Martin Klingenspor

Martin Klingenspor

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Martin Klingenspor

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The gut hormone secretin triggers a gut-brown fat-brain axis in the control of food intake.

Exp Physiol 2020 Apr 9. Epub 2020 Apr 9.

TUM School of Life Sciences, Technical University of Munich, Freising, Germany.

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http://dx.doi.org/10.1113/EP087878DOI Listing
April 2020

Proteomic and Metabolite Profiling Reveals Profound Structural and Metabolic Reorganization of Adipocyte Mitochondria in Obesity.

Obesity (Silver Spring) 2020 03 7;28(3):590-600. Epub 2020 Feb 7.

Chair of Molecular Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.

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http://dx.doi.org/10.1002/oby.22737DOI Listing
March 2020

Uncoupling protein 1 and the capacity for nonshivering thermogenesis are components of the glucose homeostatic system.

Am J Physiol Endocrinol Metab 2020 02 12;318(2):E198-E215. Epub 2019 Nov 12.

Chair for Molecular Nutritional Medicine, Technical University of Munich, TUM School of Life Sciences, Freising, Germany.

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http://dx.doi.org/10.1152/ajpendo.00121.2019DOI Listing
February 2020

Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue.

Front Endocrinol (Lausanne) 2020 21;11:73. Epub 2020 Feb 21.

Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.

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http://dx.doi.org/10.3389/fendo.2020.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046592PMC
February 2020

Systems-Genetics-Based Inference of a Core Regulatory Network Underlying White Fat Browning.

Cell Rep 2019 12;29(12):4099-4113.e5

Chair for Molecular Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; EKFZ-Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.053DOI Listing
December 2019

Fatty Acid Metabolites as Novel Regulators of Non-shivering Thermogenesis.

Handb Exp Pharmacol 2019 ;251:183-214

Molecular Nutritional Medicine, Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany.

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http://link.springer.com/10.1007/164_2018_150
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http://dx.doi.org/10.1007/164_2018_150DOI Listing
July 2019

Secretin Links Brown Fat to Food Intake: New Perspectives for Targeting Energy Balance in Humans.

Obesity (Silver Spring) 2019 06;27(6):875-877

Molecular Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.

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http://dx.doi.org/10.1002/oby.22477DOI Listing
June 2019

Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes.

Sci Rep 2019 06 11;9(1):8470. Epub 2019 Jun 11.

Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.

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http://dx.doi.org/10.1038/s41598-019-44878-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560125PMC
June 2019

Adipose Mitochondrial Respiratory Capacity in Obesity is Impaired Independently of Glycemic Status of Tissue Donors.

Obesity (Silver Spring) 2019 05 26;27(5):756-766. Epub 2019 Mar 26.

Department of Nutritional Medicine, Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising-Weihenstephan, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.22435
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http://dx.doi.org/10.1002/oby.22435DOI Listing
May 2019

A dual Ucp1 reporter mouse model for imaging and quantitation of brown and brite fat recruitment.

Mol Metab 2019 02 28;20:14-27. Epub 2018 Nov 28.

EKFZ - Else Kröner-Fresenius Zentrum for Nutritional Medicine, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; Chair for Molecular Nutritional Medicine, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183088
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http://dx.doi.org/10.1016/j.molmet.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358570PMC
February 2019

Opposing Actions of Adrenocorticotropic Hormone and Glucocorticoids on UCP1-Mediated Respiration in Brown Adipocytes.

Front Physiol 2018 17;9:1931. Epub 2019 Jan 17.

Chair for Molecular Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.

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http://dx.doi.org/10.3389/fphys.2018.01931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344423PMC
January 2019

Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablation.

Life Sci Alliance 2018 Dec 14;1(6):e201800136. Epub 2018 Nov 14.

Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.

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http://www.life-science-alliance.org/lookup/doi/10.26508/lsa
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http://dx.doi.org/10.26508/lsa.201800136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238590PMC
December 2018

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation.

Cell 2018 11 15;175(6):1561-1574.e12. Epub 2018 Nov 15.

Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany; EKFZ - Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany; ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183132
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http://dx.doi.org/10.1016/j.cell.2018.10.016DOI Listing
November 2018

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.

Behav Brain Res 2018 10 29;352:187-196. Epub 2017 Sep 29.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter-Landstr. 1, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter-Landstr. 1, 85764 Neuherberg, Germany; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Alte Akademie 8, 85354 Freising, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2017.09.048DOI Listing
October 2018

The exceptional sensitivity of brain mitochondria to copper.

Toxicol In Vitro 2018 Sep 30;51:11-22. Epub 2018 Apr 30.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, Technical University Munich, Biedersteiner Strasse 29, D-80802 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2018.04.012DOI Listing
September 2018

Brown adipocyte glucose metabolism: a heated subject.

EMBO Rep 2018 09 22;19(9). Epub 2018 Aug 22.

Chair of Molecular Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany

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http://embor.embopress.org/lookup/doi/10.15252/embr.20184640
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http://dx.doi.org/10.15252/embr.201846404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123662PMC
September 2018

Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis.

Cell Metab 2018 08 14;28(2):207-216.e3. Epub 2018 Jun 14.

Turku PET Centre, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Turku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland (UEF), Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.05.020DOI Listing
August 2018

Animal models of obesity and diabetes mellitus.

Nat Rev Endocrinol 2018 03 19;14(3):140-162. Epub 2018 Jan 19.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/nrendo.2017.161DOI Listing
March 2018

Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients.

Cell Metab 2018 03;27(3):689-701.e4

Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg, Germany; Chair for Biological Imaging, Technical University of Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.02.002DOI Listing
March 2018

Non-adrenergic control of lipolysis and thermogenesis in adipose tissues.

J Exp Biol 2018 03 7;221(Pt Suppl 1). Epub 2018 Mar 7.

Chair of Molecular Nutritional Medicine, Technical University of Munich, TUM School of Life Sciences Weihenstephan, Gregor-Mendel-Str. 2, D-85354 Freising, Germany

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http://dx.doi.org/10.1242/jeb.165381DOI Listing
March 2018

Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity.

Mol Metab 2018 02 26;8:77-85. Epub 2017 Dec 26.

Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Germany; EKFZ - Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany; ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S22128778173094
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http://dx.doi.org/10.1016/j.molmet.2017.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985227PMC
February 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Nat Commun 2018 01 18;9(1):288. Epub 2018 Jan 18.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-017-01995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773596PMC
January 2018

Active Brown Fat During F-FDG PET/CT Imaging Defines a Patient Group with Characteristic Traits and an Increased Probability of Brown Fat Redetection.

J Nucl Med 2017 07 19;58(7):1104-1110. Epub 2017 Jan 19.

Molecular Nutritional Medicine, ZIEL-Institute for Food & Health, Technical University of Munich, Freising, Germany; and.

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http://jnm.snmjournals.org/lookup/doi/10.2967/jnumed.116.183
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http://dx.doi.org/10.2967/jnumed.116.183988DOI Listing
July 2017

Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice.

Biochim Biophys Acta Mol Basis Dis 2017 06 21;1863(6):1605-1614. Epub 2017 Feb 21.

Research Center, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-Universität München, Lindwurmstrasse 4, 80337 Munich, Germany; Experimental Pediatrics and Metabolism, Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.02.021DOI Listing
June 2017

Control of adipogenesis by oxylipins, GPCRs and PPARs.

Biochimie 2017 May 27;136:3-11. Epub 2016 Dec 27.

Université Côte d'Azur, CNRS, Inserm, iBV, France. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2016.12.012DOI Listing
May 2017

Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes.

Sci Rep 2017 04 21;7(1):1020. Epub 2017 Apr 21.

ZIEL - Institute for Food and Health, Technical University of Munich, Gregor-Mendel-Str. 2, 85354, Freising, Germany.

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http://dx.doi.org/10.1038/s41598-017-01093-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430635PMC
April 2017

Meaningful respirometric measurements of UCP1-mediated thermogenesis.

Biochimie 2017 Mar 14;134:56-61. Epub 2016 Dec 14.

Chair of Molecular Nutritional Medicine, Technical University Munich, Else Kröner-Fresenius Center for Nutritional Medicine, Gregor-Mendel-Str. 2, 85354 Freising, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2016.12.005DOI Listing
March 2017

Dietary fat and gut microbiota interactions determine diet-induced obesity in mice.

Mol Metab 2016 12 13;5(12):1162-1174. Epub 2016 Oct 13.

ZIEL - Institute for Food and Health, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; Chair of Molecular Nutritional Medicine, Technical University of Munich, TUM School of Life Sciences Weihenstephan, EKFZ - Else Kröner-Fresenius-Center for Nutritional Medicine, Gregor-Mendel-Str. 2, 85354 Freising, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123202PMC
December 2016

Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice.

Physiol Rep 2016 10;4(19)

Chair of Molecular Nutritional Medicine, Technische Universität München, Else Kröner Fresenius Center for Nutritional Medicine, Freising-Weihenstephan, Germany Z I E L - Research Center for Nutrition and Food Sciences, Technische Universität München, Freising-Weihenstephan, Germany

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http://dx.doi.org/10.14814/phy2.12988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064140PMC
October 2016

Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation.

Diabetologia 2016 09 7;59(9):2005-12. Epub 2016 Jun 7.

Lehrstuhl für Molekulare Ernährungsmedizin and Else Kröner-Fresenius Center, Technische Universität München, Gregor-Mendel-Str. 2, 85354, Freising (Weihenstephan), Germany.

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http://dx.doi.org/10.1007/s00125-016-4004-6DOI Listing
September 2016

Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice.

J Breath Res 2016 Feb 10;10(1):016009. Epub 2016 Feb 10.

Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Munich, Germany. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Munich, Germany. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1088/1752-7155/10/1/016009DOI Listing
February 2016

Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lep(ob/ob) Mice.

Endocrinology 2016 Jan 22;157(1):233-44. Epub 2015 Oct 22.

Lehrstuhl für Molekulare Ernährungsmedizin (F.B., A.B., N.R., S.M., M.K.), Else Kröner-Fresenius Center and ZIEL-Research Center for Nutrition and Food Science, and Munich Center for Integrated Protein Science and Lehrstuhl für Biologische Chemie (V.M., M.S., A.S.), Technische Universität München, 85350 Freising-Weihenstephan, Germany; and XL-protein GmbH (A.S.), 85354 Freising, Germany.

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http://dx.doi.org/10.1210/en.2015-1519DOI Listing
January 2016

The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice.

Sci Rep 2015 Dec 4;5:17704. Epub 2015 Dec 4.

Chair of Molecular Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius Center for Nutritional Medicine &ZIEL-Institute for Food and Health, 85350 Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.1038/srep17704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669493PMC
December 2015

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

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http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status.

Mol Metab 2015 Sep 15;4(9):631-42. Epub 2015 Jul 15.

Molecular Nutritional Medicine, Technische Universität München, Else Kröner Fresenius Center for Nutritional Medicine, Freising, Germany.

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http://dx.doi.org/10.1016/j.molmet.2015.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563017PMC
September 2015

Inverse relationship between body mass index and mitochondrial oxidative phosphorylation capacity in human subcutaneous adipocytes.

Am J Physiol Endocrinol Metab 2015 Aug 16;309(4):E380-7. Epub 2015 Jun 16.

Technische Universität München, ZIEL Institute for Food and Health, Nutritional Medicine, Freising-Weihenstephan, Germany; Institute of Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; and

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http://dx.doi.org/10.1152/ajpendo.00524.2014DOI Listing
August 2015

Diet-induced obesity causes metabolic impairment independent of alterations in gut barrier integrity.

Mol Nutr Food Res 2015 May 20;59(5):968-78. Epub 2015 Mar 20.

Department of Molecular Nutritional Medicine, ZIEL - Research Center for Nutrition and Food Sciences, Technische Universität München, Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.1002/mnfr.201400840DOI Listing
May 2015

PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy.

Mol Pharm 2015 May 10;12(5):1431-42. Epub 2015 Apr 10.

∥XL-protein GmbH, Lise-Meitner-Strasse 30, 85354 Freising, Germany.

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http://dx.doi.org/10.1021/mp5007147DOI Listing
May 2015

Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice.

Endocrinology 2015 Mar 30;156(3):923-33. Epub 2014 Dec 30.

Molecular Nutritional Medicine, Technische Universität München, Else Kröner Fresenius Center for Nutritional Medicine, 85350 Freising, Germany.

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http://dx.doi.org/10.1210/en.2014-1689DOI Listing
March 2015

Glucose tolerance tests for systematic screening of glucose homeostasis in mice.

Curr Protoc Mouse Biol 2015 Mar 2;5(1):65-84. Epub 2015 Mar 2.

Institute of Experimental Genetics, German Mouse Clinic, Helmholtz-Zentrum München, German Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.1002/9780470942390.mo140111DOI Listing
March 2015

The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice.

J Nutr Biochem 2015 Jan 2;26(1):75-81. Epub 2014 Oct 2.

Molecular Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius-Zentrum (EKFZ) & Research Center for Nutrition and Food Sciences (ZIEL), Gregor-Mendel-Str. 2, 85350 Freising-Weihenstephan, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2014.09.002DOI Listing
January 2015

Distinct signatures of host-microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet.

ISME J 2014 Dec 6;8(12):2380-96. Epub 2014 Jun 6.

1] Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany [2] Technische Universität München, Chair of Analytical Food Chemistry, Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.1038/ismej.2014.79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260703PMC
December 2014

Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes.

EMBO Rep 2014 Oct 18;15(10):1069-76. Epub 2014 Aug 18.

Molecular Nutritional Medicine, Else Kröner Fresenius Center for Nutritional Medicine, Technische Universität München, Freising, Germany

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http://dx.doi.org/10.15252/embr.201438775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253847PMC
October 2014

A review of standardized metabolic phenotyping of animal models.

Mamm Genome 2014 Oct 9;25(9-10):497-507. Epub 2014 Sep 9.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany,

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http://dx.doi.org/10.1007/s00335-014-9532-0DOI Listing
October 2014

Intrinsic differences in BRITE adipogenesis of primary adipocytes from two different mouse strains.

Biochim Biophys Acta 2014 Sep 19;1841(9):1345-52. Epub 2014 Jun 19.

Molecular Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius Center, Freising, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2014.06.003DOI Listing
September 2014

A novel SP1/SP3 dependent intronic enhancer governing transcription of the UCP3 gene in brown adipocytes.

PLoS One 2013 31;8(12):e83426. Epub 2013 Dec 31.

Molecular Nutritional Medicine, Else Kröner-Fresenius Center & Research Center for Nutrition and Food Sciences, Technische Universität München, Freising-Weihenstephan, Germany.

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https://mediatum.ub.tum.de/doc/1210018/1210018.pdf
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http://dx.plos.org/10.1371/journal.pone.0083426
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083426PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877035PMC
August 2014

Raw coffee based dietary supplements contain carboxyatractyligenin derivatives inhibiting mitochondrial adenine-nucleotide-translocase.

Food Chem Toxicol 2014 Aug 24;70:198-204. Epub 2014 May 24.

Chair of Food Science and Molecular Sensory Science, Technische Universität München, Lise-Meitner-Str. 34, 85354 Freising, Germany; ZIEL Bioanalytics Unit, Technische Universität München, Alte Akademie 10, 85354 Freising, Germany.

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http://dx.doi.org/10.1016/j.fct.2014.05.017DOI Listing
August 2014

High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.

J Proteome Res 2014 May 28;13(5):2339-51. Epub 2014 Mar 28.

Heinrich-Heine-Universität Düsseldorf , Molecular Proteomics Laboratory, Biomedizinisches Forschungszentrum (BMFZ), Düsseldorf, Germany.

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http://dx.doi.org/10.1021/pr401157kDOI Listing
May 2014

High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity.

PLoS One 2013 16;8(8):e71661. Epub 2013 Aug 16.

Chair of Nutrition and Immunology, Technische Universität München, Freising-Weihenstephan, Germany ; Biofunctionality Unit, ZIEL - Research Center for Nutrition and Food Sciences, Technische Universität München, Freising-Weihenstephan, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071661PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745443PMC
April 2014

Online breath gas analysis in unrestrained mice by hs-PTR-MS.

Mamm Genome 2014 Apr 26;25(3-4):129-40. Epub 2013 Nov 26.

Research Unit Medical Radiation Physics and Diagnostics, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany,

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http://dx.doi.org/10.1007/s00335-013-9493-8DOI Listing
April 2014

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.

Cell 2014 Jan;156(1-2):343-58

Chair of Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius-Center for Nutritional Medicine, 85350 Freising-Weihenstephan, Germany; Nutritional Medicine Unit, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München, 85350 Freising-Weihenstephan, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany and Technische Universität München, 85350 Freising-Weihenstephan, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg 85764, Germany. Electronic address:

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http://www.cell.com/cms/attachment/2021778258/2041667086/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741301535
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http://dx.doi.org/10.1016/j.cell.2013.10.058DOI Listing
January 2014

2-O-β-D-Glucopyranosyl-carboxyatractyligenin from Coffea L. inhibits adenine nucleotide translocase in isolated mitochondria but is quantitatively degraded during coffee roasting.

Phytochemistry 2013 Sep 2;93:124-35. Epub 2013 May 2.

Chair of Food Science and Molecular Sensory Science, Technische Universität München, Lise-Meitner-Str. 34, 85354 Freising, Germany.

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http://dx.doi.org/10.1016/j.phytochem.2013.03.022DOI Listing
September 2013

Boosting mitochondrial biogenesis in white adipocytes: A route towards improved insulin sensitivity?

Mol Metab 2013 10;2(3):128-9. Epub 2013 Jul 10.

Chair for Molecular Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius Center for Nutritional Medicine & Z I E L - Research Center for Nutrition and Food Sciences, Gregor-Mendel-Str. 2, D-85350 Freising - Weihenstephan, Germany.

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http://dx.doi.org/10.1016/j.molmet.2013.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773814PMC
September 2013

Brown fat develops a brite future.

Obes Facts 2012 22;5(6):890-6. Epub 2012 Dec 22.

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http://dx.doi.org/10.1159/000346337DOI Listing
July 2013

Diet-induced obesity in ad libitum-fed mice: food texture overrides the effect of macronutrient composition.

Br J Nutr 2013 Apr 6;109(8):1518-27. Epub 2012 Aug 6.

Molecular Nutrition Unit, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München (TUM), Gregor-Mendel-Strasse 2, 85350 Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.1017/S0007114512003340DOI Listing
April 2013

Innovations in phenotyping of mouse models in the German Mouse Clinic.

Mamm Genome 2012 Oct 29;23(9-10):611-22. Epub 2012 Aug 29.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstrasse 1, 85764 Neuherberg/Munich, Germany.

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http://dx.doi.org/10.1007/s00335-012-9415-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463795PMC
October 2012

Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak.

Biochim Biophys Acta 2012 Sep 4;1817(9):1660-70. Epub 2012 Jun 4.

Institute for Diabetes and Obesity, Helmholtz Zentrum Munich, Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2012.05.014DOI Listing
September 2012