Martin K Lotz

Martin K Lotz

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Martin K Lotz

Martin K Lotz

Publications by authors named "Martin K Lotz"

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Platelet-derived growth factor-coated decellularized meniscus scaffold for integrative healing of meniscus tears.

Acta Biomater 2018 Aug 14;76:126-134. Epub 2018 Jun 14.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2018.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090559PMC
August 2018

Gene expression profiles of the meniscus avascular phenotype: A guide for meniscus tissue engineering.

J Orthop Res 2018 Jul 14;36(7):1947-1958. Epub 2018 Mar 14.

Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, California.

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http://dx.doi.org/10.1002/jor.23864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326361PMC
July 2018

Impaired Proteasomal Function in Human Osteoarthritic Chondrocytes Can Contribute to Decreased Levels of SOX9 and Aggrecan.

Arthritis Rheumatol 2018 Jul 27;70(7):1030-1041. Epub 2018 May 27.

VA San Diego Healthcare System, University of California San Diego, La Jolla, California.

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http://dx.doi.org/10.1002/art.40456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019618PMC
July 2018

Relevance of meniscal cell regional phenotype to tissue engineering.

Connect Tissue Res 2017 May - Jul;58(3-4):259-270. Epub 2016 Dec 7.

a Shiley Center for Orthopaedic Research and Education at Scripps Clinic , La Jolla , CA , USA.

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http://dx.doi.org/10.1080/03008207.2016.1268604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433889PMC
March 2018

Extracellular vesicles in cartilage homeostasis and osteoarthritis.

Curr Opin Rheumatol 2018 Jan;30(1):129-135

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.

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http://Insights.ovid.com/crossref?an=00002281-201801000-0002
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http://dx.doi.org/10.1097/BOR.0000000000000454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810945PMC
January 2018

Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration.

J Orthop Res 2017 12 4;35(12):2682-2691. Epub 2017 May 4.

Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla 92037, California.

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http://dx.doi.org/10.1002/jor.23583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650945PMC
December 2017

Transthyretin deposition promotes progression of osteoarthritis.

Aging Cell 2017 12 22;16(6):1313-1322. Epub 2017 Sep 22.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/acel.12665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676063PMC
December 2017

Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis.

J Bone Miner Res 2017 Sep 13;32(9):1773-1782. Epub 2017 Jul 13.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/jbmr.3199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585011PMC
September 2017

Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.

Proc Natl Acad Sci U S A 2016 07 1;113(28):7840-5. Epub 2016 Jul 1.

Department of Systems BioMedicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan; Core Research for the Evolutionary Science and Technology, Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo 100-0004, Japan; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1522054113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948356PMC
July 2016

Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1.

Arthritis Res Ther 2015 Oct 13;17:285. Epub 2015 Oct 13.

Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Hiroshima, 734-8551, Japan.

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http://dx.doi.org/10.1186/s13075-015-0792-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603301PMC
October 2015

Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes.

Arthritis Rheumatol 2015 Apr;67(4):966-76

Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, SERGAS, and Universidade da Coruña, A Coruña, Spain.

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http://dx.doi.org/10.1002/art.39025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380780PMC
April 2015

Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells.

J Orthop Res 2015 Apr 17;33(4):548-55. Epub 2015 Feb 17.

Department of Orthopedic Surgery, Osaka Medical College, 2-7 Daigakumachi, Osaka, 569-8686, Japan.

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http://dx.doi.org/10.1002/jor.22782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454425PMC
April 2015

Repair of cartilage defects in arthritic tissue with differentiated human embryonic stem cells.

Tissue Eng Part A 2014 Feb 19;20(3-4):683-92. Epub 2013 Oct 19.

1 Shiley Center for Orthopaedic Research and Education at Scripps Health , La Jolla, California.

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http://dx.doi.org/10.1089/ten.TEA.2012.0751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926163PMC
February 2014

Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation.

Tissue Eng Part A 2014 Jan 25;20(1-2):264-74. Epub 2013 Sep 25.

1 Shiley Center for Orthopaedic Research and Education , Scripps Clinic, La Jolla, California.

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http://dx.doi.org/10.1089/ten.TEA.2012.0618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875188PMC
January 2014

Digital micromirror device projection printing system for meniscus tissue engineering.

Acta Biomater 2013 Jul 21;9(7):7218-26. Epub 2013 Mar 21.

Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.actbio.2013.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685281PMC
July 2013

Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis: correlations with anterior cruciate ligament and cartilage changes.

Ann Rheum Dis 2013 Feb 7;72(2):271-7. Epub 2012 Aug 7.

Correspondence to Professor Martin K Lotz, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2012-20173
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http://dx.doi.org/10.1136/annrheumdis-2012-201730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538921PMC
February 2013

Zone-specific gene expression patterns in articular cartilage.

Arthritis Rheum 2013 Feb;65(2):418-28

The Scripps Research Institute and Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, California, USA.

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http://dx.doi.org/10.1002/art.37760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558601PMC
February 2013

Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels.

Tissue Eng Part A 2012 Sep 12;18(17-18):1784-92. Epub 2012 Jun 12.

Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1089/ten.TEA.2011.0506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432904PMC
September 2012

Thermal inkjet printing in tissue engineering and regenerative medicine.

Recent Pat Drug Deliv Formul 2012 Aug;6(2):149-55

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565591PMC
August 2012

In situ tissue engineering using magnetically guided three-dimensional cell patterning.

Tissue Eng Part C Methods 2012 Jul 10;18(7):496-506. Epub 2012 Feb 10.

Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1089/ten.TEC.2011.0525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381294PMC
July 2012

Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice.

Orthop Clin North Am 2012 Apr 21;43(2):173-85, v. Epub 2012 Feb 21.

Department of Bioengineering, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA.

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http://dx.doi.org/10.1016/j.ocl.2012.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321216PMC
April 2012

Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritis.

Arthritis Rheum 2012 Mar;64(3):696-704

Department of Molecular and Experimental Medicine,The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/art.33417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266452PMC
March 2012

Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA.

Nat Rev Rheumatol 2011 Aug 2;7(10):579-87. Epub 2011 Aug 2.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/nrrheum.2011.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192496PMC
August 2011

Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis.

J Orthop Res 2011 Jan;29(1):20-5

Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1002/jor.21198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976780PMC
January 2011

New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options.

Arthritis Res Ther 2010 28;12(3):211. Epub 2010 Jun 28.

Department of Molecular and Experimental Medicine, The Scripps-Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1186/ar3046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911903PMC
November 2010

Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases.

Chembiochem 2010 Nov;11(17):2393-7

Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/cbic.201000401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086843PMC
November 2010

Cartilage cell clusters.

Arthritis Rheum 2010 Aug;62(8):2206-18

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/art.27528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921934PMC
August 2010

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways.

Proc Natl Acad Sci U S A 2010 Jun 17;107(22):10202-7. Epub 2010 May 17.

Department of Molecular and Experimental Medicine and Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0913897107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890424PMC
June 2010

Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis.

Arthritis Res Ther 2009 5;11(3):R85. Epub 2009 Jun 5.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1186/ar2719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714136PMC
March 2010

Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage.

J Orthop Res 2010 Jan;28(1):96-102

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://doi.wiley.com/10.1002/jor.20944
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http://dx.doi.org/10.1002/jor.20944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905317PMC
January 2010

Rho kinase-dependent activation of SOX9 in chondrocytes.

Arthritis Rheum 2010 Jan;62(1):191-200

The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1002/art.25051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935318PMC
January 2010

Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli.

Mol Cell Biomech 2009 Sep;6(3):135-44

Division of Arthritis Research, Department of Molecular and Experimental Medicine, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785729PMC
September 2009

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses.

Arthritis Rheum 2009 Sep;60(9):2723-30

Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/art.24745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806094PMC
September 2009

Aging-related differences in chondrocyte viscoelastic properties.

Mol Cell Biomech 2009 Jun;6(2):113-9

Shiley Center for Orthopaedic Research and Education at Scripps Clinic, North Torrey Pines Road, La Jolla, CA 92037, USA.

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June 2009

Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes.

Arthritis Rheum 2008 Sep;58(9):2735-42

Scripps Research Institute, and Scripps Clinic, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1002/art.23797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562294PMC
September 2008

Detection of apoptosis in cartilage in situ and in isolated chondrocytes.

Methods Mol Med 2004 ;100:275-90

Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA, USA.

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http://dx.doi.org/10.1385/1-59259-810-2:275DOI Listing
January 2005

Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses.

Am J Physiol Endocrinol Metab 2004 Jun 28;286(6):E980-5. Epub 2004 Jan 28.

Division of Arthritis Research, The Scripps Research Institute, MEM 161, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1152/ajpendo.00243.2003DOI Listing
June 2004

WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes.

Arthritis Rheum 2004 Feb;50(2):488-97

University of California, San Diego, CA 92093-0663, USA.

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http://dx.doi.org/10.1002/art.20005DOI Listing
February 2004