Martin Hrabe de Angelis

Martin Hrabe de Angelis

UNVERIFIED PROFILE

Are you Martin Hrabe de Angelis?   Register this Author

Register author
Martin Hrabe de Angelis

Martin Hrabe de Angelis

Publications by authors named "Martin Hrabe de Angelis"

Are you Martin Hrabe de Angelis?   Register this Author

100Publications

3879Reads

50Profile Views

AMPK Subunits Harbor Largely Nonoverlapping Genetic Determinants for Body Fat Mass, Glucose Metabolism, and Cholesterol Metabolism.

Authors:
Elko Randrianarisoa Angela Lehn-Stefan Johannes Krier Anja Böhm Martin Heni Martin Hrabě De Angelis Andreas Fritsche Hans-Ulrich Häring Norbert Stefan Harald Staiger

J Clin Endocrinol Metab 2020 Jan;105(1)

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, 72076 Tübingen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1210/clinem/dgz020DOI Listing
January 2020

CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.

Authors:
Roxana Solga Juliane Behrens Anja Ziemann Adrien Riou Carolin Berwanger Lore Becker Lillian Garrett Martin Hrabe de Angelis Lisa Fischer Roland Coras Katalin Barkovits Katrin Marcus Esther Mahabir Ludwig Eichinger Rolf Schröder Angelika A Noegel Christoph S Clemen

Eur J Cell Biol 2019 Dec 11;98(5-8):151046. Epub 2019 Oct 11.

Centre for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, 50931, Cologne, Germany; Institute of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054, Erlangen, Germany; Center for Physiology and Pathophysiology, Institute of Vegetative Physiology, Medical Faculty, University of Cologne, 50931, Cologne, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ejcb.2019.151046DOI Listing
December 2019

Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.

Authors:
Sharmilee Vetrivel Natascia Tiso Andrea Kügler Martin Irmler Marion Horsch Johannes Beckers Daniela Hladik Florian Giesert Valerie Gailus-Durner Helmut Fuchs Sibylle Sabrautzki Martin Hrabě de Angelis Jochen Graw

Exp Eye Res 2019 Nov 13;188:107632. Epub 2019 Apr 13.

Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, D-85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00144835183070
Publisher Site
http://dx.doi.org/10.1016/j.exer.2019.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876282PMC
November 2019

Spectral domain - Optical coherence tomography (SD-OCT) as a monitoring tool for alterations in mouse lenses.

Authors:
Daniel Pawliczek Claudia Dalke Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Jochen Graw Oana Veronica Amarie

Exp Eye Res 2019 Nov 18;190:107871. Epub 2019 Nov 18.

Helmholtz Zentrum München GmbH - German Research Center for Environmental Health, Institute of Experimental Genetics, Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.exer.2019.107871DOI Listing
November 2019

In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria.

Authors:
Marie Lucienne Juan Antonio Aguilar-Pimentel Oana V Amarie Lore Becker Julia Calzada-Wack Patricia da Silva-Buttkus Lillian Garrett Sabine M Hölter Philipp Mayer-Kuckuk Birgit Rathkolb Jan Rozman Nadine Spielmann Irina Treise Dirk H Busch Thomas Klopstock Carsten Schmidt-Weber Eckhard Wolf Wolfgang Wurst Merima Forny Déborah Mathis Ralph Fingerhut D Sean Froese Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Matthias R Baumgartner

Biochim Biophys Acta Mol Basis Dis 2019 Nov 23:165622. Epub 2019 Nov 23.

Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland; radiz - Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.bbadis.2019.165622DOI Listing
November 2019

Soft Windowing Application to Improve Analysis of High-throughput Phenotyping Data.

Authors:
Hamed Haselimashhadi Jeremy C Mason Violeta Munoz-Fuentes Federico López-Gómez Kolawole Babalola Elif F Acar Vivek Kumar Jacqui White Ann M Flenniken Ruairidh King Ewan Straiton John Richard Seavitt Angelina Gaspero Arturo Garza Audrey E Christianson Chih-Wei Hsu Corey L Reynolds Denise G Lanza Isabel Lorenzo Jennie R Green Juan J Gallegos Ritu Bohat Rodney C Samaco Surabi Veeraragavan Jong Kyoung Kim Gregor Miller Helmult Fuchs Lillian Garrett Lore Becker Yeon Kyung Kang David Clary Soo Young Cho Masaru Tamura Nobuhiko Tanaka Kyung Dong Soo Alexandr Bezginov Ghina Bou About Marie-France Champy Laurent Vasseur Sophie Leblanc Hamid Meziane Mohammed Selloum Patrick T Reilly Nadine Spielmann Holger Maier Valerie Gailus-Durner Tania Sorg Masuya Hiroshi Obata Yuichi Jason D Heaney Mary E Dickinson Wurst Wolfgang Glauco P Tocchini-Valentini Kevin C Kent Lloyd Colin McKerlie Je Kyung Seong Herault Yann Martin Hrabé de Angelis Steve D M Brown Damian Smedley Paul Flicek Ann-Marie Mallon Helen Parkinson Terrence F Meehan

Bioinformatics 2019 Oct 8. Epub 2019 Oct 8.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/bioinformatics/btz744DOI Listing
October 2019

A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene.

Authors:
Lars R Jensen Lillian Garrett Sabine M Hölter Birgit Rathkolb Ildikó Rácz Thure Adler Cornelia Prehn Wolfgang Hans Jan Rozman Lore Becker Juan Antonio Aguilar-Pimentel Oliver Puk Kristin Moreth Monika Dopatka Diego J Walther Viola von Bohlen Und Halbach Matthias Rath Martin Delatycki Bettina Bert Heidrun Fink Katharina Blümlein Markus Ralser Anke Van Dijck Frank Kooy Zornitza Stark Sabine Müller Harry Scherthan Jozef Gecz Wolfgang Wurst Eckhard Wolf Andreas Zimmer Martin Klingenspor Jochen Graw Thomas Klopstock Dirk Busch Jerzy Adamski Helmut Fuchs Valérie Gailus-Durner Martin Hrabě de Angelis Oliver von Bohlen Und Halbach Hans-Hilger Ropers Andreas W Kuss

Biochim Biophys Acta Mol Basis Dis 2019 Sep 14;1865(9):2083-2093. Epub 2018 Dec 14.

Department of Functional Genomics, Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Felix-Hausdorff-Strasse 8, 17489 Greifswald, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.bbadis.2018.12.011DOI Listing
September 2019

Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality.

Authors:
Susanna H M Sluka Simon F Stämpfli Alexander Akhmedov Tanja Klein-Rodewald Adrián Sanz-Moreno Marion Horsch Paula Grest Andrea S Rothmeier Birgit Rathkolb Anja Schrewe Johannes Beckers Frauke Neff Eckhard Wolf Giovanni G Camici Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Thomas F Lüscher Wolfram Ruf Felix C Tanner

Haematologica 2019 Sep 5. Epub 2019 Sep 5.

Department of Cardiology, University Heart Center, University Hospital, Zurich, Switzerland

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3324/haematol.2019.218818DOI Listing
September 2019

Claudin-12 is not required for blood-brain barrier tight junction function.

Authors:
Mariana Castro Dias Caroline Coisne Pascale Baden Gaby Enzmann Lillian Garrett Lore Becker Sabine M Hölter Martin Hrabě de Angelis Urban Deutsch Britta Engelhardt

Fluids Barriers CNS 2019 Sep 12;16(1):30. Epub 2019 Sep 12.

Theodor Kocher Institute, University of Bern, Freiestr. 1, 3012, Bern, Switzerland.

View Article

Download full-text PDF

 Source
https://fluidsbarrierscns.biomedcentral.com/articles/10.1186
Publisher Site
http://dx.doi.org/10.1186/s12987-019-0150-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739961PMC
September 2019

Costs of Implementing Quality in Research Practice.

Authors:
O Meagan Littrell Claudia Stoeger Holger Maier Helmut Fuchs Martin Hrabě de Angelis Lisa A Cassis Greg A Gerhardt Richard Grondin Valérie Gailus-Durner

Handb Exp Pharmacol 2019 Sep 21. Epub 2019 Sep 21.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/164_2019_294DOI Listing
September 2019

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus.

Authors:
Mattias Backman Florian Flenkenthaler Andreas Blutke Maik Dahlhoff Erik Ländström Simone Renner Julia Philippou-Massier Stefan Krebs Birgit Rathkolb Cornelia Prehn Michal Grzybek Ünal Coskun Michael Rothe Jerzy Adamski Martin Hrabĕ de Angelis Rüdiger Wanke Thomas Fröhlich Georg J Arnold Helmut Blum Eckhard Wolf

Mol Metab 2019 08 4;26:30-44. Epub 2019 Jun 4.

Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2019.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667734PMC
August 2019

Mild maternal hyperglycemia in transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring.

Authors:
Simone Renner Ana Sofia Martins Elisabeth Streckel Christina Braun-Reichhart Mattias Backman Cornelia Prehn Nikolai Klymiuk Andrea Bähr Andreas Blutke Christina Landbrecht-Schessl Annegret Wünsch Barbara Kessler Mayuko Kurome Arne Hinrichs Sietse-Jan Koopmans Stefan Krebs Elisabeth Kemter Birgit Rathkolb Hiroshi Nagashima Helmut Blum Mathias Ritzmann Rüdiger Wanke Bernhard Aigner Jerzy Adamski Martin Hrabě de Angelis Eckhard Wolf

Dis Model Mech 2019 08 12;12(8). Epub 2019 Aug 12.

Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1242/dmm.039156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737953PMC
August 2019

Correction: From Dynamic Expression Patterns to Boundary Formation in the Presomitic Mesoderm.

Authors:
Hendrik B Tiedemann Elida Schneltzer Stefan Zeiser Bastian Hoesel Johannes Beckers Gerhard K H Przemeck Martin Hrabě de Angelis

PLoS Comput Biol 2019 Jul 2;15(7):e1007191. Epub 2019 Jul 2.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1371/journal.pcbi.1007191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605643PMC
July 2019

Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice.

Authors:
Tamara Heermann Lillian Garrett Wolfgang Wurst Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Jochen Graw Sabine M Hölter

Mol Neurobiol 2019 Jun 6;56(6):4215-4230. Epub 2018 Oct 6.

Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Centre for Environmental Health, 85764, Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/s12035-018-1365-5
Publisher Site
http://dx.doi.org/10.1007/s12035-018-1365-5DOI Listing
June 2019

Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans.

Authors:
Koichiro Abe Allison Cox Nobuhiko Takamatsu Gabriel Velez Ronald M Laxer Shirley M L Tse Vinit B Mahajan Alexander G Bassuk Helmut Fuchs Polly J Ferguson Martin Hrabe de Angelis

Proc Natl Acad Sci U S A 2019 Jun 28;116(24):11872-11877. Epub 2019 May 28.

Institute of Experimental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1819825116
Publisher Site
http://dx.doi.org/10.1073/pnas.1819825116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575637PMC
June 2019

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.

Authors:
Sandro Altamura Naidu M Vegi Philipp S Hoppe Timm Schroeder Michaela Aichler Axel Walch Katarzyna Okreglicka Lothar Hültner Manuela Schneider Camilla Ladinig Cornelia Kuklik-Roos Josef Mysliwietz Dirk Janik Frauke Neff Birgit Rathkolb Martin Hrabé de Angelis Christian Buske Ana Rita da Silva Katja Muedder Marcus Conrad Tomas Ganz Manfred Kopf Martina U Muckenthaler Georg W Bornkamm

Haematologica 2019 Jun 27. Epub 2019 Jun 27.

Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, Germany;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3324/haematol.2018.212977DOI Listing
June 2019

RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.

Authors:
Kareen Bartsch Markus Damme Tommy Regen Lore Becker Lillian Garrett Sabine M Hölter Katharina Knittler Christopher Borowski Ari Waisman Markus Glatzel Helmut Fuchs Valerie Gailus-Durner Martin Hrabe de Angelis Björn Rabe

Front Immunol 2018 29;9:587. Epub 2018 Mar 29.

Medical Faculty, Institute of Biochemistry, Christian-Albrechts-University Kiel, Kiel, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fimmu.2018.00587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890188PMC
May 2019

A Polygenic Risk Score of Lipolysis-Increasing Alleles Determines Visceral Fat Mass and Proinsulin Conversion.

Authors:
Daniela Kempe-Teufel Fausto Machicao Jürgen Machann Anja Böhm Fritz Schick Andreas Fritsche Norbert Stefan Martin Hrabě de Angelis Hans-Ulrich Häring Harald Staiger

J Clin Endocrinol Metab 2019 Apr;104(4):1090-1098

German Center for Diabetes Research (DZD), Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1210/jc.2018-02042DOI Listing
April 2019

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Authors:
Bret A Moore Brian C Leonard Lionel Sebbag Sydney G Edwards Ann Cooper Denise M Imai Ewan Straiton Luis Santos Christopher Reilly Stephen M Griffey Lynette Bower David Clary Jeremy Mason Michel J Roux Hamid Meziane Yann Herault Colin McKerlie Ann M Flenniken Lauryl M J Nutter Zorana Berberovic Celeste Owen Susan Newbigging Hibret Adissu Mohammed Eskandarian Chih-Wei Hsu Sowmya Kalaga Uchechukwu Udensi Chinwe Asomugha Ritu Bohat Juan J Gallegos John R Seavitt Jason D Heaney Arthur L Beaudet Mary E Dickinson Monica J Justice Vivek Philip Vivek Kumar Karen L Svenson Robert E Braun Sara Wells Heather Cater Michelle Stewart Sharon Clementson-Mobbs Russell Joynson Xiang Gao Tomohiro Suzuki Shigeharu Wakana Damian Smedley J K Seong Glauco Tocchini-Valentini Mark Moore Colin Fletcher Natasha Karp Ramiro Ramirez-Solis Jacqueline K White Martin Hrabe de Angelis Wolfgang Wurst Sara M Thomasy Paul Flicek Helen Parkinson Steve D M Brown Terrence F Meehan Patsy M Nishina Stephen A Murray Mark P Krebs Ann-Marie Mallon K C Kent Lloyd Christopher J Murphy Ala Moshiri

Commun Biol 2019 7;2:97. Epub 2019 Mar 7.

27Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA 95817 USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s42003-019-0349-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405960PMC
March 2019

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke.

Authors:
Ana I Casas Pamela Wm Kleikers Eva Geuss Friederike Langhauser Thure Adler Dirk H Busch Valerie Gailus-Durner Martin Hrabê de Angelis Javier Egea Manuela G Lopez Christoph Kleinschnitz Harald Hhw Schmidt

J Clin Invest 2019 Mar 18;130:1772-1778. Epub 2019 Mar 18.

Department of Pharmacology and Personalised Medicine, CARIM, Maastricht University, Maastricht, The Netherlands.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1172/JCI124283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436900PMC
March 2019

Genes Whose Gain or Loss-of-Function Increases Endurance Performance in Mice: A Systematic Literature Review.

Authors:
Fakhreddin Yaghoob Nezhad Sander A J Verbrugge Martin Schönfelder Lore Becker Martin Hrabě de Angelis Henning Wackerhage

Front Physiol 2019 22;10:262. Epub 2019 Mar 22.

Exercise Biology Group, Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fphys.2019.00262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439621PMC
March 2019

Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin.

Authors:
Michaela Keuper Lucia Berti Bernhard Raedle Stephan Sachs Anja Böhm Louise Fritsche Andreas Fritsche Hans-Ulrich Häring Martin Hrabě de Angelis Martin Jastroch Susanna M Hofmann Harald Staiger

Mol Metab 2019 02 26;20:28-37. Epub 2018 Nov 26.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358537PMC
February 2019

Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy.

Authors:
Jayasimman Rajendran Janne Purhonen Saara Tegelberg Olli-Pekka Smolander Matthias Mörgelin Jan Rozman Valerie Gailus-Durner Helmut Fuchs Martin Hrabe de Angelis Petri Auvinen Eero Mervaala Howard T Jacobs Marten Szibor Vineta Fellman Jukka Kallijärvi

EMBO Mol Med 2019 01;11(1)

Folkhälsan Research Center, Helsinki, Finland

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.15252/emmm.201809456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328925PMC
January 2019

Measuring and Interpreting Oxygen Consumption Rates in Whole Fly Head Segments.

Authors:
Louisa Jutta Dietz Anuroop Venkateswaran Venkatasubramani Annika Müller-Eigner Martin Hrabe de Angelis Axel Imhof Lore Becker Shahaf Peleg

J Vis Exp 2019 01 7(143). Epub 2019 Jan 7.

Laboratory for Metabolism and Epigenetics in Aging, Leibniz Institute for Farm Animal Biology (FBN); Laboratory for Metabolism and Epigenetics in Brain Aging, Institute of Neuroregeneration & Neurorehabilitation of Qingdao University; Molecular Biology Division, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians University of Munich;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3791/58601DOI Listing
January 2019

Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice.

Authors:
Claudia Schob Fabio Morellini Ora Ohana Lidia Bakota Mariya V Hrynchak Roland Brandt Marco D Brockmann Nicole Cichon Henrike Hartung Ileana L Hanganu-Opatz Vanessa Kraus Sarah Scharf Irm Herrmans-Borgmeyer Michaela Schweizer Dietmar Kuhl Markus Wöhr Karl J Vörckel Julia Calzada-Wack Helmut Fuchs Valérie Gailus-Durner Martin Hrabě de Angelis Craig C Garner Hans-Jürgen Kreienkamp Stefan Kindler

Transl Psychiatry 2019 01 16;9(1). Epub 2019 Jan 16.

Institute for Human Genetics, University Medical Centre Hamburg-Eppendorf, 20246, Hamburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41398-018-0327-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341115PMC
January 2019

Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Authors:
Bret A Moore Brian C Leonard Lionel Sebbag Sydney G Edwards Ann Cooper Denise M Imai Ewan Straiton Luis Santos Christopher Reilly Stephen M Griffey Lynette Bower David Clary Jeremy Mason Michel J Roux Hamid Meziane Yann Herault Colin McKerlie Ann M Flenniken Lauryl M J Nutter Zorana Berberovic Celeste Owen Susan Newbigging Hibret Adissu Mohammed Eskandarian Chih-Wei Hsu Sowmya Kalaga Uchechukwu Udensi Chinwe Asomugha Ritu Bohat Juan J Gallegos John R Seavitt Jason D Heaney Arthur L Beaudet Mary E Dickinson Monica J Justice Vivek Philip Vivek Kumar Karen L Svenson Robert E Braun Sara Wells Heather Cater Michelle Stewart Sharon Clementson-Mobbs Russell Joynson Xiang Gao Tomohiro Suzuki Shigeharu Wakana Damian Smedley J K Seong Glauco Tocchini-Valentini Mark Moore Colin Fletcher Natasha Karp Ramiro Ramirez-Solis Jacqueline K White Martin Hrabe de Angelis Wolfgang Wurst Sara M Thomasy Paul Flicek Helen Parkinson Steve D M Brown Terrence F Meehan Patsy M Nishina Stephen A Murray Mark P Krebs Ann-Marie Mallon K C Kent Lloyd Christopher J Murphy Ala Moshiri

Commun Biol 2018 21;1:236. Epub 2018 Dec 21.

27Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA 95817 USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s42003-018-0226-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303268PMC
December 2018

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.

Authors:
Ana Luisa Cardoso Adelaide Fernandes Juan Antonio Aguilar-Pimentel Martin Hrabě de Angelis Joana Ribeiro Guedes Maria Alexandra Brito Saida Ortolano Giovambattista Pani Sophia Athanasopoulou Efstathios S Gonos Markus Schosserer Johannes Grillari Pärt Peterson Bilge Guvenc Tuna Soner Dogan Angelika Meyer Ronald van Os Anne-Ulrike Trendelenburg

Ageing Res Rev 2018 Nov 30;47:214-277. Epub 2018 Jul 30.

Novartis Institutes for Biomedical Research, Musculoskeletal Disease Area, Muscle Research, Cambridge, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.arr.2018.07.004DOI Listing
November 2018

Dilution correction for dynamically influenced urinary analyte data.

Authors:
Johannes Hertel Markus Rotter Stefan Frenzel Helena U Zacharias Jan Krumsiek Birgit Rathkolb Martin Hrabe de Angelis Sylvia Rabstein Dirk Pallapies Thomas Brüning Hans J Grabe Rui Wang-Sattler

Anal Chim Acta 2018 Nov 28;1032:18-31. Epub 2018 Jul 28.

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Germany; Institute of Epidemiology, Helmholtz Zentrum München, Germany; German Center for Diabetes Research (DZD), München, Germany.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00032670183093
Publisher Site
http://dx.doi.org/10.1016/j.aca.2018.07.068DOI Listing
November 2018

Impact of Brain Fatty Acid Signaling on Peripheral Insulin Action in Mice.

Authors:
Susanne Neschen Moya Wu Christiane Fuchs Ivan Kondofersky Fabian J Theis Martin Hrabě de Angelis Hans-Ulrich Häring Tina Sartorius

Exp Clin Endocrinol Diabetes 2018 Nov 5. Epub 2018 Nov 5.

German Center for Diabetes Research (DZD), Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0735-9533
Publisher Site
http://dx.doi.org/10.1055/a-0735-9533DOI Listing
November 2018

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.

Authors:
Helmut Fuchs Juan Antonio Aguilar-Pimentel Oana V Amarie Lore Becker Julia Calzada-Wack Yi-Li Cho Lillian Garrett Sabine M Hölter Martin Irmler Martin Kistler Markus Kraiger Philipp Mayer-Kuckuk Kristin Moreth Birgit Rathkolb Jan Rozman Patricia da Silva Buttkus Irina Treise Annemarie Zimprich Kristine Gampe Christine Hutterer Claudia Stöger Stefanie Leuchtenberger Holger Maier Manuel Miller Angelika Scheideler Moya Wu Johannes Beckers Raffi Bekeredjian Markus Brielmeier Dirk H Busch Martin Klingenspor Thomas Klopstock Markus Ollert Carsten Schmidt-Weber Tobias Stöger Eckhard Wolf Wolfgang Wurst Ali Önder Yildirim Andreas Zimmer Valérie Gailus-Durner Martin Hrabě de Angelis

Behav Brain Res 2018 10 29;352:187-196. Epub 2017 Sep 29.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter-Landstr. 1, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter-Landstr. 1, 85764 Neuherberg, Germany; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Alte Akademie 8, 85354 Freising, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.bbr.2017.09.048DOI Listing
October 2018

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.

Authors:
Simone Renner Andreas Blutke Britta Dobenecker Georg Dhom Timo D Müller Brian Finan Christoffer Clemmensen Maren Bernau Istvan Novak Birgit Rathkolb Steffanie Senf Susanne Zöls Mirjam Roth Anna Götz Susanna M Hofmann Martin Hrabĕ de Angelis Rüdiger Wanke Ellen Kienzle Armin M Scholz Richard DiMarchi Mathias Ritzmann Matthias H Tschöp Eckhard Wolf

Mol Metab 2018 10 28;16:180-190. Epub 2018 Jun 28.

Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany; Center for Innovative Medical Models (CiMM), Department of Veterinary Sciences, LMU Munich, Hackerstr. 27, 85764, Oberschleißheim, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2018.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157610PMC
October 2018

RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure.

Authors:
Mamta Jain Tomer D Mann Maja Stulić Shailaja P Rao Andrijana Kirsch Dieter Pullirsch Xué Strobl Claus Rath Lukas Reissig Kristin Moreth Tanja Klein-Rodewald Raffi Bekeredjian Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Eleonore Pablik Laura Cimatti David Martin Jelena Zinnanti Wolfgang F Graier Maria Sibilia Saša Frank Erez Y Levanon Michael F Jantsch

EMBO J 2018 10 7;37(19). Epub 2018 Aug 7.

Division of Cell Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.15252/embj.201694813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166124PMC
October 2018

Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.

Authors:
Stephanie Stanelle-Bertram Kerstin Walendy-Gnirß Thomas Speiseder Swantje Thiele Ivy Asantewaa Asante Carola Dreier Nancy Mounogou Kouassi Annette Preuß Gundula Pilnitz-Stolze Ursula Müller Stefanie Thanisch Melanie Richter Robin Scharrenberg Vanessa Kraus Ronja Dörk Lynn Schau Vanessa Herder Ingo Gerhauser Vanessa Maria Pfankuche Christopher Käufer Inken Waltl Thais Moraes Julie Sellau Stefan Hoenow Jonas Schmidt-Chanasit Stephanie Jansen Benjamin Schattling Harald Ittrich Udo Bartsch Thomas Renné Ralf Bartenschlager Petra Arck Daniel Cadar Manuel A Friese Olli Vapalahti Hanna Lotter Sany Benites Lane Rolling Martin Gabriel Wolfgang Baumgärtner Fabio Morellini Sabine M Hölter Oana Amarie Helmut Fuchs Martin Hrabe de Angelis Wolfgang Löscher Froylan Calderon de Anda Gülsah Gabriel

Nat Microbiol 2018 10 10;3(10):1161-1174. Epub 2018 Sep 10.

Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41564-018-0236-1DOI Listing
October 2018

The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?

Authors:
Christoph S Clemen Lilli Winter Karl-Heinz Strucksberg Carolin Berwanger Matthias Türk Cornelia Kornblum Alexandra Florin Juan Antonio Aguilar-Pimentel Oana Veronica Amarie Lore Becker Lillian Garrett Wolfgang Hans Kristin Moreth Frauke Neff Laura Pingen Birgit Rathkolb Ildikó Rácz Jan Rozman Irina Treise Helmut Fuchs Valerie Gailus-Durner Martin Hrabe de Angelis Matthias Vorgerd Ludwig Eichinger Rolf Schröder

Biochem Biophys Res Commun 2018 09 9;503(4):2770-2777. Epub 2018 Aug 9.

Institute of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054, Erlangen, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.bbrc.2018.08.038DOI Listing
September 2018

Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.

Authors:
Irem Bayindir-Buchhalter Gretchen Wolff Sarah Lerch Tjeerd Sijmonsma Maximilian Schuster Jan Gronych Adrian T Billeter Rohollah Babaei Damir Krunic Lars Ketscher Nadine Spielmann Martin Hrabe de Angelis Jorge L Ruas Beat P Müller-Stich Mathias Heikenwalder Peter Lichter Stephan Herzig Alexandros Vegiopoulos

EMBO Mol Med 2018 08;10(8)

DKFZ Junior Group Metabolism and Stem Cell Plasticity, German Cancer Research Center, Heidelberg, Germany

View Article

Download full-text PDF

 Source
http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201
Publisher Site
http://dx.doi.org/10.15252/emmm.201708613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079535PMC
August 2018

Night Shift Work Affects Urine Metabolite Profiles of Nurses with Early Chronotype.

Authors:
Markus Rotter Stefan Brandmaier Marcela Covic Katarzyna Burek Johannes Hertel Martina Troll Erik Bader Jonathan Adam Cornelia Prehn Birgit Rathkolb Martin Hrabe de Angelis Hans Jörgen Grabe Hannelore Daniel Thomas Kantermann Volker Harth Thomas Illig Dirk Pallapies Thomas Behrens Thomas Brüning Jerzy Adamski Heiko Lickert Sylvia Rabstein Rui Wang-Sattler

Metabolites 2018 Aug 21;8(3). Epub 2018 Aug 21.

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 München-Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3390/metabo8030045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161245PMC
August 2018

Neuron-specific inactivation of alters locomotion in mice and changes interneuron composition in the spinal cord.

Authors:
Danny Schnerwitzki Sharn Perry Anna Ivanova Fabio V Caixeta Paul Cramer Sven Günther Kathrin Weber Atieh Tafreshiha Lore Becker Ingrid L Vargas Panesso Thomas Klopstock Martin Hrabe de Angelis Manuela Schmidt Klas Kullander Christoph Englert

Life Sci Alliance 2018 Aug 16;1(4):e201800106. Epub 2018 Aug 16.

Molecular Genetics Lab, Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.26508/lsa.201800106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238623PMC
August 2018

The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk.

Authors:
Eva-Maria Pastor-Arroyo Nicole Gehring Christiane Krudewig Sarah Costantino Carla Bettoni Thomas Knöpfel Sibylle Sabrautzki Bettina Lorenz-Depiereux Johanne Pastor Tim M Strom Martin Hrabě de Angelis Giovanni G Camici Francesco Paneni Carsten A Wagner Isabel Rubio-Aliaga

Kidney Int 2018 07 5;94(1):49-59. Epub 2018 May 5.

Institute of Physiology, University of Zurich, and National Center for Competence in Research NCCR Kidney.CH, Zurich, Switzerland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.kint.2018.02.017DOI Listing
July 2018

Micro-imaging of Brain Cancer Radiation Therapy Using Phase-contrast Computed Tomography.

Authors:
Giacomo E Barbone Alberto Bravin Pantaleo Romanelli Alberto Mittone Domenico Bucci Thomas Gaaβ Géraldine Le Duc Sigrid Auweter Maximilian F Reiser Markus J Kraiger Martin Hrabě de Angelis Giuseppe Battaglia Paola Coan

Int J Radiat Oncol Biol Phys 2018 07 7;101(4):965-984. Epub 2018 Apr 7.

Department of Physics, Ludwig Maximilians University, Garching, Germany; Department of Clinical Radiology, Ludwig Maximilians University, Munich, Germany. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S03603016183061
Publisher Site
http://dx.doi.org/10.1016/j.ijrobp.2018.03.063DOI Listing
July 2018

Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.

Authors:
Polyxeni Nikolakopoulou Antonios Chatzigeorgiou Ioannis Kourtzelis Louiza Toutouna Jimmy Masjkur Carina Arps-Forker Steven W Poser Jan Rozman Birgit Rathkolb Juan Antonio Aguilar-Pimentel Eckhard Wolf Martin Klingenspor Markus Ollert Carsten Schmidt-Weber Helmut Fuchs Valerie Gailus-Durner Martin Hrabe de Angelis Vasiliki Tsata Laura Sebastian Monasor Maria Troullinaki Anke Witt Vivian Anastasiou George Chrousos Chun-Xia Yi Cristina García-Cáceres Matthias H Tschöp Stefan R Bornstein Andreas Androutsellis-Theotokis

Sci Rep 2018 07 27;8(1):11335. Epub 2018 Jul 27.

Department of Medicine, Technische Universität Dresden, Dresden, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-018-29434-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063949PMC
July 2018

Fgf9 Mutation Alters Information Processing and Social Memory in Mice.

Authors:
Lillian Garrett Lore Becker Jan Rozman Oliver Puk Tobias Stoeger Ali Önder Yildirim Alexander Bohla Oliver Eickelberg Wolfgang Hans Cornelia Prehn Jerzy Adamski Thomas Klopstock Ildikó Rácz Andreas Zimmer Martin Klingenspor Helmut Fuchs Valerie Gailus-Durner Wolfgang Wurst Martin Hrabě de Angelis Jochen Graw Sabine M Hölter

Mol Neurobiol 2018 Jun 10;55(6):4580-4595. Epub 2017 Jul 10.

Institutes of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/s12035-017-0659-3
Publisher Site
http://dx.doi.org/10.1007/s12035-017-0659-3DOI Listing
June 2018

Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia.

Authors:
Daniel Komnig Karen Gertz Pardes Habib Kay W Nolte Tareq Meyer Marc A Brockmann Matthias Endres Birgit Rathkolb Martin Hrabě de Angelis Jörg B Schulz Björn H Falkenburger Arno Reich

J Neurochem 2018 05 20;145(3):258-270. Epub 2018 Feb 20.

Department of Neurology, RWTH Aachen University, Aachen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/jnc.14296DOI Listing
May 2018

Genetic and Molecular Insights Into Genotype-Phenotype Relationships in Osteopathia Striata With Cranial Sclerosis (OSCS) Through the Analysis of Novel Mouse Wtx Mutant Alleles.

Authors:
Glenda Comai Agnès Boutet Kristina Tanneberger Filippo Massa Ana-Sofia Rocha Aurelie Charlet Clara Panzolini Fariba Jian Motamedi Robert Brommage Wolfgang Hans Thomas Funck-Brentano Martin Hrabe de Angelis Christine Hartmann Martine Cohen-Solal Jürgen Behrens Andreas Schedl

J Bone Miner Res 2018 05 1;33(5):875-887. Epub 2018 Mar 1.

Université Côte d'Azur, INSERM, CNRS, Institut de Biologie Valrose (iBV), Nice, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/jbmr.3387DOI Listing
May 2018

Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.

Authors:
Jie Jia Thomas M Conlon Rim Sj Sarker Demet Taşdemir Natalia F Smirnova Barkha Srivastava Stijn E Verleden Gizem Güneş Xiao Wu Cornelia Prehn Jiaqi Gao Katharina Heinzelmann Jutta Lintelmann Martin Irmler Stefan Pfeiffer Michael Schloter Ralf Zimmermann Martin Hrabé de Angelis Johannes Beckers Jerzy Adamski Hasan Bayram Oliver Eickelberg Ali Önder Yildirim

EMBO Mol Med 2018 05;10(5)

Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Munich, Germany

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.15252/emmm.201708349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938615PMC
May 2018

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.

Authors:
Arne Hinrichs Barbara Kessler Mayuko Kurome Andreas Blutke Elisabeth Kemter Maren Bernau Armin M Scholz Birgit Rathkolb Simone Renner Sebastian Bultmann Heinrich Leonhardt Martin Hrabĕ de Angelis Hiroshi Nagashima Andreas Hoeflich Werner F Blum Martin Bidlingmaier Rüdiger Wanke Maik Dahlhoff Eckhard Wolf

Mol Metab 2018 05 15;11:113-128. Epub 2018 Mar 15.

Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Feodor-Lynen-Str. 25, 81377 Munich, Germany; Center for Innovative Medical Models (CiMM), Department of Veterinary Sciences, LMU Munich, Hackerstr. 27, 85764 Oberschleißheim, Germany; Meiji University International Institute for Bio-Resource Research, 1-1-1 Higashimita, Tama, Kawasaki, 214-8571, Japan; German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Feodor-Lynen-Str. 25, 81377 Munich, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001387PMC
May 2018

hIAPP forms toxic oligomers in plasma.

Authors:
Diana C Rodriguez Camargo Divita Garg Katalin Buday Andras Franko Andres Rodriguez Camargo Fabian Schmidt Sarah J Cox Saba Suladze Martin Haslbeck Yonatan G Mideksa Gerd Gemmecker Michaela Aichler Gabriele Mettenleiter Michael Schulz Axel Karl Walch Martin Hrabě de Angelis Matthias J Feige Cesar A Sierra Marcus Conrad Konstantinos Tripsianes Ayyalusamy Ramamoorthy Bernd Reif

Chem Commun (Camb) 2018 May;54(43):5426-5429

Institute for Advanced Study, Technische Universität München, 85748 Garching, Germany.

View Article

Download full-text PDF

 Source
http://xlink.rsc.org/?DOI=C8CC03097A
Publisher Site
http://dx.doi.org/10.1039/c8cc03097aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970100PMC
May 2018

Bacterial encapsulins as orthogonal compartments for mammalian cell engineering.

Authors:
Felix Sigmund Christoph Massner Philipp Erdmann Anja Stelzl Hannes Rolbieski Mitul Desai Sarah Bricault Tobias P Wörner Joost Snijder Arie Geerlof Helmut Fuchs Martin Hrabĕ de Angelis Albert J R Heck Alan Jasanoff Vasilis Ntziachristos Jürgen Plitzko Gil G Westmeyer

Nat Commun 2018 05 18;9(1):1990. Epub 2018 May 18.

Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany.

View Article

Download full-text PDF

 Source
http://www.nature.com/articles/s41467-018-04227-3
Publisher Site
http://dx.doi.org/10.1038/s41467-018-04227-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959871PMC
May 2018

Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review.

Authors:
Sander A J Verbrugge Martin Schönfelder Lore Becker Fakhreddin Yaghoob Nezhad Martin Hrabě de Angelis Henning Wackerhage

Front Physiol 2018 22;9:553. Epub 2018 May 22.

Exercise Biology Group, Faculty of Sport and Health Sciences, Technical University of Munich, Munich, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fphys.2018.00553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992403PMC
May 2018

The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation.

Authors:
Violeta Muñoz-Fuentes Pilar Cacheiro Terrence F Meehan Juan Antonio Aguilar-Pimentel Steve D M Brown Ann M Flenniken Paul Flicek Antonella Galli Hamed Haseli Mashhadi Martin Hrabě de Angelis Jong Kyoung Kim K C Kent Lloyd Colin McKerlie Hugh Morgan Stephen A Murray Lauryl M J Nutter Patrick T Reilly John R Seavitt Je Kyung Seong Michelle Simon Hannah Wardle-Jones Ann-Marie Mallon Damian Smedley Helen E Parkinson

Conserv Genet 2018 19;19(4):995-1005. Epub 2018 May 19.

1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s10592-018-1072-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061128PMC
May 2018

Analysis of locomotor behavior in the German Mouse Clinic.

Authors:
Annemarie Zimprich Manuela A Östereicher Lore Becker Petra Dirscherl Luise Ernst Helmut Fuchs Valerie Gailus-Durner Lillian Garrett Florian Giesert Lisa Glasl Angelika Hummel Jan Rozman Martin Hrabě de Angelis Daniela Vogt-Weisenhorn Wolfgang Wurst Sabine M Hölter

J Neurosci Methods 2018 04 5;300:77-91. Epub 2017 May 5.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, Ingolstaedter Landstr.1, 85764 Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jneumeth.2017.05.005DOI Listing
April 2018

Pharmacogenetics of oral antidiabetic therapy.

Authors:
Anna-Maria Ordelheide Martin Hrabě de Angelis Hans-Ulrich Häring Harald Staiger

Pharmacogenomics 2018 04 27;19(6):577-587. Epub 2018 Mar 27.

Institute for Diabetes Research & Metabolic Diseases of the Helmholtz Centre Munich at the Eberhard Karls University Tübingen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2217/pgs-2017-0195DOI Listing
April 2018

Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis.

Authors:
Maria Sakkou Panagiotis Chouvardas Lydia Ntari Alejandro Prados Kristin Moreth Helmut Fuchs Valerie Gailus-Durner Martin Hrabe de Angelis Maria C Denis Niki Karagianni George Kollias

JCI Insight 2018 04 5;3(7). Epub 2018 Apr 5.

Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1172/jci.insight.98864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928856PMC
April 2018

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

Authors:
Irina Treise Eva M Huber Tanja Klein-Rodewald Wolfgang Heinemeyer Simon A Grassmann Michael Basler Thure Adler Birgit Rathkolb Laura Helming Christian Andres Matthias Klaften Christina Landbrecht Thomas Wieland Tim M Strom Kathy D McCoy Andrew J Macpherson Eckhard Wolf Marcus Groettrup Markus Ollert Frauke Neff Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Michael Groll Dirk H Busch

Sci Rep 2018 04 13;8(1):5975. Epub 2018 Apr 13.

Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Trogerstr. 30, 81675, Munich, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-018-24199-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899138PMC
April 2018

Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.

Authors:
Viola André Christine Gau Angelika Scheideler Juan A Aguilar-Pimentel Oana V Amarie Lore Becker Lillian Garrett Wolfgang Hans Sabine M Hölter Dirk Janik Kristin Moreth Frauke Neff Manuela Östereicher Ildiko Racz Birgit Rathkolb Jan Rozman Raffi Bekeredjian Jochen Graw Martin Klingenspor Thomas Klopstock Markus Ollert Carsten Schmidt-Weber Eckhard Wolf Wolfgang Wurst Valérie Gailus-Durner Markus Brielmeier Helmut Fuchs Martin Hrabé de Angelis

PLoS Biol 2018 04 16;16(4):e2005019. Epub 2018 Apr 16.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1371/journal.pbio.2005019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922977PMC
April 2018

A Vitamin E-Enriched Antioxidant Diet Interferes with the Acute Adaptation of the Liver to Physical Exercise in Mice.

Authors:
Miriam Hoene Martin Irmler Johannes Beckers Martin Hrabě de Angelis Hans-Ulrich Häring Cora Weigert

Nutrients 2018 Apr 28;10(5). Epub 2018 Apr 28.

Division of Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine IV, University Hospital Tübingen, 72076 Tübingen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3390/nu10050547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986427PMC
April 2018

Animal models of obesity and diabetes mellitus.

Authors:
Maximilian Kleinert Christoffer Clemmensen Susanna M Hofmann Mary C Moore Simone Renner Stephen C Woods Peter Huypens Johannes Beckers Martin Hrabe de Angelis Annette Schürmann Mostafa Bakhti Martin Klingenspor Mark Heiman Alan D Cherrington Michael Ristow Heiko Lickert Eckhard Wolf Peter J Havel Timo D Müller Matthias H Tschöp

Nat Rev Endocrinol 2018 03 19;14(3):140-162. Epub 2018 Jan 19.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/nrendo.2017.161DOI Listing
March 2018

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.

Authors:
Xianming Wang Michael Sterr Ingo Burtscher Shen Chen Anja Hieronimus Fausto Machicao Harald Staiger Hans-Ulrich Häring Gabriele Lederer Thomas Meitinger Filippo M Cernilogar Gunnar Schotta Martin Irmler Johannes Beckers Martin Hrabě de Angelis Michael Ray Christopher V E Wright Mostafa Bakhti Heiko Lickert

Mol Metab 2018 03 31;9:57-68. Epub 2018 Jan 31.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Parkring 11, 85748, Garching, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Chair of ß-Cell Biology, Technische Universität München, Ismaningerstraße 22, 81675 München, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2018.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870105PMC
March 2018

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.

Authors:
Kan Xie Devon P Ryan Brandon L Pearson Kristin S Henzel Frauke Neff Ramon O Vidal Magali Hennion Isabelle Lehmann Melvin Schleif Susanne Schröder Thure Adler Birgit Rathkolb Jan Rozman Anna-Lena Schütz Cornelia Prehn Michel E Mickael Marco Weiergräber Jerzy Adamski Dirk H Busch Gerhard Ehninger Anna Matynia Walker S Jackson Eckhard Wolf Helmut Fuchs Valerie Gailus-Durner Stefan Bonn Martin Hrabě de Angelis Dan Ehninger

Proc Natl Acad Sci U S A 2018 03 21;115(10):E2348-E2357. Epub 2018 Feb 21.

Molecular and Cellular Cognition Lab, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1073/pnas.1707337115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877957PMC
March 2018

Rapid and transient oxygen consumption increase following acute HDAC/KDAC inhibition in Drosophila tissue.

Authors:
Lore Becker Melanie Schmitt Nogueira Caroline Klima Martin Hrabe de Angelis Shahaf Peleg

Sci Rep 2018 03 8;8(1):4199. Epub 2018 Mar 8.

Munich Center of Integrated Protein Science and Biomedical Center, Ludwig-Maximilians University of Munich, Planegg-Martinsried, 80336, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-018-22674-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843646PMC
March 2018

Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test.

Authors:
Rohit Babbar Martin Heni Andreas Peter Martin Hrabě de Angelis Hans-Ulrich Häring Andreas Fritsche Hubert Preissl Bernhard Schölkopf Róbert Wagner

Front Endocrinol (Lausanne) 2018 19;9:82. Epub 2018 Mar 19.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University Hospital of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fendo.2018.00082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868129PMC
March 2018

The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation.

Authors:
Marcel Oliver Schmidt Khalid Ammar Garman Yong Gu Lee Chong Zuo Patrick James Beck Mingjun Tan Juan Antonio Aguilar-Pimentel Markus Ollert Carsten Schmidt-Weber Helmut Fuchs Valerie Gailus-Durner Martin Hrabe de Angelis Elena Tassi Anna Tate Riegel Anton Wellstein

J Invest Dermatol 2018 01 31;138(1):179-188. Epub 2017 Aug 31.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jid.2017.07.847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742071PMC
January 2018

The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells.

Authors:
Christoph Hoffmann Selina Höckele Lisa Kappler Martin Hrabĕ de Angelis Hans-Ulrich Häring Cora Weigert

Sci Rep 2018 01 15;8(1):737. Epub 2018 Jan 15.

Division of Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-017-18658-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768688PMC
January 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Authors:
Jan Rozman Birgit Rathkolb Manuela A Oestereicher Christine Schütt Aakash Chavan Ravindranath Stefanie Leuchtenberger Sapna Sharma Martin Kistler Monja Willershäuser Robert Brommage Terrence F Meehan Jeremy Mason Hamed Haselimashhadi Tertius Hough Ann-Marie Mallon Sara Wells Luis Santos Christopher J Lelliott Jacqueline K White Tania Sorg Marie-France Champy Lynette R Bower Corey L Reynolds Ann M Flenniken Stephen A Murray Lauryl M J Nutter Karen L Svenson David West Glauco P Tocchini-Valentini Arthur L Beaudet Fatima Bosch Robert B Braun Michael S Dobbie Xiang Gao Yann Herault Ala Moshiri Bret A Moore K C Kent Lloyd Colin McKerlie Hiroshi Masuya Nobuhiko Tanaka Paul Flicek Helen E Parkinson Radislav Sedlacek Je Kyung Seong Chi-Kuang Leo Wang Mark Moore Steve D Brown Matthias H Tschöp Wolfgang Wurst Martin Klingenspor Eckhard Wolf Johannes Beckers Fausto Machicao Andreas Peter Harald Staiger Hans-Ulrich Häring Harald Grallert Monica Campillos Holger Maier Helmut Fuchs Valerie Gailus-Durner Thomas Werner Martin Hrabe de Angelis

Nat Commun 2018 01 18;9(1):288. Epub 2018 Jan 18.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41467-017-01995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773596PMC
January 2018

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.

Authors:
Andras Franko Diana C Rodriguez Camargo Annett Böddrich Divita Garg Andres Rodriguez Camargo Birgit Rathkolb Dirk Janik Michaela Aichler Annette Feuchtinger Frauke Neff Helmut Fuchs Erich E Wanker Bernd Reif Hans-Ulrich Häring Andreas Peter Martin Hrabě de Angelis

Sci Rep 2018 01 18;8(1):1116. Epub 2018 Jan 18.

Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-017-18807-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773570PMC
January 2018

Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin.

Authors:
Laura Stirm Peter Huypens Steffen Sass Richa Batra Louise Fritsche Sara Brucker Harald Abele Anita M Hennige Fabian Theis Johannes Beckers Martin Hrabě de Angelis Andreas Fritsche Hans-Ulrich Häring Harald Staiger

Sci Rep 2018 01 22;8(1):1366. Epub 2018 Jan 22.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-018-19200-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778051PMC
January 2018

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

Authors:
Jason Flannick Christian Fuchsberger Anubha Mahajan Tanya M Teslovich Vineeta Agarwala Kyle J Gaulton Lizz Caulkins Ryan Koesterer Clement Ma Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Dennis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmus Njølstad Jonathan C Levy Massimo Mangino Lori L Bonnycastle Thomas Schwarzmayr João Fadista Gabriela L Surdulescu Christian Herder Christopher J Groves Thomas Wieland Jette Bork-Jensen Ivan Brandslund Cramer Christensen Heikki A Koistinen Alex S F Doney Leena Kinnunen Tõnu Esko Andrew J Farmer Liisa Hakaste Dylan Hodgkiss Jasmina Kravic Valeri Lyssenko Mette Hollensted Marit E Jørgensen Torben Jørgensen Claes Ladenvall Johanne Marie Justesen Annemari Käräjämäki Jennifer Kriebel Wolfgang Rathmann Lars Lannfelt Torsten Lauritzen Narisu Narisu Allan Linneberg Olle Melander Lili Milani Matt Neville Marju Orho-Melander Lu Qi Qibin Qi Michael Roden Olov Rolandsson Amy Swift Anders H Rosengren Kathleen Stirrups Andrew R Wood Evelin Mihailov Christine Blancher Mauricio O Carneiro Jared Maguire Ryan Poplin Khalid Shakir Timothy Fennell Mark DePristo Martin Hrabé de Angelis Panos Deloukas Anette P Gjesing Goo Jun Peter Nilsson Jacquelyn Murphy Robert Onofrio Barbara Thorand Torben Hansen Christa Meisinger Frank B Hu Bo Isomaa Fredrik Karpe Liming Liang Annette Peters Cornelia Huth Stephen P O'Rahilly Colin N A Palmer Oluf Pedersen Rainer Rauramaa Jaakko Tuomilehto Veikko Salomaa Richard M Watanabe Ann-Christine Syvänen Richard N Bergman Dwaipayan Bharadwaj Erwin P Bottinger Yoon Shin Cho Giriraj R Chandak Juliana C N Chan Kee Seng Chia Mark J Daly Shah B Ebrahim Claudia Langenberg Paul Elliott Kathleen A Jablonski Donna M Lehman Weiping Jia Ronald C W Ma Toni I Pollin Manjinder Sandhu Nikhil Tandon Philippe Froguel Inês Barroso Yik Ying Teo Eleftheria Zeggini Ruth J F Loos Kerrin S Small Janina S Ried Ralph A DeFronzo Harald Grallert Benjamin Glaser Andres Metspalu Nicholas J Wareham Mark Walker Eric Banks Christian Gieger Erik Ingelsson Hae Kyung Im Thomas Illig Paul W Franks Gemma Buck Joseph Trakalo David Buck Inga Prokopenko Reedik Mägi Lars Lind Yossi Farjoun Katharine R Owen Anna L Gloyn Konstantin Strauch Tiinamaija Tuomi Jaspal Singh Kooner Jong-Young Lee Taesung Park Peter Donnelly Andrew D Morris Andrew T Hattersley Donald W Bowden Francis S Collins Gil Atzmon John C Chambers Timothy D Spector Markku Laakso Tim M Strom Graeme I Bell John Blangero Ravindranath Duggirala E Shyong Tai Gilean McVean Craig L Hanis James G Wilson Mark Seielstad Timothy M Frayling James B Meigs Nancy J Cox Rob Sladek Eric S Lander Stacey Gabriel Karen L Mohlke Thomas Meitinger Leif Groop Goncalo Abecasis Laura J Scott Andrew P Morris Hyun Min Kang David Altshuler Noël P Burtt Jose C Florez Michael Boehnke Mark I McCarthy

Sci Data 2018 01 23;5:180002. Epub 2018 Jan 23.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/sdata.2018.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779067PMC
January 2018

High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4 T cells in both mice and humans.

Authors:
Nicola Manfrini Sara Ricciardi Annarita Miluzio Maya Fedeli Alessandra Scagliola Simone Gallo Daniela Brina Thure Adler Dirk H Busch Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Stefano Biffo

Dev Comp Immunol 2017 12 22;77:69-76. Epub 2017 Jul 22.

National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi" - INGM, Via F. Sforza 35, 20122 Milan, Italy; Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milan, Italy. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.dci.2017.07.022DOI Listing
December 2017

A systemic view on the distribution of diet-derived methanol and hepatic acetone in mice.

Authors:
Martin Kistler Andreea Muntean Vera Höllriegl Georg Matuschek Ralf Zimmermann Christoph Hoeschen Martin Hrabě de Angelis Jan Rozman

J Breath Res 2017 12 6;12(1):017102. Epub 2017 Dec 6.

Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Munich, Germany. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Munich, Germany. German Centre for Diabetes Research (DZD), Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1088/1752-7163/aa8a15DOI Listing
December 2017

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.

Authors:
G Sebastian Hönes Helena Rakov John Logan Xiao-Hui Liao Eugenie Werbenko Andrea S Pollard Stine M Præstholm Majken S Siersbæk Eddy Rijntjes Janina Gassen Sören Latteyer Kathrin Engels Karl-Heinz Strucksberg Petra Kleinbongard Denise Zwanziger Jan Rozman Valerie Gailus-Durner Helmut Fuchs Martin Hrabe de Angelis Ludger Klein-Hitpass Josef Köhrle David L Armstrong Lars Grøntved J H Duncan Bassett Graham R Williams Samuel Refetoff Dagmar Führer Lars C Moeller

Proc Natl Acad Sci U S A 2017 12 11;114(52):E11323-E11332. Epub 2017 Dec 11.

Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany;

View Article

Download full-text PDF

 Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1706801115
Publisher Site
http://dx.doi.org/10.1073/pnas.1706801115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748168PMC
December 2017

Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.

Authors:
Katharina Essig Desheng Hu Joao C Guimaraes Dominik Alterauge Stephanie Edelmann Timsse Raj Jan Kranich Gesine Behrens Alexander Heiseke Stefan Floess Juliane Klein Andreas Maiser Susan Marschall Martin Hrabĕ de Angelis Heinrich Leonhardt Cornelis F Calkhoven Elfriede Noessner Thomas Brocker Jochen Huehn Anne B Krug Mihaela Zavolan Dirk Baumjohann Vigo Heissmeyer

Immunity 2017 12 12;47(6):1067-1082.e12. Epub 2017 Dec 12.

Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany; Research Unit Molecular Immune Regulation, Helmholtz Zentrum München, 81377 München, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.immuni.2017.11.008DOI Listing
December 2017

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

Authors:
Jason Flannick Christian Fuchsberger Anubha Mahajan Tanya M Teslovich Vineeta Agarwala Kyle J Gaulton Lizz Caulkins Ryan Koesterer Clement Ma Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Dennis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmus Njølstad Jonathan C Levy Massimo Mangino Lori L Bonnycastle Thomas Schwarzmayr João Fadista Gabriela L Surdulescu Christian Herder Christopher J Groves Thomas Wieland Jette Bork-Jensen Ivan Brandslund Cramer Christensen Heikki A Koistinen Alex S F Doney Leena Kinnunen Tõnu Esko Andrew J Farmer Liisa Hakaste Dylan Hodgkiss Jasmina Kravic Valeri Lyssenko Mette Hollensted Marit E Jørgensen Torben Jørgensen Claes Ladenvall Johanne Marie Justesen Annemari Käräjämäki Jennifer Kriebel Wolfgang Rathmann Lars Lannfelt Torsten Lauritzen Narisu Narisu Allan Linneberg Olle Melander Lili Milani Matt Neville Marju Orho-Melander Lu Qi Qibin Qi Michael Roden Olov Rolandsson Amy Swift Anders H Rosengren Kathleen Stirrups Andrew R Wood Evelin Mihailov Christine Blancher Mauricio O Carneiro Jared Maguire Ryan Poplin Khalid Shakir Timothy Fennell Mark DePristo Martin Hrabé de Angelis Panos Deloukas Anette P Gjesing Goo Jun Peter Nilsson Jacquelyn Murphy Robert Onofrio Barbara Thorand Torben Hansen Christa Meisinger Frank B Hu Bo Isomaa Fredrik Karpe Liming Liang Annette Peters Cornelia Huth Stephen P O'Rahilly Colin N A Palmer Oluf Pedersen Rainer Rauramaa Jaakko Tuomilehto Veikko Salomaa Richard M Watanabe Ann-Christine Syvänen Richard N Bergman Dwaipayan Bharadwaj Erwin P Bottinger Yoon Shin Cho Giriraj R Chandak Juliana Cn Chan Kee Seng Chia Mark J Daly Shah B Ebrahim Claudia Langenberg Paul Elliott Kathleen A Jablonski Donna M Lehman Weiping Jia Ronald C W Ma Toni I Pollin Manjinder Sandhu Nikhil Tandon Philippe Froguel Inês Barroso Yik Ying Teo Eleftheria Zeggini Ruth J F Loos Kerrin S Small Janina S Ried Ralph A DeFronzo Harald Grallert Benjamin Glaser Andres Metspalu Nicholas J Wareham Mark Walker Eric Banks Christian Gieger Erik Ingelsson Hae Kyung Im Thomas Illig Paul W Franks Gemma Buck Joseph Trakalo David Buck Inga Prokopenko Reedik Mägi Lars Lind Yossi Farjoun Katharine R Owen Anna L Gloyn Konstantin Strauch Tiinamaija Tuomi Jaspal Singh Kooner Jong-Young Lee Taesung Park Peter Donnelly Andrew D Morris Andrew T Hattersley Donald W Bowden Francis S Collins Gil Atzmon John C Chambers Timothy D Spector Markku Laakso Tim M Strom Graeme I Bell John Blangero Ravindranath Duggirala E Shyong Tai Gilean McVean Craig L Hanis James G Wilson Mark Seielstad Timothy M Frayling James B Meigs Nancy J Cox Rob Sladek Eric S Lander Stacey Gabriel Karen L Mohlke Thomas Meitinger Leif Groop Goncalo Abecasis Laura J Scott Andrew P Morris Hyun Min Kang David Altshuler Noël P Burtt Jose C Florez Michael Boehnke Mark I McCarthy

Sci Data 2017 12 19;4:170179. Epub 2017 Dec 19.

Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/sdata.2017.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735917PMC
December 2017

High-throughput extraction and quantification method for targeted metabolomics in murine tissues.

Authors:
Sven Zukunft Cornelia Prehn Cornelia Röhring Gabriele Möller Martin Hrabě de Angelis Jerzy Adamski Janina Tokarz

Metabolomics 2018 30;14(1):18. Epub 2017 Dec 30.

Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s11306-017-1312-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748028PMC
December 2017

The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.

Authors:
Christian Vogl Tanvi Butola Natja Haag Torben J Hausrat Michael G Leitner Michel Moutschen Philippe P Lefèbvre Carsten Speckmann Lillian Garrett Lore Becker Helmut Fuchs Martin Hrabe de Angelis Sandor Nietzsche Michael M Kessels Dominik Oliver Matthias Kneussel Manfred W Kilimann Nicola Strenzke

EMBO Rep 2017 11 11;18(11):2015-2029. Epub 2017 Sep 11.

Auditory Systems Physiology Group Department of Otolaryngology University Medical Center Göttingen, Göttingen, Germany

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.15252/embr.201643689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666617PMC
November 2017

The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.

Authors:
Kim Clarke Sara Ricciardi Tim Pearson Izwan Bharudin Peter K Davidsen Michela Bonomo Daniela Brina Alessandra Scagliola Deborah M Simpson Robert J Beynon Farhat Khanim John Ankers Mark A Sarzynski Sujoy Ghosh Addolorata Pisconti Jan Rozman Martin Hrabe de Angelis Chris Bunce Claire Stewart Stuart Egginton Mark Caddick Malcolm Jackson Claude Bouchard Stefano Biffo Francesco Falciani

Cell Rep 2017 Nov;21(6):1507-1520

Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.celrep.2017.10.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695912PMC
November 2017

Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.

Authors:
Isabel Egaña Hiroshi Kaito Anja Nitzsche Lore Becker Carolina Ballester-Lopez Colin Niaudet Milena Petkova Wei Liu Michael Vanlandewijck Alexandra Vernaleken Thomas Klopstock Helmut Fuchs Valerie Gailus-Durner Martin Hrabe de Angelis Helge Rask-Andersen Henrik J Johansson Janne Lehtiö Liqun He Ali Ö Yildirim Mats Hellström

Sci Rep 2017 11 13;7(1):15453. Epub 2017 Nov 13.

Science for life laboratory, Department of Immunology, Genetics and Pathology, The Rudbeck laboratory, Uppsala University, Uppsala, Sweden.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-017-14894-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684320PMC
November 2017

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Authors:
Mary E Dickinson Ann M Flenniken Xiao Ji Lydia Teboul Michael D Wong Jacqueline K White Terrence F Meehan Wolfgang J Weninger Henrik Westerberg Hibret Adissu Candice N Baker Lynette Bower James M Brown L Brianna Caddle Francesco Chiani Dave Clary James Cleak Mark J Daly James M Denegre Brendan Doe Mary E Dolan Sarah M Edie Helmut Fuchs Valerie Gailus-Durner Antonella Galli Alessia Gambadoro Juan Gallegos Shiying Guo Neil R Horner Chih-Wei Hsu Sara J Johnson Sowmya Kalaga Lance C Keith Louise Lanoue Thomas N Lawson Monkol Lek Manuel Mark Susan Marschall Jeremy Mason Melissa L McElwee Susan Newbigging Lauryl M J Nutter Kevin A Peterson Ramiro Ramirez-Solis Douglas J Rowland Edward Ryder Kaitlin E Samocha John R Seavitt Mohammed Selloum Zsombor Szoke-Kovacs Masaru Tamura Amanda G Trainor Ilinca Tudose Shigeharu Wakana Jonathan Warren Olivia Wendling David B West Leeyean Wong Atsushi Yoshiki Wolfgang Wurst Daniel G MacArthur Glauco P Tocchini-Valentini Xiang Gao Paul Flicek Allan Bradley William C Skarnes Monica J Justice Helen E Parkinson Mark Moore Sara Wells Robert E Braun Karen L Svenson Martin Hrabe de Angelis Yann Herault Tim Mohun Ann-Marie Mallon R Mark Henkelman Steve D M Brown David J Adams K C Kent Lloyd Colin McKerlie Arthur L Beaudet Maja Bućan Stephen A Murray

Nature 2017 11 8;551(7680):398. Epub 2017 Nov 8.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/nature24643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849394PMC
November 2017

Iopromide exposure in Typha latifolia L.: Evaluation of uptake, translocation and different transformation mechanisms in planta.

Authors:
Hao Cui Martin Hrabě de Angelis Peter Schröder

Water Res 2017 10 4;122:290-298. Epub 2017 Jun 4.

Research Unit Environmental Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.watres.2017.06.004DOI Listing
October 2017

Modeling coexistence of oscillation and Delta/Notch-mediated lateral inhibition in pancreas development and neurogenesis.

Authors:
Hendrik B Tiedemann Elida Schneltzer Johannes Beckers Gerhard K H Przemeck Martin Hrabě de Angelis

J Theor Biol 2017 10 23;430:32-44. Epub 2017 Jun 23.

Institute of Experimental Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany; Chair of Experimental Genetics, School of Life Sciences Weihenstephan, Technische Universität München, Alte Akademie 8, 85354 Freising, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jtbi.2017.06.006DOI Listing
October 2017

Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.

Authors:
Nicola Manfrini Sara Ricciardi Annarita Miluzio Maya Fedeli Alessandra Scagliola Simone Gallo Thure Adler Dirk H Busch Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Stefano Biffo

Data Brief 2017 Oct 30;14:653-658. Epub 2017 Aug 30.

National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi" - INGM, via F. Sforza 35, 20122 Milan, Italy.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S23523409173040
Publisher Site
http://dx.doi.org/10.1016/j.dib.2017.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591389PMC
October 2017

Fibroblast Growth Factor 21-Metabolic Role in Mice and Men.

Authors:
Harald Staiger Michaela Keuper Lucia Berti Martin Hrabe de Angelis Hans-Ulrich Häring

Endocr Rev 2017 10;38(5):468-488

Interfaculty Center for Pharmacogenomics and Pharma Research, Eberhard Karls University Tübingen, 72076 Tübingen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1210/er.2017-00016DOI Listing
October 2017

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Authors:
Carmelo Quarta Christoffer Clemmensen Zhimeng Zhu Bin Yang Sini S Joseph Dominik Lutter Chun-Xia Yi Elisabeth Graf Cristina García-Cáceres Beata Legutko Katrin Fischer Robert Brommage Philippe Zizzari Bernardo S Franklin Martin Krueger Marco Koch Sabine Vettorazzi Pengyun Li Susanna M Hofmann Mostafa Bakhti Aimée Bastidas-Ponce Heiko Lickert Tim M Strom Valerie Gailus-Durner Ingo Bechmann Diego Perez-Tilve Jan Tuckermann Martin Hrabě de Angelis Darleen Sandoval Daniela Cota Eicke Latz Randy J Seeley Timo D Müller Richard D DiMarchi Brian Finan Matthias H Tschöp

Cell Metab 2017 Oct 21;26(4):620-632.e6. Epub 2017 Sep 21.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Ingolstädter Landstraße, 85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.cmet.2017.08.023DOI Listing
October 2017

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

Authors:
Michael R Bowl Michelle M Simon Neil J Ingham Simon Greenaway Luis Santos Heather Cater Sarah Taylor Jeremy Mason Natalja Kurbatova Selina Pearson Lynette R Bower Dave A Clary Hamid Meziane Patrick Reilly Osamu Minowa Lois Kelsey Glauco P Tocchini-Valentini Xiang Gao Allan Bradley William C Skarnes Mark Moore Arthur L Beaudet Monica J Justice John Seavitt Mary E Dickinson Wolfgang Wurst Martin Hrabe de Angelis Yann Herault Shigeharu Wakana Lauryl M J Nutter Ann M Flenniken Colin McKerlie Stephen A Murray Karen L Svenson Robert E Braun David B West K C Kent Lloyd David J Adams Jacqui White Natasha Karp Paul Flicek Damian Smedley Terrence F Meehan Helen E Parkinson Lydia M Teboul Sara Wells Karen P Steel Ann-Marie Mallon Steve D M Brown

Nat Commun 2017 10 12;8(1):886. Epub 2017 Oct 12.

Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41467-017-00595-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638796PMC
October 2017

Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors.

Authors:
Michaela Keuper Stephan Sachs Ellen Walheim Lucia Berti Bernhard Raedle Daniel Tews Pamela Fischer-Posovszky Martin Wabitsch Martin Hrabě de Angelis Gabi Kastenmüller Matthias H Tschöp Martin Jastroch Harald Staiger Susanna M Hofmann

Mol Metab 2017 10 19;6(10):1226-1239. Epub 2017 Jul 19.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Medizinische Klinik und Poliklinik IV, Klinikum der LMU, 80336 München, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641636PMC
October 2017

Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP.

Authors:
Bodil Ingerslev Jakob S Hansen Christoph Hoffmann Jens O Clemmesen Niels H Secher Mika Scheler Martin Hrabĕ de Angelis Hans U Häring Bente K Pedersen Cora Weigert Peter Plomgaard

Mol Metab 2017 10 8;6(10):1286-1295. Epub 2017 Jul 8.

The Centre of Inflammation and Metabolism, The Centre for Physical Activity Research, Rigshospitalet, Copenhagen University Hospital, Denmark; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2017.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641605PMC
October 2017

Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance.

Authors:
Sibylle Sabrautzki Gabriele Kaiser Gerhard K H Przemeck Felicia Gerst Estela Lorza-Gil Madhura Panse Tina Sartorius Miriam Hoene Susan Marschall Hans-Ulrich Häring Martin Hrabě de Angelis Susanne Ullrich

Mol Metab 2017 10 18;6(10):1304-1312. Epub 2017 Jul 18.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the University of Tübingen (IDM), 72076 Tübingen, Germany; University Hospital Tübingen, Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2017.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641630PMC
October 2017

Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma.

Authors:
Antonio Aguilar-Pimentel Anke Graessel Francesca Alessandrini Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Dennis Russkamp Adam Chaker Markus Ollert Simon Blank Jan Gutermuth Carsten B Schmidt-Weber

PLoS One 2017 1;12(6):e0178563. Epub 2017 Jun 1.

Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Member of the German Center for Lung research (DZL), Munich, Germany.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178563PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453633PMC
September 2017

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.

Authors:
Martin H Schludi Lore Becker Lillian Garrett Tania F Gendron Qihui Zhou Franziska Schreiber Bastian Popper Leda Dimou Tim M Strom Juliane Winkelmann Anne von Thaden Kristin Rentzsch Stephanie May Meike Michaelsen Benjamin M Schwenk Jing Tan Benedikt Schoser Marianne Dieterich Leonard Petrucelli Sabine M Hölter Wolfgang Wurst Helmut Fuchs Valerie Gailus-Durner Martin Hrabe de Angelis Thomas Klopstock Thomas Arzberger Dieter Edbauer

Acta Neuropathol 2017 08 13;134(2):241-254. Epub 2017 Apr 13.

German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00401-017-1711-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508040PMC
August 2017

: effects on motor phenotypes and the sensorimotor system in mice.

Authors:
Aaro V Salminen Lillian Garrett Barbara Schormair Jan Rozman Florian Giesert Kristina M Niedermeier Lore Becker Birgit Rathkolb Ildikó Rácz Martin Klingenspor Thomas Klopstock Eckhard Wolf Andreas Zimmer Valérie Gailus-Durner Miguel Torres Helmut Fuchs Martin Hrabě de Angelis Wolfgang Wurst Sabine M Hölter Juliane Winkelmann

Dis Model Mech 2017 08 23;10(8):981-991. Epub 2017 Jun 23.

Institute of Neurogenomics, Helmholtz Zentrum München, 85764 Neuherberg, Germany

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1242/dmm.030080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560065PMC
August 2017

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

Authors:
Terrence F Meehan Nathalie Conte David B West Julius O Jacobsen Jeremy Mason Jonathan Warren Chao-Kung Chen Ilinca Tudose Mike Relac Peter Matthews Natasha Karp Luis Santos Tanja Fiegel Natalie Ring Henrik Westerberg Simon Greenaway Duncan Sneddon Hugh Morgan Gemma F Codner Michelle E Stewart James Brown Neil Horner Melissa Haendel Nicole Washington Christopher J Mungall Corey L Reynolds Juan Gallegos Valerie Gailus-Durner Tania Sorg Guillaume Pavlovic Lynette R Bower Mark Moore Iva Morse Xiang Gao Glauco P Tocchini-Valentini Yuichi Obata Soo Young Cho Je Kyung Seong John Seavitt Arthur L Beaudet Mary E Dickinson Yann Herault Wolfgang Wurst Martin Hrabe de Angelis K C Kent Lloyd Ann M Flenniken Lauryl M J Nutter Susan Newbigging Colin McKerlie Monica J Justice Stephen A Murray Karen L Svenson Robert E Braun Jacqueline K White Allan Bradley Paul Flicek Sara Wells William C Skarnes David J Adams Helen Parkinson Ann-Marie Mallon Steve D M Brown Damian Smedley

Nat Genet 2017 Aug 26;49(8):1231-1238. Epub 2017 Jun 26.

William Harvey Research Institute, Queen Mary University of London, London, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ng.3901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546242PMC
August 2017

The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.

Authors:
Andreas Blutke Simone Renner Florian Flenkenthaler Mattias Backman Serena Haesner Elisabeth Kemter Erik Ländström Christina Braun-Reichhart Barbara Albl Elisabeth Streckel Birgit Rathkolb Cornelia Prehn Alessandra Palladini Michal Grzybek Stefan Krebs Stefan Bauersachs Andrea Bähr Andreas Brühschwein Cornelia A Deeg Erica De Monte Michaela Dmochewitz Caroline Eberle Daniela Emrich Robert Fux Frauke Groth Sophie Gumbert Antonia Heitmann Arne Hinrichs Barbara Keßler Mayuko Kurome Miriam Leipig-Rudolph Kaspar Matiasek Hazal Öztürk Christiane Otzdorff Myriam Reichenbach Horst Dieter Reichenbach Alexandra Rieger Birte Rieseberg Marco Rosati Manuel Nicolas Saucedo Anna Schleicher Marlon R Schneider Kilian Simmet Judith Steinmetz Nicole Übel Patrizia Zehetmaier Andreas Jung Jerzy Adamski Ünal Coskun Martin Hrabě de Angelis Christian Simmet Mathias Ritzmann Andrea Meyer-Lindenberg Helmut Blum Georg J Arnold Thomas Fröhlich Rüdiger Wanke Eckhard Wolf

Mol Metab 2017 08 13;6(8):931-940. Epub 2017 Jun 13.

Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, and Center for Innovative Medical Models (CiMM), LMU Munich, Feodor-Lynen-Str. 25, D-81377 Munich, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Feodor-Lynen-Str. 25, D-81377 Munich, Germany. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S22128778173031
Publisher Site
http://dx.doi.org/10.1016/j.molmet.2017.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518720PMC
August 2017

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 mutant mice.

Authors:
Sudhir Kumar Birgit Rathkolb Sibylle Sabrautzki Stefan Krebs Elisabeth Kemter Lore Becker Johannes Beckers Raffi Bekeredjian Robert Brommage Julia Calzada-Wack Lillian Garrett Sabine M Hölter Marion Horsch Martin Klingenspor Thomas Klopstock Kristin Moreth Frauke Neff Jan Rozman Helmut Fuchs Valérie Gailus-Durner Martin Hrabe de Angelis Eckhard Wolf Bernhard Aigner

J Biomed Sci 2017 Aug 17;24(1):57. Epub 2017 Aug 17.

Chair for Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, 81377, Munich, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12929-017-0365-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559776PMC
August 2017

A Low-Frequency Inactivating Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.

Authors:
Alisa Manning Heather M Highland Jessica Gasser Xueling Sim Taru Tukiainen Pierre Fontanillas Niels Grarup Manuel A Rivas Anubha Mahajan Adam E Locke Pablo Cingolani Tune H Pers Ana Viñuela Andrew A Brown Ying Wu Jason Flannick Christian Fuchsberger Eric R Gamazon Kyle J Gaulton Hae Kyung Im Tanya M Teslovich Thomas W Blackwell Jette Bork-Jensen Noël P Burtt Yuhui Chen Todd Green Christopher Hartl Hyun Min Kang Ashish Kumar Claes Ladenvall Clement Ma Loukas Moutsianas Richard D Pearson John R B Perry N William Rayner Neil R Robertson Laura J Scott Martijn van de Bunt Johan G Eriksson Antti Jula Seppo Koskinen Terho Lehtimäki Aarno Palotie Olli T Raitakari Suzanne B R Jacobs Jennifer Wessel Audrey Y Chu Robert A Scott Mark O Goodarzi Christine Blancher Gemma Buck David Buck Peter S Chines Stacey Gabriel Anette P Gjesing Christopher J Groves Mette Hollensted Jeroen R Huyghe Anne U Jackson Goo Jun Johanne Marie Justesen Massimo Mangino Jacquelyn Murphy Matt Neville Robert Onofrio Kerrin S Small Heather M Stringham Joseph Trakalo Eric Banks Jason Carey Mauricio O Carneiro Mark DePristo Yossi Farjoun Timothy Fennell Jacqueline I Goldstein George Grant Martin Hrabé de Angelis Jared Maguire Benjamin M Neale Ryan Poplin Shaun Purcell Thomas Schwarzmayr Khalid Shakir Joshua D Smith Tim M Strom Thomas Wieland Jaana Lindstrom Ivan Brandslund Cramer Christensen Gabriela L Surdulescu Timo A Lakka Alex S F Doney Peter Nilsson Nicholas J Wareham Claudia Langenberg Tibor V Varga Paul W Franks Olov Rolandsson Anders H Rosengren Vidya S Farook Farook Thameem Sobha Puppala Satish Kumar Donna M Lehman Christopher P Jenkinson Joanne E Curran Daniel Esten Hale Sharon P Fowler Rector Arya Ralph A DeFronzo Hanna E Abboud Ann-Christine Syvänen Pamela J Hicks Nicholette D Palmer Maggie C Y Ng Donald W Bowden Barry I Freedman Tõnu Esko Reedik Mägi Lili Milani Evelin Mihailov Andres Metspalu Narisu Narisu Leena Kinnunen Lori L Bonnycastle Amy Swift Dorota Pasko Andrew R Wood João Fadista Toni I Pollin Nir Barzilai Gil Atzmon Benjamin Glaser Barbara Thorand Konstantin Strauch Annette Peters Michael Roden Martina Müller-Nurasyid Liming Liang Jennifer Kriebel Thomas Illig Harald Grallert Christian Gieger Christa Meisinger Lars Lannfelt Solomon K Musani Michael Griswold Herman A Taylor Gregory Wilson Adolfo Correa Heikki Oksa William R Scott Uzma Afzal Sian-Tsung Tan Marie Loh John C Chambers Jobanpreet Sehmi Jaspal Singh Kooner Benjamin Lehne Yoon Shin Cho Jong-Young Lee Bok-Ghee Han Annemari Käräjämäki Qibin Qi Lu Qi Jinyan Huang Frank B Hu Olle Melander Marju Orho-Melander Jennifer E Below David Aguilar Tien Yin Wong Jianjun Liu Chiea-Chuen Khor Kee Seng Chia Wei Yen Lim Ching-Yu Cheng Edmund Chan E Shyong Tai Tin Aung Allan Linneberg Bo Isomaa Thomas Meitinger Tiinamaija Tuomi Liisa Hakaste Jasmina Kravic Marit E Jørgensen Torsten Lauritzen Panos Deloukas Kathleen E Stirrups Katharine R Owen Andrew J Farmer Timothy M Frayling Stephen P O'Rahilly Mark Walker Jonathan C Levy Dylan Hodgkiss Andrew T Hattersley Teemu Kuulasmaa Alena Stančáková Inês Barroso Dwaipayan Bharadwaj Juliana Chan Giriraj R Chandak Mark J Daly Peter J Donnelly Shah B Ebrahim Paul Elliott Tasha Fingerlin Philippe Froguel Cheng Hu Weiping Jia Ronald C W Ma Gilean McVean Taesung Park Dorairaj Prabhakaran Manjinder Sandhu James Scott Rob Sladek Nikhil Tandon Yik Ying Teo Eleftheria Zeggini Richard M Watanabe Heikki A Koistinen Y Antero Kesaniemi Matti Uusitupa Timothy D Spector Veikko Salomaa Rainer Rauramaa Colin N A Palmer Inga Prokopenko Andrew D Morris Richard N Bergman Francis S Collins Lars Lind Erik Ingelsson Jaakko Tuomilehto Fredrik Karpe Leif Groop Torben Jørgensen Torben Hansen Oluf Pedersen Johanna Kuusisto Gonçalo Abecasis Graeme I Bell John Blangero Nancy J Cox Ravindranath Duggirala Mark Seielstad James G Wilson Josee Dupuis Samuli Ripatti Craig L Hanis Jose C Florez Karen L Mohlke James B Meigs Markku Laakso Andrew P Morris Michael Boehnke David Altshuler Mark I McCarthy Anna L Gloyn Cecilia M Lindgren

Diabetes 2017 07 24;66(7):2019-2032. Epub 2017 Mar 24.

Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2337/db16-1329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482074PMC
July 2017

Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state.

Authors:
Philipp Schommers Anna Thurau Insa Bultmann-Mellin Maria Guschlbauer Andreas R Klatt Jan Rozman Martin Klingenspor Martin Hrabe de Angelis Jens Alber Dirk Gründemann Anja Sterner-Kock Rudolf J Wiesner

Mol Metab 2017 07 5;6(7):737-747. Epub 2017 May 5.

Institute of Vegetative Physiology, Medical Faculty, University of Köln, 50931 Köln, Germany.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S22128778173026
Publisher Site
http://dx.doi.org/10.1016/j.molmet.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485244PMC
July 2017

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

Authors:
Kan Xie Frauke Neff Astrid Markert Jan Rozman Juan Antonio Aguilar-Pimentel Oana Veronica Amarie Lore Becker Robert Brommage Lillian Garrett Kristin S Henzel Sabine M Hölter Dirk Janik Isabelle Lehmann Kristin Moreth Brandon L Pearson Ildiko Racz Birgit Rathkolb Devon P Ryan Susanne Schröder Irina Treise Raffi Bekeredjian Dirk H Busch Jochen Graw Gerhard Ehninger Martin Klingenspor Thomas Klopstock Markus Ollert Michael Sandholzer Carsten Schmidt-Weber Marco Weiergräber Eckhard Wolf Wolfgang Wurst Andreas Zimmer Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Dan Ehninger

Nat Commun 2017 07 24;8(1):155. Epub 2017 Jul 24.

DZNE, German Center for Neurodegenerative Diseases, Ludwig-Erhard-Allee 2, 53175, Bonn, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41467-017-00178-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537224PMC
July 2017

N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes.

Authors:
Michaela Aichler Daniela Borgmann Jan Krumsiek Achim Buck Patrick E MacDonald Jocelyn E Manning Fox James Lyon Peter E Light Susanne Keipert Martin Jastroch Annette Feuchtinger Nikola S Mueller Na Sun Andrew Palmer Theodore Alexandrov Martin Hrabe de Angelis Susanne Neschen Matthias H Tschöp Axel Walch

Cell Metab 2017 Jun;25(6):1334-1347.e4

Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg 85764, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.cmet.2017.04.012DOI Listing
June 2017

A Fast, Easy, and Customizable Eight-Color Flow Cytometric Method for Analysis of the Cellular Content of Bronchoalveolar Lavage Fluid in the Mouse.

Authors:
François Daubeuf Julien Becker Juan Antonio Aguilar-Pimentel Claudine Ebel Martin Hrabě de Angelis Yann Hérault Nelly Frossard

Curr Protoc Mouse Biol 2017 Jun 19;7(2):88-99. Epub 2017 Jun 19.

Laboratoire d'Innovation Thérapeutique, Faculté de Pharmacie, Université de Strasbourg, Illkirch, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/cpmo.26DOI Listing
June 2017

Prevalence of sexual dimorphism in mammalian phenotypic traits.

Authors:
Natasha A Karp Jeremy Mason Arthur L Beaudet Yoav Benjamini Lynette Bower Robert E Braun Steve D M Brown Elissa J Chesler Mary E Dickinson Ann M Flenniken Helmut Fuchs Martin Hrabe de Angelis Xiang Gao Shiying Guo Simon Greenaway Ruth Heller Yann Herault Monica J Justice Natalja Kurbatova Christopher J Lelliott K C Kent Lloyd Ann-Marie Mallon Judith E Mank Hiroshi Masuya Colin McKerlie Terrence F Meehan Richard F Mott Stephen A Murray Helen Parkinson Ramiro Ramirez-Solis Luis Santos John R Seavitt Damian Smedley Tania Sorg Anneliese O Speak Karen P Steel Karen L Svenson Shigeharu Wakana David West Sara Wells Henrik Westerberg Shay Yaacoby Jacqueline K White

Nat Commun 2017 06 26;8:15475. Epub 2017 Jun 26.

The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ncomms15475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490203PMC
June 2017

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

Authors:
Rhea van den Bruck Patrick P Weil Thomas Ziegenhals Philipp Schreiner Stefan Juranek Daniel Gödde Silvia Vogel Frauke Schuster Valerie Orth Johannes Dörner Daniel Pembaur Meike Röper Stefan Störkel Hubert Zirngibl Stefan Wirth Andreas C W Jenke Jan Postberg Nikolas Boy Jana Heringer Gisela Haege Esther M Glahn Georg F Hoffmann Sven F Garbade Peter Burgard Stefan Kölker Cho-Ming Chao Faady Yahya Alena Moiseenko Amit Shrestha Negah Ahmadvand Jennifer Quantius Jochen Wilhelm Elie El-Agha Klaus-Peter Zimmer Saverio Bellusci Christian Staufner Stefan Kölker Holger Prokisch Georg F Hoffmann Stephan Seeliger Matthias Müller Andreas Hippe Henrik Steinkraus Roland Wauer Burkhard Lachmann Sigrun R Hofmann Christian M Hedrich Jakob Zierk Farhad Arzideh Rainer Haeckel Wolfgang Rascher Manfred Rauh Markus Metzler Sebastian Thieme Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Michelle P Ashton Malte von Bonin Matthias Kuhn Christian M Hedrich Ezio Bonifacio Reinhard Berner Sebastian Brenner Johanna Hammersen Cristina Has Nora Naumann-Bartsch Daniel Stachel Dimitra Kiritsi Stephan Söder Mathilde Tardieu Markus Metzler Leena Bruckner-Tuderman Holm Schneider F Bohne D Langer R Cencic T Eggermann U Zechner J Pelletier F Zepp T Enklaar D Prawitt Martin Pech Markus Weckmann Femke-Anouska Heinsen Andre Franke Christine Happle Anna-Maria Dittrich Gesine Hansen Oliver Fuchs Erika von Mutius Brian G Oliver Matthias V Kopp Claudia Paret Alexandra Russo Johanna Theruvath Bettina Keller Khalifa El Malki Nadine Lehmann Arthur Wingerter Marie A Neu Gerhold-Ay Aslihan Wolfgang Wagner Clemens Sommer Torsten Pietsch Larissa Seidmann Jörg Faber Felix Schreiner Merle Ackermann Michael Michalik Eva Rother Andras Bilkei-Gorzo Ildiko Racz Laura Bindila Beat Lutz Jörg Dötsch Andreas Zimmer Joachim Woelfle Hendrik S Fischer Tim L Ullrich Christoph Bührer Christoph Czernik Gerd Schmalisch Robert Stein Sigrun R Hofmann Judith Hagenbuchner Ursula Kiechl-Kohlendorfer Petra Obexer Michael J Ausserlechner Niki T Loges Adrien Tobias Frommer Julia Wallmeier Heymut Omran Soner Öner-Sieben Martina Gimpfl Jan Rozman Martin Irmler Johannes Beckers Martin Hrabe De Angelis Adelbert Roscher Eckhard Wolf Regina Ensenauer Karolina Nemes Michael Frühwald Martin Hasselblatt Reiner Siebert Uwe Kordes Marcel Kool Haicui Wang Holly Hardy Osama Refai Katy E S Barwick Holly H Zimmerman Joachim Weis Emma L Baple Andrew H Crosby Sebahattin Cirak C Hellmuth O Uhl M Standl J Heinrich E Thiering B Koletzko Lena Blümel Kornelius Kerl Daniel Picard Michael C Frühwald Max C Liebau Guido Reifenberger Arndt Borkhardt Martin Hasselblatt Marc Remke D Tews M Wabitsch P Fischer-Posovszky Mike-Andrew Westhoff Lisa Nonnenmacher Julia Langhans Lukas Schneele Nancy Trenkler Klaus-Michael Debatin

Mol Cell Pediatr 2017 May;4(Suppl 1)

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s40348-017-0071-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435609PMC
May 2017

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.

Authors:
Aimilios Kaklamanos Jan Rozman Manolis Roulis Niki Karagianni Maria Armaka Moya Wu Laura Brachthäuser Julia Calzada-Wack Marion Horsch Johannes Beckers Birgit Rathkolb Thure Adler Frauke Neff Eckhard Wolf Valerie Gailus-Durner Helmut Fuchs Martin Hrabe de Angelis George Kollias

Sci Rep 2017 05 25;7(1):2397. Epub 2017 May 25.

Biomedical Sciences Research Center (B.S.R.C.) "Alexander Fleming", 16672, Vari, Greece.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-017-02581-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445072PMC
May 2017

The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.

Authors:
Diana C Rodriguez Camargo Konstantinos Tripsianes Katalin Buday Andras Franko Christoph Göbl Christoph Hartlmüller Riddhiman Sarkar Michaela Aichler Gabriele Mettenleiter Michael Schulz Annett Böddrich Christian Erck Henrik Martens Axel Karl Walch Tobias Madl Erich E Wanker Marcus Conrad Martin Hrabě de Angelis Bernd Reif

Sci Rep 2017 03 13;7:44041. Epub 2017 Mar 13.

Helmholtz Zentrum München, Ingolstädter Landstr. 1, Neuherberg 85764, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep44041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347123PMC
March 2017