Martin Landray

Martin Landray

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Martin Landray

Martin Landray

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Serious Adverse Effects of Extended-Release Niacin/Laropiprant: Results From the Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE) Trial.

Clin Ther 2019 Aug 22. Epub 2019 Aug 22.

MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.clinthera.2019.06.012DOI Listing
August 2019

Cost-effectiveness of lipid lowering with statins and ezetimibe in chronic kidney disease.

Kidney Int 2019 Jul 12;96(1):170-179. Epub 2019 Mar 12.

Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, UK; Centre for Primary Care and Public Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595178PMC
July 2019

Impact of ADCY9 Genotype on Response to Anacetrapib.

Circulation 2019 Jul 23. Epub 2019 Jul 23.

Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.041546DOI Listing
July 2019

Trends in the Incidence and Recurrence of Inpatient-Treated Spontaneous Pneumothorax, 1968-2016.

JAMA 2018 10;320(14):1471-1480

Unit of Health-Care Epidemiology, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.14299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233798PMC
October 2018

Increasing the use of mobile technology-derived endpoints in clinical trials.

Clin Trials 2018 06 5;15(3):313-315. Epub 2018 Feb 5.

1 Medical Research Council Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1177/1740774518755393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992831PMC
June 2018

Declining comorbidity-adjusted mortality rates in English patients receiving maintenance renal replacement therapy.

Kidney Int 2018 05 12;93(5):1165-1174. Epub 2018 Feb 12.

Medical Research Council Population Health Research Unit, Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, UK; Oxford Kidney Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912929PMC
May 2018

Impact of CKD on Household Income.

Kidney Int Rep 2018 May 23;3(3):610-618. Epub 2017 Dec 23.

Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, UK.

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http://dx.doi.org/10.1016/j.ekir.2017.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976816PMC
May 2018

Lowering LDL cholesterol reduces cardiovascular risk independently of presence of inflammation.

Kidney Int 2018 04 14;93(4):1000-1007. Epub 2017 Nov 14.

Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978933PMC
April 2018

Impact of Apolipoprotein(a) Isoform Size on Lipoprotein(a) Lowering in the HPS2-THRIVE Study.

Circ Genom Precis Med 2018 02;11(2):e001696

From the Medical Research Council Population Health Research Unit (S.P., M.R.H., R.H., C.B., J.A.); and the Clinical Trial Service Unit and Epidemiological Studies Unit (S.P., J.C.H., M.R.H., E.V.-M., R.H., A.O., C.B., R.C., M.L., J.A.), Nuffield Department of Population Health, University of Oxford, United Kingdom; Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle (S.M.); and Center for Preventive Medicine, University of Oslo, Norway (T.R.P.). A complete list of collaborators in HPS2-THRIVE (Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events) is given in reference 13.

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http://dx.doi.org/10.1161/CIRCGEN.117.001696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841847PMC
February 2018

The Association of Serum Free Light Chains With Mortality and Progression to End-Stage Renal Disease in Chronic Kidney Disease: Systematic Review and Individual Patient Data Meta-analysis.

Mayo Clin Proc 2017 11 1;92(11):1671-1681. Epub 2017 Nov 1.

Centre for Kidney Research and Innovation, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.

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http://dx.doi.org/10.1016/j.mayocp.2017.08.021DOI Listing
November 2017

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease.

N Engl J Med 2017 09 28;377(13):1217-1227. Epub 2017 Aug 28.

Clinical Trial Service Unit and Medical Research Council Population Health Research Unit, University of Oxford, Oxford, United Kingdom

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http://dx.doi.org/10.1056/NEJMoa1706444DOI Listing
September 2017

Evidence for Reverse Causality in the Association Between Blood Pressure and Cardiovascular Risk in Patients With Chronic Kidney Disease.

Hypertension 2017 02 27;69(2):314-322. Epub 2016 Dec 27.

From the Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), (W.H., N.S., P.K.J., M.M., J.E., R.H., S.L., C.A.R., M.J.L., C.B.) and Medical Research Council-Population Health Research Unit (MRC-PHRU) (P.K.J., J.E., R.H., S.L., C.B.), Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom; Centre for Nephrology, University College London, United Kingdom (D.C.W.); Dunedin School of Medicine, University of Otago, New Zealand (R.W.); Newcastle-upon-Tyne Hospitals NHS Foundation Trust, United Kingdom (C.T.); National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (L.A.); and Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland (A.W.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222554PMC
February 2017

Feasibility of Obtaining Measures of Lifestyle From a Smartphone App: The MyHeart Counts Cardiovascular Health Study.

JAMA Cardiol 2017 01;2(1):67-76

Department of Medicine, Stanford University, Stanford, California2Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California4Department of Genetics, Stanford University, Stanford, California.

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http://dx.doi.org/10.1001/jamacardio.2016.4395DOI Listing
January 2017

Effect of Processing Delay and Storage Conditions on Urine Albumin-to-Creatinine Ratio.

Clin J Am Soc Nephrol 2016 10 21;11(10):1794-1801. Epub 2016 Sep 21.

Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Oxford, United Kingdom.

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http://dx.doi.org/10.2215/CJN.13341215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053802PMC
October 2016

Smoking and Adverse Outcomes in Patients With CKD: The Study of Heart and Renal Protection (SHARP).

Am J Kidney Dis 2016 Sep 23;68(3):371-80. Epub 2016 Apr 23.

Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2016.02.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996629PMC
September 2016

Effects of Vascular and Nonvascular Adverse Events and of Extended-Release Niacin With Laropiprant on Health and Healthcare Costs.

Circ Cardiovasc Qual Outcomes 2016 07 12;9(4):348-54. Epub 2016 Jul 12.

From the Health Economics Research Centre (S.K., A.G., B.M.) and Clinical Trial Service Unit and Epidemiological Studies Unit (R.H., J.C.H., S.P., M.J.L., R.C., J.A.), Nuffield Department of Population Health, University of Oxford, United Kingdom.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.115.002592DOI Listing
July 2016

Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology.

Eur Heart J 2016 Mar 15;37(9):747-54. Epub 2015 Jun 15.

Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, University of Birmingham and Sandwell and West Birmingham Hospitals National Health Service Trust, Wolfson Drive, Birmingham B15 2TT, UK Atrial Fibrillation Competence NETwork (AFNET) e.V., Münster, Germany

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http://dx.doi.org/10.1093/eurheartj/ehv213DOI Listing
March 2016

Impact of Educational Attainment on Health Outcomes in Moderate to Severe CKD.

Am J Kidney Dis 2016 Jan 16;67(1):31-9. Epub 2015 Sep 16.

Health Economics Research Centre, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2015.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685934PMC
January 2016

Evidence for the prevention and treatment of stroke in dialysis patients.

Semin Dial 2015 Jan-Feb;28(1):35-47. Epub 2014 Jul 7.

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Oxford Kidney Unit, Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.

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http://dx.doi.org/10.1111/sdi.12281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320775PMC
October 2015

Neprilysin inhibition in chronic kidney disease.

Nephrol Dial Transplant 2015 May 18;30(5):738-43. Epub 2014 Aug 18.

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.

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http://dx.doi.org/10.1093/ndt/gfu269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425478PMC
May 2015

Alemtuzumab induction therapy in kidney transplantation - Authors' reply.

Lancet 2015 Feb;385(9970):771

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S0140-6736(15)60432-9DOI Listing
February 2015

Use of gel-based separator tubes to stabilise phosphate in mailed blood samples.

Clin Chim Acta 2015 Jan 2;439:112-4. Epub 2014 Oct 2.

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, UK.

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http://dx.doi.org/10.1016/j.cca.2014.09.025DOI Listing
January 2015

Niacin for reduction of cardiovascular risk.

N Engl J Med 2014 11;371(20):1943-4

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http://dx.doi.org/10.1056/NEJMc1411240DOI Listing
November 2014

Effects of lowering LDL cholesterol on progression of kidney disease.

J Am Soc Nephrol 2014 Aug 1;25(8):1825-33. Epub 2014 May 1.

Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;

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http://dx.doi.org/10.1681/ASN.2013090965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116066PMC
August 2014

Evaluating the contribution of the cause of kidney disease to prognosis in CKD: results from the Study of Heart and Renal Protection (SHARP).

Am J Kidney Dis 2014 Jul 5;64(1):40-8. Epub 2014 Mar 5.

Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2013.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068325PMC
July 2014

Randomized clinical trials--removing obstacles.

N Engl J Med 2013 12;369(23):2269

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http://dx.doi.org/10.1056/NEJMc1312901DOI Listing
December 2013

Clinical trials: how to get closer to the right answer with less effort.

Authors:
Martin Landray

Eur Heart J 2013 Nov;34(41):3166-7

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November 2013

Randomized clinical trials--removing unnecessary obstacles.

N Engl J Med 2013 Sep;369(11):1061-5

Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1056/NEJMsb1300760DOI Listing
September 2013

[ACEI/ARB use among high risk patients with coronary heart disease in China: a cross-sectional study].

Zhonghua Xin Xue Guan Bing Za Zhi 2013 Jan;41(1):18-22

China Oxford Centre for International Health Research Cardiovascular Institute, Beijing, People's Republic of China.

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January 2013

Underuse of statins in patients with atherosclerotic ischemic stroke in China.

Chin Med J (Engl) 2012 May;125(10):1703-7

Department of Epidemiology & Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China.

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May 2012

Serum free light chains and the risk of ESRD and death in CKD.

Clin J Am Soc Nephrol 2011 Dec 27;6(12):2829-37. Epub 2011 Oct 27.

Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.2215/CJN.03350411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255360PMC
December 2011

[Current statin use for patients with atherosclerotic cardiovascular disease in 39 large Chinese hospitals].

Zhonghua Xin Xue Guan Bing Za Zhi 2011 May;39(5):397-401

China Oxford Centre for International Health Research Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

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May 2011

[A cross-sectional study on the use of statin among patients with atherosclerotic ischemic stroke in China].

Zhonghua Liu Xing Bing Xue Za Zhi 2010 Aug;31(8):925-8

China Oxford Centre for International Health Research Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China; On Behalf of HPS2-THRIVE China Collaborative Group. Email:

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August 2010

Lipids in chronic kidney disease.

J Ren Care 2010 May;36 Suppl 1:27-33

Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/j.1755-6686.2010.00173.xDOI Listing
May 2010

Dual blockade of the renin-angiotensin system: are two better than one?

Nephrol Dial Transplant 2009 Dec 17;24(12):3602-7. Epub 2009 Sep 17.

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http://dx.doi.org/10.1093/ndt/gfp458DOI Listing
December 2009

Reassuring results with regard to the effect of donor nephrectomy on cardiovascular outcomes.

Nat Clin Pract Nephrol 2009 Mar 20;5(3):126-7. Epub 2009 Jan 20.

University of Oxford, Clinical Trial Service Unit, Oxford, UK.

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http://dx.doi.org/10.1038/ncpneph1035DOI Listing
March 2009

Analyses of cancer data from three ezetimibe trials.

N Engl J Med 2008 Sep 2;359(13):1357-66. Epub 2008 Sep 2.

Clinical Trial Service Unit & Epidemiological Studies Unit, Oxford University, Oxford, United Kingdom.

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http://dx.doi.org/10.1056/NEJMsa0806603DOI Listing
September 2008

Commentary: Controversies in NICE guidance on chronic kidney disease.

BMJ 2008 Sep 29;337:a1793. Epub 2008 Sep 29.

Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford OX3 7LF.

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http://dx.doi.org/10.1136/bmj.a1793DOI Listing
September 2008

Misleading associations between cholesterol and vascular outcomes in dialysis patients: the need for randomized trials.

Semin Dial 2007 Nov-Dec;20(6):498-503

Clinical Trial Service Unit & Epidemiological Studies Unit, Oxford, UK.

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http://dx.doi.org/10.1111/j.1525-139X.2007.00340.xDOI Listing
February 2008

A practical method of measuring glomerular filtration rate by iohexol clearance using dried capillary blood spots.

Nephron Clin Pract 2007 ;106(3):c104-12

Renal Studies Group, Clinical Trial Service Unit, Old Road Campus, Oxford, UK.

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http://dx.doi.org/10.1159/000102997DOI Listing
September 2007

Which cardiovascular risk factors matter in chronic kidney disease?

Nephrol Dial Transplant 2007 Jan 13;22(1):9-11. Epub 2006 Oct 13.

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK.

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http://dx.doi.org/10.1093/ndt/gfl580DOI Listing
January 2007

Statin therapy in kidney disease populations: potential benefits beyond lipid lowering and the need for clinical trials.

Curr Opin Nephrol Hypertens 2004 Nov;13(6):601-5

Clinical Trial Service Unit and Epidemiological Studies Unit, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK.

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November 2004

Homocysteine, renal function, and risk of cardiovascular disease.

Kidney Int Suppl 2003 May(84):S131-3

Clinical Trial Service Unit, Radcliffe Infirmary, Oxford, United Kingdom.

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http://dx.doi.org/10.1046/j.1523-1755.63.s84.7.xDOI Listing
May 2003

Cardiovascular risk factors in predialysis patients: baseline data from the Chronic Renal Impairment in Birmingham (CRIB) study.

Kidney Int Suppl 2003 May(84):S201-3

Centre for Nephrology, Royal Free Campus, University College London, United Kingdom.

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http://dx.doi.org/10.1046/j.1523-1755.63.s84.45.xDOI Listing
May 2003

ABC of antithrombotic therapy: An overview of antithrombotic therapy.

BMJ 2002 Oct;325(7367):762-5

The Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1124276PMC
http://dx.doi.org/10.1136/bmj.325.7367.762DOI Listing
October 2002