Martin W Brechbiel

Martin W Brechbiel

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Martin W Brechbiel

Publications by authors named "Martin W Brechbiel"

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"Controls? Controls?? We Don't Need No Stinkin' Controls!"

Cancer Biother Radiopharm 2019 Aug 18;34(6):343-344. Epub 2019 Jun 18.

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http://dx.doi.org/10.1089/cbr.2019.29007.mwbDOI Listing
August 2019

Two Days at the Hunter College Symposium on Radiometals in New York City.

Cancer Biother Radiopharm 2018 Oct 15;33(8):307. Epub 2018 Sep 15.

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http://dx.doi.org/10.1089/cbr.2018.29004.mwbDOI Listing
October 2018

On Reviewing.

Cancer Biother Radiopharm 2018 06;33(5):167-168

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http://dx.doi.org/10.1089/cbr.2018.29003.mwbDOI Listing
June 2018

Exploration of a F(ab') Fragment as the Targeting Agent of α-Radiation Therapy: A Comparison of the Therapeutic Benefit of Intraperitoneal and Intravenous Administered Radioimmunotherapy.

Cancer Biother Radiopharm 2018 Jun;33(5):182-193

1 Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland.

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http://dx.doi.org/10.1089/cbr.2018.2434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011368PMC
June 2018

More Thoughts on Standards and Reproducibility.

Cancer Biother Radiopharm 2018 04;33(3):85-86

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http://dx.doi.org/10.1089/cbr.2018.29002.mwbDOI Listing
April 2018

A New Era of Cancer Biotherapy and Radiopharmaceuticals.

Cancer Biother Radiopharm 2018 02;33(1):1-2

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http://dx.doi.org/10.1089/cbr.2018.29001.mwbDOI Listing
February 2018

Comparative studies on the therapeutic benefit of targeted α-particle radiation therapy for the treatment of disseminated intraperitoneal disease.

Dalton Trans 2017 Oct;46(42):14591-14601

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda MD, USA.

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http://dx.doi.org/10.1039/c7dt01819cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664163PMC
October 2017

Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model.

PLoS One 2016 28;11(7):e0159904. Epub 2016 Jul 28.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159904PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965152PMC
August 2017

Targeted α-Particle Radiation Therapy of HER1-Positive Disseminated Intraperitoneal Disease: An Investigation of the Human Anti-EGFR Monoclonal Antibody, Panitumumab.

Transl Oncol 2017 Aug 31;10(4):535-545. Epub 2017 May 31.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1016/j.tranon.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458064PMC
August 2017

Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers.

EJNMMI Res 2016 Dec 17;6(1):26. Epub 2016 Mar 17.

Tumour Targeting Laboratory, Ludwig Institute for Cancer Research and Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1186/s13550-016-0180-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796444PMC
December 2016

(2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy.

J Nucl Med 2016 Oct 26;57(10):1569-1575. Epub 2016 May 26.

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland

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http://dx.doi.org/10.2967/jnumed.116.174300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367442PMC
October 2016

Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

Chemistry 2016 Aug 15;22(35):12332-9. Epub 2016 Jun 15.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.

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http://dx.doi.org/10.1002/chem.201600922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013196PMC
August 2016

Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from (177)Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts.

Int J Mol Sci 2016 May 16;17(5). Epub 2016 May 16.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive MSC-1002, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/ijms17050736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881558PMC
May 2016

Synthesis and characterization of gadolinium-Peptidomimetic complex as an αvβ3 integrin targeted MR contrast agent.

Bioorg Med Chem Lett 2015 4;25(10):2056-9. Epub 2015 Apr 4.

Radioimmune & Inorganic Chemistry Section, ROB, NCI, NIH, 10 Center Drive, Building 10, Rm B3B69, Bethesda, MD 20892-1002, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X150030
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http://dx.doi.org/10.1016/j.bmcl.2015.03.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417025PMC
February 2016

Evaluation of cetuximab as a candidate for targeted α-particle radiation therapy of HER1-positive disseminated intraperitoneal disease.

MAbs 2015 ;7(1):255-64

a Radioimmune & Inorganic Chemistry Section; Radiation Oncology Branch; Center for Cancer Research; National Cancer Institute; National Institutes of Health ; Bethesda MD USA.

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http://dx.doi.org/10.4161/19420862.2014.985160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622630PMC
September 2015

Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer.

J Clin Oncol 2015 Aug 29;33(24):2609-16. Epub 2015 Jun 29.

Marika Ciprotti, Niall C. Tebbutt, Fook-Thean Lee, Sze-Ting Lee, Hui K. Gan, Wendie Hopkins, Fiona E. Scott, Andrew M. Scott, Ludwig Institute for Cancer Research; David C. McKee, Graeme J. O'Keefe, Sylvia J. Gong, Geoffrey Chong, Bridget Chappell, Andrew M. Scott, Austin Health, Melbourne, Australia; Martin W. Brechbiel, National Cancer Institute, Bethesda, MD; Archie N. Tse, Jonathan Greenberg, Daiichi Sankyo Co., Ltd, Parsippany, NJ; Mendel Jansen, Daiichi Sankyo Development Ltd, Gerrards Cross, Buckinghamshire, United Kingdom; Manabu Matsumura, Masakatsu Kotsuma, Rira Watanabe, Daiichi Sankyo Co., Ltd, Tokyo, Japan; Robert A. Beckman, Georgetown University Medical Center and Ralph Venhaus, Ludwig Institute for Cancer Research, New York, NY.

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http://ascopubs.org/doi/10.1200/JCO.2014.60.4256
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http://dx.doi.org/10.1200/JCO.2014.60.4256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881374PMC
August 2015

Toxicological Studies of 212Pb Intravenously or Intraperitoneally Injected into Mice for a Phase 1 Trial.

Pharmaceuticals (Basel) 2015 Jul 24;8(3):416-34. Epub 2015 Jul 24.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/ph8030416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588175PMC
July 2015

Bench to Bedside: Stability Studies of GMP Produced Trastuzumab-TCMC in Support of a Clinical Trial.

Pharmaceuticals (Basel) 2015 Jul 29;8(3):435-54. Epub 2015 Jul 29.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/ph8030435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588176PMC
July 2015

Impact of α-targeted radiation therapy on gene expression in a pre-clinical model for disseminated peritoneal disease when combined with paclitaxel.

PLoS One 2014 30;9(9):e108511. Epub 2014 Sep 30.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108511PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182481PMC
June 2015

First-In-Human Study Demonstrating Tumor-Angiogenesis by PET/CT Imaging with (68)Ga-NODAGA-THERANOST, a High-Affinity Peptidomimetic for αvβ3 Integrin Receptor Targeting.

Cancer Biother Radiopharm 2015 May;30(4):152-9

1 THERANOSTICS Center for Molecular Radiotherapy and Molecular Imaging, Zentralklinik Bad Berka, ENETS Center of Excellence , Bad Berka, Germany .

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http://dx.doi.org/10.1089/cbr.2014.1747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426302PMC
May 2015

In vitro and in vivo analysis of indocyanine green-labeled panitumumab for optical imaging-a cautionary tale.

Bioconjug Chem 2014 Oct 3;25(10):1801-10. Epub 2014 Oct 3.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute , 10 Center Drive, Bethesda, Maryland 20892, United States.

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http://pubs.acs.org/doi/10.1021/bc500312w
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http://dx.doi.org/10.1021/bc500312wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198103PMC
October 2014

Evaluation of platinum chemotherapy in combination with HER2-targeted α-particle radiation.

Cancer Biother Radiopharm 2013 Jul-Aug;28(6):441-9. Epub 2013 Jun 11.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1089/cbr.2012.1423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715768PMC
May 2014

Rational design, synthesis, and evaluation of tetrahydroxamic acid chelators for stable complexation of zirconium(IV).

Chemistry 2014 May 16;20(19):5584-91. Epub 2014 Apr 16.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 (USA), Fax: (+1) 301-402-1923.

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http://dx.doi.org/10.1002/chem.201304115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123539PMC
May 2014

Wide-field in vivo background free imaging by selective magnetic modulation of nanodiamond fluorescence.

Biomed Opt Express 2014 Apr 14;5(4):1190-202. Epub 2014 Mar 14.

Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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https://www.osapublishing.org/boe/abstract.cfm?uri=boe-5-4-1
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http://dx.doi.org/10.1364/BOE.5.001190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985990PMC
April 2014

Molecular imaging of death receptor 5 occupancy and saturation kinetics in vivo by humanized monoclonal antibody CS-1008.

Clin Cancer Res 2013 Nov 17;19(21):5984-93. Epub 2013 Sep 17.

Authors' Affiliations: Tumour Targeting Laboratory and Oncogenic Transcription Laboratory, Ludwig Institute for Cancer Research; Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia; Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Cancer Research Centre, Bethesda, Maryland; Clinical Development-Oncology, Daiichi Sankyo Pharmaceutical Development, Edison, New Jersey; and Global Project Management Department, Daiichi Sankyo Co. Ltd., Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3104DOI Listing
November 2013

Gene expression profiling upon (212) Pb-TCMC-trastuzumab treatment in the LS-174T i.p. xenograft model.

Cancer Med 2013 Oct 19;2(5):646-53. Epub 2013 Sep 19.

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/cam4.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892796PMC
October 2013

Mapping biological behaviors by application of longer-lived positron emitting radionuclides.

Adv Drug Deliv Rev 2013 Jul 2;65(8):1098-111. Epub 2012 Nov 2.

Radioimmune & Inorganic Chemistry Section, ROB, NCI, NIH, Bethesda, MD 20892-1002, USA.

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http://dx.doi.org/10.1016/j.addr.2012.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593806PMC
July 2013

Methodology for labeling proteins and peptides with lead-212 (212Pb).

Nucl Med Biol 2013 Jul 17;40(5):592-9. Epub 2013 Apr 17.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, Bethesda, MD 20892-1002, USA.

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http://dx.doi.org/10.1016/j.nucmedbio.2013.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665721PMC
July 2013

Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation.

Nanoscale 2013 Jun;5(12):5252-6

Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA.

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http://dx.doi.org/10.1039/c3nr00333gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957245PMC
June 2013

Silica encapsulation of fluorescent nanodiamonds for colloidal stability and facile surface functionalization.

J Am Chem Soc 2013 May 22;135(21):7815-8. Epub 2013 Apr 22.

Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Building 50, Room 3517, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/ja4016815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689586PMC
May 2013

Orthotopic pleural mesothelioma in mice: SPECT/CT and MR imaging with HER1- and HER2-targeted radiolabeled antibodies.

Radiology 2013 Apr 17;267(1):173-82. Epub 2013 Jan 17.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, and Molecular Imaging Program, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B69F, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1148/radiol.12121021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606545PMC
April 2013

Sensitization of tumor to ²¹²Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51.

Int J Radiat Oncol Biol Phys 2013 Mar 29;85(4):1119-26. Epub 2012 Nov 29.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1088, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2012.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594422PMC
March 2013

Production of [(211)At]-astatinated radiopharmaceuticals and applications in targeted α-particle therapy.

Cancer Biother Radiopharm 2013 Feb 17;28(1):1-20. Epub 2012 Oct 17.

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1089/cbr.2012.1292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545490PMC
February 2013

Molecular pathways: targeted α-particle radiation therapy.

Clin Cancer Res 2013 Feb 10;19(3):530-7. Epub 2012 Dec 10.

Radioimmune & Inorganic Chemistry Section, ROB, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563752PMC
February 2013

Investigation of Zr(IV) and 89Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging.

Chem Commun (Camb) 2013 Feb 19;49(10):1002-4. Epub 2012 Dec 19.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1039/c2cc37549dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538910PMC
February 2013

Biodegradable polydisulfide dendrimer nanoclusters as MRI contrast agents.

ACS Nano 2012 Nov 29;6(11):9416-24. Epub 2012 Oct 29.

Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/nn304160pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508381PMC
November 2012

Synthesis and characterization of αvβ₃-targeting peptidomimetic chelate conjugates for PET and SPECT imaging.

Bioorg Med Chem Lett 2012 Sep 14;22(17):5517-22. Epub 2012 Jul 14.

Radioimmune & Inorganic Chemistry Section, ROB, NCI, NIH, 10 Center Drive, MSC-1002, Rm B3B69, Bethesda, MD 20892-1002, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423540PMC
September 2012

(111)In- and (203)Pb-Labeled Cyclic RGD Peptide Conjugate as an α(v)β(3) Integrin-Binding Radiotracer.

J Labelled Comp Radiopharm 2012 Sep 5;55(11):423-426. Epub 2012 Sep 5.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, 10 Center Drive, Bethesda, MD 20892.

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http://dx.doi.org/10.1002/jlcr.2965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496268PMC
September 2012

An overview of targeted alpha therapy.

Tumour Biol 2012 Jun 6;33(3):573-90. Epub 2011 Dec 6.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, 10 Center Drive, Building 10, Rm B3B69, Bethesda, MD 20892-1002, USA.

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http://dx.doi.org/10.1007/s13277-011-0286-yDOI Listing
June 2012

Preparation of cystamine core dendrimer and antibody-dendrimer conjugates for MRI angiography.

Mol Pharm 2012 Mar 21;9(3):374-81. Epub 2011 Sep 21.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, 10 Center Drive, Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/mp2003219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235272PMC
March 2012

(212)Pb-radioimmunotherapy induces G(2) cell-cycle arrest and delays DNA damage repair in tumor xenografts in a model for disseminated intraperitoneal disease.

Mol Cancer Ther 2012 Mar 11;11(3):639-48. Epub 2012 Jan 11.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297706PMC
March 2012

PET and MRI of metastatic peritoneal and pulmonary colorectal cancer in mice with human epidermal growth factor receptor 1-targeted 89Zr-labeled panitumumab.

J Nucl Med 2012 Jan;53(1):113-20

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://jnm.snmjournals.org/cgi/doi/10.2967/jnumed.111.094169
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http://dx.doi.org/10.2967/jnumed.111.094169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252203PMC
January 2012

Synthesis and evaluation of a bifunctional chelate for development of Bi(III)-labeled radioimmunoconjugates.

Bioorg Med Chem Lett 2011 Dec 7;21(24):7513-5. Epub 2011 Jul 7.

Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, 3101 S. Dearborn St., LS 182, Chicago, IL 60616, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.06.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741339PMC
December 2011

Pre-Clinical Assessment of Lu-Labeled Trastuzumab Targeting HER2 for Treatment and Management of Cancer Patients with Disseminated Intraperitoneal Disease.

Pharmaceuticals (Basel) 2011 Dec;5(1):1-15

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; (G.L.R.); (K.E.B.); (L.M.M.K.); (M.W.B.).

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http://www.mdpi.com/1424-8247/5/1/1
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http://dx.doi.org/10.3390/ph5010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250925PMC
December 2011

86Y based PET radiopharmaceuticals: radiochemistry and biological applications.

Med Chem 2011 Sep;7(5):380-8

Imaging Sciences, Translational Research Sciences, Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184346PMC
http://dx.doi.org/10.2174/157340611796799249DOI Listing
September 2011

Towards translation of 212Pb as a clinical therapeutic; getting the lead in!

Dalton Trans 2011 Jun 4;40(23):6068-76. Epub 2011 Mar 4.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, NIH, Building 10, Room 1B40, 10 Center Drive, Bethesda, Maryland 20892-1088, USA.

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http://dx.doi.org/10.1039/c0dt01387kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109156PMC
June 2011

In Vitro and In Vivo Pre-Clinical Analysis of a F(ab')(2) Fragment of Panitumumab for Molecular Imaging and Therapy of HER1 Positive Cancers.

EJNMMI Res 2011 Jun;1(1)

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda MD 20892;

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http://dx.doi.org/10.1186/2191-219X-1-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155408PMC
June 2011

Preparation, characterization and in vivo assessment of Gd-albumin and Gd-dendrimer conjugates as intravascular contrast-enhancing agents for MRI.

J Inorg Biochem 2011 May 2;105(5):722-7. Epub 2011 Apr 2.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S016201341100028
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http://dx.doi.org/10.1016/j.jinorgbio.2011.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081896PMC
May 2011

Targeting HER2: a report on the in vitro and in vivo pre-clinical data supporting trastuzumab as a radioimmunoconjugate for clinical trials.

MAbs 2010 Sep-Oct;2(5):550-64. Epub 2010 Sep 1.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/mabs.2.5.13054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958576PMC
April 2011

HER1-targeted 86Y-panitumumab possesses superior targeting characteristics than 86Y-cetuximab for PET imaging of human malignant mesothelioma tumors xenografts.

PLoS One 2011 Mar 25;6(3):e18198. Epub 2011 Mar 25.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018198PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064677PMC
March 2011

PET imaging of tumor angiogenesis in mice with VEGF-A-targeted (86)Y-CHX-A″-DTPA-bevacizumab.

Int J Cancer 2011 Feb;128(4):920-6

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1002/ijc.25409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939172PMC
February 2011

Improved speciation characteristics of PEGylated indocyanine green-labeled Panitumumab: revisiting the solution and spectroscopic properties of a near-infrared emitting anti-HER1 antibody for optical imaging of cancer.

Bioconjug Chem 2010 Dec 12;21(12):2305-12. Epub 2010 Nov 12.

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1002, USA.

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http://pubs.acs.org/doi/abs/10.1021/bc100336b
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http://dx.doi.org/10.1021/bc100336bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075340PMC
December 2010

Macromolecular and dendrimer-based magnetic resonance contrast agents.

Acta Radiol 2010 Sep;51(7):751-67

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3109/02841851.2010.491091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922462PMC
September 2010

PET imaging of HER1-expressing xenografts in mice with 86Y-CHX-A''-DTPA-cetuximab.

Eur J Nucl Med Mol Imaging 2010 Jul 13;37(7):1368-76. Epub 2010 Feb 13.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00259-009-1370-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891840PMC
July 2010

Poly(amidoamine) dendrimer based MRI contrast agents exhibiting enhanced relaxivities derived via metal preligation techniques.

Bioconjug Chem 2010 Jun;21(6):1014-7

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/bc1000802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889128PMC
June 2010

Preparation, biological evaluation, and pharmacokinetics of the human anti-HER1 monoclonal antibody panitumumab labeled with 86Y for quantitative PET of carcinoma.

J Nucl Med 2010 Jun 19;51(6):942-50. Epub 2010 May 19.

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.2967/jnumed.109.071290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892806PMC
June 2010

Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics.

Chem Rev 2010 May;110(5):2921-59

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/cr900232tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868950PMC
May 2010

Improved efficacy of alpha-particle-targeted radiation therapy: dual targeting of human epidermal growth factor receptor-2 and tumor-associated glycoprotein 72.

Cancer 2010 Feb;116(4 Suppl):1059-66

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://doi.wiley.com/10.1002/cncr.24793
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http://dx.doi.org/10.1002/cncr.24793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498458PMC
February 2010

Toward preparation of antibody-based imaging probe libraries for dual-modality positron emission tomography and fluorescence imaging.

Bioorg Med Chem 2009 Jul 27;17(14):5176-81. Epub 2009 May 27.

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 1B40, 10 Center Drive, Bethesda, MD 20892-1088, USA.

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http://dx.doi.org/10.1016/j.bmc.2009.05.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759299PMC
July 2009

A new approach in the preparation of dendrimer-based bifunctional diethylenetriaminepentaacetic acid MR contrast agent derivatives.

Bioconjug Chem 2009 Jul;20(7):1412-8

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, and Molecular Imaging Program, National Cancer Institute, 10 Center Drive, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/bc900057zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737254PMC
July 2009

Growing applications of "click chemistry" for bioconjugation in contemporary biomedical research.

Cancer Biother Radiopharm 2009 Jun;24(3):289-302

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1002, USA.

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http://dx.doi.org/10.1089/cbr.2008.0626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811415PMC
June 2009

Radioimmunoimaging with longer-lived positron-emitting radionuclides: potentials and challenges.

Bioconjug Chem 2009 May;20(5):825-41

Radiation Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1021/bc800299fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397469PMC
May 2009

Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''-Re(Arg11)CCMSH.

Nucl Med Biol 2009 May 26;36(4):345-54. Epub 2009 Mar 26.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.nucmedbio.2009.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752876PMC
May 2009

Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy.

Prostate 2009 Jan;69(1):92-104

Tumour Targeting Laboratory, Ludwig Institute for Cancer Research, Melbourne Centre for ClinicalSciences, Austin Hospital, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1002/pros.20856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597150PMC
January 2009

A novel side-bridged hybrid phosphonate/acetate pendant cyclam: synthesis, characterization, and 64Cu small animal PET imaging.

Bioorg Med Chem 2009 Jan 6;17(2):548-52. Epub 2008 Dec 6.

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10 Center Drive, Bethesda, MA 20892-1088, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S096808960801161
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http://dx.doi.org/10.1016/j.bmc.2008.11.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636550PMC
January 2009

Synthesis and biological evaluation of a novel decadentate ligand DEPA.

Bioorg Med Chem Lett 2008 Nov 19;18(21):5792-5. Epub 2008 Sep 19.

Physical Sciences Department, Illinois Institute of Technology, LS 182, Chicago, IL 60616, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.09.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784163PMC
November 2008

Synthesis, characterization, and biological evaluation of integrin alphavbeta3-targeted PAMAM dendrimers.

Mol Pharm 2008 Jul-Aug;5(4):527-39. Epub 2008 Jun 7.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, USA.

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http://dx.doi.org/10.1021/mp800022aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574599PMC
October 2008

Cetuximab: preclinical evaluation of a monoclonal antibody targeting EGFR for radioimmunodiagnostic and radioimmunotherapeutic applications.

Cancer Biother Radiopharm 2008 Oct;23(5):619-31

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586878PMC
http://dx.doi.org/10.1089/cbr.2008.0493DOI Listing
October 2008

Evaluation of a maleimido derivative of CHX-A'' DTPA for site-specific labeling of affibody molecules.

Bioconjug Chem 2008 Aug 12;19(8):1579-87. Epub 2008 Jul 12.

Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1021/bc800110yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561312PMC
August 2008

Tumor targeting by a multivalent single-chain Fv (scFv) anti-Lewis Y antibody construct.

Cancer Biother Radiopharm 2008 Aug;23(4):411-23

Tumour Targeting Program, Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg, Victoria, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663784PMC
http://dx.doi.org/10.1089/cbr.2007.0450DOI Listing
August 2008

Novel bimodal bifunctional ligands for radioimmunotherapy and targeted MRI.

Bioconjug Chem 2008 Jul 20;19(7):1439-47. Epub 2008 Jun 20.

Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois 60616, USA.

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http://dx.doi.org/10.1021/bc800050xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2497452PMC
July 2008

Synthesis of a cross-bridged cyclam derivative for peptide conjugation and 64Cu radiolabeling.

Bioconjug Chem 2008 Jul 3;19(7):1476-84. Epub 2008 Jul 3.

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, UAS.

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http://dx.doi.org/10.1021/bc800039eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2505184PMC
July 2008

A dual CT-MR dendrimer contrast agent as a surrogate marker for convection-enhanced delivery of intracerebral macromolecular therapeutic agents.

Contrast Media Mol Imaging 2008 Jan-Feb;3(1):2-8

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1088, USA.

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http://dx.doi.org/10.1002/cmmi.223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278235PMC
June 2008

A novel bifunctional maleimido CHX-A'' chelator for conjugation to thiol-containing biomolecules.

Bioorg Med Chem Lett 2008 Apr 10;18(8):2679-83. Epub 2008 Mar 10.

Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 1B40, 10 Center Drive, Bethesda, MD 20892-1088, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346453PMC
April 2008

Rational design and generation of a bimodal bifunctional ligand for antibody-targeted radiation cancer therapy.

J Med Chem 2008 Jan 7;51(1):118-25. Epub 2007 Dec 7.

Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois 60616, USA.

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http://dx.doi.org/10.1021/jm070401qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396554PMC
January 2008

Preparation and preliminary evaluation of a biotin-targeted, lectin-targeted dendrimer-based probe for dual-modality magnetic resonance and fluorescence imaging.

Bioconjug Chem 2007 Sep-Oct;18(5):1474-82. Epub 2007 Aug 21.

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, USA.

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http://pubs.acs.org/doi/abs/10.1021/bc0701085
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http://dx.doi.org/10.1021/bc0701085DOI Listing
November 2007

Novel synthetic ligands for targeted PET imaging and radiotherapy of copper.

Bioorg Med Chem Lett 2007 Nov 18;17(22):6107-10. Epub 2007 Sep 18.

Chemistry Division, Biological, Chemical, and Physical Science Department, Illinois Institute of Technology, 3101 S. Dearborn Street, Chicago, IL 60616, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.09.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410210PMC
November 2007

Targeted alpha-therapy: past, present, future?

Dalton Trans 2007 Nov 11(43):4918-28. Epub 2007 Sep 11.

Radioimmune & Inorganic Chemistry Section Radiation Oncology Branch, NCI, NIH Building 10, Room 1B40 10 Center Drive Bethesda, MD 20892-1088, USA.

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http://dx.doi.org/10.1039/b704726fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408446PMC
November 2007

Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view.

Nucl Med Biol 2007 Oct 8;34(7):757-78. Epub 2007 Jun 8.

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1088, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096980510700092
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http://dx.doi.org/10.1016/j.nucmedbio.2007.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212602PMC
October 2007

Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging.

J Med Chem 2007 Sep 29;50(19):4759-65. Epub 2007 Aug 29.

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm070657w
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http://dx.doi.org/10.1021/jm070657wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366096PMC
September 2007

Radioimmunotherapy with alpha-particle emitting 213Bi-C-functionalized trans-cyclohexyl-diethylenetriaminepentaacetic acid-humanized 3S193 is enhanced by combination with paclitaxel chemotherapy.

Clin Cancer Res 2007 Sep;13(18 Pt 2):5604s-5612s

Tumour Targeting Program, Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1071DOI Listing
September 2007

Radiotherapy of CD45-expressing Daudi tumors in nude mice with yttrium-90-labeled, PEGylated anti-CD45 antibody.

Cancer Biother Radiopharm 2007 Aug;22(4):488-500

Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1089/cbr.2007.366DOI Listing
August 2007

Toward improved syntheses of dendrimer-based magnetic resonance imaging contrast agents: new bifunctional diethylenetriaminepentaacetic acid ligands and nonaqueous conjugation chemistry.

J Med Chem 2007 Jul 7;50(14):3185-93. Epub 2007 Jun 7.

Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm061324m
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http://dx.doi.org/10.1021/jm061324mDOI Listing
July 2007

The emerging role of molecular imaging and targeted therapeutics in peritoneal carcinomatosis.

Expert Opin Drug Deliv 2007 Jul;4(4):389-402

Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, USA.

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http://dx.doi.org/10.1517/17425247.4.4.389DOI Listing
July 2007

Pharmacokinetics and toxicity of (213)Bi-labeled PAI2 in preclinical targeted alpha therapy for cancer.

Cancer Biol Ther 2007 Jun 5;6(6):898-904. Epub 2007 Mar 5.

Centre for Experimental Radiation Oncology, Cancer Care Centre, St. George Hospital, Kogarah, Australia.

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http://dx.doi.org/10.4161/cbt.6.6.4097DOI Listing
June 2007