Publications by authors named "Martin R Wilkins"

100Publications

Hypoxia-induced pulmonary hypertension-Utilizing experiments of nature.

Br J Pharmacol 2021 Jan 28;178(1):121-131. Epub 2020 Aug 28.

National Heart and Lung Institute (NHLI), Imperial College London, Hammersmith Hospital, London, UK.

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January 2021

Editorial: Pulmonary Hypertension: Mechanisms and Management, History and Future.

Front Med (Lausanne) 2020 21;7:125. Epub 2020 Apr 21.

Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom.

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April 2020

The application of 'omics' to pulmonary arterial hypertension.

Br J Pharmacol 2021 Jan 28;178(1):108-120. Epub 2020 Apr 28.

National Heart and Lung Institute, Imperial College London, London, UK.

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January 2021

TORward a Molecular Convergence Point in Pulmonary Arterial Hypertension With mTOR.

JACC Basic Transl Sci 2018 Dec 31;3(6):763-765. Epub 2018 Dec 31.

Department of Medicine, Imperial College of London, London, United Kingdom.

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December 2018

CLIC4/Arf6 Pathway.

Circ Res 2019 01;124(1):52-65

From the Centre for Pharmacology and Therapeutics (V.B.A.-S., G.R., C.C.-N., A.S.M., M.R.W., L.Z., M.G., O.D., B.W.-S.), Department of Medicine, Imperial College London, United Kingdom.

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January 2019

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Authors:
Christopher J Rhodes Ken Batai Marta Bleda Matthias Haimel Laura Southgate Marine Germain Michael W Pauciulo Charaka Hadinnapola Jurjan Aman Barbara Girerd Amit Arora Jo Knight Ken B Hanscombe Jason H Karnes Marika Kaakinen Henning Gall Anna Ulrich Lars Harbaum Inês Cebola Jorge Ferrer Katie Lutz Emilia M Swietlik Ferhaan Ahmad Philippe Amouyel Stephen L Archer Rahul Argula Eric D Austin David Badesch Sahil Bakshi Christopher Barnett Raymond Benza Nitin Bhatt Harm J Bogaard Charles D Burger Murali Chakinala Colin Church John G Coghlan Robin Condliffe Paul A Corris Cesare Danesino Stéphanie Debette C Gregory Elliott Jean Elwing Melanie Eyries Terry Fortin Andre Franke Robert P Frantz Adaani Frost Joe G N Garcia Stefano Ghio Hossein-Ardeschir Ghofrani J Simon R Gibbs John Harley Hua He Nicholas S Hill Russel Hirsch Arjan C Houweling Luke S Howard Dunbar Ivy David G Kiely James Klinger Gabor Kovacs Tim Lahm Matthias Laudes Rajiv D Machado Robert V MacKenzie Ross Keith Marsolo Lisa J Martin Shahin Moledina David Montani Steven D Nathan Michael Newnham Andrea Olschewski Horst Olschewski Ronald J Oudiz Willem H Ouwehand Andrew J Peacock Joanna Pepke-Zaba Zia Rehman Ivan Robbins Dan M Roden Erika B Rosenzweig Ghulam Saydain Laura Scelsi Robert Schilz Werner Seeger Christian M Shaffer Robert W Simms Marc Simon Olivier Sitbon Jay Suntharalingam Haiyang Tang Alexander Y Tchourbanov Thenappan Thenappan Fernando Torres Mark R Toshner Carmen M Treacy Anton Vonk Noordegraaf Quinten Waisfisz Anna K Walsworth Robert E Walter John Wharton R James White Jeffrey Wilt Stephen J Wort Delphine Yung Allan Lawrie Marc Humbert Florent Soubrier David-Alexandre Trégouët Inga Prokopenko Richard Kittles Stefan Gräf William C Nichols Richard C Trembath Ankit A Desai Nicholas W Morrell Martin R Wilkins

Lancet Respir Med 2019 03 5;7(3):227-238. Epub 2018 Dec 5.

Department of Medicine, Imperial College London, London, UK. Electronic address:

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March 2019

Recent advances in pulmonary arterial hypertension.

F1000Res 2018 24;7. Epub 2018 Jul 24.

Department of Medicine, Imperial College London, London, UK.

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July 2018

Fractal Analysis of Right Ventricular Trabeculae in Pulmonary Hypertension.

Radiology 2018 08 5;288(2):386-395. Epub 2018 Jun 5.

From the MRC London Institute of Medical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Rd, London W12 0HS, England (T.J.W.D., M.Q., A.d.M., P.J.O., P.F.T., S.A.C., D.P.O.); National Heart and Lung Institute (T.J.W.D., J.S.R.G., S.A.C.), and Division of Experimental Medicine, Department of Medicine (G.M.J.W., J.W., M.R.W.), Imperial College London, London, England; National Heart Centre Singapore, Singapore, and Duke-NUS Graduate Medical School, Singapore (J.C., S.A.C.); and Department of Cardiology, National Pulmonary Hypertension Service, Imperial College Healthcare NHS Trust, London, England (L.S.G.E.H., J.S.R.G.).

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August 2018

New Therapeutic Approaches in Pulmonary Arterial Hypertension: The Pantheon Is Getting Crowded.

Circulation 2018 05;137(22):2390-2392

Department of Medicine, Imperial College London, UK (M.R.W.).

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May 2018

Apoptosis Signal-Regulating Kinase 1 Inhibition in Pulmonary Hypertension. Too Much to ASK?

Authors:
Martin R Wilkins

Am J Respir Crit Care Med 2018 02;197(3):286-288

1 Department of Medicine Imperial College London London, United Kingdom.

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February 2018

Machine Learning of Three-dimensional Right Ventricular Motion Enables Outcome Prediction in Pulmonary Hypertension: A Cardiac MR Imaging Study.

Radiology 2017 05 16;283(2):381-390. Epub 2017 Jan 16.

From the MRC Clinical Sciences Centre, Du Cane Rd, London W12 0NN, England (T.J.W.D., A.d.M., W.S., T.F., S.A.C., D.P.O.); Division of Experimental Medicine, Department of Medicine (T.J.W.D, T.F., G.M.J.W., J.W., C.J.R., M.R.W.), Department of Computing (W.S., D.R.), and National Heart and Lung Institute (J.S.R.G.), Imperial College London, London, England; National Heart Centre Singapore, Singapore and Duke-NUS Graduate Medical School, Singapore (S.A.C.); and Department of Cardiology, National Pulmonary Hypertension Service, Imperial College Healthcare NHS Trust, London, England (L.S.G.E.H., J.S.R.G.).

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May 2017

Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.

Circulation 2017 01 21;135(5):460-475. Epub 2016 Nov 21.

From the Department of Medicine, Imperial College London, Hammersmith Campus, United Kingdom (C.J.R., P.G., J.W., K.C.R.-A., G.W., M.R.W.); Department of Medicine, University of Cambridge School of Clinical Medicine, United Kingdom (C.H., M.B., M.H., M.R.T., S.G., N.W.M.); Cardiology Department, Royal Free Hospital, London, United Kingdom (G.C.); Institute of Cellular Medicine, Newcastle University and the Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom (P.A.C.); National Pulmonary Hypertension Service, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom (L.S.H., J.S.R.G.); National Heart and Lung Institute, Imperial College London, Hammersmith Campus, United Kingdom (L.S.H., J.S.R.G.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, United Kingdom (D.G.K.); Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, United Kingdom (D.G.K., A.L.); Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, United Kingdom (A.J.P.); Pulmonary Vascular Disease Unit, Papworth Hospital, Cambridge, United Kingdom (J.P.Z., M.R.T.); Pulmonary Hypertension Service, Royal Brompton Hospital, London, United Kingdom (S.J.W.); and Department of Haematology, University of Cambridge, United Kingdom (S.G.).

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January 2017

Neutrophil Extracellular Traps Promote Angiogenesis: Evidence From Vascular Pathology in Pulmonary Hypertension.

Arterioscler Thromb Vasc Biol 2016 10 28;36(10):2078-87. Epub 2016 Jul 28.

From the Department of Medicine, Centre for Pharmacology and Therapeutics (L.A., V.A.-S., L.D., A.J.A., M.R.W., B.W.-S.) and Centre for Haematology (T.M.K.), Experimental Medicine, Imperial College London, United Kingdom; and Pulmonary Vascular Diseases Unit, Papworth Hospital NHS Foundation Trust, Papworth Everard Cambridge, United Kingdom (J.P.-Z., M.S., C.H., M.T.).

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October 2016

Riociguat: Mode of Action and Clinical Development in Pulmonary Hypertension.

Chest 2017 02 2;151(2):468-480. Epub 2016 Jun 2.

Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI.

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February 2017

Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future.

Pharmacol Ther 2016 08 29;164:195-203. Epub 2016 Apr 29.

Department of Medicine, Imperial College London, W12 0NN, United Kingdom. Electronic address:

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August 2016

Use of responder threshold criteria to evaluate the response to treatment in the phase III CHEST-1 study.

J Heart Lung Transplant 2015 Mar 16;34(3):348-55. Epub 2015 Feb 16.

Clinic for Respiratory Medicine, Hannover Medical School, Hannover, Germany, and Member of the German Centre of Lung Research (DZL).

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March 2015

Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.

Circ Res 2015 May 12;116(10):1680-90. Epub 2015 Mar 12.

From the Centre for Pharmacology and Therapeutics, Department of Medicine (E.C., A.A., L.W., J.W., O.D., S.B., M.R.W., L.Z.) and Division of Brain Sciences, Department of Medicine (K.N.A.), Imperial College London, Hammersmith Hospital, London, United Kingdom; and Clinical Biochemistry, Imperial College Healthcare NHS Trust, London, United Kingdom (M.B.).

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May 2015

Pathophysiology and treatment of high-altitude pulmonary vascular disease.

Circulation 2015 Feb;131(6):582-90

From Experimental Medicine, Imperial College London, Hammersmith Hospital, United Kingdom (M.R.W., H.-A.G., L.Z.); Excellence Cluster Cardio-Pulmonary System, Universities of Giessen, Germany (M.R.W., H.-A.G., N.W., L.Z.); University of Giessen Marburg Lung Center, Justus-Liebig-University, Germany (M.R.W., H.-A.G., N.W., L.Z.); Kerckhoff Clinic, Bad Nauheim, Germany (H.-A.G.); Institute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan (A.A.).

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February 2015

Effects of tetrahydrobiopterin oral treatment in hypoxia-induced pulmonary hypertension in rat.

Pulm Circ 2014 Sep;4(3):462-70

Centre for Pharmacology and Therapeutics, Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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September 2014

Response to pulmonary arterial hypertension drug therapies in patients with pulmonary arterial hypertension and cardiovascular risk factors.

Pulm Circ 2014 Dec;4(4):669-78

National Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare National Health Service (NHS) Trust, London, United Kingdom ; National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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December 2014

α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.

Circ Cardiovasc Genet 2014 Dec 4;7(6):920-9. Epub 2014 Nov 4.

From the Department of Medicine, Imperial College London, London, United Kingdom (M.R.W., J.W., C.J.R., S.R.); National Academy of Sciences of Kyrgyz Republic, Bishkek, Kyrgyz Republic (A.A.A.); Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, London, United Kingdom (J.V., T.J.A.); NIHR BRC Clinical Genome Informatics Facility, Imperial College London, London, United Kingdom (D.K., S.G.B., M.M.); Cardiology Research, Bayer Pharma AG, Wuppertal, Germany (S.G., J.-P.S.); Department of Pharmacology, The School of Pharmacy, Martin-Luther-University, Halle, Germany (J.-P.S.); Department of Pulmonary Pharmacotherapy, University of Giessen and Marburg Lung Center, Giessen, Germany (B.K.); Department of Medicine, University of Cambridge, Cambridge, United Kingdom (N.W.M.); Department of Pharmacology, Toxicology, and Clinical Pharmacy, University of Braunschweig-Center of Pharmaceutical Engineering, Braunschweig, Germany (I.N., S.B.); and Department of Chemistry, The Scripps Research Institute, La Jolla, CA (N.B.S., M.A.M.).

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December 2014

Pulmonary hypertension: the value of experimental medicine in new drug development.

Authors:
Martin R Wilkins

Pulm Circ 2014 Jun;4(2):149-50

Experimental Medicine, Imperial College, London, United Kingdom.

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June 2014

miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.

Biochem J 2014 Aug;462(1):103-12

*Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, Du Cane Road, London W12 0NN, U.K.

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August 2014

Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.

Circulation 2014 Apr 6;129(17):1770-80. Epub 2014 Feb 6.

Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, UK (B.W.-S., V.B.A.-S., K.H.L., H.T., R.J.E., C.J.R., J.W., L.Z., M.R.W.); Cardiovascular Pulmonary Research Group, University of Colorado Denver Health Sciences Center, Aurora (D.C.I., C.L., Z.L., K.R.S.); Division of Nephrology, Department of Internal Medicine, St. Louis University, St. Louis MO (J.C.E.); Laboratory of Cancer Biology & Genetics, Centre for Cancer Research, Bethesda, MD (S.H.Y.); and National Pulmonary Hypertension Service and National Heart & Lung Institute, Imperial College Healthcare NHS Trust, London, UK (L.S.H., J.S.R.G.).

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April 2014

Definitions and diagnosis of pulmonary hypertension.

J Am Coll Cardiol 2013 Dec;62(25 Suppl):D42-50

Division of Pulmonary Sciences and Critical Care Medicine and Cardiology, University of Colorado, Denver, Colorado.

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December 2013

Regulating cell-based regenerative medicine: the challenges ahead.

Regen Med 2014 Jan;9(1):81-7

UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, UK.

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January 2014

Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension.

Rheumatology (Oxford) 2014 Feb 22;53(2):285-92. Epub 2013 Oct 22.

Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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February 2014

Pulmonary hypertension: old targets revisited (statins, PPARs, beta-blockers).

Handb Exp Pharmacol 2013 ;218:531-48

Imperial College London, Hammersmith Hospital, London, W12 ONN, UK.

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July 2014

Pulmonary hypertension: biomarkers.

Handb Exp Pharmacol 2013 ;218:77-103

Imperial College London, Hammersmith Hospital, London, W12 0NN, UK.

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July 2014

Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.

Circulation 2013 Sep 30;128(11):1214-24. Epub 2013 Jul 30.

Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, Hammersmith Hospital, London, UK (L.Z., A.A., L.W., O.D., J.C., E.C., H.J., G.B., M.R.W.); Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (W.F.); Max-Planck Institute for Heart and Lung Research and University of Giessen and Marburg Lung Center, German Center for Lung Research, Bad Nauheim, Germany (S.D., S.S.P.); Comprehensive Cancer Imaging Centre, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, UK (G.T., Q.N., E.O.A.); Department of Histopathology, Imperial College London, UK (M.A.E.-B.); National Heart and Lung Institute, Imperial College London, and National Pulmonary Hypertension Service, Department of Cardiology, Hammersmith Hospital, London, UK (L.S.H., J.S.R.G.); Biological Imaging Centre, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK (W.G.); and Center for Diagnosis and Management of Pulmonary Vascular Diseases, Department of Cardiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.H.).

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September 2013

Update in pulmonary vascular diseases 2012.

Am J Respir Crit Care Med 2013 Jul;188(1):23-8

Department of Medicine, Imperial College London, UK.

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July 2013

Advancing clinical trial design in pulmonary hypertension.

Pulm Circ 2013 Jan;3(1):217-25

Aptiv Solutions, Innovation Centre, Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2FX, UK.

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January 2013

Developing treatments for pulmonary arterial hypertension.

Authors:
Martin R Wilkins

Pulm Circ 2013 Jan;3(1):156-9

Imperial College London, Hammersmith Campus, London, UK.

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January 2013

A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers.

PLoS One 2012 20;7(12):e51395. Epub 2012 Dec 20.

The National Institute for Health Research-Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, United Kingdom.

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June 2013

Clinical, ethical and financial implications of incidental imaging findings: experience from a phase I trial in healthy elderly volunteers.

PLoS One 2012 16;7(11):e49814. Epub 2012 Nov 16.

The National Institute for Health Research (NIHR)-Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom.

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June 2013

Comparison of 18F-FDG uptake by right ventricular myocardium in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease.

Pulm Circ 2012 Jul;2(3):365-72

Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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July 2012

Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.

Circulation 2012 Jul 18;126(4):455-67. Epub 2012 Jun 18.

Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, Du Cane Rd, London W12 ONN, UK.

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July 2012

Atorvastatin in pulmonary arterial hypertension (APATH) study.

Eur Respir J 2012 Jul 23;40(1):67-74. Epub 2012 Feb 23.

Pulmonary Vascular Diseases State Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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July 2012

Mechanisms of disease: pulmonary arterial hypertension.

Nat Rev Cardiol 2011 Jun 21;8(8):443-55. Epub 2011 Jun 21.

Max-Planck-Institute for Heart and Lung Research, Parkstrasse 1, 61231 Bad Nauheim, Germany. ralph.schermuly@ innere.med. uni-giessen.de

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June 2011

Differences in ventilatory inefficiency between pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.

Chest 2011 Nov 28;140(5):1284-1291. Epub 2011 Apr 28.

National Pulmonary Hypertension Service (London), Hammersmith Hospital, Imperial College Healthcare NHS Trust, National Heart and Lung Institute, Imperial College London, London, England. Electronic address:

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November 2011

Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension.

Exp Lung Res 2011 Feb 15;37(1):26-34. Epub 2010 Nov 15.

Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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February 2011

Proteomic analysis of lung tissues from patients with pulmonary arterial hypertension.

Circulation 2010 Nov 1;122(20):2058-67. Epub 2010 Nov 1.

Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, UK.

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November 2010

Endothelial progenitor cells in pulmonary arterial hypertension.

Trends Cardiovasc Med 2010 Jan;20(1):22-9

Adult Congenital Heart Center and Center for Pulmonary Hypertension, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College of Science and Medicine, SW3 6NP London, UK.

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January 2010

Simvastatin as a treatment for pulmonary hypertension trial.

Am J Respir Crit Care Med 2010 May;181(10):1106-13

Experimental Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, United Kingdom.

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May 2010

Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.

J Cereb Blood Flow Metab 2010 Sep 28;30(9):1608-18. Epub 2010 Apr 28.

Department of Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London, UK.

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September 2010

The effects of sitaxentan on sildenafil pharmacokinetics and pharmacodynamics in healthy subjects.

Br J Clin Pharmacol 2010 Jan;69(1):23-6

Encysive Pharmaceuticals, Department of Medical Information, Houston, TX, USA.

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January 2010

[Future treatment of pulmonary arterial hypertension].

Zhonghua Yi Xue Za Zhi 2009 Aug;89(30):2097-8

Department of Experimental Medicine and Toxicology, Imperial College London, UK.

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August 2009

Therapeutic targets in pulmonary arterial hypertension.

Pharmacol Ther 2009 Jan 28;121(1):69-88. Epub 2008 Oct 28.

Department of Experimental Medicine and Toxicology, Imperial College London, and National Pulmonary Hypertension Service, Hammersmith Hospital, United Kingdom.

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January 2009

Emerging concepts and translational priorities in pulmonary arterial hypertension.

Circulation 2008 Sep;118(14):1486-95

Department of Medicine, Cardiology Division, Pulmonary Hypertension Program, University of Alberta, Edmonton, Alberta, Canada.

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September 2008

Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension.

Am J Respir Crit Care Med 2008 Oct 8;178(8):861-9. Epub 2008 Aug 8.

Centre for Clinical Pharmacology, University College London, The Rayne Building, 5 University Street, London WC1E 5JJ, UK.

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October 2008

Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension.

Am J Respir Crit Care Med 2008 Sep 19;178(5):534-41. Epub 2008 Jun 19.

Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.

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September 2008

Genome-wide scan for premature hypertension supports linkage to chromosome 2 in a large Kyrgyz family.

Hypertension 2006 Nov 25;48(5):908-13. Epub 2006 Sep 25.

Department of Experimental Medicine and Toxicology, Imperial College London, London, United Kingdom.

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November 2006