Publications by authors named "Martin Hirst"

100Publications

Dynamics of the cell-free DNA methylome of metastatic prostate cancer during androgen-targeting treatment.

Epigenomics 2020 Aug 1;12(15):1317-1332. Epub 2020 Sep 1.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, M5G 1X5, Canada.

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http://dx.doi.org/10.2217/epi-2020-0173DOI Listing
August 2020

Epigenomic programming in early fetal brain development.

Epigenomics 2020 Jun 17;12(12):1053-1070. Epub 2020 Jul 17.

Department of Microbiology & Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

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http://dx.doi.org/10.2217/epi-2019-0319DOI Listing
June 2020

The Pathognomonic FOXL2 C134W Mutation Alters DNA-Binding Specificity.

Cancer Res 2020 Sep 8;80(17):3480-3491. Epub 2020 Jul 8.

Department of Microbiology and Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-20-0104DOI Listing
September 2020

Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation.

Oncogene 2020 02 26;39(9):1957-1968. Epub 2019 Nov 26.

Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada.

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http://dx.doi.org/10.1038/s41388-019-1111-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044112PMC
February 2020

Histone Chaperone Paralogs Have Redundant, Cooperative, and Divergent Functions in Yeast.

Genetics 2019 12 11;213(4):1301-1316. Epub 2019 Oct 11.

Department Biochemistry and Microbiology, University of Victoria, BC V8W 3P6, Canada

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http://dx.doi.org/10.1534/genetics.119.302235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893378PMC
December 2019

Autophagy Regulation of Metabolism Is Required for CD8 T Cell Anti-tumor Immunity.

Cell Rep 2019 04;27(2):502-513.e5

Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.037DOI Listing
April 2019

Clonal Analysis of Mouse Mammary Luminal Epithelial Cell Transplants.

Stem Cells Dev 2019 03 31;28(5):353-355. Epub 2019 Jan 31.

1 Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada.

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https://www.liebertpub.com/doi/10.1089/scd.2018.0158
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http://dx.doi.org/10.1089/scd.2018.0158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393769PMC
March 2019

Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues.

Front Genet 2018 4;9:610. Epub 2018 Dec 4.

Department of Cellular & Physiological Sciences, Faculty of Medicine, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fgene.2018.00610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290329PMC
December 2018

High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations.

Stem Cell Reports 2018 08 2;11(2):578-592. Epub 2018 Aug 2.

Department of Microbiology and Immunology and Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC V5Z 1L3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093082PMC
August 2018

RUNX1 promotes cell growth in human T-cell acute lymphoblastic leukemia by transcriptional regulation of key target genes.

Exp Hematol 2018 08 5;64:84-96. Epub 2018 May 5.

Terry Fox Laboratory/Department of Pathology, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2018.04.008DOI Listing
August 2018

Generation of Native Chromatin Immunoprecipitation Sequencing Libraries for Nucleosome Density Analysis.

J Vis Exp 2017 12 12(130). Epub 2017 Dec 12.

Department of Microbiology and Immunology, Michael Smith Laboratories Centre for High-Throughput Biology, University of British Columbia; Canada's Michael Smith Genome Science Center, BC Cancer Agency;

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http://dx.doi.org/10.3791/56085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755553PMC
December 2017

Characterization of the human thyroid epigenome.

J Endocrinol 2017 Nov 14;235(2):153-165. Epub 2017 Aug 14.

Canada's Michael Smith Genome Sciences CentreBC Cancer Agency, Vancouver, Canada

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http://dx.doi.org/10.1530/JOE-17-0145DOI Listing
November 2017

Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b.

Epigenetics Chromatin 2017 12;10:36. Epub 2017 Jul 12.

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA USA.

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http://dx.doi.org/10.1186/s13072-017-0143-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506665PMC
October 2017

Whole-genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia.

Exp Hematol 2017 09 8;53:48-58. Epub 2017 Jun 8.

Institut National de la Santé et de la Recherche Médicale (INSERM) U935, Villejuif, France; Service d'Hématologie Biologique, Institut Federatif d'Hematologie Interpôle Paris Sud-IFHIPS (AP-HP) Kremlin Bicêtre, Paris, France; Université Paris-Sud, Faculté de Médecine Kremlin Bicêtre, and INSERM UMS 33, Villejuif, France; Human Pluripotent Stem Cell Core Facility, ESTeam Paris Sud-INGESTEM, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.05.007DOI Listing
September 2017

Draft Genome Sequence of the Pelagic Photoferrotroph .

Genome Announc 2017 Mar 30;5(13). Epub 2017 Mar 30.

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1128/genomeA.01584-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374249PMC
March 2017

SnapShot: Epigenomic Assays.

Cell 2016 Nov;167(5):1430-1430.e1

Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency Research Centre, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Department of Microbiology and Immunology, Michael Smith Laboratories Centre for High-Throughput Biology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163153
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http://dx.doi.org/10.1016/j.cell.2016.11.015DOI Listing
November 2016

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.

Cell 2016 Nov;167(5):1145-1149

Department of Microbiology and Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.11.007DOI Listing
November 2016

Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility.

Cell Rep 2016 11;17(8):2112-2124

Department of Microbiology and Immunology, Michael Smith Laboratories Centre for High-Throughput Biology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Canada's Michael Smith Genome Science Center, BC Cancer Agency Vancouver, BC V5Z 4S6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.055DOI Listing
November 2016

Robust high-performance nanoliter-volume single-cell multiple displacement amplification on planar substrates.

Proc Natl Acad Sci U S A 2016 07 13;113(30):8484-9. Epub 2016 Jul 13.

Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4; Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada V6T 1Z4

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http://dx.doi.org/10.1073/pnas.1520964113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968760PMC
July 2016

Putative BRAF activating fusion in a medullary thyroid cancer.

Cold Spring Harb Mol Case Stud 2016 Mar;2(2):a000729

Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 4S6, Canada;; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada;; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

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http://dx.doi.org/10.1101/mcs.a000729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849853PMC
March 2016

The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy.

BMC Cancer 2015 Dec 18;15:984. Epub 2015 Dec 18.

Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1186/s12885-015-1955-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683857PMC
December 2015

MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation.

Nat Commun 2015 Aug 6;6:7953. Epub 2015 Aug 6.

1] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada V5Z 1L3 [2] Department of Medical Genetics, University of British Columbia, Vancouver, Canada V6T 1Z3.

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http://dx.doi.org/10.1038/ncomms8953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918335PMC
August 2015

Integrative analysis of 111 reference human epigenomes.

Nature 2015 Feb;518(7539):317-30

1] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, Massachusetts 02139, USA. [2] The Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature14248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530010PMC
February 2015

Loss of the Notch effector RBPJ promotes tumorigenesis.

J Exp Med 2015 Jan 15;212(1):37-52. Epub 2014 Dec 15.

Genome Sciences Centre, Integrative Oncology Department, and Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada Genome Sciences Centre, Integrative Oncology Department, and Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada Experimental Medicine Program and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver V6T 2B5, British Columbia, Canada Experimental Medicine Program and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver V6T 2B5, British Columbia, Canada

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http://www.imls.uzh.ch/static/CMS_publications/robinson/lite
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http://www.jem.org/lookup/doi/10.1084/jem.20121192
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http://dx.doi.org/10.1084/jem.20121192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291530PMC
January 2015

The diagnosis that never was.

Authors:
Martin Hirst

Nurs Older People 2014 Oct;26(9):11

InDependent Diabetes Trust, Northampton.

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http://dx.doi.org/10.7748/nop.26.9.11.s14DOI Listing
October 2014

Draft Genome Sequences of Six Rhodobacter capsulatus Strains, YW1, YW2, B6, Y262, R121, and DE442.

Genome Announc 2014 Feb 13;2(1). Epub 2014 Feb 13.

Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1128/genomeA.00050-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924369PMC
February 2014

Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells.

Cell Stem Cell 2014 Feb 16;14(2):253-63. Epub 2014 Jan 16.

Department of Microbiology and Immunology, Centre for High-Throughput Biology, University of British Columbia, 2125 East Mall, Vancouver, BC V6T 1Z4, Canada; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10(th) Avenue, Vancouver, BC V5Z 1L3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2013.12.011DOI Listing
February 2014

Regulatory variation: an emerging vantage point for cancer biology.

Wiley Interdiscip Rev Syst Biol Med 2014 Jan-Feb;6(1):37-59. Epub 2013 Nov 19.

Centre for High-Throughput Biology, Department of Microbiology & Immunology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/wsbm.1250DOI Listing
October 2014

A clinically validated diagnostic second-generation sequencing assay for detection of hereditary BRCA1 and BRCA2 mutations.

J Mol Diagn 2013 Nov 4;15(6):796-809. Epub 2013 Oct 4.

Cancer Genetics Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jmoldx.2013.07.004DOI Listing
November 2013

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.

Nature 2013 Aug 30;500(7461):222-6. Epub 2013 Jun 30.

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Obstetrics and Gynecology and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California 94143, USA.

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http://santoslab.ucsf.edu/sites/santoslab.ucsf.edu/files/wys
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http://www.nature.com/doifinder/10.1038/nature12362
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http://dx.doi.org/10.1038/nature12362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893718PMC
August 2013

Estimating absolute methylation levels at single-CpG resolution from methylation enrichment and restriction enzyme sequencing methods.

Genome Res 2013 Sep 26;23(9):1541-53. Epub 2013 Jun 26.

Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1101/gr.152231.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759729PMC
September 2013

The shaping and functional consequences of the microRNA landscape in breast cancer.

Nature 2013 May 5;497(7449):378-82. Epub 2013 May 5.

Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1038/nature12108DOI Listing
May 2013

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

N Engl J Med 2013 05 1;368(22):2059-74. Epub 2013 May 1.

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http://dx.doi.org/10.1056/NEJMoa1301689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767041PMC
May 2013

Epigenomics: sequencing the methylome.

Authors:
Martin Hirst

Methods Mol Biol 2013 ;973:39-54

Department of Microbiology and Immunology, Centre for High-Throughput Biology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1007/978-1-62703-281-0_3DOI Listing
July 2013

Spark: a navigational paradigm for genomic data exploration.

Genome Res 2012 Nov 7;22(11):2262-9. Epub 2012 Sep 7.

Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, V5Z 4S6, Canada.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.140665.112
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http://dx.doi.org/10.1101/gr.140665.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483555PMC
November 2012

Next generation sequencing based approaches to epigenomics.

Brief Funct Genomics 2010 Dec;9(5-6):455-65

Genome Sciences Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1093/bfgp/elq035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080743PMC
December 2010

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.

J Clin Invest 2010 Dec 1;120(12):4569-82. Epub 2010 Nov 1.

Hematology and Oncology Division, and Department of Pharmacology, Weill Cornell Medical College, New York, New York, USA. Department of Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, New York, New York, USA. Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada. Department of Pathology, Weill Cornell Medical College, New York, New York, USA. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. The University of Kansas Cancer Center, Kansas University Medical Center, Kansas City, Kansas, USA. Centre for Lymphoid Cancers and the Departments of Pathology and Experimental Therapeutics, British Columbia Cancer Agency, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1172/JCI42869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993589PMC
December 2010