Publications by authors named "Martin Gleave"

100Publications

Clusterin regulates macrophage expansion, polarization and phagocytic activity in response to inflammation in the kidneys.

Immunol Cell Biol 2020 Sep 15. Epub 2020 Sep 15.

Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.

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http://dx.doi.org/10.1111/imcb.12405DOI Listing
September 2020

Small Renal Mass Surveillance: Histology-specific Growth Rates in a Biopsy-characterized Cohort.

Eur Urol 2020 Sep 14;78(3):460-467. Epub 2020 Jul 14.

Division of Urology, Department of Surgery, Princess Margaret Cancer Centre and the University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.eururo.2020.06.053DOI Listing
September 2020

LIN28B promotes the development of neuroendocrine prostate cancer.

J Clin Invest 2020 Oct;130(10):5338-5348

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1172/JCI135373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524485PMC
October 2020

Deep Docking: A Deep Learning Platform for Augmentation of Structure Based Drug Discovery.

ACS Cent Sci 2020 Jun 19;6(6):939-949. Epub 2020 May 19.

Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia V6H3Z6, Canada.

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http://dx.doi.org/10.1021/acscentsci.0c00229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318080PMC
June 2020

Plasma Circulating Tumor DNA and Clonal Hematopoiesis in Metastatic Renal Cell Carcinoma.

Clin Genitourin Cancer 2020 08 8;18(4):322-331.e2. Epub 2020 Jan 8.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, British Columbia, Canada; Department of Medical Oncology, BC Cancer, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.clgc.2019.12.018DOI Listing
August 2020

Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019.

Eur Urol 2020 04 27;77(4):508-547. Epub 2020 Jan 27.

University of Bern, Bern, Switzerland; Department of Medical Oncology and Haematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

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http://dx.doi.org/10.1016/j.eururo.2020.01.012DOI Listing
April 2020

Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28.

Mol Cell 2020 03 22;77(5):970-984.e7. Epub 2020 Jan 22.

Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany; Center for Regenerative Therapies Dresden, TU-Dresden, Dresden 01307, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060810PMC
March 2020

Design and Characterization of Injectable Poly(Lactic-Co-Glycolic Acid) Pastes for Sustained and Local Drug Release.

Pharm Res 2020 Jan 21;37(3):36. Epub 2020 Jan 21.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s11095-019-2730-4DOI Listing
January 2020

A polymeric paste-drug formulation for intratumoral treatment of prostate cancer.

Prostate Cancer Prostatic Dis 2020 06 25;23(2):324-332. Epub 2019 Nov 25.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/s41391-019-0190-xDOI Listing
June 2020

Characterization of a Prostate- and Prostate Cancer-Specific Circular RNA Encoded by the Androgen Receptor Gene.

Mol Ther Nucleic Acids 2019 Dec 24;18:916-926. Epub 2019 Oct 24.

Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2019.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883311PMC
December 2019

Towards precision oncology in advanced prostate cancer.

Nat Rev Urol 2019 11 7;16(11):645-654. Epub 2019 Oct 7.

Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41585-019-0237-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858516PMC
November 2019

Predicting complications following radical cystectomy with the ACS NSQIP universal surgical risk calculator.

World J Urol 2020 May 27;38(5):1215-1220. Epub 2019 Aug 27.

Department of Urologic Sciences, University of British Columbia, Level 6, 2775 Laurel St, Vancouver, BC, V6N 2W6, Canada.

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http://dx.doi.org/10.1007/s00345-019-02915-3DOI Listing
May 2020

GnRH Antagonists Have Direct Inhibitory Effects On Castration-Resistant Prostate Cancer Via Intracrine Androgen and AR-V7 Expression.

Mol Cancer Ther 2019 10 24;18(10):1811-1821. Epub 2019 Jul 24.

Department of Urologic Surgery, University of California at Davis, Sacramento, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1337DOI Listing
October 2019

Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer.

Sci Rep 2019 05 24;9(1):7826. Epub 2019 May 24.

The Vancouver Prostate Centre, Department of Urological Sciences, University of British Columbia, 2775 Laurel Street, Vancouver, British Columbia, V6H 3Z6, Canada.

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http://www.nature.com/articles/s41598-019-44346-5
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http://dx.doi.org/10.1038/s41598-019-44346-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534589PMC
May 2019

RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression.

Eur Urol 2019 08 23;76(2):157-166. Epub 2019 Mar 23.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838193019
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http://dx.doi.org/10.1016/j.eururo.2019.03.011DOI Listing
August 2019

Re: Radiotherapy to the Primary Tumour for Newly Diagnosed, Metastatic Prostate Cancer (STAMPEDE).

Eur Urol 2019 04 5;75(4):692-693. Epub 2019 Jan 5.

Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183104
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http://dx.doi.org/10.1016/j.eururo.2018.12.035DOI Listing
April 2019

Health-related Quality of Life for Abiraterone Plus Prednisone Versus Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer: Results from a Phase II Randomized Trial.

Eur Urol 2019 06 24;75(6):940-947. Epub 2018 Dec 24.

Department of Medical Oncology, BC Cancer Vancouver Centre, Vancouver, BC, Canada; Department of Urological Sciences, The Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183102
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http://dx.doi.org/10.1016/j.eururo.2018.12.015DOI Listing
June 2019

Subtle Protective Roles of Clusterin in Gastric Metaplasia After Acute Oxyntic Atrophy.

Cell Mol Gastroenterol Hepatol 2019 22;7(1):246-250.e1. Epub 2018 Sep 22.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Medicine, St. Olav's University Hospital, Trondheim, Norway. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X183013
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http://dx.doi.org/10.1016/j.jcmgh.2018.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305871PMC
April 2019

Loss of Nuclear Functions of HOXA10 Is Associated With Testicular Cancer Proliferation.

Front Oncol 2018 7;8:594. Epub 2018 Dec 7.

Department of Urologic Sciences, Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fonc.2018.00594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292994PMC
December 2018

Correction: A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome.

Oncogene 2019 03;38(13):2436

Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/s41388-018-0587-3DOI Listing
March 2019

Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer.

Eur J Med Chem 2018 Dec 11;160:108-119. Epub 2018 Sep 11.

Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia, V6H 3Z6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.09.023DOI Listing
December 2018

Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers.

Nat Commun 2018 10 4;9(1):4080. Epub 2018 Oct 4.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://www.nature.com/articles/s41467-018-06177-2
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http://dx.doi.org/10.1038/s41467-018-06177-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172226PMC
October 2018

Characterization of Precursor-Dependent Steroidogenesis in Human Prostate Cancer Models.

Cancers (Basel) 2018 Sep 20;10(10). Epub 2018 Sep 20.

The Vancouver Prostate Centre at Vancouver General Hospital, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.

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http://dx.doi.org/10.3390/cancers10100343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210088PMC
September 2018

A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome.

Oncogene 2019 02 7;38(7):913-934. Epub 2018 Sep 7.

Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/s41388-018-0488-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514858PMC
February 2019

SRRM4 gene expression correlates with neuroendocrine prostate cancer.

Prostate 2019 01 28;79(1):96-104. Epub 2018 Aug 28.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/pros.23715DOI Listing
January 2019

Natural history of prostatic lesions on serial multiparametric magnetic resonance imaging.

Can Urol Assoc J 2018 Aug 6;12(8):270-275. Epub 2018 Apr 6.

Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.4859/cuaj.4859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114162PMC
August 2018

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Cell 2018 07 19;174(3):758-769.e9. Epub 2018 Jul 19.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA; Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA; Department of Radiation Oncology, UCSF, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425931PMC
July 2018

Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.

J Clin Oncol 2018 08 9;36(24):2492-2503. Epub 2018 Jul 9.

Rahul Aggarwal, Li Zhang, Felix Y. Feng, Paul Lloyd, Jack Youngren, Adam Foye, Denise Playdle, Charles J. Ryan, and Eric J. Small, University of California San Francisco, San Francisco; Alana S. Weinstein, Verena Friedl, Can Zhang, Christopher K. Wong, Vlado Uzunangelov, Artem Sokolov, Yulia Newton, and Joshua M. Stuart, University of California Santa Cruz, Santa Cruz; Owen N. Witte and Matthew Rettig, University of California Los Angeles, Los Angeles; Christopher P. Evans and Primo Lara, University of California Davis, Davis, CA; Jiaoti Huang, Duke University, Durham, NC; Joshi J. Alumkal, George V. Thomas, and Tomasz M. Beer, Oregon Health Sciences University, Portland, OR; Martin Gleave and Kim N. Chi, University of British Columbia, Vancouver, British Columbia, Canada; Lawrence True, University of Washington, Seattle, WA; Himisha Beltran and Mark A. Rubin, Weill Cornell Medicine, New York, NY; and Francesca Demichelis, University of Trento, Trento, Italy.

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http://dx.doi.org/10.1200/JCO.2017.77.6880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366813PMC
August 2018

Long term deficiency of vitamin D in germ cell testicular cancer survivors.

Oncotarget 2018 Apr 20;9(30):21078-21085. Epub 2018 Apr 20.

Department of Medicine and Surgery, Division of Medical Oncology, Centro di Riferimento Tumori Rari Regione Campania, University of Naples "Federico II", Napoli, Italy.

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http://dx.doi.org/10.18632/oncotarget.24925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940414PMC
April 2018

Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells.

Proc Natl Acad Sci U S A 2018 05 30;115(20):E4584-E4593. Epub 2018 Apr 30.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1802415115
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http://dx.doi.org/10.1073/pnas.1802415115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960326PMC
May 2018

Co-targeting driver pathways in prostate cancer: two birds with one stone.

EMBO Mol Med 2018 04;10(4)

The Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.15252/emmm.201808928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887904PMC
April 2018

Molecular model for neuroendocrine prostate cancer progression.

BJU Int 2018 10 24;122(4):560-570. Epub 2018 Apr 24.

Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.

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http://doi.wiley.com/10.1111/bju.14207
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http://dx.doi.org/10.1111/bju.14207DOI Listing
October 2018

Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer.

Eur Urol 2018 06 12;73(6):949-960. Epub 2018 Mar 12.

Vancouver Prostate Centre, Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Experimental Therapeutics, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.02.019DOI Listing
June 2018

The impact of time to metastasis on overall survival in patients with prostate cancer.

World J Urol 2018 Jul 27;36(7):1039-1046. Epub 2018 Feb 27.

Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s00345-018-2236-4DOI Listing
July 2018

Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer.

Cancer Res 2018 05 27;78(10):2691-2704. Epub 2018 Feb 27.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3677DOI Listing
May 2018

Clinical and molecular features of treatment-related neuroendocrine prostate cancer.

Int J Urol 2018 04 3;25(4):345-351. Epub 2018 Feb 3.

Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/iju.13526DOI Listing
April 2018

PSA screening: Time to overcome our brand confusion.

Can Urol Assoc J 2017 Oct;11(10):295-296

Department of Urology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.5489/cuaj.4913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963439PMC
October 2017

A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer.

Invest New Drugs 2018 04 18;36(2):278-287. Epub 2017 Dec 18.

Division of Medical Oncology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s10637-017-0553-xDOI Listing
April 2018

Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer.

J Natl Cancer Inst 2017 Dec;109(12)

Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada; Institute of Biosciences and Medical Technology, University of Tampere, Tampere, Finland; Department of Medicine and Department of Radiation Oncology, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA; Oregon Health and Science University (OHSU) Knight Cancer Institute, Portland, OR; Department of Urology, University of California, Davis, School of Medicine, Sacremento, CA; Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, Canada.

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http://dx.doi.org/10.1093/jnci/djx118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440274PMC
December 2017

Quantification of large scale DNA organization for predicting prostate cancer recurrence.

Cytometry A 2017 12 30;91(12):1164-1174. Epub 2017 Nov 30.

BC Cancer Research Centre, Department of Integrative Oncology, Vancouver, BC, Canada.

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http://doi.wiley.com/10.1002/cyto.a.23287
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http://dx.doi.org/10.1002/cyto.a.23287DOI Listing
December 2017

A prospective randomized pilot study evaluating an ERAS protocol versus a standard protocol for patients treated with radical cystectomy and urinary diversion for bladder cancer.

World J Urol 2018 Feb 7;36(2):215-220. Epub 2017 Nov 7.

Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1007/s00345-017-2109-2DOI Listing
February 2018

Establishment of a neuroendocrine prostate cancer model driven by the RNA splicing factor SRRM4.

Oncotarget 2017 Sep 3;8(40):66878-66888. Epub 2017 Aug 3.

Department of Urologic Sciences, Vancouver Prostate Centre, The University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.18632/oncotarget.19916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620142PMC
September 2017