Publications by authors named "Martin Picard"

100Publications

Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood.

Brain Behav Immun Health 2020 May 6;5. Epub 2020 May 6.

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, United States.

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http://dx.doi.org/10.1016/j.bbih.2020.100080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561023PMC
May 2020

The biology of human hair greying.

Biol Rev Camb Philos Soc 2020 Sep 23. Epub 2020 Sep 23.

Dr. Philip Frost Department for Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida, 33136, U.S.A.

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http://dx.doi.org/10.1111/brv.12648DOI Listing
September 2020

The social nature of mitochondria: Implications for human health.

Neurosci Biobehav Rev 2020 Jul 8. Epub 2020 Jul 8.

Laboratory of Behavioral Genetics, Brain Mind Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland.

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http://dx.doi.org/10.1016/j.neubiorev.2020.04.017DOI Listing
July 2020

Mitochondrial Psychobiology: Foundations and Applications.

Curr Opin Behav Sci 2019 Aug 14;28:142-151. Epub 2019 Jun 14.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

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http://dx.doi.org/10.1016/j.cobeha.2019.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339630PMC
August 2019

Circadian regulation of mitochondrial uncoupling and lifespan.

Nat Commun 2020 04 21;11(1):1927. Epub 2020 Apr 21.

Department of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.

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http://dx.doi.org/10.1038/s41467-020-15617-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174288PMC
April 2020

Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts.

Epigenetics 2019 10 12;14(10):961-976. Epub 2019 Jun 12.

a Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center , New York , NY , USA.

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http://dx.doi.org/10.1080/15592294.2019.1626651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691995PMC
October 2019

Accelerating research on biological aging and mental health: Current challenges and future directions.

Psychoneuroendocrinology 2019 08 5;106:293-311. Epub 2019 Apr 5.

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Medical Center, New York, NY, USA; Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Medical Center, New York, NY, USA; Columbia Aging Center, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589133PMC
August 2019

Predictors of ccf-mtDNA reactivity to acute psychological stress identified using machine learning classifiers: A proof-of-concept.

Psychoneuroendocrinology 2019 09 7;107:82-92. Epub 2019 May 7.

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, 10032, USA; Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York, NY, 10032, USA; Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637411PMC
September 2019

Acute psychological stress increases serum circulating cell-free mitochondrial DNA.

Psychoneuroendocrinology 2019 08 28;106:268-276. Epub 2019 Mar 28.

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, 10032, USA; New York State Psychiatric Institute, New York, NY, 10032, USA; Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York, NY, 10032, USA; Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, 10032, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064530183121
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http://dx.doi.org/10.1016/j.psyneuen.2019.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589121PMC
August 2019

Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network.

Cell Rep 2019 01 15;26(4):996-1009.e4. Epub 2019 Jan 15.

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA; Department of Neurology and Columbia Translational Neuroscience Initiative, H. Houston Merritt Center, Columbia University Irving Medical Center, New York, NY, USA; Columbia University Aging Center, Columbia University, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193001
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http://dx.doi.org/10.1016/j.celrep.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513570PMC
January 2019

LC-MS/MS-based quantification of efflux transporter proteins at the BBB.

J Pharm Biomed Anal 2019 Feb 8;164:496-508. Epub 2018 Nov 8.

Inserm, UMR-S 1144, Response Variability to Psychotropics, Paris, France; Université Paris Descartes, Paris, France; Université Paris Diderot, Paris, France; UF Hormonologie, Hôpital Cochin, AP HP, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183071
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http://dx.doi.org/10.1016/j.jpba.2018.11.013DOI Listing
February 2019

Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy.

Cell Metab 2019 01 30;29(1):78-90.e5. Epub 2018 Aug 30.

Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia and University of Pennsylvania, Colket Translational Research Building, Room 6060, 3501 Civic Center Boulevard, Philadelphia, PA 19104-4302, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717513PMC
January 2019

Multilevel heterogeneity of mitochondrial respiratory chain deficiency.

J Pathol 2018 Nov 25;246(3):261-265. Epub 2018 Sep 25.

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1002/path.5146DOI Listing
November 2018

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses.

Nat Cell Biol 2018 07 27;20(7):755-765. Epub 2018 Jun 27.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.nature.com/articles/s41556-018-0133-0
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http://dx.doi.org/10.1038/s41556-018-0133-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716149PMC
July 2018

Protective role of Parkin in skeletal muscle contractile and mitochondrial function.

J Physiol 2018 07 30;596(13):2565-2579. Epub 2018 May 30.

Departments of Critical Care and Medicine, McGill University Health Centre and Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1113/JP275604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023825PMC
July 2018

Reply.

Environ Mol Mutagen 2019 06 14;60(5):465. Epub 2018 Mar 14.

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Medical Center, New York, NY, 10032.

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http://dx.doi.org/10.1002/em.22181DOI Listing
June 2019

A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress.

Biol Psychiatry 2018 07 3;84(1):9-17. Epub 2018 Feb 3.

Department of Psychiatry, University of California-San Francisco, San Francisco, California.

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http://dx.doi.org/10.1016/j.biopsych.2018.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014908PMC
July 2018

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder.

Neuropsychopharmacology 2018 06 30;43(7):1557-1564. Epub 2018 Jan 30.

Department of OB/GYN and Reproductive Sciences, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41386-017-0001-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983469PMC
June 2018

Do statins, ACE inhibitors or sartans improve outcome in primary glioblastoma?

J Neurooncol 2018 May 8;138(1):163-171. Epub 2018 Feb 8.

Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.

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http://link.springer.com/10.1007/s11060-018-2786-8
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http://dx.doi.org/10.1007/s11060-018-2786-8DOI Listing
May 2018

Psychological Stress and Mitochondria: A Systematic Review.

Psychosom Med 2018 Feb/Mar;80(2):141-153

From the Department of Psychiatry, Division of Behavioral Medicine (Picard), Department of Neurology, The H. Houston Merritt Center, Columbia Translational Neuroscience Initiative (Picard), and Columbia Aging Center (Picard), Columbia University; and Laboratory for Neuroendocrinology (McEwen), The Rockefeller University, New York, New York.

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http://Insights.ovid.com/crossref?an=00006842-201802000-0000
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http://dx.doi.org/10.1097/PSY.0000000000000545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901654PMC
March 2019

Psychological Stress and Mitochondria: A Conceptual Framework.

Psychosom Med 2018 Feb/Mar;80(2):126-140

From the Department of Psychiatry, Division of Behavioral Medicine (Picard), Department of Neurology, The H. Houston Merritt Center, Columbia Translational Neuroscience Initiative (Picard), and Columbia Aging Center (Picard), Columbia University; and Laboratory for Neuroendocrinology (McEwen), The Rockefeller University, New York, New York.

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http://dx.doi.org/10.1097/PSY.0000000000000544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901651PMC
March 2019

An energetic view of stress: Focus on mitochondria.

Front Neuroendocrinol 2018 04 12;49:72-85. Epub 2018 Jan 12.

Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, EPFL, 1015 Lausanne, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S00913022183000
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http://dx.doi.org/10.1016/j.yfrne.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964020PMC
April 2018

Mitochondrial DNA, nuclear context, and the risk for carcinogenesis.

Environ Mol Mutagen 2019 06 14;60(5):455-462. Epub 2018 Jan 14.

Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, Ontario, M5G1X8, Canada.

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http://dx.doi.org/10.1002/em.22169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045969PMC
June 2019

Reconstitution of the activity of RND efflux pumps: a "bottom-up" approach.

Res Microbiol 2018 Sep - Oct;169(7-8):442-449. Epub 2017 Dec 5.

Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, CNRS UMR 7099, Institut de Biologie Physico-Chimique (IBPC), Université Paris Diderot, Sorbonne Paris Cité, PSL Research University, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.resmic.2017.11.004DOI Listing
November 2018

Biochemical Reconstitution and Characterization of Multicomponent Drug Efflux Transporters.

Methods Mol Biol 2018 ;1700:113-145

Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA.

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http://dx.doi.org/10.1007/978-1-4939-7454-2_8DOI Listing
July 2018

Evidence Suggesting Absence of Mitochondrial DNA Methylation.

Front Genet 2017 1;8:166. Epub 2017 Nov 1.

Section of Integrative Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fgene.2017.00166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671948PMC
November 2017

Independent impacts of aging on mitochondrial DNA quantity and quality in humans.

BMC Genomics 2017 Nov 21;18(1):890. Epub 2017 Nov 21.

Division of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA.

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http://dx.doi.org/10.1186/s12864-017-4287-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697406PMC
November 2017

Associations Between Cellular Aging Markers and Metabolic Syndrome: Findings From the CARDIA Study.

J Clin Endocrinol Metab 2018 01;103(1):148-157

Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, California.

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http://dx.doi.org/10.1210/jc.2017-01625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761498PMC
January 2018

Mitochondrial Nanotunnels.

Trends Cell Biol 2017 11 19;27(11):787-799. Epub 2017 Sep 19.

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Department of Neurology, The Merritt Center and Columbia Translational Neuroscience Initiative, Columbia University Medical Center, New York, NY, USA; Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2017.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749270PMC
November 2017

Reconstitution of Membrane Proteins in Liposomes.

Methods Mol Biol 2017 ;1635:259-282

Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, UMR 7099, Institut de Biologie Physico-Chimique, FRC 550, Centre National de la Recherche Scientifique, Université Paris 7, 13, rue Pierre-et-Marie-Curie, 75005, Paris, France.

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http://dx.doi.org/10.1007/978-1-4939-7151-0_14DOI Listing
April 2018

Mitochondrial DNA 3243A>G heteroplasmy is associated with changes in cytoskeletal protein expression and cell mechanics.

J R Soc Interface 2017 06;14(131)

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1098/rsif.2017.0071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493791PMC
June 2017

Mitochondrial Nexus to Allostatic Load Biomarkers.

Psychosom Med 2017 01;79(1):114-117

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Medical Center, New York, NY Department of Neurology and the Columbia Translational Neuroscience Initiative, H Houston Merritt Center, Columbia University Medical Center, New York, NY. E-mail: Department of Psychiatry, Division of Behavioral Medicine, Columbia University Medical Center, New York, NY Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY.

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http://dx.doi.org/10.1097/PSY.0000000000000414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901647PMC
January 2017

Genetic Evidence for Elevated Pathogenicity of Mitochondrial DNA Heteroplasmy in Autism Spectrum Disorder.

PLoS Genet 2016 Oct 28;12(10):e1006391. Epub 2016 Oct 28.

Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1006391
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http://dx.doi.org/10.1371/journal.pgen.1006391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085253PMC
October 2016

The rise of mitochondria in medicine.

Mitochondrion 2016 09 14;30:105-16. Epub 2016 Jul 14.

Faculty of Pharmacy, Université de Montreal, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.mito.2016.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023480PMC
September 2016

'Multimorbidity' as the manifestation of network disturbances.

J Eval Clin Pract 2017 Feb 15;23(1):199-208. Epub 2016 Jul 15.

Division of Behavioral Medicine, Department of Psychiatry, Department of Neurology and CTNI, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1111/jep.12587DOI Listing
February 2017

Expanding Our Understanding of mtDNA Deletions.

Cell Metab 2016 07;24(1):3-4

Wellcome Trust Centre for Mitochondrial Research and Newcastle Centre for Ageing and Vitality, Institute of Neurosciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.06.024DOI Listing
July 2016

Disentangling (Epi)Genetic and Environmental Contributions to the Mitochondrial 3243A>G Mutation Phenotype: Phenotypic Destiny in Mitochondrial Disease?

JAMA Neurol 2016 08;73(8):923-5

H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2016.1676DOI Listing
August 2016

Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis.

Nucleic Acids Res 2016 06 30;44(11):5313-29. Epub 2016 Apr 30.

Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK Newcastle University Centre for Ageing and Vitality, Institute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK

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http://dx.doi.org/10.1093/nar/gkw382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914118PMC
June 2016

The ageing neuromuscular system and sarcopenia: a mitochondrial perspective.

J Physiol 2016 08 7;594(16):4499-512. Epub 2016 May 7.

Newcastle University Centre for Ageing and Vitality, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1113/JP271212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983621PMC
August 2016

Tripartite assembly of RND multidrug efflux pumps.

Nat Commun 2016 Feb 12;7:10731. Epub 2016 Feb 12.

Université de Bordeaux, CBMN UMR 5248, Bordeaux INP, IECB, Pessac F-33600, France.

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http://dx.doi.org/10.1038/ncomms10731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754349PMC
February 2016

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress.

Proc Natl Acad Sci U S A 2015 Dec 16;112(48):E6614-23. Epub 2015 Nov 16.

Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1515733112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672794PMC
December 2015

Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons.

Ann Neurol 2016 Mar 28;79(3):366-78. Epub 2016 Jan 28.

Wellcome Trust Centre for Mitochondrial Research and Medical Research Council/Biotechnology and Biological Sciences Research Council Centre for Ageing and Vitality, Institute of Neurosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/ana.24571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819690PMC
March 2016

New OprM structure highlighting the nature of the N-terminal anchor.

Front Microbiol 2015 1;6:667. Epub 2015 Jul 1.

Laboratoire de Cristallographie et RMN Biologiques, CNRS UMR 8015, Faculté de Pharmacie, Université Paris Descartes Paris, France.

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http://dx.doi.org/10.3389/fmicb.2015.00667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486845PMC
July 2015

Mitochondrial synapses: intracellular communication and signal integration.

Authors:
Martin Picard

Trends Neurosci 2015 Aug 15;38(8):468-74. Epub 2015 Jul 15.

Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia and the University of Pennsylvania, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2015.06.001DOI Listing
August 2015

Mitochondrial DNA copy number is reduced in male combat veterans with PTSD.

Prog Neuropsychopharmacol Biol Psychiatry 2016 Jan 26;64:10-7. Epub 2015 Jun 26.

Department of OB/GYN and Reproductive Science, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.pnpbp.2015.06.012DOI Listing
January 2016

Catch me if you can: a biotinylated proteoliposome affinity assay for the investigation of assembly of the MexA-MexB-OprM efflux pump from Pseudomonas aeruginosa.

Front Microbiol 2015 2;6:541. Epub 2015 Jun 2.

Laboratoire de Cristallographie et RMN Biologiques, Faculté de Pharmacie de Paris, UMR 8015 CNRS - Université Paris 089 Descartes , Paris, France.

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http://dx.doi.org/10.3389/fmicb.2015.00541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451422PMC
June 2015

The trajectory of life. Decreasing physiological network complexity through changing fractal patterns.

Front Physiol 2015 2;6:169. Epub 2015 Jun 2.

Thoracic Surgery and Critical Care Medicine, University of Ottawa and Associate Scientist, Ottawa Hospital Research Institute Ottawa, ON, Canada.

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http://dx.doi.org/10.3389/fphys.2015.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451341PMC
June 2015

In vitro transport activity of the fully assembled MexAB-OprM efflux pump from Pseudomonas aeruginosa.

Nat Commun 2015 Apr 22;6:6890. Epub 2015 Apr 22.

Laboratoire de Cristallographie et RMN Biologiques, UMR 8015, CNRS, Université Paris Descartes, Faculté de Pharmacie de Paris, 4 Avenue de l'Observatoire, 75006 Paris, France.

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http://dx.doi.org/10.1038/ncomms7890DOI Listing
April 2015

Relationship between Autophagy and Ventilator-induced Diaphragmatic Dysfunction.

Anesthesiology 2015 Jun;122(6):1349-61

From the Meakins Christie Laboratories and Respiratory Division, McGill University Health Centre Research Institute, Montreal, Quebec, Canada (I.A., B.J., F.L., T.L., C.L., C.G., S.H., B.J.P.); Department of Critical Care Medicine and Anesthesiology, Saint Eloi Teaching Hospital, Montpellier, France, and Centre National de la Recherche Scientifique (CNRS 9214), Institut National de la Santé et de la Recherche Médicale (INSERM U-1046), Montpellier University, Montpellier, France (B.J.); Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania (M.P.); and Department of Critical Care, McGill University Health Centre, Montreal, Quebec, Canada (S.H.).

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http://dx.doi.org/10.1097/ALN.0000000000000656DOI Listing
June 2015

Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm.

J Appl Physiol (1985) 2015 May 12;118(9):1161-71. Epub 2015 Mar 12.

Meakins-Christie Laboratories, McGill University Health Centre Research Institute, Montreal, Quebec, Canada; Critical Care and Respiratory Divisions, McGill University Health Centre, Montreal, Quebec, Canada;

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http://dx.doi.org/10.1152/japplphysiol.00873.2014DOI Listing
May 2015

Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study.

Neuro Oncol 2015 May 11;17(5):708-17. Epub 2015 Mar 11.

University of Alabama at Birmingham, Birmingham, Alabama (L.B.N.); Baylor University Medical Center, Dallas, Texas (K.L.F.); Henry Ford Hospital, Detroit, Michigan (T.M.); Clinic for Neurosurgery, Clinical Center of Serbia, Medical Faculty University of Belgrade, Belgrade, Serbia (D.G.); Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Radiotherapy and Chemotherapy Clinic, Gliwice, Poland (R.T.); Samsung Medical Center, Seoul, South Korea (D.H.N.); Centrum Onkologii Ziemi Lubelskiej, Lublin, Poland (M.M.); St. Luke's Brain Tumor Center, St. Luke's Hospital, Kansas City, Missouri (M.S.); Barrow Neurological Institute, Phoenix, Arizona (L.A.); Medical Oncology Unit 1, IOV, IRCCS, Padova, Italy (V.Z.); Policlinico di Modena, Modena, Italy (R.D.); Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (J.R.P.); Merck KGaA, Darmstadt, Germany (C.H., M.P.); Department of Clinical Neurosciences, University Hospital Lausanne, Lausanne, Switzerland (M.E.H.); Institute of Pathology, University Hospital Lausanne, Lausanne, Switzerland (B.L.); Dana-Farber Cancer Institute, Boston, Massachusetts (D.A.R.).

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http://dx.doi.org/10.1093/neuonc/nou356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482861PMC
May 2015

Trans-mitochondrial coordination of cristae at regulated membrane junctions.

Nat Commun 2015 Feb 17;6:6259. Epub 2015 Feb 17.

Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ncomms7259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332397PMC
February 2015

Focus on the Outer Membrane Factor OprM, the Forgotten Player from Efflux Pumps Assemblies.

Antibiotics (Basel) 2015 Nov 12;4(4):544-66. Epub 2015 Nov 12.

Laboratoire de Cristallographie et RMN Biologiques, CNRS UMR 8015, Faculté de Pharmacie, Université Paris Descartes, 75006 Paris, France.

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http://dx.doi.org/10.3390/antibiotics4040544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790312PMC
November 2015

Does cilengitide deserve another chance?-Authors' reply.

Lancet Oncol 2014 Dec 24;15(13):e585-e586. Epub 2014 Nov 24.

University Hospital Zurich, 8006 Zurich, Switzerland; European Organisation for Research and Treatment of Cancer, Brussels, Belgium.

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http://dx.doi.org/10.1016/S1470-2045(14)71121-0DOI Listing
December 2014

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming.

Proc Natl Acad Sci U S A 2014 Sep 5;111(38):E4033-42. Epub 2014 Sep 5.

Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1414028111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183335PMC
September 2014

Surfactant bilayers maintain transmembrane protein activity.

Biophys J 2014 Sep;107(5):1129-1135

Sorbonnes Université Univ Paris 6, UMR 7371, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, Paris, France; CNRS, UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, France; INSERM, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156668PMC
September 2014

Amphipol-mediated screening of molecular orthoses specific for membrane protein targets.

J Membr Biol 2014 Oct 3;247(9-10):925-40. Epub 2014 Aug 3.

Laboratoire de Modélisation et Ingénierie des Protéines, IBBMC UMR 8619, CNRS/Université Paris Sud, 91405, Orsay, France.

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http://dx.doi.org/10.1007/s00232-014-9707-3DOI Listing
October 2014

Solution behavior and crystallization of cytochrome bc₁ in the presence of amphipols.

J Membr Biol 2014 Oct 19;247(9-10):981-96. Epub 2014 Jun 19.

UMR 7099, Centre National de la Recherche Scientifique/Université Paris-7, Institut de Biologie Physico-Chimique, FRC 550, 13, rue Pierre-et-Marie-Curie, 75005, Paris, France.

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http://dx.doi.org/10.1007/s00232-014-9694-4DOI Listing
October 2014

Chronic stress increases vulnerability to diet-related abdominal fat, oxidative stress, and metabolic risk.

Psychoneuroendocrinology 2014 Aug 13;46:14-22. Epub 2014 Apr 13.

Department of Psychiatry, University of California, San Francisco, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2014.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104274PMC
August 2014

Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids.

Nat Rev Endocrinol 2014 May 25;10(5):303-10. Epub 2014 Mar 25.

Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/nrendo.2014.22DOI Listing
May 2014

In vitro investigation of the MexAB efflux pump from Pseudomonas aeruginosa.

J Vis Exp 2014 Feb 17(84):e50894. Epub 2014 Feb 17.

Laboratoire de Cristallographie & RMN Biologiques, CNRS & Université Paris Descartes;

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http://dx.doi.org/10.3791/50894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124871PMC
February 2014

Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses.

Longev Healthspan 2013 Aug 1;2(1):13. Epub 2013 Aug 1.

Department of Critical Care, McGill University Health Centre, 687 Pine Ave West, Montreal, QC H3A 1A1, Canada.

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http://dx.doi.org/10.1186/2046-2395-2-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922934PMC
August 2013

Mitochondria impact brain function and cognition.

Proc Natl Acad Sci U S A 2014 Jan 23;111(1):7-8. Epub 2013 Dec 23.

Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1073/pnas.1321881111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890847PMC
January 2014

Allostatic load as a tool for monitoring physiological dysregulations and comorbidities in patients with severe mental illnesses.

Harv Rev Psychiatry 2013 Nov-Dec;21(6):296-313

From the Department of Psychiatry and Center for Neuropsychiatric Research of Traumatic Stress, Charles University, Czech Republic (Dr. Bizik); University of Pennsylvania and Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia (Dr. Picard); Department of Psychology and Center for Research in Human Development, Concordia University, Canada (Ms. Nijjar); Department of Psychiatry (Drs. Tourjman and Lupien), Fernand-Seguin Research Centre at Louis-H. Lafontaine Hospital (Drs. Tourjman and Lupien, and Mr. Juster), and Center for Studies on Human Stress (Dr. Lupien and Mr. Juster), University of Montreal; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University (Dr. McEwen); Department of Neurology and Neurosurgery, McGill University (Mr. Juster).

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http://dx.doi.org/10.1097/HRP.0000000000000012DOI Listing
July 2014

Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle.

J Appl Physiol (1985) 2013 Nov 22;115(10):1562-71. Epub 2013 Aug 22.

Mitochondrial Research Group, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom;

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http://dx.doi.org/10.1152/japplphysiol.00819.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841825PMC
November 2013

Hoechst likes to play hide and seek...use it with caution!

Anal Biochem 2013 Sep 3;440(2):117-9. Epub 2013 Jun 3.

Laboratoire de Cristallographie et RMN Biologiques (CNRS UMR 8015), Faculté de Pharmacie, Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.

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http://dx.doi.org/10.1016/j.ab.2013.05.019DOI Listing
September 2013

Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging.

Diabetes 2013 Mar;62(3):672-8

Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.2337/db12-1203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581215PMC
March 2013

Mitochondrial morphology transitions and functions: implications for retrograde signaling?

Am J Physiol Regul Integr Comp Physiol 2013 Mar 30;304(6):R393-406. Epub 2013 Jan 30.

Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1152/ajpregu.00584.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602821PMC
March 2013

Mitochondrial morphology, topology, and membrane interactions in skeletal muscle: a quantitative three-dimensional electron microscopy study.

J Appl Physiol (1985) 2013 Jan 25;114(2):161-71. Epub 2012 Oct 25.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1152/japplphysiol.01096.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544498PMC
January 2013

Integrins as therapeutic targets.

Trends Pharmacol Sci 2012 Jul 25;33(7):405-12. Epub 2012 May 25.

Department of Cellular Pharmacology - Oncology Platform, Merck KGaA, Frankfurterstrasse 250, 64271 Darmstadt, Germany.

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http://dx.doi.org/10.1016/j.tips.2012.04.002DOI Listing
July 2012

Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis.

Electrophoresis 2012 Apr;33(8):1282-7

Laboratoire de Cristallographie et RMN Biologiques, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1002/elps.201100541DOI Listing
April 2012

Photo-induced proton gradients for the in vitro investigation of bacterial efflux pumps.

Sci Rep 2012 7;2:306. Epub 2012 Mar 7.

Laboratoire de Cristallographie et RMN Biologiques (CNRS UMR8015), Faculté de Pharmacie, Université Paris Descartes , Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France.

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http://dx.doi.org/10.1038/srep00306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296093PMC
April 2013

Mitochondria: starving to reach quorum?: Insight into the physiological purpose of mitochondrial fusion.

Bioessays 2012 Apr 30;34(4):272-4. Epub 2012 Jan 30.

Department of Kinesiology, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1002/bies.201100179DOI Listing
April 2012

Activity monitoring of functional OprM using a biomimetic microfluidic device.

Analyst 2012 Feb 4;137(4):847-52. Epub 2012 Jan 4.

SATIE, UMR 8029 CNRS, Ecole Normale Supérieure de Cachan, 61 Avenue du Président Wilson, 94235, Cachan Cedex, France.

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http://dx.doi.org/10.1039/c2an16007bDOI Listing
February 2012

Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function.

Am J Physiol Cell Physiol 2012 Feb 26;302(4):C629-41. Epub 2011 Oct 26.

Department of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1152/ajpcell.00368.2011DOI Listing
February 2012

Pathways to aging: the mitochondrion at the intersection of biological and psychosocial sciences.

Authors:
Martin Picard

J Aging Res 2011 26;2011:814096. Epub 2011 Sep 26.

Department of Kinesiology and Physical Education, McGill University, 475 Pine Avenue, Montreal, QC, Canada H2W 1S4.

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http://www.hindawi.com/journals/jar/2011/814096/
Publisher Site
http://dx.doi.org/10.4061/2011/814096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180824PMC
November 2011