Martin J S Dyer

Martin J S Dyer

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Martin J S Dyer

Martin J S Dyer

Publications by authors named "Martin J S Dyer"

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Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies.

Haematologica 2019 May 22;104(5):1016-1025. Epub 2018 Nov 22.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, UK

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http://dx.doi.org/10.3324/haematol.2018.204701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518917PMC
May 2019

Differential activation of pro-survival pathways in response to CD40LG/IL4 stimulation in chronic lymphocytic leukaemia cells.

Br J Haematol 2019 Mar 20;184(5):867-869. Epub 2018 Apr 20.

Mechanisms of Cancer and Ageing Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/bjh.15197DOI Listing
March 2019

CUDC-907 blocks multiple pro-survival signals and abrogates microenvironment protection in CLL.

J Cell Mol Med 2019 Jan 24;23(1):340-348. Epub 2018 Oct 24.

Mechanisms of Cancer and Ageing Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/jcmm.13935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307843PMC
January 2019

Paradoxical activation of alternative pro-survival pathways determines resistance to MEK inhibitors in chronic lymphocytic leukaemia.

Br J Haematol 2018 Sep 2;182(6):921-924. Epub 2017 Aug 2.

Mechanisms of Cancer and Ageing Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/bjh.14880DOI Listing
September 2018

Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.

Cancer Res 2017 09 18;77(18):4785-4796. Epub 2017 Jul 18.

Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3233DOI Listing
September 2017

Targeting anti-apoptotic BCL2 family proteins in haematological malignancies - from pathogenesis to treatment.

Br J Haematol 2017 08 27;178(3):364-379. Epub 2017 Apr 27.

Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/bjh.14684DOI Listing
August 2017

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

Nat Commun 2017 02 6;8:14175. Epub 2017 Feb 6.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/ncomms14175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303820PMC
February 2017

Pro-survival signal inhibition by CDK inhibitor dinaciclib in Chronic Lymphocytic Leukaemia.

Br J Haematol 2016 Nov 29;175(4):641-651. Epub 2016 Jul 29.

Mechanisms of Cancer and Ageing Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/bjh.14285DOI Listing
November 2016

Posttranscriptional Upregulation of p53 by Reactive Oxygen Species in Chronic Lymphocytic Leukemia.

Cancer Res 2016 11 7;76(21):6311-6319. Epub 2016 Sep 7.

Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0843DOI Listing
November 2016

New Agents to Treat Chronic Lymphocytic Leukemia.

N Engl J Med 2016 06;374(22):2185-6

Ernest and Helen Scott Haematological Research Institute, Leicester, United Kingdom

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http://dx.doi.org/10.1056/NEJMc1602674DOI Listing
June 2016

A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome.

Case Rep Hematol 2014 1;2014:120714. Epub 2014 Oct 1.

Ernest and Helen Scott Haematological Research Institute and Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK ; Ernest and Helen Scott Haematological Research Institute and Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1155/2014/120714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198823PMC
October 2014

Prdm6 is essential for cardiovascular development in vivo.

PLoS One 2013 21;8(11):e81833. Epub 2013 Nov 21.

Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany ; German Cancer Consortium (DKTK), Heidelberg, Germany ; German Cancer Research Center (DKFZ), Heidelberg, Germany ; Laboratory of Signaling in the Immune System, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081833PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836774PMC
August 2014

Breaking good: the inexorable rise of BTK inhibitors in the treatment of chronic lymphocytic leukaemia.

Br J Haematol 2014 Jul 18;166(1):12-22. Epub 2014 Apr 18.

Department of of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK; The Ernest and Helen Scott Haematological Research Institute, University of Leicester.

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http://dx.doi.org/10.1111/bjh.12895DOI Listing
July 2014

Ofatumumab monotherapy in relapsed/refractory mantle cell lymphoma--a phase II trial.

Br J Haematol 2014 May 8;165(4):575-8. Epub 2014 Feb 8.

Department of Haematology, Derriford Hospital, Plymouth, UK.

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http://dx.doi.org/10.1111/bjh.12769DOI Listing
May 2014

Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.

Genes Chromosomes Cancer 2014 Apr 21;53(4):309-16. Epub 2014 Jan 21.

Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany; Department of Pediatrics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1002/gcc.22141DOI Listing
April 2014

Efficacy of vemurafenib in hairy-cell leukemia.

N Engl J Med 2014 Jan;370(3):286-8

University of Leicester, Leicester, United Kingdom

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http://dx.doi.org/10.1056/NEJMc1310849DOI Listing
January 2014

ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets.

Br J Haematol 2013 Oct 4;163(1):139-42. Epub 2013 Jul 4.

Department of Biochemistry, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/bjh.12457DOI Listing
October 2013

Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia.

Br J Haematol 2013 Aug 27;162(3):360-70. Epub 2013 May 27.

Department of Cancer Studies and Molecular Medicine, MRC Toxicology Unit, University of Leicester, Leicester, UK.

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http://doi.wiley.com/10.1111/bjh.12401
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http://dx.doi.org/10.1111/bjh.12401DOI Listing
August 2013

The detection of chromosomal translocations involving the immunoglobulin loci in B-cell malignancies.

Authors:
Martin J S Dyer

Methods Mol Biol 2013 ;971:123-33

Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1007/978-1-62703-269-8_7DOI Listing
June 2013

Safety and efficacy of ofatumumab in patients with fludarabine and alemtuzumab refractory chronic lymphocytic leukaemia.

Authors:
Martin J S Dyer

Ther Adv Hematol 2012 Aug;3(4):199-207

Professor of Haemato-Oncology and Honorary Consultant Physician, Department of Cancer Studies and Molecular Medicine, Leicester University, Hodgkin Building Room 405, Lancaster Road, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1177/2040620712445329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627333PMC
August 2012

The CBFA2T3/ACSF3 locus is recurrently involved in IGH chromosomal translocation t(14;16)(q32;q24) in pediatric B-cell lymphoma with germinal center phenotype.

Genes Chromosomes Cancer 2012 Apr;51(4):338-43

Institute of Human Genetics, University Hospital Schleswig-Holstein Campus Kiel/Christian-Albrechts University, Kiel, Germany.

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April 2012

Bilateral subdural hygromas following intrathecal methotrexate.

Br J Haematol 2011 Dec 19;155(5):536. Epub 2011 Sep 19.

Department of Haematology, Leicester Royal Infirmary, Leicester, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08797.xDOI Listing
December 2011

Primary lymphoma-like lesions of the uterine cervix; sheep in wolves' clothing.

Br J Haematol 2011 Jun 16;153(6):791-4. Epub 2011 Mar 16.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08659.xDOI Listing
June 2011

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

Blood 2011 Jun 11;117(26):7145-54. Epub 2011 May 11.

Medical Research Council Toxicology Unit, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1182/blood-2011-03-344812DOI Listing
June 2011

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.

Biochem Biophys Res Commun 2011 May 13;408(2):344-9. Epub 2011 Apr 13.

MRC Toxicology Unit, University of Leicester, LE1 9HN Leicester, United Kingdom.

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http://dx.doi.org/10.1016/j.bbrc.2011.04.043DOI Listing
May 2011

pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1.

Trends Cell Biol 2011 Jan 18;21(1):20-8. Epub 2010 Oct 18.

Centre for Cancer & Inflammation, Institute of Cancer, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom.

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http://dx.doi.org/10.1016/j.tcb.2010.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014425PMC
January 2011

Proteomic analysis of B-cell malignancies.

J Proteomics 2010 Sep 24;73(10):1804-22. Epub 2010 Mar 24.

MRC Toxicology Unit, Hodgkin Building, Lancaster Rd, University of Leicester, Leicester, LE1 9HN, UK.

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http://dx.doi.org/10.1016/j.jprot.2010.03.010DOI Listing
September 2010

Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes.

J Biol Chem 2010 Feb 26;285(8):5117-21. Epub 2009 Dec 26.

Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois 60612, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C109.082727
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http://dx.doi.org/10.1074/jbc.C109.082727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820736PMC
February 2010

Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers?

Blood 2010 Feb 30;115(8):1490-9. Epub 2009 Dec 30.

MRC Toxicology Unit and Department of Cancer Studies and Molecular Medicine, University of Leicester, Lancaster Road, Leicester, United Kingdom.

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http://dx.doi.org/10.1182/blood-2009-09-235986DOI Listing
February 2010

Genetic variation in CXCR4 and risk of chronic lymphocytic leukemia.

Blood 2009 Nov 7;114(23):4843-6. Epub 2009 Oct 7.

Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, United Kingdom.

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http://dx.doi.org/10.1182/blood-2009-07-235184DOI Listing
November 2009

Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis.

Proc Natl Acad Sci U S A 2009 Oct 5;106(42):18022-7. Epub 2009 Oct 5.

Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612, USA.

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http://www.pnas.org/content/106/42/18022.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.0905565106
Publisher Site
http://dx.doi.org/10.1073/pnas.0905565106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764923PMC
October 2009

Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma.

Mol Cell Proteomics 2009 Jul 2;8(7):1501-15. Epub 2009 Apr 2.

Medical Research Council, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M800515-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709182PMC
July 2009

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia.

Blood 2009 Apr 13;113(18):4403-13. Epub 2008 Nov 13.

Medical Research Council Toxicology Unit, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1182/blood-2008-08-173310DOI Listing
April 2009

Caspase cleavage of Itch in chronic lymphocytic leukemia cells.

Biochem Biophys Res Commun 2009 Feb 13;379(3):659-64. Epub 2008 Dec 13.

Medical Research Council, Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, Leicester, UK.

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http://dx.doi.org/10.1016/j.bbrc.2008.11.154DOI Listing
February 2009

t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

Blood 2008 Jan 16;111(1):387-91. Epub 2007 Oct 16.

Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1182/blood-2007-07-092015DOI Listing
January 2008

BCL2 expression in chronic lymphocytic leukemia: lack of association with the BCL2 938A>C promoter single nucleotide polymorphism.

Blood 2008 Jan 24;111(2):874-7. Epub 2007 Oct 24.

Medical Research Council Toxicology Unit, and Department of Haematology, University Hospitals, Leicester, UK.

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http://dx.doi.org/10.1182/blood-2007-07-098681DOI Listing
January 2008