research Center for Hepato-Biliary-Pancreatic Diseases-IRCHD, University of Milano-Bicocca, Monza, Italy.

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http://dx.doi.org/10.1038/ajg.2014.203DOI Listing
October 2014

Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload.

Cell Metab 2014 Aug;20(2):359-67

Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, INF 350, 69120 Heidelberg, Germany; Molecular Medicine Partnership Unit, 69120 Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131140031
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http://dx.doi.org/10.1016/j.cmet.2014.07.007DOI Listing
August 2014

How mutant HFE causes hereditary hemochromatosis.

Blood 2014 Aug;124(8):1212-3

UNIVERSITY OF HEIDELBERG; MOLECULAR MEDICINE PARTNERSHIP UNIT.

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http://dx.doi.org/10.1182/blood-2014-07-581744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141508PMC
August 2014

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.

Blood 2014 Jul 1;124(1):106-10. Epub 2014 May 1.

Childhood Leukemia Research Institute, Edmond and Lily Safra Children Hospital, Sheba Medical Center, Ramat Gan, Israel; Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;

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http://dx.doi.org/10.1182/blood-2013-10-529685DOI Listing
July 2014

Atherogenesis and iron: from epidemiology to cellular level.

Front Pharmacol 2014 5;5:94. Epub 2014 May 5.

MTA-DE Vascular Biology, Thrombosis and Hemostasis Research Group, Hungarian Academy of Sciences Debrecen, Hungary ; Department of Medicine, University of Debrecen Debrecen, Hungary.

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http://dx.doi.org/10.3389/fphar.2014.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017151PMC
June 2014

A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis.

PLoS Comput Biol 2014 Jan 2;10(1):e1003421. Epub 2014 Jan 2.

Institute of Molecular Biology (IMB), Mainz, Germany ; BioQuant, Heidelberg, Germany.

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http://dx.doi.org/10.1371/journal.pcbi.1003421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879105PMC
January 2014

Computerized image analysis of iron-stained macrophages.

Ann Hematol 2013 Sep 17;92(9):1195-9. Epub 2013 Apr 17.

Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital of Heidelberg, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00277-013-1740-2DOI Listing
September 2013

Out of balance--systemic iron homeostasis in iron-related disorders.

Nutrients 2013 Aug 2;5(8):3034-61. Epub 2013 Aug 2.

Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, University of Muenster, Muenster 48149, Germany.

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http://www.mdpi.com/2072-6643/5/8/3034
Publisher Site
http://dx.doi.org/10.3390/nu5083034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775241PMC
August 2013

Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells.

Aging Cell 2013 Apr 28;12(2):280-91. Epub 2013 Feb 28.

Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Claude D. Pepper Older Americans Independence Center, Boston Medical Center, Boston, MA 02118, USA.

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http://dx.doi.org/10.1111/acel.12052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602280PMC
April 2013

The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice.

Haematologica 2013 Mar 14;98(3):444-7. Epub 2012 Sep 14.

Department of Pediatric Oncology, Hematology and Immunology, University Hospital of Heidelberg, Germany.

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http://dx.doi.org/10.3324/haematol.2012.069807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659953PMC
March 2013

Administration of recombinant erythropoietin alone does not improve the phenotype in iron refractory iron deficiency anemia patients.

Ann Hematol 2013 Mar 20;92(3):387-94. Epub 2012 Nov 20.

Department of Pediatric Hematology and Oncology, University Medical Center Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00277-012-1618-8DOI Listing
March 2013

Novel mutations in the ferritin-L iron-responsive element that only mildly impair IRP binding cause hereditary hyperferritinaemia cataract syndrome.

Orphanet J Rare Dis 2013 Feb 19;8:30. Epub 2013 Feb 19.

Institute of Predictive and Personalized Medicine of Cancer IMPPC, Ctra. de Can Ruti, Camí de les Escoles s/n, 08916, Badalona, Barcelona, Spain.

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http://dx.doi.org/10.1186/1750-1172-8-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585816PMC
February 2013

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.

Biochim Biophys Acta 2013 Jan 31;1832(1):76-84. Epub 2012 Aug 31.

Department of Pediatric Oncology, Hematology and Immunology, University Hospital of Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbadis.2012.08.013DOI Listing
January 2013

Regulation of iron homeostasis by microRNAs.

Cell Mol Life Sci 2012 Dec 9;69(23):3945-52. Epub 2012 Jun 9.

Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, 69120, Heidelberg, Germany,

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http://www.springerlink.com/index/PQ84587403588M71.pdf
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http://link.springer.com/content/pdf/10.1007/s00018-012-1031
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http://link.springer.com/10.1007/s00018-012-1031-4
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http://dx.doi.org/10.1007/s00018-012-1031-4DOI Listing
December 2012

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.

J Hepatol 2012 Nov 21;57(5):1052-60. Epub 2012 Jun 21.

University of Heidelberg, Department of Pediatric Oncology, Hematology and Immunology, Heidelberg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01688278120044
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http://dx.doi.org/10.1016/j.jhep.2012.06.015DOI Listing
November 2012

Pegylated interferon-α induced hypoferremia is associated with the immediate response to treatment in hepatitis C.

Hepatology 2012 Aug 11;56(2):492-500. Epub 2012 Jun 11.

Centre for Liver Disease, Mater Misericordiae University Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1002/hep.25666DOI Listing
August 2012

Quantitative magnetic analysis reveals ferritin-like iron as the most predominant iron-containing species in the murine Hfe-haemochromatosis.

Biochim Biophys Acta 2012 Jul 20;1822(7):1147-53. Epub 2012 Mar 20.

School of Physics, M013, The University of Western Australia, 6009, Crawley, Australia.

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http://dx.doi.org/10.1016/j.bbadis.2012.03.008DOI Listing
July 2012

Mycobacteria-induced anaemia revisited: a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin.

Immunobiology 2011 Oct 20;216(10):1127-34. Epub 2011 Apr 20.

IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.

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http://dx.doi.org/10.1016/j.imbio.2011.04.004DOI Listing
October 2011

Growth differentiation factor 15 in patients with congenital dyserythropoietic anaemia (CDA) type II.

J Mol Med (Berl) 2011 Aug 8;89(8):811-6. Epub 2011 Apr 8.

Department of Paediatric Oncology, Haematology and Immunology, University of Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00109-011-0751-5DOI Listing
August 2011

A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA.

Biochem J 2010 Nov;431(3):363-71

Department of Pediatric Oncology, Haematology and Immunology, University Hospital of Heidelberg, Germany.

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http://dx.doi.org/10.1042/BJ20100668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958558PMC
November 2010

Two to tango: regulation of Mammalian iron metabolism.

Cell 2010 Jul;142(1):24-38

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cell.2010.06.028DOI Listing
July 2010

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression.

Blood 2010 Apr 29;115(13):2657-65. Epub 2009 Dec 29.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2009-09-238105DOI Listing
April 2010

Hyperferritinaemia-cataract syndrome: worldwide mutations and phenotype of an increasingly diagnosed genetic disorder.

Hum Genomics 2010 Apr;4(4):250-62

Center for Alcohol Research and Salem Medical Center, University of Heidelberg, Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525215PMC
April 2010

The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays.

BMC Bioinformatics 2010 Mar 1;11:112. Epub 2010 Mar 1.

MMPU, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1186/1471-2105-11-112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838865PMC
March 2010

RNA degradation compromises the reliability of microRNA expression profiling.

BMC Biotechnol 2009 Dec 21;9:102. Epub 2009 Dec 21.

Genomics Core Facility, EMBL, Meyerhofstrasse 1 D-69117 Heidelberg, Germany.

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http://bmcbiotechnol.biomedcentral.com/articles/10.1186/1472
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http://dx.doi.org/10.1186/1472-6750-9-102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805631PMC
December 2009

SELDI-TOF MS detection of urinary hepcidin.

Biochimie 2009 Oct 22;91(10):1335-8. Epub 2009 Apr 22.

Department of Pediatric Oncology, Haematology and Immunology, University Hospital of Heidelberg; Molecular Medicine Partnership Unit, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.biochi.2009.04.010DOI Listing
October 2009

Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis.

J Alzheimers Dis 2009 ;16(4):879-95

Department of Pediatric Oncology, Haematology and Immunology, University Hospital of Heidelberg, Molecular Medicine Partnership Unit, Heidelberg, Germany.

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http://dx.doi.org/10.3233/JAD-2009-1010DOI Listing
July 2009

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.

J Mol Med (Berl) 2009 May 20;87(5):471-80. Epub 2009 Feb 20.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 153, 69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00109-009-0447-2
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May 2009