Martin Glennie

Martin Glennie

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Martin Glennie

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Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity.

Cancer Cell 2020 Jun 21;37(6):850-866.e7. Epub 2020 May 21.

Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton, UK; Institute for Life Sciences, University of Southampton, Southampton, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280789PMC
June 2020

FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion.

J Immunother Cancer 2020 Jun;8(1)

Antibody & Vaccine Group, Centre for Cancer Immunology, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, Hampshire, UK

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http://dx.doi.org/10.1136/jitc-2020-000619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304853PMC
June 2020

Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression.

Cancer Immunol Res 2019 11 26;7(11):1876-1890. Epub 2019 Aug 26.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0835DOI Listing
November 2019

The Use of Anti-CD40 mAb in Cancer.

Curr Top Microbiol Immunol 2017;405:165-207

Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1007/82_2014_427DOI Listing
May 2019

Impact of Human FcγR Gene Polymorphisms on IgG-Triggered Cytokine Release: Critical Importance of Cell Assay Format.

Front Immunol 2019 7;10:390. Epub 2019 Mar 7.

Antibody and Vaccine Group, Centre for Cancer Immunology, Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.00390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417454PMC
March 2019

Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking.

Sci Rep 2018 02 2;8(1):2278. Epub 2018 Feb 2.

Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

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http://www.nature.com/articles/s41598-018-20656-y
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http://dx.doi.org/10.1038/s41598-018-20656-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797108PMC
February 2018

Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

Cancer Cell 2017 Dec 30;32(6):777-791.e6. Epub 2017 Nov 30.

Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK; Cancer Research UK Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734932PMC
December 2017

Obinutuzumab induces superior B-cell cytotoxicity to rituximab in rheumatoid arthritis and systemic lupus erythematosus patient samples.

Rheumatology (Oxford) 2017 07;56(7):1227-1237

Centre for Rheumatology, University College London, London, UK2Roche Pharmaceutical Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland3Academic Unit of Cancer Sciences, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1093/rheumatology/kex067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808665PMC
July 2017

STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy.

Cancer Res 2017 07 16;77(13):3619-3631. Epub 2017 May 16.

Antibody & Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500176PMC
July 2017

Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms.

J Immunol 2017 05 12;198(10):3999-4011. Epub 2017 Apr 12.

Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom

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http://dx.doi.org/10.4049/jimmunol.1601473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424080PMC
May 2017

OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential.

Clin Cancer Res 2016 Aug 31;22(16):4236-48. Epub 2016 Mar 31.

Dermatopharmacology, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Dermatology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987192PMC
August 2016

Antitumor Efficacy of Radiation plus Immunotherapy Depends upon Dendritic Cell Activation of Effector CD8+ T Cells.

Cancer Immunol Res 2016 07 30;4(7):621-630. Epub 2016 May 30.

Targeted Therapy Group, Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Sciences Centre, United Kingdom.

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http://cancerimmunolres.aacrjournals.org/cgi/doi/10.1158/232
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http://dx.doi.org/10.1158/2326-6066.CIR-15-0253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348028PMC
July 2016

Influence of immunoglobulin isotype on therapeutic antibody function.

Blood 2016 Mar 13;127(9):1097-101. Epub 2016 Jan 13.

Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton, Faculty of Medicine, General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1182/blood-2015-09-625343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797141PMC
March 2016

CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses.

Eur J Immunol 2015 Dec 6;45(12):3289-301. Epub 2015 Nov 6.

Department of Pathology, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1002/eji.201445291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752831PMC
December 2015

Comparing the efficacy and neuroinflammatory potential of three anti-abeta antibodies.

Acta Neuropathol 2015 Nov 3;130(5):699-711. Epub 2015 Oct 3.

Centre for Biological Sciences, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1007/s00401-015-1484-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612324PMC
November 2015

Development of Next-Generation Immunomodulatory Antibodies for Cancer Therapy through Optimization of the IgG Framework.

Cancer Cell 2015 Sep;28(3):273-5

Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108150029
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http://dx.doi.org/10.1016/j.ccell.2015.08.008DOI Listing
September 2015

Mogamulizumab and the treatment of CCR4-positive T-cell lymphomas.

Immunotherapy 2014 ;6(11):1187-206

Cancer Research UK Centre, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, SO16 6YD, UK.

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https://www.futuremedicine.com/doi/10.2217/imt.14.94
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http://dx.doi.org/10.2217/imt.14.94DOI Listing
July 2015

Clinical and biological effects of an agonist anti-CD40 antibody: a Cancer Research UK phase I study.

Clin Cancer Res 2015 Mar 14;21(6):1321-8. Epub 2015 Jan 14.

Cancer Research UK Centre, University of Southampton, Southampton, United Kingdom. NIHR/CRUK Experimental Cancer Medicine Centre, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2355DOI Listing
March 2015

Activatory and inhibitory Fcγ receptors augment rituximab-mediated internalization of CD20 independent of signaling via the cytoplasmic domain.

J Biol Chem 2015 Feb 7;290(9):5424-37. Epub 2015 Jan 7.

From the Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton, Faculty of Medicine, General Hospital, Southampton SO16 6YD, United Kingdom and

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http://dx.doi.org/10.1074/jbc.M114.593806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342459PMC
February 2015

Fcγ receptor-mediated inflammation inhibits axon regeneration.

PLoS One 2014 11;9(2):e88703. Epub 2014 Feb 11.

Department of Neurology, University of Texas Medical School at Houston, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088703PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921223PMC
October 2014

Inhibitory FcγRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity.

Blood 2014 Jan 13;123(5):669-77. Epub 2013 Nov 13.

Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton, Faculty of Medicine, General Hospital, Southampton, United Kingdom;

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http://dx.doi.org/10.1182/blood-2013-04-490821DOI Listing
January 2014

Immunotherapy targeting inhibitory Fcγ receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization.

J Immunol 2013 Oct 11;191(8):4130-40. Epub 2013 Sep 11.

Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton, Faculty of Medicine, General Hospital, Southampton SO16 6YD, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1301430DOI Listing
October 2013

Neutrophils: "neu players" in antibody therapy?

Blood 2013 Oct;122(18):3093-4

UNIVERSITY OF SOUTHAMPTON.

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http://dx.doi.org/10.1182/blood-2013-09-525451DOI Listing
October 2013

Novel antibodies targeting immune regulatory checkpoints for cancer therapy.

Br J Clin Pharmacol 2013 Aug;76(2):233-47

Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1111/bcp.12164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731598PMC
August 2013

Immunomodulatory monoclonal antibodies combined with peptide vaccination provide potent immunotherapy in an aggressive murine neuroblastoma model.

Clin Cancer Res 2013 Jul 6;19(13):3545-55. Epub 2013 May 6.

Antibody and Vaccine Group, Cancer Research UK Experimental Cancer Medicine Centre, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743027PMC
July 2013

Antibody-peptide-MHC fusion conjugates target non-cognate T cells to kill tumour cells.

Cancer Immunol Immunother 2013 Jun 19;62(6):1093-105. Epub 2013 Apr 19.

Antibody and Vaccine Group MP88, Cancer Sciences Unit, Faculty of Medicine, General Hospital, University of Southampton, Tremona Road, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1007/s00262-013-1408-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869625PMC
June 2013

FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs.

Cancer Immunol Immunother 2013 May 31;62(5):941-8. Epub 2013 Mar 31.

Antibody and Vaccine Group, MP88, Cancer Sciences Unit, Faculty of Medicine, Southampton University Hospital, Tremona Road, Southampton, SO16 0XA, UK.

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http://dx.doi.org/10.1007/s00262-013-1398-6DOI Listing
May 2013

Agonistic CD40 antibodies and cancer therapy.

Clin Cancer Res 2013 Mar;19(5):1035-43

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590838PMC
March 2013

Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction.

Acta Neuropathol 2012 Oct 18;124(4):479-90. Epub 2012 May 18.

Centre for of Biological Sciences, University of Southampton, Southampton General Hospital, UK.

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http://dx.doi.org/10.1007/s00401-012-0995-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444701PMC
October 2012

Development and characterisation of monoclonal antibodies specific for the murine inhibitory FcγRIIB (CD32B).

Eur J Immunol 2012 Aug 4;42(8):2109-20. Epub 2012 Jul 4.

Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, General Hospital, Southampton, UK.

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http://dx.doi.org/10.1002/eji.201142302DOI Listing
August 2012

Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody.

J Immunol 2011 Aug 8;187(4):1754-63. Epub 2011 Jul 8.

Division of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1101135DOI Listing
August 2011

Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy.

J Immunol 2011 Jul 8;187(2):726-32. Epub 2011 Jun 8.

Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1002581DOI Listing
July 2011

Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration.

J Immunol 2011 Jun 13;186(12):7215-24. Epub 2011 May 13.

Central Nervous System Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 6YD, United Kingdom.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0903833
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http://dx.doi.org/10.4049/jimmunol.0903833DOI Listing
June 2011

Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies.

Blood 2011 Apr 4;117(17):4519-29. Epub 2011 Mar 4.

Targeted Therapy Group, Paterson Institute for Cancer Research, School of Cancer and Enabling Sciences, University of Manchester, Manchester Academic Health Sciences Center, Manchester, UK.

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http://dx.doi.org/10.1182/blood-2010-07-296913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099571PMC
April 2011

Ligation of CD11c during vaccination promotes germinal centre induction and robust humoral responses without adjuvant.

Immunology 2010 Sep 10;131(1):141-51. Epub 2010 May 10.

Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton, UK.

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http://dx.doi.org/10.1111/j.1365-2567.2010.03285.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966766PMC
September 2010

CD20 as a target for therapeutic type I and II monoclonal antibodies.

Semin Hematol 2010 Apr;47(2):107-14

Tenovus Laboratory, Cancer Sciences Division, University of Southampton School of Medicine, General Hospital, Southampton, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S003719631000002
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http://dx.doi.org/10.1053/j.seminhematol.2010.01.001DOI Listing
April 2010

Anti-CD20 monoclonal antibodies: historical and future perspectives.

Haematologica 2010 Jan 22;95(1):135-43. Epub 2009 Sep 22.

Tenovus Laboratory, Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.3324/haematol.2008.001628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805725PMC
January 2010

Complement: help or hindrance?

Blood 2009 Dec;114(27):5567-8; author reply 5568

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http://dx.doi.org/10.1182/blood-2009-10-249466DOI Listing
December 2009

Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity.

J Immunol 2009 Jun;182(12):8026-36

University of Edinburgh/Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0900107
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http://dx.doi.org/10.4049/jimmunol.0900107DOI Listing
June 2009

Optimising anti-tumour CD8 T-cell responses using combinations of immunomodulatory antibodies.

Eur J Immunol 2008 Sep;38(9):2499-511

Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, Tremona Road, Southampton, UK.

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http://dx.doi.org/10.1002/eji.200838208DOI Listing
September 2008

CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses.

Eur J Immunol 2008 Aug;38(8):2263-73

Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, Southampton, UK.

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http://dx.doi.org/10.1002/eji.200838302DOI Listing
August 2008

Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling.

J Biol Chem 2008 Jun 21;283(25):16971-84. Epub 2008 Apr 21.

Cancer Sciences Division, General Hospital, Southampton University School of Medicine, Southampton SO16 6YD, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M708459200DOI Listing
June 2008

Mechanisms of killing by anti-CD20 monoclonal antibodies.

Mol Immunol 2007 Sep;44(16):3823-37

Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton SO16 6YD, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01615890070026
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http://dx.doi.org/10.1016/j.molimm.2007.06.151DOI Listing
September 2007

Intimate cell conjugate formation and exchange of membrane lipids precede apoptosis induction in target cells during antibody-dependent, granulocyte-mediated cytotoxicity.

J Immunol 2007 Jul;179(1):337-45

Institute for Clinical Immunology, Division of Hematology/Oncology, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.4049/jimmunol.179.1.337DOI Listing
July 2007

Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation.

Blood 2007 Jun 20;109(11):4810-5. Epub 2007 Feb 20.

Cancer Sciences Division, School of Medicine, Tenovus Research Laboratory, University of Southampton, Tremona Road, Southampton, UK.

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http://dx.doi.org/10.1182/blood-2006-11-057216DOI Listing
June 2007

Immunostimulatory monoclonal antibodies for cancer therapy.

Nat Rev Cancer 2007 Feb;7(2):95-106

Centro de Investigación Médica Aplicada (CIMA) and Clínica Universitaria, Universidad de Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1038/nrc2051DOI Listing
February 2007

Microscopic intratumoral dosimetry of radiolabeled antibodies is a critical determinant of successful radioimmunotherapy in B-cell lymphoma.

Cancer Res 2007 Feb;67(3):1335-43

Cancer Sciences Division, School of Medicine, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2495DOI Listing
February 2007

Therapeutic potential of immunostimulatory monoclonal antibodies.

Clin Sci (Lond) 2006 Aug;111(2):93-106

Cancer Research UK Medical Oncology Unit, The Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1042/CS20060024DOI Listing
August 2006

Cyclophosphamide inhibition of anti-CD40 monoclonal antibody-based therapy of B cell lymphoma is dependent on CD11b+ cells.

Cancer Res 2005 Aug;65(16):7493-501

Cancer Research UK Oncology Unit, Tenovus Research Laboratory, Cancer Sciences Division, School of Medicine, Southampton General Hospital, Southampton, Hampshire.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3808DOI Listing
August 2005

Does the vagus nerve inform the brain about preclinical tumours and modulate them?

Lancet Oncol 2005 Apr;6(4):245-8

School of Psychology, University of Southampton, UK.

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http://dx.doi.org/10.1016/S1470-2045(05)70096-6DOI Listing
April 2005

The biology of CD20 and its potential as a target for mAb therapy.

Curr Dir Autoimmun 2005 ;8:140-74

Tenovus Research Laboratory, Cancer Sciences Division, Southampton University, Southampton General Hospital, Southampton, UK.

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http://dx.doi.org/10.1159/000082102DOI Listing
January 2005

A new anti-idiotype antibody capable of binding rituximab on the surface of lymphoma cells.

Blood 2004 Oct 22;104(8):2540-2. Epub 2004 Jun 22.

Tenovus Research Laboratory, Cancer Sciences Division, School of Medicine, University General Hospital, Tremona Road, Southampton, SO16 6YD United Kingdom.

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http://dx.doi.org/10.1182/blood-2004-05-1733DOI Listing
October 2004

Multivalent conjugates of poly-gamma-D-glutamic acid from Bacillus licheniformis with antibody F(ab') and glycopeptide ligands.

Bioconjug Chem 2003 Nov-Dec;14(6):1148-55

Department of Chemistry, University of Warwick, Coventry, UK.

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http://dx.doi.org/10.1021/bc020019mDOI Listing
July 2004

Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents.

Blood 2004 Apr 9;103(7):2738-43. Epub 2003 Oct 9.

Tenovus Research Laboratory, Cancer Sciences Division, School of Medicine, General Hospital, Southampton, UK.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2003-06-20
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http://dx.doi.org/10.1182/blood-2003-06-2031DOI Listing
April 2004

Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway.

Haematologica 2004 Apr;89(4):435-43

Department of Immunology,Tbilisi State University, Georgia.

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April 2004

Antibody-induced intracellular signaling works in combination with radiation to eradicate lymphoma in radioimmunotherapy.

Blood 2004 Feb 23;103(4):1485-94. Epub 2003 Oct 23.

Cancer Sciences Division, School of Medicine, Southampton University Hospital, United Kingdom.

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http://dx.doi.org/10.1182/blood-2003-06-2037DOI Listing
February 2004

CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts.

Cancer Res 2003 Sep;63(17):5480-9

Tenovus Research Laboratory, Cancer Sciences Division, School of Medicine, General Hospital, Tremona Road, Southampton, SO16 6YD United Kingdom.

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September 2003

Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell-dependent immunity to B-cell lymphoma.

Blood 2003 Aug 24;102(4):1449-57. Epub 2003 Apr 24.

Cancer Research UK Oncology Unit, Tenovus Research Laboratory, Cancer Sciences Division, School of Medicine, Southampton General Hospital, United Kingdom.

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http://dx.doi.org/10.1182/blood-2002-12-3717DOI Listing
August 2003

Renaissance of cancer therapeutic antibodies.

Drug Discov Today 2003 Jun;8(11):503-10

Tenovus Research Laboratory, Cancer Sciences Division, University of Southampton, Southampton General Hospital, S016 6YD, Southampton, UK.

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http://dx.doi.org/10.1016/s1359-6446(03)02714-4DOI Listing
June 2003

Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts.

Blood 2003 Feb 19;101(3):1045-52. Epub 2002 Sep 19.

Tenovus Research Laboratory and Medical Oncology, Cancer Sciences Division, School of Medicine, General Hospital, Southampton, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-06-17
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http://dx.doi.org/10.1182/blood-2002-06-1761DOI Listing
February 2003

The mechanisms of action of rituximab in the elimination of tumor cells.

Semin Oncol 2003 Feb;30(1S2):3-8

Cancer Sciences Division, Southampton University School of Medicine, Southampton, UK United Kingdom.

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February 2003

The mechanisms of action of rituximab in the elimination of tumor cells.

Semin Oncol 2003 Feb;30(1 Suppl 2):3-8

Cancer Sciences Division, Southampton University School of Medicine, Southampton, UK.

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February 2003

Chimeric IgA antibodies against HLA class II effectively trigger lymphoma cell killing.

Blood 2002 Dec 8;100(13):4574-80. Epub 2002 Aug 8.

Division of Hematology/Oncology, Department of Medicine III, University Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1182/blood-2002-03-0687DOI Listing
December 2002

The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis.

Blood 2002 Nov;100(9):3068-76

Tenovus Research Laboratory, Cancer Sciences Division, University of Southampton School of Medicine, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood.V100.9.306
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November 2002

T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody.

J Immunol 2002 Mar;168(6):2720-8

Tenovus Research Laboratory, Cancer Sciences Division, University School of Medicine, Southampton General Hospital, Southampton, United Kingdom.

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March 2002