Publications by authors named "Martin Sillesen"

45Publications

Modulation of Brain Transcriptome By Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock.

Shock 2020 Jul 7. Epub 2020 Jul 7.

*Department of Surgery, University of Michigan, Ann Arbor, MI, United States †Department of Internal Medicine, Oregon Health & Science University, Portland, OR, United States ‡Bioinformatics Core Facility, University of Michigan, Ann Arbor, MI, United States §Department of Surgical Gastroenterology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark ||Center for Surgical Translational and Artificial Intelligence Research (CSTAR), Copenhagen University Hospital, Rigshospitalet, Denmark.

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http://dx.doi.org/10.1097/SHK.0000000000001605DOI Listing
July 2020

Ketamine for rapid sequence intubation in adult trauma patients: A retrospective observational study.

Acta Anaesthesiol Scand 2020 Jun 12. Epub 2020 Jun 12.

Department of Anesthesia, Center of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/aas.13651DOI Listing
June 2020

Smoking and risk of surgical bleeding: nationwide analysis of 5,452,411 surgical cases.

Transfusion 2020 May 22. Epub 2020 May 22.

Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/trf.15852DOI Listing
May 2020

De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation.

Am J Hum Genet 2020 04 19;106(4):570-583. Epub 2020 Mar 19.

Department of Pediatrics, Baylor College of Medicine (BCM), Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Division of Neurology and Developmental Neuroscience, Department of Pediatrics, BCM, Houston, TX 77030, USA; Department of Molecular and Human Genetics, BCM, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA; Program in Development, Disease Models, and Therapeutics, BCM, Houston, TX 77030, USA; Department of Neuroscience, BCM, Houston, TX 77030, USA; McNair Medical Institute, The Robert and Janice McNair Foundation, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2020.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118694PMC
April 2020

Identification of a new genetic variant associated with cholecystitis: A multicenter genome-wide association study.

J Trauma Acute Care Surg 2020 07;89(1):173-178

From the Division of Trauma (A.B., A.G., K.B., M.E.H., C.N., M.C., N.K., A.M., G.V., H.M.A.K.), Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesia (A.B., M.C., M.S.), Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Biomedical Informatics (M.R.F.), Harvard Medical School; and Pulmonary and Critical Care Medicine (M.R.F.), Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1097/TA.0000000000002647DOI Listing
July 2020

The effect of fluid resuscitation strategy on monocyte and T-cell surface markers.

J Surg Res 2018 10 12;230:20-27. Epub 2018 May 12.

Department of Surgical Gastroenterology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Institute for Inflammation Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2018.04.029DOI Listing
October 2018

Ketamine as a Rapid Sequence Induction Agent in the Trauma Population: A Systematic Review.

Anesth Analg 2019 03;128(3):504-510

From the Department of Anesthesia, Center of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1213/ANE.0000000000003568DOI Listing
March 2019

Tubastatin A prevents hemorrhage-induced endothelial barrier dysfunction.

J Trauma Acute Care Surg 2018 02;84(2):386-392

Department of Surgery (P.J.B., B.C.N., I.H., Z.C., M.S., B.L., Y.L., H.B.A.), University of Michigan, Ann Arbor, Michigan, and Department of Surgical Gastroenterology (P.J.B., M.S.), Rigshospitalet, University of Copenhagen Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1097/TA.0000000000001753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780204PMC
February 2018

Transfusion Strategies are Associated with Epigenetic Changes Following Blunt Trauma.

Shock 2018 07;50(1):24-30

Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan.

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http://dx.doi.org/10.1097/SHK.0000000000001035DOI Listing
July 2018

The effect of resuscitation strategy on the longitudinal immuno-inflammatory response to blunt trauma.

Injury 2017 Dec 28;48(12):2670-2674. Epub 2017 Sep 28.

Department of Surgical Gastroenterology, Copenhagen University Hospital, Rigshospitalet, Denmark; Institute for Inflammation Research, Copenhagen University Hospital, Rigshospitalet, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.injury.2017.09.026DOI Listing
December 2017

Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury.

J Neurosci Res 2018 04 25;96(4):711-719. Epub 2017 Jul 25.

Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/jnr.24125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785554PMC
April 2018

Valproic acid modulates platelet and coagulation function ex vivo.

Blood Coagul Fibrinolysis 2017 Sep;28(6):479-484

aDepartment of Surgery, University of Michigan Hospital, Ann Arbor, Michigan bDepartment of Neurological Surgery, Case Western Reserve University, Cleveland, Ohio, USA cDepartment of Surgical Gastroenterology dInstitute for Inflammation Research, Copenhagen University Hospital, Rigshospitalet, Denmark.

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http://dx.doi.org/10.1097/MBC.0000000000000626DOI Listing
September 2017

Fresh Frozen Plasma Modulates Brain Gene Expression in a Swine Model of Traumatic Brain Injury and Shock: A Network Analysis.

J Am Coll Surg 2017 01 8;224(1):49-58. Epub 2016 Oct 8.

Department of Surgery, University of Michigan, Ann Arbor, MI. Electronic address:

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http://dx.doi.org/10.1016/j.jamcollsurg.2016.09.015DOI Listing
January 2017

Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock.

J Neurotrauma 2016 08 8;33(16):1514-21. Epub 2016 Apr 8.

1 Department of Surgery, University of Michigan Hospital , Ann Arbor, Michigan.

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http://dx.doi.org/10.1089/neu.2015.4163DOI Listing
August 2016

No Correlation Between Work-Hours and Operative Volumes--A Comparison Between United States and Danish Operative Volumes Achieved During Surgical Residency.

J Surg Educ 2016 May-Jun;73(3):461-5. Epub 2015 Dec 18.

Department of Surgery, Copenhagen University Hospital, Hillerød, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jsurg.2015.11.007DOI Listing
January 2017

Effect of Transfusion Strategy in Acute Non-variceal Upper Gastrointestinal Bleeding: A Nationwide Study of 5861 Hospital Admissions in Denmark.

World J Surg 2016 May;40(5):1129-36

Department of Surgical Gastroenterology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.

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http://link.springer.com/10.1007/s00268-015-3370-4
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http://dx.doi.org/10.1007/s00268-015-3370-4DOI Listing
May 2016

Histone deactylase gene expression profiles are associated with outcomes in blunt trauma patients.

J Trauma Acute Care Surg 2016 Jan;80(1):26-32; discussion 32-3

From the Departments of Surgical Gastroenterology (M.S., P.S., P.J.B., L.B.S., J.H.), and Surgery (R.F.), and Institute for Inflammation Research (M.S.), Copenhagen University Hospital, Rigshospitalet, Denmark; Division of Trauma, Emergency Surgery and Surgical Critical Care (M.S.), Massachusetts General Hospital, Boston, Massachusetts; Department of Surgery (T.B., S.E.D., H.B.A.), University of Michigan, Ann Arbor, Michigan; Department of Anesthesiology (S.E.D.), Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/TA.0000000000000896DOI Listing
January 2016

Statins improve the resolution of established murine venous thrombosis: reductions in thrombus burden and vein wall scarring.

PLoS One 2015 13;10(2):e0116621. Epub 2015 Feb 13.

Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116621PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334538PMC
January 2016

Coagulation changes following traumatic brain injury and shock.

Authors:
Martin Sillesen

Dan Med J 2014 Dec;61(12):B4974

Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark.

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December 2014

Fresh frozen plasma resuscitation provides neuroprotection compared to normal saline in a large animal model of traumatic brain injury and polytrauma.

J Neurotrauma 2015 Mar 19;32(5):307-13. Epub 2014 Dec 19.

1 Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital/Harvard Medical School , Boston, Massachusetts.

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http://dx.doi.org/10.1089/neu.2014.3535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347890PMC
March 2015

Resuscitation speed affects brain injury in a large animal model of traumatic brain injury and shock.

Scand J Trauma Resusc Emerg Med 2014 Aug 14;22:46. Epub 2014 Aug 14.

Department of Surgery, University of Michigan Hospital, 2920 Taubman Center/5331, 1500 E, Medical Center Drive, Ann Arbor 48109, MI, USA.

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http://dx.doi.org/10.1186/s13049-014-0046-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143574PMC
August 2014

Effect of valproic acid and injury on lesion size and endothelial glycocalyx shedding in a rodent model of isolated traumatic brain injury.

J Trauma Acute Care Surg 2014 Aug;77(2):292-7

From the Department of Surgery (C.H.J., M.A.D., M.S.), Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Capital Region Blood Bank (C.H.J., M.S., S.R.O., P.I.J.) and Department of Intensive Care (A.P.), Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Surgery (H.B.A.), University of Michigan, Ann Arbor, Michigan; and Department of Surgery (P.I.J.), University of Texas Medical School at Houston, Houston, Texas.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/TA.0000000000000333DOI Listing
August 2014

Effect of pharmacologic resuscitation on the brain gene expression profiles in a swine model of traumatic brain injury and hemorrhage.

J Trauma Acute Care Surg 2014 Dec;77(6):906-12; discussion 912

From the Department of Surgery (S.E.D., T.B., B.L., G.J., Y.L., H.B.A.), University of Michigan Hospital, Ann Arbor, Michigan; Department of Anesthesiology (S.E.D.), Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands; Department of Surgery (M.S.), Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Department of Surgery (M.S.), Copenhagen University Hospital, Hillerød, Denmark; and Biomedical Research Core Facilities (C.N.J.), DNA Sequencing Core Lab, University of Michigan, Ann Arbor, Michigan.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/TA.0000000000000345DOI Listing
December 2014

Histone deacetylase inhibitor treatment attenuates coagulation imbalance in a lethal murine model of sepsis.

Surgery 2014 Aug 21;156(2):214-20. Epub 2014 Jun 21.

Department of Surgery, University of Michigan, Ann Arbor, MI. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2014.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267526PMC
August 2014

Normal saline influences coagulation and endothelial function after traumatic brain injury and hemorrhagic shock in pigs.

Surgery 2014 Sep 19;156(3):556-63. Epub 2014 Jun 19.

Department of Surgery, University of Michigan Hospital, Ann Arbor, MI. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2014.04.016DOI Listing
September 2014

Fresh frozen plasma resuscitation attenuates platelet dysfunction compared with normal saline in a large animal model of multisystem trauma.

J Trauma Acute Care Surg 2014 Apr;76(4):998-1007

From the Division of Trauma, Emergency Surgery and Surgical Critical Care (M.S., C.H.J., A.I., J.O.H., D.D., M.Du., M.De., G.C.V.), Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Department of Anesthesia (M.S., L.S.R.), Center of Head and Orthopedics, and Capital Region Blood Bank (P.I.J., C.H.J.), Copenhagen University Hospital, Rigshospitalet, Denmark; Department of Surgery (P.I.J.), University of Texas Medical School at Houston, Texas; and Department of Surgery (G.J., H.B.A.), University of Michigan, Ann Arbor, Michigan.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/TA.0000000000000193DOI Listing
April 2014

Assessment of coagulopathy, endothelial injury, and inflammation after traumatic brain injury and hemorrhage in a porcine model.

J Trauma Acute Care Surg 2014 Jan;76(1):12-9; discussion 19-20

From the Division of Trauma, Emergency Surgery and Surgical Critical Care (M.S., C.H.J., A.I., J.O.H., M.D., G.V.), Department of Surgery, Massachusetts GeneralHospital/Harvard Medical School, Boston, Massachusetts; Department of Surgery (G.J., I.H., H.B.A.), University of Michigan, Ann Arbor, Michigan; and Department of Surgery (P.I.J.), University of Texas Medical School, Houston, Texas; and Department of Anesthesia (M.S., L.S.R.), Center of Head and Orthopedics, and Capital Region Blood Bank (C.H.J., P.I.J.), Copenhagen University Hospital, Rigshospitalet, Denmark.

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http://dx.doi.org/10.1097/TA.0b013e3182aaa675DOI Listing
January 2014

Early treatment with lyophilized plasma protects the brain in a large animal model of combined traumatic brain injury and hemorrhagic shock.

J Trauma Acute Care Surg 2013 Dec;75(6):976-83

From the Division of Trauma, Emergency Surgery and Surgical Critical Care, (A.M.I., G.J., M.S., M.D., C.H.J., J.O.H., J.L., M.A.D., G.C.V., H.B.A.), Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; and Department of Surgery (G.J., B.L., H.B.A.), University of Michigan Hospital, Ann Arbor, Michigan.

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http://dx.doi.org/10.1097/TA.0b013e31829e2186DOI Listing
December 2013

Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury.

J Trauma Acute Care Surg 2013 Dec;75(6):968-74; discussion 974-5

From the Division of Trauma, Emergency Surgery and Surgical Critical Care (J.O.H., A.M.I., G.J., B.L., Y.L., M.S., C.H.J., J.L., M.A.D., H.B.A.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; and the Department of Surgery (G.J., B.L., H.B.A.), University of Michigan Hospital, Ann Arbor, Michigan.

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http://dx.doi.org/10.1097/TA.0b013e31829a021aDOI Listing
December 2013

Synergistic effects of fresh frozen plasma and valproic acid treatment in a combined model of traumatic brain injury and hemorrhagic shock.

Surgery 2013 Aug;154(2):388-96

Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.surg.2013.05.008DOI Listing
August 2013

Pharmacologic modulation of cerebral metabolic derangement and excitotoxicity in a porcine model of traumatic brain injury and hemorrhagic shock.

Surgery 2013 Aug;154(2):234-43

Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.surg.2013.04.008DOI Listing
August 2013

Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion.

Surgery 2013 Aug;154(2):197-205

Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.surg.2013.04.002DOI Listing
August 2013

Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage.

J Trauma Acute Care Surg 2013 May;74(5):1252-9

Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Denmark.

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http://dx.doi.org/10.1097/TA.0b013e31828c7a6bDOI Listing
May 2013

Detection of extracellular genomic DNA scaffold in human thrombus: implications for the use of deoxyribonuclease enzymes in thrombolysis.

J Vasc Interv Radiol 2012 May;23(5):712-8

Division of Vascular Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S105104431200134
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http://dx.doi.org/10.1016/j.jvir.2012.01.072DOI Listing
May 2012

Pregnancy with prosthetic heart valves - 30 years' nationwide experience in Denmark.

Eur J Cardiothorac Surg 2011 Aug 28;40(2):448-54. Epub 2011 Jan 28.

Department of Cardiothoracic Surgery, Aarhus University Hospital, Skejby, Denmark.

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http://dx.doi.org/10.1016/j.ejcts.2010.12.011DOI Listing
August 2011

Referral of patients with ST-segment elevation acute myocardial infarction directly to the catheterization suite based on prehospital teletransmission of 12-lead electrocardiogram.

J Electrocardiol 2008 Jan-Feb;41(1):49-53

Department of Cardiology, The Heart Center, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jelectrocard.2007.08.058DOI Listing
February 2008

[Telemedicine in the transmission of prehospitalisation ECGs of patients with suspected acute myocardial infarction].

Ugeskr Laeger 2006 Mar;168(11):1133-6

H:S Rigshospitalets Hjertecenter, Hjertemedicinsk Klinik B og Traumecenter, København Ø.

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March 2006