Publications by authors named "Martin Clynes"

100Publications

Development of whole-cell and cell-free biosensors for the detection and differentiation of organic and inorganic forms of copper.

Metallomics 2020 Nov 8;12(11):1729-1734. Epub 2020 Oct 8.

National Institute for Cellular Biotechnology and SSPC-SFI Centre for Pharmaceuticals, Dublin City University, Dublin 9, Ireland.

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November 2020

Gene expression profiling of copper-resistant Caco-2 clones.

Metallomics 2020 Oct;12(10):1521-1529

National Institute for Cellular Biotechnology and SSPC-SFI, Centre for Pharmaceuticals, Dublin City University, Glasnevin, Dublin D09 W6Y4, Ireland.

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October 2020

Proteomic analysis of pancreatic ductal adenocarcinoma.

Expert Rev Proteomics 2020 06 11;17(6):453-467. Epub 2020 Aug 11.

National Institute for Cellular Biotechnology, Dublin City University , Dublin, Ireland.

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June 2020

Altered gene expression in CHO cells following polyamine starvation.

Biotechnol Lett 2020 Jun 20;42(6):927-936. Epub 2020 Feb 20.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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June 2020

LC-MS proteomic profiling of Caco-2 human intestinal cells exposed to the copper-chelating agent, triethylenetetramine: A preliminary study.

Biochem Biophys Res Commun 2020 04 8;524(4):847-852. Epub 2020 Feb 8.

Alltech Ireland, European Bioscience Centre, Summerhill Rd, Sarney, Dunboyne, Co. Meath, Ireland.

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April 2020

Characterisation and proteomic profiling of continuously exposed Cu-resistant variants of the Caco-2 cell line.

Toxicol In Vitro 2020 Jun 22;65:104773. Epub 2020 Jan 22.

Alltech Ireland, European Bioscience Centre, Summerhill Rd, Sarney, Dunboyne, Co. Meath, Ireland.

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June 2020

Investigation and circumvention of transfection inhibition by ferric ammonium citrate in serum-free media for Chinese hamster ovary cells.

Biotechnol Prog 2020 05 30;36(3):e2954. Epub 2019 Dec 30.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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May 2020

An arginase-based system for selection of transfected CHO cells without the use of toxic chemicals.

J Biol Chem 2019 12 30;294(49):18756-18768. Epub 2019 Oct 30.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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December 2019

Reinventing the Wheel: Synthetic Circular RNAs for Mammalian Cell Engineering.

Trends Biotechnol 2020 02 14;38(2):217-230. Epub 2019 Aug 14.

National Institute for Cellular Biotechnology, and Synthesis and Solid State Pharmaceutical Centre (SSPC)-Science Foundation Ireland (SFI) Centre for Pharmaceuticals, Dublin City University, Dublin 9, Ireland.

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February 2020

Zinc supplementation increases protein titer of recombinant CHO cells.

Cytotechnology 2019 Oct 8;71(5):915-924. Epub 2019 Aug 8.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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October 2019

Why we need good mentoring.

Nat Rev Cancer 2019 09 29;19(9):489-493. Epub 2019 Jul 29.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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September 2019

Copper-induced non-monotonic dose response in Caco-2 cells.

In Vitro Cell Dev Biol Anim 2019 Apr 23;55(4):221-225. Epub 2019 Feb 23.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, D09 W6Y4, Ireland.

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April 2019

A proteomic profiling dataset of recombinant Chinese hamster ovary cells showing enhanced cellular growth following miR-378 depletion.

Data Brief 2018 Dec 27;21:2679-2688. Epub 2018 Nov 27.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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December 2018

Continuous translation of circularized mRNA improves recombinant protein titer.

Metab Eng 2019 03 4;52:284-292. Epub 2019 Jan 4.

National Institute for Cellular Biotechnology, Dublin City University, Dublin D09 NR58, Ireland. Electronic address:

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March 2019

Improved yield of rhEPO in CHO cells with synthetic 5' UTR.

Biotechnol Lett 2019 Feb 30;41(2):231-239. Epub 2018 Nov 30.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, D09 NR58, Ireland.

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February 2019

Unexpected fluctuations of trace element levels in cell culture medium in vitro: caveat emptor.

In Vitro Cell Dev Biol Anim 2018 Sep 16;54(8):555-558. Epub 2018 Aug 16.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, D09 W6Y4, Ireland.

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September 2018

The Expression Pattern of the Phosphoproteome Is Significantly Changed During the Growth Phases of Recombinant CHO Cell Culture.

Biotechnol J 2018 Oct 27;13(10):e1700221. Epub 2018 Aug 27.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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October 2018

Leaky Expression of the TET-On System Hinders Control of Endogenous miRNA Abundance.

Biotechnol J 2019 Mar 18;14(3):e1800219. Epub 2018 Jul 18.

National Institute for Cellular Biotechnology, Dublin City University, D09 NR58, Dublin, Ireland.

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March 2019

miR-CATCH Identifies Biologically Active miRNA Regulators of the Pro-Survival Gene XIAP, in Chinese Hamster Ovary Cells.

Biotechnol J 2018 Mar 30;13(3):e1700299. Epub 2017 Oct 30.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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March 2018

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease.

EBioMedicine 2017 Sep 16;23:173-184. Epub 2017 Aug 16.

Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland. Electronic address:

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September 2017

Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift.

J Proteome Res 2017 07 6;16(7):2339-2358. Epub 2017 Jun 6.

National Institute for Cellular Biotechnology, Dublin City University , Glasnevin, Dublin 9, Ireland.

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July 2017

Phosphopeptide Enrichment and LC-MS/MS Analysis to Study the Phosphoproteome of Recombinant Chinese Hamster Ovary Cells.

Methods Mol Biol 2017 ;1603:195-208

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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February 2018

Filter-Aided Sample Preparation (FASP) for Improved Proteome Analysis of Recombinant Chinese Hamster Ovary Cells.

Methods Mol Biol 2017 ;1603:187-194

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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February 2018

Conditional Knockdown of Endogenous MicroRNAs in CHO Cells Using TET-ON-SanDI Sponge Vectors.

Methods Mol Biol 2017 ;1603:87-100

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, 9, Ireland.

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February 2018

Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells.

Metab Eng 2017 05 8;41:11-22. Epub 2017 Feb 8.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address:

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May 2017

Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics.

Biotechnol Prog 2016 11 4;32(6):1547-1558. Epub 2016 Sep 4.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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November 2016

Proteomic strategies in the search for novel pancreatic cancer biomarkers and drug targets: recent advances and clinical impact.

Expert Rev Proteomics 2016 ;13(4):383-94

a Department of Proteomics, National Institute for Cellular Biotechnology , Dublin City University , Glasnevin , Dublin 9 , Ireland.

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December 2016

Proteomic differences in recombinant CHO cells producing two similar antibody fragments.

Biotechnol Bioeng 2016 09 16;113(9):1902-12. Epub 2016 Mar 16.

Vienna Institute of BioTechnology (VIBT), University of Natural Resources and Life Sciences, Muthgasse 18, B, 5th Floor, 1190 Vienna, Austria.

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September 2016

The iron-responsive microsomal proteome of Aspergillus fumigatus.

J Proteomics 2016 Mar 29;136:99-111. Epub 2015 Dec 29.

Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland. Electronic address:

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March 2016

Transferrin-bound proteins as potential biomarkers for advanced breast cancer patients.

BBA Clin 2014 Dec 16;2:24-30. Epub 2014 Sep 16.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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December 2014

Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype.

Biotechnol J 2015 Jul 24;10(7):1029-40. Epub 2015 Jun 24.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland.

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July 2015

Towards next generation CHO cell biology: Bioinformatics methods for RNA-Seq-based expression profiling.

Biotechnol J 2015 Jul 9;10(7):950-66. Epub 2015 Jun 9.

The National Institute for Bioprocessing Research and Training, Fosters Avenue, Blackrock, Dublin, Ireland.

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July 2015

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression.

BMC Cancer 2015 Apr 30;15:329. Epub 2015 Apr 30.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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April 2015

Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism.

Expert Opin Drug Metab Toxicol 2015 May 2;11(5):795-809. Epub 2015 Apr 2.

Dublin City University, National Institute for Cellular Biotechnology (NICB) , Glasnevin, Dublin 9 , Ireland +353 1 7005700 ; +353 1 7005484 ;

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May 2015

Predictive biomarkers for dasatinib treatment in melanoma.

Oncoscience 2014 12;1(2):158-66. Epub 2014 Mar 12.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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January 2015

Conserved microRNA function as a basis for Chinese hamster ovary cell engineering.

Biotechnol Lett 2015 Apr 21;37(4):787-98. Epub 2014 Dec 21.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland,

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April 2015

Exposure of a corneal epithelial cell line (hTCEpi) to Demodex-associated Bacillus proteins results in an inflammatory response.

Invest Ophthalmol Vis Sci 2014 Oct 2;55(10):7019-28. Epub 2014 Oct 2.

Department of Biology, National University of Ireland Maynooth, County Kildare, Ireland.

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October 2014

Bone disease in multiple myeloma: pathophysiology and management.

Cancer Growth Metastasis 2014 10;7:33-42. Epub 2014 Aug 10.

National Institute for cellular Biotechnology, Dublin City University, Dublin, Ireland. ; Hematology Department, Mater Misericordaie University Hospital, Dublin, Ireland.

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September 2014

PP2A inhibition overcomes acquired resistance to HER2 targeted therapy.

Mol Cancer 2014 Jun 24;13:157. Epub 2014 Jun 24.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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June 2014

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.

Blood 2014 Aug 16;124(7):999-1009. Epub 2014 Jun 16.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland; and.

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August 2014

Identification and functional validation of RAD23B as a potential protein in human breast cancer progression.

J Proteome Res 2014 Jul 19;13(7):3212-22. Epub 2014 Jun 19.

National Institute for Cellular Biotechnology, Dublin City University , Glasnevin, Dublin 9, Ireland.

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July 2014

In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies.

Front Oncol 2014 6;4:40. Epub 2014 Mar 6.

National Institute for Cellular Biotechnology, Dublin City University , Dublin , Ireland ; Department of Histopathology, St James' Hospital, Trinity College Dublin , Dublin , Ireland.

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March 2014

Cell culture models for study of differentiated adipose cells.

Authors:
Martin Clynes

Stem Cell Res Ther 2014 Dec 16;5(6):137. Epub 2014 Dec 16.

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December 2014

CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors.

Biotechnol J 2014 Mar 10;9(3):396-404. Epub 2013 Dec 10.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland.

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March 2014

Proteomics in uveal melanoma.

Exp Eye Res 2014 Jan 19;118:1-12. Epub 2013 Sep 19.

National Institute for Cellular Biotechnology, Dublin City University, Collins Avenue, Glasnevin, Dublin 9, Ireland. Electronic address:

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January 2014

A gene expression profile indicative of early stage HER2 targeted therapy response.

Mol Cancer 2013 Jul 1;12:69. Epub 2013 Jul 1.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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July 2013

Transcriptomic analysis of clonal growth rate variation during CHO cell line development.

J Biotechnol 2013 Jul 4;166(3):105-13. Epub 2013 May 4.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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July 2013

EGFR and HER2 inhibition in pancreatic cancer.

Invest New Drugs 2013 Jun 18;31(3):558-66. Epub 2012 Oct 18.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, Ireland.

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June 2013

Development, validation and application of a sensitive LC-MS/MS method for the quantification of thalidomide in human serum, cells and cell culture medium.

J Chromatogr B Analyt Technol Biomed Life Sci 2012 Aug 20;902:16-26. Epub 2012 Jun 20.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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August 2012

Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines.

Mol Cancer 2012 Jun 18;11:41. Epub 2012 Jun 18.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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June 2012

Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells.

J Biotechnol 2012 Aug 15;160(3-4):251-62. Epub 2012 Mar 15.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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August 2012

Engineering CHO cell growth by stable manipulation of miRNA expression.

BMC Proc 2011 22;5 Suppl 8:P22. Epub 2011 Nov 22.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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April 2015

Olfactomedin III expression contributes to anoikis-resistance in clonal variants of a human lung squamous carcinoma cell line.

Exp Cell Res 2012 Mar 13;318(5):593-602. Epub 2012 Jan 13.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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March 2012

CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture.

Biotechnol Bioeng 2012 Jun 4;109(6):1368-70. Epub 2012 Jan 4.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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June 2012

Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer.

Prostate 2012 Aug 7;72(11):1193-9. Epub 2011 Dec 7.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland.

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August 2012

A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis.

J Cyst Fibros 2012 Mar 28;11(2):100-7. Epub 2011 Oct 28.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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March 2012