Martin R Sprick

Martin R Sprick

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Martin R Sprick

Martin R Sprick

Publications by authors named "Martin R Sprick"

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Still a hopeless case for personalized oncology? Pancreatic cancer revisited.

Oncoscience 2019 Jan 22;6(1-2):285-286. Epub 2018 Aug 22.

Member of the German Cancer Consortium (DKTK), Institute of Pathology, Technical University Munich, 81675 Munich, Germany.

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http://dx.doi.org/10.18632/oncoscience.464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382256PMC
January 2019

Survival of pancreatic cancer cells lacking KRAS function.

Nat Commun 2017 10 23;8(1):1090. Epub 2017 Oct 23.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-017-00942-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653666PMC
October 2017

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival.

Cell Rep 2017 04;19(4):785-797

Section of Molecular Dermatology, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; Department of Dermatology and Allergology, Medical Faculty of the RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.celrep.2017.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413585PMC
April 2017

High prevalence of incidental and symptomatic venous thromboembolic events in patients with advanced pancreatic cancer under palliative chemotherapy: A retrospective cohort study.

Pancreatology 2017 Jul - Aug;17(4):629-634. Epub 2017 Apr 22.

National Center for Tumor Diseases (NCT), Department of Medical Oncology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.pan.2017.04.012DOI Listing
April 2017

Identification and Validation of Novel Subtype-Specific Protein Biomarkers in Pancreatic Ductal Adenocarcinoma.

Pancreas 2017 03;46(3):311-322

From the *German Cancer Research Center (DKFZ), Heidelberg, Germany; †Princess Margaret Cancer Center, Toronto, Ontario, Canada; ‡Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany; and §Novartis Pharma AG, Basel, Switzerland.

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http://dx.doi.org/10.1097/MPA.0000000000000743DOI Listing
March 2017

Martin Leverkus, 1965-2016.

Cell Death Discov 2017 23;3:16093. Epub 2017 Jan 23.

DKFZ , Heidelberg, Germany.

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http://dx.doi.org/10.1038/cddiscovery.2016.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253417PMC
January 2017

Impact of apoptotic circulating tumor cells (aCTC) in metastatic breast cancer.

Breast Cancer Res Treat 2016 11 1;160(2):277-290. Epub 2016 Oct 1.

Department of Obstetrics and Gynecology, University of Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s10549-016-3997-3DOI Listing
November 2016

Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma.

Oncoimmunology 2016 7;5(12):e1240859. Epub 2016 Oct 7.

Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center, Heidelberg, Germany; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1080/2162402X.2016.1240859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215250PMC
October 2016

Protein profile of basal prostate epithelial progenitor cells--stage-specific embryonal antigen 4 expressing cells have enhanced regenerative potential in vivo.

J Cell Mol Med 2016 Apr 5;20(4):721-30. Epub 2016 Feb 5.

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.

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http://dx.doi.org/10.1111/jcmm.12785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125324PMC
April 2016

The influence of prostatic anatomy and neurotrophins on basal prostate epithelial progenitor cells.

Prostate 2016 Jan 7;76(1):114-21. Epub 2015 Oct 7.

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.

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http://dx.doi.org/10.1002/pros.23109DOI Listing
January 2016

Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin.

Stem Cell Reports 2015 Mar 19;4(3):503-18. Epub 2015 Feb 19.

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375832PMC
March 2015

Bortezomib sensitizes primary meningioma cells to TRAIL-induced apoptosis by enhancing formation of the death-inducing signaling complex.

J Neuropathol Exp Neurol 2014 Nov;73(11):1034-46

From the Department of Gastroenterology, Heidelberg University Hospital (RK, TMG); German Cancer Research Center, Division of Signaling and Functional Genomics (CB); Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg University (CB); and HI-STEM gGmbH/German Cancer Research Center Heidelberg (MRS), Heidelberg, Germany; National Cancer Institute Regina Elena (TLH), Rome, Italy; Translational Centre for Regenerative Medicine Leipzig and Faculty of Medicine (HH, L-XX) and Departments of Neurosurgery (L-XX, WK, JM) and Neuropathology (WCM, MB), University of Leipzig, Leipzig, Germany; Ames Laboratory-US DOE, and Department of Physics and Astronomy, Iowa State University, Ames, Iowa (TK); Departments of Cardiology (MK) and Pathology (PS), University Hospital Heidelberg, Heidelberg, Germany; and Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, London, United Kingdom (HW).

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http://dx.doi.org/10.1097/NEN.0000000000000129DOI Listing
November 2014

Development and characteristics of preclinical experimental models for the research of rare neuroendocrine bladder cancer.

J Urol 2013 Dec 29;190(6):2263-70. Epub 2013 Jun 29.

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), German Cancer Research Center, Heidelberg, Germany; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2013.06.053DOI Listing
December 2013

Label retaining cells in cancer--the dormant root of evil?

Cancer Lett 2013 Nov 23;341(1):73-9. Epub 2013 Apr 23.

HI-STEM gGmbH/DKFZ Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.canlet.2013.04.019DOI Listing
November 2013

Potential role of soluble TRAIL in epithelial injury in children with severe RSV infection.

Am J Respir Cell Mol Biol 2010 Jun 27;42(6):697-705. Epub 2009 Jul 27.

Emma Children's Hospital, Academic Medical Center, Pediatric Intensive Care Unit, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2009-0100OC
Publisher Site
http://dx.doi.org/10.1165/rcmb.2009-0100OCDOI Listing
June 2010

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.

Nat Cell Biol 2010 May 25;12(5):468-76. Epub 2010 Apr 25.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncb2048DOI Listing
May 2010

The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation.

Cancer Res 2010 Jan 12;70(2):719-29. Epub 2010 Jan 12.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, and Department of Pathology, Academic Medical Center, 1105AZ Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1820DOI Listing
January 2010

One renegade cancer stem cell?

Cell Cycle 2009 Mar 26;8(6):803-8. Epub 2009 Mar 26.

Laboratory for Experimental Oncology and Radiobiology, LEXOR, CEMM, AMC UvA, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/cc.8.6.7935DOI Listing
March 2009

NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.

J Invest Dermatol 2008 May 8;128(5):1134-47. Epub 2007 Nov 8.

Laboratory for Experimental Dermatology, Department of Dermatology and Venerology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.

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http://dx.doi.org/10.1038/sj.jid.5701141DOI Listing
May 2008

TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window.

Hepatology 2007 Mar;45(3):649-58

Division of Apoptosis Regulation, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/hep.21555DOI Listing
March 2007

The interplay between the Bcl-2 family and death receptor-mediated apoptosis.

Biochim Biophys Acta 2004 Mar;1644(2-3):125-32

Department of Apoptosis Regulation, DKFZ Heidelberg, D040, Tumour Immunology Program, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2003.11.002DOI Listing
March 2004

TRAIL-induced apoptosis and gene induction in HaCaT keratinocytes: differential contribution of TRAIL receptors 1 and 2.

J Invest Dermatol 2003 Jul;121(1):149-55

University of Würzburg Medical School, Department of Dermatology, Würzburg, Germany.

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http://dx.doi.org/10.1046/j.1523-1747.2003.12332.xDOI Listing
July 2003

TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus.

J Immunol 2003 Feb;170(4):1814-21

Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.4049/jimmunol.170.4.1814DOI Listing
February 2003