Publications by authors named "Martin Schuler"

100Publications

ERK phosphorylation as a marker of RAS activity and its prognostic value in non-small cell lung cancer.

Lung Cancer 2020 Sep 10;149:10-16. Epub 2020 Sep 10.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany; Division of Thoracic Oncology, West German Cancer Center, Ruhrlandklinik, University Hospital Essen, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2020.09.005DOI Listing
September 2020

Assessment of coronary artery disease during hospitalization for cancer treatment.

Clin Res Cardiol 2020 Aug 2. Epub 2020 Aug 2.

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, Medical Faculty, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.

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http://dx.doi.org/10.1007/s00392-020-01719-5DOI Listing
August 2020

HDAC inhibition synergizes with ALK inhibitors to overcome resistance in a novel ALK mutated lung adenocarcinoma model.

Lung Cancer 2020 06 18;144:20-29. Epub 2020 Apr 18.

Department of Thoracic Surgery, West German Cancer Center, University Hospital Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2020.04.002DOI Listing
June 2020

Crizotinib in and Deregulated NSCLC-Letter.

Clin Cancer Res 2020 Apr;26(7):1774

Institute of Pathology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3740DOI Listing
April 2020

The zoospores of the thraustochytrid Aurantiochytrium limacinum: Transcriptional reprogramming and lipid metabolism associated to their specific functions.

Environ Microbiol 2020 May 16;22(5):1901-1916. Epub 2020 Mar 16.

Laboratoire de Physiologie Cellulaire Végétale, Université Grenoble Alpes, CEA, CNRS, INRA, IRIG-LPCV, 38054, Grenoble Cedex 9, France.

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http://dx.doi.org/10.1111/1462-2920.14978DOI Listing
May 2020

An integrated perfusion machine preserves injured human livers for 1 week.

Nat Biotechnol 2020 02 13;38(2):189-198. Epub 2020 Jan 13.

Department of Surgery and Transplantation, Swiss Hepato-Pancreato-Biliary (HPB) Center, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/s41587-019-0374-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008032PMC
February 2020

Afatinib for the Treatment of NSCLC Harboring Uncommon EGFR Mutations: A Database of 693 Cases.

J Thorac Oncol 2020 May 10;15(5):803-815. Epub 2020 Jan 10.

Department of Solid Tumor Oncology, Levine Cancer Institute, Atrium Health, Charlotte, North Carolina.

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http://dx.doi.org/10.1016/j.jtho.2019.12.126DOI Listing
May 2020

Clinical response to crizotinib and emergence of resistance in lung adenocarcinoma harboring a MET c-Cbl binding site mutation.

Lung Cancer 2020 01 26;139:165-168. Epub 2019 Nov 26.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany; Division of Thoracic Oncology, West German Lung Center, Ruhrlandklinik - University Hospital Essen, University Duisburg-Essen, Germany; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Germany.

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http://dx.doi.org/10.1016/j.lungcan.2019.11.020DOI Listing
January 2020

Detection of TGF-β in pleural effusions for diagnosis and prognostic stratification of malignant pleural mesothelioma.

Lung Cancer 2020 01 18;139:124-132. Epub 2019 Nov 18.

Department of Thoracic Surgery, Ruhrlandklinik, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Tueschener Weg 40, 45239, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2019.11.013DOI Listing
January 2020

The lipid metabolism in thraustochytrids.

Prog Lipid Res 2019 10 6;76:101007. Epub 2019 Sep 6.

Laboratoire de Physiologie Cellulaire Végétale, Université Grenoble Alpes, CNRS, CEA, INRA, 38054 Grenoble Cedex 9, France. Electronic address:

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http://dx.doi.org/10.1016/j.plipres.2019.101007DOI Listing
October 2019

Pretreatment metabolic tumour volume in stage IIIA/B non-small-cell lung cancer uncovers differences in effectiveness of definitive radiochemotherapy schedules: analysis of the ESPATUE randomized phase 3 trial.

Eur J Nucl Med Mol Imaging 2019 Jul 1;46(7):1439-1447. Epub 2019 Feb 1.

Department of Radiation Oncology, West German Cancer Center, University of Duisburg-Essen Medical School, Hufelandstr. 55, 45122, Essen, Germany.

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http://dx.doi.org/10.1007/s00259-019-4270-xDOI Listing
July 2019

Cardio-oncology - strategies for management of cancer-therapy related cardiovascular disease.

Int J Cardiol 2019 04 11;280:163-175. Epub 2019 Jan 11.

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, Medical Faculty, University Hospital Essen, Hufelandstr. 55, 45147 Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2019.01.038DOI Listing
April 2019

Rapid and Highly Sensitive Detection of Therapeutically Relevant Oncogenic Driver Mutations in EBUS-TBNA Specimens From Patients With Lung Adenocarcinoma.

Clin Lung Cancer 2018 11 22;19(6):e879-e884. Epub 2018 Aug 22.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany; German Cancer Consortium, Partner Site University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1016/j.cllc.2018.08.016DOI Listing
November 2018

Predictors of outpatients' request for palliative care service at a medical oncology clinic of a German comprehensive cancer center.

Support Care Cancer 2018 Oct 5;26(10):3641-3647. Epub 2018 May 5.

Department of Psychosomatic Medicine and Psychotherapy, University of Duisburg Essen, LVR-Klinikum Essen, 45122, Essen, Germany.

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http://dx.doi.org/10.1007/s00520-018-4245-7DOI Listing
October 2018

CUP Syndrome-Metastatic Malignancy with Unknown Primary Tumor.

Dtsch Arztebl Int 2018 03;115(10):157-162

West German Cancer Center, Clinic for Internal Medicine (Tumor Research), University Hospital Essen; West German Cancer Center, Clinic for Internal Medicine (Tumor Research), University Hospital Essen, German Cancer Consortium (DKTK) Location University Hospital Essen; West German Cancer Center, Clinic for Nuclear Medicine, University Hospital Essen, German Cancer Consortium (DKTK) Location University Hospital Essen; Institute of Pathology, Ruhr-University Bochum.

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http://dx.doi.org/10.3238/arztebl.2018.0157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881077PMC
March 2018

Phosphorylation of p70 Ribosomal Protein S6 Kinase β-1 is an Independent Prognostic Parameter in Metastatic Colorectal Cancer.

Clin Colorectal Cancer 2018 06 17;17(2):e331-e352. Epub 2018 Feb 17.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany; German Cancer Consortium, Partner Site University Hospital Essen, Essen, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15330028173044
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http://dx.doi.org/10.1016/j.clcc.2018.02.003DOI Listing
June 2018

Phosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study.

J Clin Oncol 2018 05 5;36(13):1291-1299. Epub 2018 Feb 5.

Dejan Juric, Massachusetts General Hospital Cancer Center, Boston; Alan Huang, Novartis Institutes for BioMedical Research, Cambridge, MA; Jordi Rodon and Josep Tabernero, Vall d'Hebron University Hospital and Institute of Oncology, Universitat Autònoma de Barcelona; Marta Gil-Martin, Catalan Institute of Oncology - Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain; Filip Janku, The University of Texas MD Anderson Cancer Center, Houston, TX; Howard A. Burris, Sarah Cannon Research Institute and Tennessee Oncology; Jordan Berlin, Vanderbilt-Ingram Cancer Center, Nashville, TN; Jan H.M. Schellens, Netherlands Cancer Institute, Amsterdam, the Netherlands; Mark R. Middleton, National Institute for Health Research, Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom; Martin Schuler, West German Cancer Center, University Duisburg-Essen, and German Cancer Consortium, Partner Site University Hospital Essen, Essen; Ruth Seggewiss-Bernhardt, Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany; Hope S. Rugo, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; Douglas Bootle, David Demanse, Lars Blumenstein, and Cornelia Quadt, Novartis Pharma AG, Basel, Switzerland; Christina Coughlin, Novartis Pharmaceuticals Corporation, East Hanover, NJ; and José Baselga, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://ascopubs.org/doi/10.1200/JCO.2017.72.7107
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http://dx.doi.org/10.1200/JCO.2017.72.7107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920739PMC
May 2018

Modulation of Biomarker Expression by Osimertinib: Results of the Paired Tumor Biopsy Cohorts of the AURA Phase I Trial.

J Thorac Oncol 2017 10 24;12(10):1588-1594. Epub 2017 Jul 24.

Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2017.07.011DOI Listing
October 2017

Hepatic arterial infusion chemotherapy for extensive liver metastases of breast cancer: efficacy, safety and prognostic parameters.

J Cancer Res Clin Oncol 2017 Oct 23;143(10):2131-2141. Epub 2017 Jun 23.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg Essen, 45122, Essen, Germany.

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http://dx.doi.org/10.1007/s00432-017-2462-yDOI Listing
October 2017

Deregulated BCL-2 family proteins impact on repair of DNA double-strand breaks and are targets to overcome radioresistance in lung cancer.

J Cancer Res Clin Oncol 2017 Sep 21;143(9):1733-1744. Epub 2017 Apr 21.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122, Essen, Germany.

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http://dx.doi.org/10.1007/s00432-017-2427-1DOI Listing
September 2017

Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study.

J Clin Oncol 2017 Jan 21;35(2):157-165. Epub 2016 Nov 21.

Lucia Nogova, Reinhard Buettner, and Jürgen Wolf, University Hospital Cologne, Cologne; Martin Schuler, University Hospital Essen, and German Cancer Consortium (DKTK), Essen, Germany; Lecia V. Sequist, Massachusetts General Hospital; Geoffrey I. Shapiro, Dana-Farber Cancer Institute, Boston, MA; Jose Manuel Perez Garcia, Vall d'Hebron Institut d'Oncologia, Barcelona; Manuel Hidalgo, Spanish National Cancer Research Centre, Madrid, Spain; Fabrice Andre, Gustave Roussy, Villejuif; Jean-Pierre Delord, Institute Universitaire du Cancer de Toulouse, Toulouse; Philippe A. Cassier, Centre Regional Leon-Berard, Lyon; Mario Campone, Institute de Cancerologie de l'Ouest-René Gauducheau, Nantes, France; Jan H.M. Schellens, Netherlands Cancer Institute, Amsterdam, and Utrecht University, Utrecht, the Netherlands; D. Ross Camidge, University of Colorado, Aurora, CO; Ulka Vaishampayan, Barbara Ann Karmanos Cancer Institute, Detroit, MI; Howard Burris, Sarah Cannon Research Institute, Nashville; G. Gary Tian, The West Clinic, Memphis, TN; Zev A. Wainberg, UCLA School of Medicine, Los Angeles, CA; Wan-Teck Lim, National Cancer Centre, Singapore; Patricia LoRusso, Yale Cancer Center, New Haven, CT; Katie Parker, Xueying Chen, Somesh Choudhury, and Randi Isaacs, Novartis Pharmaceuticals Corporation, East Hanover, NJ; Dale Porter, Novartis Institutes for Biomedical Research, Cambridge, MA; Francois Ringeisen, Novartis Pharma AG; and Diana Graus-Porta, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1200/JCO.2016.67.2048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865065PMC
January 2017

High Prevalence of Concomitant Oncogene Mutations in Prospectively Identified Patients with ROS1-Positive Metastatic Lung Cancer.

J Thorac Oncol 2017 01 27;12(1):54-64. Epub 2016 Aug 27.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany; Division of Thoracic Oncology, West German Lung Center, Ruhrlandklinik, University Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.08.137DOI Listing
January 2017

Standardized Uptake Decrease on [18F]-Fluorodeoxyglucose Positron Emission Tomography After Neoadjuvant Chemotherapy Is a Prognostic Classifier for Long-Term Outcome After Multimodality Treatment: Secondary Analysis of a Randomized Trial for Resectable Stage IIIA/B Non-Small-Cell Lung Cancer.

J Clin Oncol 2016 07 31;34(21):2526-33. Epub 2016 May 31.

Christoph Pöttgen, Thomas Gauler, Alexander Bellendorf, Maja Guberina, Andreas Bockisch, Sebastian Cordes, Martin H. Schuler, Karl-Heinz Jöckel, Wilfried Eberhardt, and Martin Stuschke, University Hospital Essen; University of Duisburg-Essen; Stefan Welter, Georgios Stamatis, and Kaid Darwiche, Ruhrlandklinik, Essen; Nina Schwenzer and Frank Heinzelmann, University Hospital Tübingen; University of Tübingen, Tübingen; and Godehard Friedel, Robert-Bosch-Krankenhaus; Klinikum Schillerhöhe, Gerlingen, Germany.

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http://dx.doi.org/10.1200/JCO.2015.65.5167DOI Listing
July 2016

Circulating Tumor Cell Composition in Renal Cell Carcinoma.

PLoS One 2016 21;11(4):e0153018. Epub 2016 Apr 21.

Molecular Oncology Risk-Profile Evaluation, Department of Medical Oncology, West German Cancer Center, University Duisburg-Essen, Essen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153018PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839694PMC
February 2017

Phase III Study of Surgery Versus Definitive Concurrent Chemoradiotherapy Boost in Patients With Resectable Stage IIIA(N2) and Selected IIIB Non-Small-Cell Lung Cancer After Induction Chemotherapy and Concurrent Chemoradiotherapy (ESPATUE).

J Clin Oncol 2015 Dec 2;33(35):4194-201. Epub 2015 Nov 2.

Wilfried Ernst Erich Eberhardt, Christoph Pöttgen, Thomas Christoph Gauler, Sebastian Cordes, Rodrigo Hepp, Diana Lütke-Brintrup, Nils Lehmann, Martin Schuler, Karl-Heinz Jöckel, and Martin Stuschke, West German Cancer Center, University Hospital Essen, Essen; Stefan Welter and Georgios Stamatis, Ruhrlandklinik, Essen-Heidhausen; Godehard Friedel, Stefanie Veit, and Martin Kimmich, Robert-Bosch-Krankenhaus Klinik Schillerhöhe, Gerlingen; Vanessa Heinrich, Wilfried Budach, and Werner Spengler, Universitätsklinikum Tübingen, Tübingen; Berthold Fischer and Heinz Schmidberger, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, Mainz; Claus Belka, Klinikum der Universität München, München, Germany; and Dirk De Ruysscher, Maastro Clinic, Maastricht, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2015.62.6812DOI Listing
December 2015

Lung Cancer Screening Using Low Dose CT Scanning in Germany. Extrapolation of results from the National Lung Screening Trial.

Dtsch Arztebl Int 2015 Sep;112(38):637-44

Center for Clinical Epidemiology; Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, School of Public Health, Department of Epidemiology, Boston University, USA, German Cancer Consortium (DKTK), Heidelberg, West German Cancer Center, Clinic for Internal Medicine (Tumor Research), University Hospital Essen, Department of Thoracic Oncology, Ruhrlandklinik, University Hospital Essen, Department of Interventional Pneumology, Ruhrlandklinik, University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen.

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https://www.aerzteblatt.de/10.3238/arztebl.2015.0637
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http://dx.doi.org/10.3238/arztebl.2015.0637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593930PMC
September 2015

Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations.

N Engl J Med 2015 Aug;373(8):726-36

From Memorial Sloan Kettering Cancer Center, New York (D.M.H., E.L.D., J.B.); Vanderbilt University Medical Center, Nashville (I.P., E.C.); University of Texas M.D. Anderson Cancer Center, Houston (V.S.); Massachusetts General Hospital, Boston (J.E.F., N.S.R.); Royal Marsden Hospital, Sutton, Surrey, United Kingdom (I.C.); Centre Léon Bérard, Lyon (J.-Y.B.), Institut Gustave Roussy, Villejuif (A.H.), Centre François Baclesse, Centre Hospitalier Universitaire Côte de Nacre, Caen (R.G.), and Institut Bergonié Cancer Center, Bordeaux (A.I.) - all in France; University Hospital of Cologne, Cologne (J.W.), Universitätsmedizin Mannheim, Mannheim (R.-D.H.), West German Cancer Center, University Hospital Essen, Essen (M.S.), and German Cancer Consortium, Heidelberg (M.S.) - all in Germany; Vall d'Hebron University Hospital and Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona (M.E.E.-F., J.T.), and Hospital Universitario Madrid Sanchinarro, Madrid (M.H.) - both in Spain; and F. Hoffmann-La Roche, Basel, Switzerland (S.F.L., M.M., F.S., M.L.V.).

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http://dx.doi.org/10.1056/NEJMoa1502309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971773PMC
August 2015

Targeted Therapy for Patients with BRAF-Mutant Lung Cancer: Results from the European EURAF Cohort.

J Thorac Oncol 2015 Oct;10(10):1451-7

*Tumorzentrum, Luzerner Kantonsspital, Luzern, Switzerland; †Hôpital Larrey, Centre Hospital-Universitaire, Université Paul Sabatier, Toulouse, France; ‡Institut Claudius Regaud IUCT-O, Toulouse, France; §Institut Gustave Roussy, Villejuif, France; ¶VU University Medical Center, Amsterdam, The Netherlands; ‖Center of Integrated Oncology Cologne, University Hospital Cologne, Cologne, Germany; #Centre Pluridisciplinaire d'Oncologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; **Onkologie/Hämatologie, Kantonsspital St. Gallen, St. Gallen, Switzerland; ††Medizinische Klinik, St. Claraspital, Basel, Switzerland; ‡‡Service de pneumologie et oncologie thoracique, Hopital Universitaire, Caen, France; §§University Hospital Essen, Essen, Germany; ¶¶University Hospital Zurich, Zurich, Switzerland; ‖‖Clinique Teissier, Valenciennes, France; ##Centre Hospitalier Intercommunal de Creteil, Créteil, France; ***University Hospital Innsbruck, Innsbruck, Austria; †††University Hospital Basel, Basel, Switzerland; ‡‡‡Heidelberg University Medical Center, Mannheim, Germany; §§§Hopital du Haut Lévèque, Pessac, France; ¶¶¶Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; and ‖‖‖Centre Hospitalier Universitaire, Université de Caen-Basse Normandie, Caen, France.

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http://dx.doi.org/10.1097/JTO.0000000000000625DOI Listing
October 2015

Comprehensive genomic profiles of small cell lung cancer.

Nature 2015 Aug 13;524(7563):47-53. Epub 2015 Jul 13.

1] Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany. [2] Department of Pathology, University Hospital Cologne, 50937 Cologne, Germany.

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http://dx.doi.org/10.1038/nature14664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861069PMC
August 2015

Accelerated radiotherapy and concurrent chemotherapy for patients with contralateral central or mediastinal lung cancer relapse after pneumonectomy.

J Thorac Dis 2015 Mar;7(3):264-72

1 Department of Radiotherapy; West German Cancer Center, University of Duisburg-Essen, Hufelandstr, 55, D-45122 Essen, Germany ; 2 Division of Interventional Pneumology, 3 Division of Thoracic Surgery, Ruhrlandklinik, West German Lung Center, University of Duisburg-Essen, Tüschener Weg 40, D-45239 Essen, Germany ; 4 Department of Medical Oncology, West German Cancer Center; University of Duisburg-Essen, Hufelandstr, 55, D-45122 Essen, Germany ; 5 Division of Thoracic Oncology, Ruhrlandklinik, West German Lung Center, University of Duisburg-Essen, Tüschener Weg 40, D-45239 Essen, Germany ; 6 German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.3978/j.issn.2072-1439.2015.01.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387447PMC
March 2015

Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor.

PLoS One 2015 17;10(3):e0120531. Epub 2015 Mar 17.

Dept. of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Sarcoma Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120531PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364009PMC
February 2016

Experience with afatinib in patients with non-small cell lung cancer progressing after clinical benefit from gefitinib and erlotinib.

Oncologist 2014 Oct 17;19(10):1100-9. Epub 2014 Sep 17.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany; Division of Thoracic Oncology, Ruhrlandklinik, West German Lung Center, University Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany, Department of Medical Oncology, Klinik Löwenstein, Löwenstein, Germany; Department of Respiratory Medicine, Evangelische· Lungenklinik, Berlin, Germany; Department of Pneumology, Evangelisches Diakonissenkrankenhaus, Leipzig, Germany; Translational Lung Research Center Heidelberg, Heidelberg, Germany; Department of Pneumology and Thoracic Oncology, Klinik Schillerhoehe, Gerlingen, Germany; Department of Hematology and Medical Oncology, Zentralklinik, Bad Berka, Germany; Haemato-Oncology Hamburg, Hamburg, Germany; Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, Germany.

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http://dx.doi.org/10.1634/theoncologist.2014-0103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200993PMC
October 2014

Detection of disseminated tumor cells in bone marrow and circulating tumor cells in blood of patients with early-stage male breast cancer.

J Cancer Res Clin Oncol 2015 Jan 10;141(1):87-92. Epub 2014 Aug 10.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany,

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http://link.springer.com/content/pdf/10.1007/s00432-014-1784
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http://link.springer.com/10.1007/s00432-014-1784-2
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http://dx.doi.org/10.1007/s00432-014-1784-2DOI Listing
January 2015

Prognostic impact of Bcl-2 depends on tumor histology and expression of MALAT-1 lncRNA in non-small-cell lung cancer.

J Thorac Oncol 2014 Sep;9(9):1294-304

*Department of Medicine A, Hematology, Oncology and Pulmonology, University Hospital Muenster; †Institute of Biostatistics and Clinical Research, Westfaelische Wilhelms-Universitaet Muenster; ‡Gerhard-Domagk Institute of Pathology, University Hospital Muenster, Muenster; §Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen; ‖German Cancer Consortium (DKTK), Heidelberg; ¶Integrated Functional Genomics, Interdisciplinary Center for Clinical Research, University of Muenster, Muenster; #Chest Surgery, Klinikum St. Georg, Ostercappeln, Ostercappeln, Germany; and **Department of Medicine, Hematology and Oncology, University of Halle, Halle, Germany.

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http://dx.doi.org/10.1097/JTO.0000000000000243DOI Listing
September 2014

Assessment of folate receptor-α and epidermal growth factor receptor expression in pemetrexed-treated non-small-cell lung cancer patients.

Clin Lung Cancer 2014 Sep 3;15(5):320-30.e1-3. Epub 2014 Jun 3.

Division of Medical Oncology, Department of Medicine, University of Colorado Denver, Aurora, CO. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2014.05.002DOI Listing
September 2014

LUX-Lung 3: redundancy, toxicity or a major step forward? Afatinib as front-line therapy for patients with metastatic EGFR-mutated lung cancer.

Future Oncol 2014 Mar;10(4):533-40

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Hufelandstraße 55, 45122 Essen, Germany.

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http://dx.doi.org/10.2217/fon.14.9DOI Listing
March 2014

Ceritinib in ALK-rearranged non-small-cell lung cancer.

N Engl J Med 2014 Mar;370(13):1189-97

From Massachusetts General Hospital, Boston (A.T.S., J.A.E.); Seoul National University Hospital, Seoul, South Korea (D.-W.K.); Fox Chase Cancer Center, Philadelphia (R.M.); National Cancer Center and Genome Institute of Singapore, Singapore (D.S.W.T.); Vall d'Hebron University, Barcelona (E.F.); University of Washington, Seattle (L.Q.M.C.); University of Colorado, Denver (D.R.C.); University Hospital KU Leuven, Leuven, Belgium (J.V.); Huntsman Cancer Institute, Salt Lake City (S.S.); Istituto Europeo di Oncologia (T.D.P.) and Istituto di Ricovero e Cura a Carattere Scientifico Istituto Clinico Humanitas (A.S.) - both in Milan; Memorial Sloan-Kettering Cancer Center, New York (G.J.R.); Peter MacCallum Cancer Center, Melbourne, VIC, Australia (B.J.S.); Center for Integrated Oncology, University Hospital Cologne, Cologne (J.W.), Thoraxklinik, University of Heidelberg, Translational Lung Research Center Heidelberg, German Center for Lung Research (M.T.), and German Cancer Consortium (M.S.), Heidelberg, and University Duisburg-Essen, Essen (M.S.) - all in Germany; Princess Margaret Cancer Center, Toronto (G.L.); and Novartis Institutes for BioMedical Research, Cambridge, MA (Y.Y.L., M.G., A.L.B.).

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http://dx.doi.org/10.1056/NEJMoa1311107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079055PMC
March 2014

Targeted therapies in gastroesophageal cancer.

Eur J Cancer 2014 May 1;50(7):1247-58. Epub 2014 Feb 1.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.01.009DOI Listing
May 2014

Development of a highly sensitive and specific method for detection of circulating tumor cells harboring somatic mutations in non-small-cell lung cancer patients.

PLoS One 2014 21;9(1):e85350. Epub 2014 Jan 21.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany ; Division of Thoracic Oncology, Ruhrlandklinik, West German Lung Center, University Duisburg-Essen, Essen, Germany ; German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085350PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897440PMC
October 2014

A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.

J Biol Chem 2014 Feb 30;289(8):5208-16. Epub 2013 Dec 30.

From the Zentrum für Medizinische Biotechnologie, Universität Duisburg-Essen, 45117 Essen, Germany.

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http://dx.doi.org/10.1074/jbc.M113.487736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931077PMC
February 2014

Afatinib, erlotinib and gefitinib in the first-line therapy of EGFR mutation-positive lung adenocarcinoma: a review.

Onkologie 2013 19;36(9):510-8. Epub 2013 Aug 19.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Germany.

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http://dx.doi.org/10.1159/000354627DOI Listing
May 2014

Symptom control and quality of life in LUX-Lung 3: a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations.

J Clin Oncol 2013 Sep 1;31(27):3342-50. Epub 2013 Jul 1.

James Chih-Hsin Yang, National Taiwan University Hospital, Taipei, Taiwan; Vera Hirsh, McGill University, Montreal, Quebec, Canada; Martin Schuler, West German Cancer Center, University Duisburg-Essen, Essen; Juliane Lungershausen, Boehringer Ingelheim GmbH, Ingelheim, Germany; Nobuyuki Yamamoto, Shizuoka Cancer Center, Shizuoka, Japan; Kenneth J. O'Byrne, St James' Hospital, Dublin, Ireland; Tony S.K. Mok, State Key Laboratory of Southern China, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Hong Kong; Victoria Zazulina, Mehdi Shahidi, and Dan Massey, Boehringer Ingelheim Limited, Bracknell; Michael Palmer, Keele University, Keele, United Kingdom; and Lecia V. Sequist, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2012.46.1764DOI Listing
September 2013

Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.

J Clin Oncol 2013 Sep 1;31(27):3327-34. Epub 2013 Jul 1.

Lecia V. Sequist, Massachusetts General Hospital and Harvard Medical School, Boston, MA; James Chih-Hsin Yang, National Taiwan University Hospital; Chun-Ming Tsai, Taipei Veterans General Hospital, Taipei; Wu-Chou Su, National Cheng Kung University Hospital, Tainan, Taiwan; Nobuyuki Yamamoto, Shizuoka Cancer Center, Shizuoka; Terufumi Kato, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan; Kenneth O'Byrne, St James' Hospital, Dublin, Ireland; Vera Hirsh, McGill University, Montreal, Quebec, Canada; Tony Mok, Prince of Wales Hospital, Hong Kong, China; Sarayut Lucien Geater, Songklanagarind Hospital, Songkla, Thailand; Sergey Orlov, Pavlov State Medical University, St Petersburg; Vera Gorbunova, GU Russian Oncological Research Centre, Moscow, Russia; Michael Boyer, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; Jaafar Bennouna, Institut de Cancérologie de l'Ouest-site René Gauducheau, Nantes, France; Ki Hyeong Lee, Chungbuk National University Hospital, Cheongju, South Korea; Riyaz Shah, Maidstone and Tunbridge Wells National Health Service Trust, Maidstone Hospital, Maidstone; Dan Massey, Victoria Zazulina, and Mehdi Shahidi, Boehringer Ingelheim, Bracknell, United Kingdom; and Martin Schuler, West German Cancer Center, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1200/JCO.2012.44.2806DOI Listing
September 2013

Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers.

ACS Chem Biol 2013 Sep 5;8(9):1869-75. Epub 2013 Jul 5.

Chemical Genomics Centre of the Max-Planck-Society , Otto-Hahn-Strasse 15, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1021/cb4003464DOI Listing
September 2013

Clinical perspective of afatinib in non-small cell lung cancer.

Lung Cancer 2013 Aug 10;81(2):155-61. Epub 2013 May 10.

Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

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http://dx.doi.org/10.1016/j.lungcan.2013.02.021DOI Listing
August 2013