Publications by authors named "Martin Clynes"

100Publications

Genomic Profiling and Functional Analysis of let-7c miRNA-mRNA Interactions Identify to Be Involved in Invasion and Progression of Pancreatic Cancer.

Authors:
Shannon R Nelson Sandra Roche Maura Cotter Pablo Anton Garcia Daniela Reitmeier Elisabeth Zollbrecht Fiona O'Neill Martin Clynes Padraig Doolan Jai P Medha Niall Swan AnneMarie Larkin Naomi Walsh

J Oncol 2020 24;2020:2951921. Epub 2020 Dec 24.

National Institute for Cellular Biotechnology, School of Biotechnology, Dublin City University, Dublin 9, Ireland.

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December 2020

Development of whole-cell and cell-free biosensors for the detection and differentiation of organic and inorganic forms of copper.

Authors:
Alan Costello Joanne Parker Martin Clynes Richard Murphy

Metallomics 2020 Nov 8;12(11):1729-1734. Epub 2020 Oct 8.

National Institute for Cellular Biotechnology and SSPC-SFI Centre for Pharmaceuticals, Dublin City University, Dublin 9, Ireland.

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November 2020

Proteomic Analysis of Cell Lines and Primary Tumors in Pancreatic Cancer Identifies Proteins Expressed Only In Vitro and Only In Vivo.

Authors:
Orla Coleman Michael Henry Fiona OʼNeill Sandra Roche Niall Swan Justin Geoghegan Kevin Conlon Gerard McVey Michael Moriarty Paula Meleady Martin Clynes

Pancreas 2020 09;49(8):1109-1116

From the National Institute for Cellular Biotechnology, Dublin City University.

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September 2020

Gene expression profiling of copper-resistant Caco-2 clones.

Authors:
Charles O'Doherty Joanne Keenan Fiona O'Neill Martin Clynes Indre Sinkunaite Karina Horgan Richard Murphy Finbarr O'Sullivan

Metallomics 2020 Oct;12(10):1521-1529

National Institute for Cellular Biotechnology and SSPC-SFI, Centre for Pharmaceuticals, Dublin City University, Glasnevin, Dublin D09 W6Y4, Ireland.

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October 2020

Proteomic analysis of pancreatic ductal adenocarcinoma.

Authors:
Paula Meleady Rozana Abdul Rahman Michael Henry Michael Moriarty Martin Clynes

Expert Rev Proteomics 2020 06 11;17(6):453-467. Epub 2020 Aug 11.

National Institute for Cellular Biotechnology, Dublin City University , Dublin, Ireland.

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June 2020

Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition.

Authors:
Nicoló Zuin Fantoni Zara Molphy Sinéad O'Carroll Georgia Menounou George Mitrikas Marios G Krokidis Chryssostomos Chatgilialoglu John Colleran Anna Banasiak Martin Clynes Sandra Roche Suainibhe Kelly Vickie McKee Andrew Kellett

Chemistry 2020 Jun 10. Epub 2020 Jun 10.

School of Chemical Sciences and National Institute for Cellular, Biotechnology, Dublin City University, Glasnevin, Dublin, 9, Ireland.

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June 2020

DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models.

Authors:
Michael C Johnston Julie A Nicoll Kelly M Redmond Peter Smyth Michelle K Greene William J McDaid Darren K W Chan N Crawford Katie J Stott Jennifer P Fox Ninfa L Straubinger Sandra Roche Martin Clynes Robert M Straubinger Daniel B Longley Christopher J Scott

J Control Release 2020 Aug 3;324:610-619. Epub 2020 Jun 3.

Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Ireland. Electronic address:

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August 2020

Subphysiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells.

Authors:
Ioanna Tzani Craig Monger Krishna Motheramgari Clair Gallagher Ryan Hagan Paul Kelly Alan Costello Justine Meiller Patrick Floris Lin Zhang Martin Clynes Jonathan Bones Niall Barron Colin Clarke

Biotechnol Bioeng 2020 08 4;117(8):2489-2503. Epub 2020 Jun 4.

National Institute for Bioprocessing Research and Training, Dublin, Ireland.

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August 2020

Altered gene expression in CHO cells following polyamine starvation.

Authors:
Berta Capella Roca Padraig Doolan Niall Barron Fiona O'Neill Martin Clynes

Biotechnol Lett 2020 Jun 20;42(6):927-936. Epub 2020 Feb 20.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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June 2020

LC-MS proteomic profiling of Caco-2 human intestinal cells exposed to the copper-chelating agent, triethylenetetramine: A preliminary study.

Authors:
Charles O'Doherty Finbarr O'Sullivan Michael Henry Paula Meleady Martin Clynes Karina Horgan Joanne Keenan Richard Murphy

Biochem Biophys Res Commun 2020 04 8;524(4):847-852. Epub 2020 Feb 8.

Alltech Ireland, European Bioscience Centre, Summerhill Rd, Sarney, Dunboyne, Co. Meath, Ireland.

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April 2020

Establishment and Characterisation by Expression Microarray of Patient-Derived Xenograft Panel of Human Pancreatic Adenocarcinoma Patients.

Authors:
Sandra Roche Fiona O'Neill Jean Murphy Niall Swan Justine Meiller Neil T Conlon Justin Geoghegan Kevin Conlon Ray McDermott Rozana Rahman Sinead Toomey Ninfa L Straubinger Robert M Straubinger Robert O'Connor Gerard McVey Michael Moriarty Martin Clynes

Int J Mol Sci 2020 Jan 31;21(3). Epub 2020 Jan 31.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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January 2020

Characterisation and proteomic profiling of continuously exposed Cu-resistant variants of the Caco-2 cell line.

Authors:
Charles O'Doherty Joanne Keenan Michael Henry Paula Meleady Indre Sinkunaite Martin Clynes Finbarr O'Sullivan Karina Horgan Richard Murphy

Toxicol In Vitro 2020 Jun 22;65:104773. Epub 2020 Jan 22.

Alltech Ireland, European Bioscience Centre, Summerhill Rd, Sarney, Dunboyne, Co. Meath, Ireland.

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June 2020

Investigation and circumvention of transfection inhibition by ferric ammonium citrate in serum-free media for Chinese hamster ovary cells.

Authors:
Berta Capella Roca Nga T Lao Martin Clynes Padraig Doolan

Biotechnol Prog 2020 05 30;36(3):e2954. Epub 2019 Dec 30.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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May 2020

PRDX3 is associated with metastasis and poor survival in uveal melanoma.

Authors:
Pathma Ramasamy Anne-Marie Larkin Annett Linge Damien Tiernan Fionnuala McAree Noel Horgan Paul Moriarty Stephen Beatty Conor C Murphy Martin Clynes Susan Kennedy Paula Meleady

J Clin Pathol 2020 Jul 26;73(7):408-412. Epub 2019 Nov 26.

National Institute for Cellular Biotechnology, Dublin, Ireland.

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July 2020

An arginase-based system for selection of transfected CHO cells without the use of toxic chemicals.

Authors:
Berta Capella Roca Nga Lao Niall Barron Padraig Doolan Martin Clynes

J Biol Chem 2019 12 30;294(49):18756-18768. Epub 2019 Oct 30.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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December 2019

Reinventing the Wheel: Synthetic Circular RNAs for Mammalian Cell Engineering.

Authors:
Alan Costello Nga T Lao Niall Barron Martin Clynes

Trends Biotechnol 2020 02 14;38(2):217-230. Epub 2019 Aug 14.

National Institute for Cellular Biotechnology, and Synthesis and Solid State Pharmaceutical Centre (SSPC)-Science Foundation Ireland (SFI) Centre for Pharmaceuticals, Dublin City University, Dublin 9, Ireland.

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February 2020

Zinc supplementation increases protein titer of recombinant CHO cells.

Authors:
Berta Capella Roca Antonio Alarcón Miguez Joanne Keenan Srinivas Suda Niall Barron Donal O'Gorman Padraig Doolan Martin Clynes

Cytotechnology 2019 Oct 8;71(5):915-924. Epub 2019 Aug 8.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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October 2019

Why we need good mentoring.

Authors:
Martin Clynes Anita Corbett Julie Overbaugh

Nat Rev Cancer 2019 09 29;19(9):489-493. Epub 2019 Jul 29.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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September 2019

Improvements in single-use bioreactor film material composition leads to robust and reliable Chinese hamster ovary cell performance.

Authors:
Paul S Kelly Noemi Dorival-García Samantha Paré Sara Carillo Christine Ta Antonio Alarcon Miguez Orla Coleman Emma Harper Maeve Shannon Michael Henry Lisa Connolly Martin Clynes Paula Meleady Jonathan Bones Niall Barron

Biotechnol Prog 2019 07 6;35(4):e2824. Epub 2019 May 6.

National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Co. Dublin, Ireland.

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July 2019

Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq.

Authors:
Colin Clarke Clair Gallagher Ronan M Kelly Michael Henry Paula Meleady Christopher C Frye Matthew D Osborne Ciaran P Brady Niall Barron Martin Clynes

Biotechnol Bioeng 2019 06 21;116(6):1556-1562. Epub 2019 Mar 21.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, Ireland.

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June 2019

Copper-induced non-monotonic dose response in Caco-2 cells.

Authors:
Charles O'Doherty Joanne Keenan Karina Horgan Richard Murphy Finbarr O'Sullivan Martin Clynes

In Vitro Cell Dev Biol Anim 2019 Apr 23;55(4):221-225. Epub 2019 Feb 23.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, D09 W6Y4, Ireland.

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April 2019

A proteomic profiling dataset of recombinant Chinese hamster ovary cells showing enhanced cellular growth following miR-378 depletion.

Authors:
Orla Coleman Alan Costello Michael Henry Nga T Lao Niall Barron Martin Clynes Paula Meleady

Data Brief 2018 Dec 27;21:2679-2688. Epub 2018 Nov 27.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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December 2018

Increased growth rate and productivity following stable depletion of miR-7 in a mAb producing CHO cell line causes an increase in proteins associated with the Akt pathway and ribosome biogenesis.

Authors:
Orla Coleman Srinivas Suda Justine Meiller Michael Henry Markus Riedl Niall Barron Martin Clynes Paula Meleady

J Proteomics 2019 03 11;195:23-32. Epub 2019 Jan 11.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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March 2019

Continuous translation of circularized mRNA improves recombinant protein titer.

Authors:
Alan Costello Nga T Lao Niall Barron Martin Clynes

Metab Eng 2019 03 4;52:284-292. Epub 2019 Jan 4.

National Institute for Cellular Biotechnology, Dublin City University, Dublin D09 NR58, Ireland. Electronic address:

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March 2019

Improved yield of rhEPO in CHO cells with synthetic 5' UTR.

Authors:
Alan Costello Nga T Lao Niall Barron Martin Clynes

Biotechnol Lett 2019 Feb 30;41(2):231-239. Epub 2018 Nov 30.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, D09 NR58, Ireland.

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February 2019

Acute exposure to organic and inorganic sources of copper: Differential response in intestinal cell lines.

Authors:
Joanne Keenan Finbarr O'Sullivan Michael Henry Laura Breen Padraig Doolan Indre Sinkunaite Paula Meleady Martin Clynes Karina Horgan Richard Murphy

Food Sci Nutr 2018 Nov 20;6(8):2499-2514. Epub 2018 Oct 20.

Alltech Dunboyne Ireland.

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November 2018

A Comparative Quantitative LC-MS/MS Profiling Analysis of Human Pancreatic Adenocarcinoma, Adjacent-Normal Tissue, and Patient-Derived Tumour Xenografts.

Authors:
Orla Coleman Michael Henry Fiona O'Neill Sandra Roche Niall Swan Lorraine Boyle Jean Murphy Justine Meiller Neil T Conlon Justin Geoghegan Kevin C Conlon Vincent Lynch Ninfa L Straubinger Robert M Straubinger Gerard McVey Michael Moriarty Paula Meleady Martin Clynes

Proteomes 2018 Nov 6;6(4). Epub 2018 Nov 6.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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November 2018

Depletion of endogenous miRNA-378-3p increases peak cell density of CHO DP12 cells and is correlated with elevated levels of ubiquitin carboxyl-terminal hydrolase 14.

Authors:
Alan Costello Orla Coleman Nga T Lao Michael Henry Paula Meleady Niall Barron Martin Clynes

J Biotechnol 2018 Dec 31;288:30-40. Epub 2018 Oct 31.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, D09 NR58, Ireland.

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December 2018

Unexpected fluctuations of trace element levels in cell culture medium in vitro: caveat emptor.

Authors:
Joanne Keenan Karina Horgan Martin Clynes Indre Sinkunaite Patrick Ward Richard Murphy Finbarr O'Sullivan

In Vitro Cell Dev Biol Anim 2018 Sep 16;54(8):555-558. Epub 2018 Aug 16.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, D09 W6Y4, Ireland.

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September 2018

The Expression Pattern of the Phosphoproteome Is Significantly Changed During the Growth Phases of Recombinant CHO Cell Culture.

Authors:
Prashant Kaushik Michael Henry Martin Clynes Paula Meleady

Biotechnol J 2018 Oct 27;13(10):e1700221. Epub 2018 Aug 27.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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October 2018

Leaky Expression of the TET-On System Hinders Control of Endogenous miRNA Abundance.

Authors:
Alan Costello Nga T Lao Clair Gallagher Berta Capella Roca Lourdes A N Julius Srinivas Suda Jens Ducrée Damien King Roland Wagner Niall Barron Martin Clynes

Biotechnol J 2019 Mar 18;14(3):e1800219. Epub 2018 Jul 18.

National Institute for Cellular Biotechnology, Dublin City University, D09 NR58, Dublin, Ireland.

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March 2019

Clonal variation in productivity and proteolytic clipping of an Fc-fusion protein in CHO cells: Proteomic analysis suggests a role for defective protein folding and the UPR.

Authors:
Michael Henry Clair Gallagher Ronan M Kelly Christopher C Frye Matthew D Osborne Ciaran P Brady Niall Barron Martin Clynes Paula Meleady

J Biotechnol 2018 Sep 31;281:21-30. Epub 2018 May 31.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address:

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September 2018

Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine.

Authors:
Finbarr O'Sullivan Joanne Keenan Sinead Aherne Fiona O'Neill Colin Clarke Michael Henry Paula Meleady Laura Breen Niall Barron Martin Clynes Karina Horgan Padraig Doolan Richard Murphy

World J Gastroenterol 2017 Nov;23(41):7369-7386

Alltech, Dunboyne, Meath, A86 X006, Ireland.

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November 2017

miR-CATCH Identifies Biologically Active miRNA Regulators of the Pro-Survival Gene XIAP, in Chinese Hamster Ovary Cells.

Authors:
Alan Griffith Paul S Kelly Sebastian Vencken Nga T Lao Catherine M Greene Martin Clynes Niall Barron

Biotechnol J 2018 Mar 30;13(3):e1700299. Epub 2017 Oct 30.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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March 2018

A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer.

Authors:
Dermot O'Sullivan Paul Dowling Helena Joyce Edel McAuley Andrew McCann Michael Henry Brianan McGovern Paul Barham Fergal C Kelleher Jean Murphy Susan Kennedy Niall Swan Michael Moriarty Martin Clynes Annemarie Larkin

Br J Cancer 2017 Oct 7;117(9):1326-1335. Epub 2017 Sep 7.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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October 2017

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease.

Authors:
Michelle M White Patrick Geraghty Elaine Hayes Stephen Cox William Leitch Bader Alfawaz Gillian M Lavelle Oliver J McElvaney Ryan Flannery Joanne Keenan Paula Meleady Michael Henry Martin Clynes Cedric Gunaratnam Noel G McElvaney Emer P Reeves

EBioMedicine 2017 Sep 16;23:173-184. Epub 2017 Aug 16.

Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland. Electronic address:

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September 2017

Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients.

Authors:
Kay Reen Ting Michael Henry Justine Meiller Annemarie Larkin Martin Clynes Paula Meleady Despina Bazou Paul Dowling Peter O'Gorman

BBA Clin 2017 Dec 7;8:28-34. Epub 2017 Jun 7.

Mater Misericordiae University Hospital, Dublin 7, Ireland.

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December 2017

Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift.

Authors:
Michael Henry Martin Power Prashant Kaushik Orla Coleman Martin Clynes Paula Meleady

J Proteome Res 2017 07 6;16(7):2339-2358. Epub 2017 Jun 6.

National Institute for Cellular Biotechnology, Dublin City University , Glasnevin, Dublin 9, Ireland.

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July 2017

Phosphopeptide Enrichment and LC-MS/MS Analysis to Study the Phosphoproteome of Recombinant Chinese Hamster Ovary Cells.

Authors:
Michael Henry Orla Coleman Prashant Martin Clynes Paula Meleady

Methods Mol Biol 2017 ;1603:195-208

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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February 2018

Filter-Aided Sample Preparation (FASP) for Improved Proteome Analysis of Recombinant Chinese Hamster Ovary Cells.

Authors:
Orla Coleman Michael Henry Martin Clynes Paula Meleady

Methods Mol Biol 2017 ;1603:187-194

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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February 2018

Conditional Knockdown of Endogenous MicroRNAs in CHO Cells Using TET-ON-SanDI Sponge Vectors.

Authors:
Alan Costello Nga Lao Martin Clynes Niall Barron

Methods Mol Biol 2017 ;1603:87-100

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, 9, Ireland.

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February 2018

Proteomic analysis of bronchoalveolar lavage fluid (BALF) from lung cancer patients using label-free mass spectrometry.

Authors:
Abduladim Hmmier Michael Emmet O'Brien Vincent Lynch Martin Clynes Ross Morgan Paul Dowling

BBA Clin 2017 Jun 6;7:97-104. Epub 2017 Mar 6.

Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.

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June 2017

Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells.

Authors:
Paul S Kelly Colin Clarke Alan Costello Craig Monger Justine Meiller Heena Dhiman Nicole Borth Michael J Betenbaugh Martin Clynes Niall Barron

Metab Eng 2017 05 8;41:11-22. Epub 2017 Feb 8.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address:

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May 2017

Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome.

Authors:
Paul Dowling Benvon Moran Edel McAuley Paula Meleady Michael Henry Martin Clynes Mairin McMenamin Niamh Leonard Mary Monks Bairbre Wynne Patrick Ormond Annemarie Larkin

Oncol Lett 2016 Nov 7;12(5):3296-3304. Epub 2016 Sep 7.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Republic of Ireland.

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November 2016

Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics.

Authors:
Paul S Kelly Shane McSweeney Orla Coleman Sara Carillo Michael Henry Deepak Chandran Andrew Kellett Jonathan Bones Martin Clynes Paula Meleady Niall Barron

Biotechnol Prog 2016 11 4;32(6):1547-1558. Epub 2016 Sep 4.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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November 2016

Proteomic strategies in the search for novel pancreatic cancer biomarkers and drug targets: recent advances and clinical impact.

Authors:
Orla Coleman Michael Henry Gerard McVey Martin Clynes Michael Moriarty Paula Meleady

Expert Rev Proteomics 2016 ;13(4):383-94

a Department of Proteomics, National Institute for Cellular Biotechnology , Dublin City University , Glasnevin , Dublin 9 , Ireland.

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December 2016

Proteomic differences in recombinant CHO cells producing two similar antibody fragments.

Authors:
Wolfgang Sommeregger Patrick Mayrhofer Willibald Steinfellner David Reinhart Michael Henry Martin Clynes Paula Meleady Renate Kunert

Biotechnol Bioeng 2016 09 16;113(9):1902-12. Epub 2016 Mar 16.

Vienna Institute of BioTechnology (VIBT), University of Natural Resources and Life Sciences, Muthgasse 18, B, 5th Floor, 1190 Vienna, Austria.

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September 2016

Clinical utility of C-terminal telopeptide of type 1 collagen in multiple myeloma.

Authors:
Kay R Ting Jennifer J Brady Abdul Hameed Giao Le Justine Meiller Estelle Verburgh Christopher Bayers Dalia Benjamin Kenneth C Anderson Paul G Richardson Paul Dowling Martin Clynes Maria C Fitzgibbon Peter O'Gorman

Br J Haematol 2016 Apr 20;173(1):82-8. Epub 2016 Jan 20.

Department of Haematology, Mater Misericordiae University Hospital, Dublin 7, Ireland.

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April 2016

The iron-responsive microsomal proteome of Aspergillus fumigatus.

Authors:
Nicola M Moloney Rebecca A Owens Paula Meleady Michael Henry Stephen K Dolan Eoin Mulvihill Martin Clynes Sean Doyle

J Proteomics 2016 Mar 29;136:99-111. Epub 2015 Dec 29.

Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland. Electronic address:

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March 2016

Transferrin-bound proteins as potential biomarkers for advanced breast cancer patients.

Authors:
Paul Dowling Valentina Palmerini Michael Henry Paula Meleady Vincent Lynch Jo Ballot Giuseppe Gullo John Crown Michael Moriarty Martin Clynes

BBA Clin 2014 Dec 16;2:24-30. Epub 2014 Sep 16.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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December 2014

Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype.

Authors:
Paul S Kelly Laura Breen Clair Gallagher Shane Kelly Michael Henry Nga T Lao Paula Meleady Donal O'Gorman Martin Clynes Niall Barron

Biotechnol J 2015 Jul 24;10(7):1029-40. Epub 2015 Jun 24.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland.

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July 2015

Towards next generation CHO cell biology: Bioinformatics methods for RNA-Seq-based expression profiling.

Authors:
Craig Monger Paul S Kelly Clair Gallagher Martin Clynes Niall Barron Colin Clarke

Biotechnol J 2015 Jul 9;10(7):950-66. Epub 2015 Jun 9.

The National Institute for Bioprocessing Research and Training, Fosters Avenue, Blackrock, Dublin, Ireland.

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July 2015

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression.

Authors:
Sinéad T Aherne Stephen F Madden David J Hughes Barbara Pardini Alessio Naccarati Miroslav Levy Pavel Vodicka Paul Neary Paul Dowling Martin Clynes

BMC Cancer 2015 Apr 30;15:329. Epub 2015 Apr 30.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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April 2015

Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism.

Authors:
Helena Joyce Andrew McCann Martin Clynes Annemarie Larkin

Expert Opin Drug Metab Toxicol 2015 May 2;11(5):795-809. Epub 2015 Apr 2.

Dublin City University, National Institute for Cellular Biotechnology (NICB) , Glasnevin, Dublin 9 , Ireland +353 1 7005700 ; +353 1 7005484 ;

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May 2015

Prolonged pre-incubation increases the susceptibility of Galleria mellonella larvae to bacterial and fungal infection.

Authors:
Niall Browne Carla Surlis Amie Maher Clair Gallagher James C Carolan Martin Clynes Kevin Kavanagh

Virulence 2015 18;6(5):458-65. Epub 2015 Mar 18.

a Department of Biology; Maynooth University ; Maynooth , Kildare , Ireland.

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April 2016

Predictive biomarkers for dasatinib treatment in melanoma.

Authors:
Alex J Eustace Susan Kennedy Anne-Marie Larkin Thamir Mahgoub Dimitrios Tryfonopoulos Lorraine O'Driscoll Martin Clynes John Crown Norma O'Donovan

Oncoscience 2014 12;1(2):158-66. Epub 2014 Mar 12.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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January 2015

Glycosylation patterns of kidney proteins differ in rat diabetic nephropathy.

Authors:
Alessandra Ravidà Luca Musante Marjut Kreivi Ilkka Miinalainen Barry Byrne Mayank Saraswat Michael Henry Paula Meleady Martin Clynes Harry Holthofer

Kidney Int 2015 May 14;87(5):963-74. Epub 2015 Jan 14.

Centre for BioAnalytical Sciences, Dublin City University, Dublin, Ireland.

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May 2015

Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer.

Authors:
Paul Dowling David J Hughes Anne Marie Larkin Justine Meiller Michael Henry Paula Meleady Vincent Lynch Barbara Pardini Alessio Naccarati Miroslav Levy Pavel Vodicka Paul Neary Martin Clynes

Clin Chim Acta 2015 Feb 23;441:133-41. Epub 2014 Dec 23.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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February 2015

Conserved microRNA function as a basis for Chinese hamster ovary cell engineering.

Authors:
Paul S Kelly Clair Gallagher Martin Clynes Niall Barron

Biotechnol Lett 2015 Apr 21;37(4):787-98. Epub 2014 Dec 21.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland,

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April 2015

Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer.

Authors:
Paul Dowling Damian Pollard AnneMarie Larkin Michael Henry Paula Meleady Kathy Gately Kenneth O'Byrne Martin P Barr Vincent Lynch Jo Ballot John Crown Michael Moriarty Emmet O'Brien Ross Morgan Martin Clynes

Mol Biosyst 2015 Mar 8;11(3):743-52. Epub 2014 Dec 8.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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March 2015

Identification of proteins found to be significantly altered when comparing the serum proteome from Multiple Myeloma patients with varying degrees of bone disease.

Authors:
Paul Dowling Catriona Hayes Kay Reen Ting Abdul Hameed Justine Meiller Constantine Mitsiades Kenneth C Anderson Martin Clynes Colin Clarke Paul Richardson Peter O'Gorman

BMC Genomics 2014 Oct 17;15:904. Epub 2014 Oct 17.

Department of Biology, National University of Ireland, Maynooth, Co, Kildare, Ireland.

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October 2014

Exposure of a corneal epithelial cell line (hTCEpi) to Demodex-associated Bacillus proteins results in an inflammatory response.

Authors:
Frederick W McMahon Clair Gallagher Niamh O'Reilly Martin Clynes Finbarr O'Sullivan Kevin Kavanagh

Invest Ophthalmol Vis Sci 2014 Oct 2;55(10):7019-28. Epub 2014 Oct 2.

Department of Biology, National University of Ireland Maynooth, County Kildare, Ireland.

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October 2014

Bone disease in multiple myeloma: pathophysiology and management.

Authors:
Abdul Hameed Jennifer J Brady Paul Dowling Martin Clynes Peter O'Gorman

Cancer Growth Metastasis 2014 10;7:33-42. Epub 2014 Aug 10.

National Institute for cellular Biotechnology, Dublin City University, Dublin, Ireland. ; Hematology Department, Mater Misericordaie University Hospital, Dublin, Ireland.

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September 2014

Comparative transcriptomic analysis of cultivated limbal epithelium and donor corneal tissue reveals altered wound healing gene expression.

Authors:
Clair Gallagher Colin Clarke Sinéad T Aherne Kishore R Katikireddy Padraig Doolan Vincent Lynch Sandra Shaw Andra Bobart-Hone Conor Murphy Martin Clynes William Power Finbarr O'Sullivan

Invest Ophthalmol Vis Sci 2014 Aug 14;55(9):5795-805. Epub 2014 Aug 14.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland.

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August 2014

PP2A inhibition overcomes acquired resistance to HER2 targeted therapy.

Authors:
Martina Sj McDermott Brigid C Browne Neil T Conlon Neil A O'Brien Dennis J Slamon Michael Henry Paula Meleady Martin Clynes Paul Dowling John Crown Norma O'Donovan

Mol Cancer 2014 Jun 24;13:157. Epub 2014 Jun 24.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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June 2014

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.

Authors:
Kerstin Pohl Elaine Hayes Joanne Keenan Michael Henry Paula Meleady Kevin Molloy Bakr Jundi David A Bergin Cormac McCarthy Oliver J McElvaney Michelle M White Martin Clynes Emer P Reeves Noel G McElvaney

Blood 2014 Aug 16;124(7):999-1009. Epub 2014 Jun 16.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland; and.

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August 2014

Identification and functional validation of RAD23B as a potential protein in human breast cancer progression.

Authors:
Annett Linge Priyanka Maurya Katrin Friedrich Gustavo B Baretton Shane Kelly Michael Henry Martin Clynes Annemarie Larkin Paula Meleady

J Proteome Res 2014 Jul 19;13(7):3212-22. Epub 2014 Jun 19.

National Institute for Cellular Biotechnology, Dublin City University , Glasnevin, Dublin 9, Ireland.

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July 2014

Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry.

Authors:
Ashling Holland Thomas Schmitt-John Paul Dowling Paula Meleady Michael Henry Martin Clynes Kay Ohlendieck

Biosci Rep 2014 Jul 1;34(4). Epub 2014 Jul 1.

*Department of Biology, National University of Ireland, Maynooth, Co. Kildare, Ireland.

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July 2014

7B7: a novel antibody directed against the Ku70/Ku80 heterodimer blocks invasion in pancreatic and lung cancer cells.

Authors:
Dermot O'Sullivan Michael Henry Helena Joyce Naomi Walsh Edel Mc Auley Paul Dowling Niall Swan Michael Moriarty Paul Barnham Martin Clynes Annemarie Larkin

Tumour Biol 2014 Jul 18;35(7):6983-97. Epub 2014 Apr 18.

National Institute for Cellular Biotechnology (NICB), Dublin City University, Glasnevin, Dublin 9, Ireland.

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July 2014

In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies.

Authors:
Martina McDermott Alex J Eustace Steven Busschots Laura Breen John Crown Martin Clynes Norma O'Donovan Britta Stordal

Front Oncol 2014 6;4:40. Epub 2014 Mar 6.

National Institute for Cellular Biotechnology, Dublin City University , Dublin , Ireland ; Department of Histopathology, St James' Hospital, Trinity College Dublin , Dublin , Ireland.

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March 2014

Cell culture models for study of differentiated adipose cells.

Authors:
Martin Clynes

Stem Cell Res Ther 2014 Dec 16;5(6):137. Epub 2014 Dec 16.

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December 2014

Increased outer arm and core fucose residues on the N-glycans of mutated alpha-1 antitrypsin protein from alpha-1 antitrypsin deficient individuals.

Authors:
Cormac McCarthy Radka Saldova M Emmet O'Brien David A Bergin Tomás P Carroll Joanne Keenan Paula Meleady Michael Henry Martin Clynes Pauline M Rudd Emer P Reeves Noel G McElvaney

J Proteome Res 2014 Feb 13;13(2):596-605. Epub 2013 Dec 13.

Respiratory Research Division, Royal College of Surgeons in Ireland , Beaumont Hospital, Dublin 9, Ireland.

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February 2014

CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors.

Authors:
Noelia Sanchez Paul Kelly Clair Gallagher Nga T Lao Colin Clarke Martin Clynes Niall Barron

Biotechnol J 2014 Mar 10;9(3):396-404. Epub 2013 Dec 10.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland.

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March 2014

Proteomics in uveal melanoma.

Authors:
Pathma Ramasamy Conor C Murphy Martin Clynes Noel Horgan Paul Moriarty Damien Tiernan Stephen Beatty Susan Kennedy Paula Meleady

Exp Eye Res 2014 Jan 19;118:1-12. Epub 2013 Sep 19.

National Institute for Cellular Biotechnology, Dublin City University, Collins Avenue, Glasnevin, Dublin 9, Ireland. Electronic address:

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January 2014

BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome.

Authors:
Stephen F Madden Colin Clarke Patricia Gaule Sinead T Aherne Norma O'Donovan Martin Clynes John Crown William M Gallagher

Breast Cancer Res 2013 ;15(4):R52

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December 2014

A gene expression profile indicative of early stage HER2 targeted therapy response.

Authors:
Fiona O'Neill Stephen F Madden Martin Clynes John Crown Padraig Doolan Sinéad T Aherne Robert O'Connor

Mol Cancer 2013 Jul 1;12:69. Epub 2013 Jul 1.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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July 2013

MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3.

Authors:
Noelia Sanchez Mark Gallagher Nga Lao Clair Gallagher Colin Clarke Padraig Doolan Sinead Aherne Alfonso Blanco Paula Meleady Martin Clynes Niall Barron

PLoS One 2013 6;8(6):e65671. Epub 2013 Jun 6.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland.

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January 2014

Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis.

Authors:
Colin Clarke Stephen F Madden Padraig Doolan Sinead T Aherne Helena Joyce Lorraine O'Driscoll William M Gallagher Bryan T Hennessy Michael Moriarty John Crown Susan Kennedy Martin Clynes

Carcinogenesis 2013 Oct 5;34(10):2300-8. Epub 2013 Jun 5.

National Institute for Cellular Biotechnology and.

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October 2013

Proteomic profiling of cardiomyopathic tissue from the aged mdx model of Duchenne muscular dystrophy reveals a drastic decrease in laminin, nidogen and annexin.

Authors:
Ashling Holland Paul Dowling Margit Zweyer Dieter Swandulla Michael Henry Martin Clynes Kay Ohlendieck

Proteomics 2013 Aug 8;13(15):2312-23. Epub 2013 Jul 8.

Department of Biology, National University of Ireland, Maynooth, Ireland.

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August 2013

Transcriptomic analysis of clonal growth rate variation during CHO cell line development.

Authors:
Padraig Doolan Colin Clarke Paula Kinsella Laura Breen Paula Meleady Mark Leonard Lin Zhang Martin Clynes Sinead T Aherne Niall Barron

J Biotechnol 2013 Jul 4;166(3):105-13. Epub 2013 May 4.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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July 2013

The interaction of bortezomib with multidrug transporters: implications for therapeutic applications in advanced multiple myeloma and other neoplasias.

Authors:
Robert O'Connor Melissa G Ooi Justine Meiller Jana Jakubikova Steffen Klippel Jake Delmore Paul Richardson Kenneth Anderson Martin Clynes Constantine S Mitsiades Peter O'Gorman

Cancer Chemother Pharmacol 2013 May 16;71(5):1357-68. Epub 2013 Apr 16.

School of Nursing and Human Sciences, Dublin City University, Dublin 9, Ireland.

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May 2013

Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate.

Authors:
Colin Clarke Michael Henry Padraig Doolan Shane Kelly Sinead Aherne Noelia Sanchez Paul Kelly Paula Kinsella Laura Breen Stephen F Madden Lin Zhang Mark Leonard Martin Clynes Paula Meleady Niall Barron

BMC Genomics 2012 Nov 21;13:656. Epub 2012 Nov 21.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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November 2012

EGFR and HER2 inhibition in pancreatic cancer.

Authors:
Naomi Walsh Susan Kennedy AnneMarie Larkin Brendan Corkery Lorraine O'Driscoll Martin Clynes John Crown Norma O'Donovan

Invest New Drugs 2013 Jun 18;31(3):558-66. Epub 2012 Oct 18.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, Ireland.

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June 2013

Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein.

Authors:
Britta Stordal Marion Hamon Victoria McEneaney Sandra Roche Jean-Pierre Gillet John J O'Leary Michael Gottesman Martin Clynes

PLoS One 2012 11;7(7):e40717. Epub 2012 Jul 11.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland.

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January 2013

Development, validation and application of a sensitive LC-MS/MS method for the quantification of thalidomide in human serum, cells and cell culture medium.

Authors:
Sandra Roche Louise Sewell Justine Meiller Kasper Pedersen Rajesh Rajpal Peter O'Gorman Martin Clynes Robert O'Connor

J Chromatogr B Analyt Technol Biomed Life Sci 2012 Aug 20;902:16-26. Epub 2012 Jun 20.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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August 2012

Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines.

Authors:
Fiona O'Neill Stephen F Madden Sinead T Aherne Martin Clynes John Crown Padraig Doolan Robert O'Connor

Mol Cancer 2012 Jun 18;11:41. Epub 2012 Jun 18.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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June 2012

Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did Not.

Authors:
Annett Linge Susan Kennedy Deirdre O'Flynn Stephen Beatty Paul Moriarty Michael Henry Martin Clynes Annemarie Larkin Paula Meleady

Invest Ophthalmol Vis Sci 2012 Jul 9;53(8):4634-43. Epub 2012 Jul 9.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Ireland.

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July 2012

Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea.

Authors:
Niamh O'Reilly Clair Gallagher Kishore Reddy Katikireddy Martin Clynes Finbarr O'Sullivan Kevin Kavanagh

Invest Ophthalmol Vis Sci 2012 May 31;53(6):3250-9. Epub 2012 May 31.

Department of Biology, NUI Maynooth, Co. Kildare, Ireland.

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May 2012

Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells.

Authors:
Paula Meleady Mark Gallagher Colin Clarke Michael Henry Noelia Sanchez Niall Barron Martin Clynes

J Biotechnol 2012 Aug 15;160(3-4):251-62. Epub 2012 Mar 15.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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August 2012

Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics.

Authors:
Paula Meleady Raimund Hoffrogge Michael Henry Oliver Rupp Juan Hernandez Bort Colin Clarke Karina Brinkrolf Shane Kelly Benjamin Müller Padraig Doolan Matthias Hackl Tim Frederik Beckmann Thomas Noll Johannes Grillari Niall Barron Alf Pühler Martin Clynes Nicole Borth

Biotechnol Bioeng 2012 Jun 2;109(6):1386-94. Epub 2012 Mar 2.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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June 2012

Engineering CHO cell growth by stable manipulation of miRNA expression.

Authors:
Noëlia Sanchez Nga Lao Clair Gallagher Martin Clynes Niall Barron

BMC Proc 2011 22;5 Suppl 8:P22. Epub 2011 Nov 22.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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April 2015

Characterization and response of newly developed high-grade glioma cultures to the tyrosine kinase inhibitors, erlotinib, gefitinib and imatinib.

Authors:
Paula Kinsella Rachel Howley Padraig Doolan Colin Clarke Stephen F Madden Martin Clynes Michael Farrell Verena Amberger-Murphy

Exp Cell Res 2012 Mar 20;318(5):641-52. Epub 2012 Jan 20.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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March 2012

Olfactomedin III expression contributes to anoikis-resistance in clonal variants of a human lung squamous carcinoma cell line.

Authors:
Joanne Keenan Helena Joyce Sinead Aherne Shirley O'Dea Padraig Doolan Vincent Lynch Martin Clynes

Exp Cell Res 2012 Mar 13;318(5):593-602. Epub 2012 Jan 13.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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March 2012

CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture.

Authors:
Colin Clarke Padraig Doolan Niall Barron Paula Meleady Stephen F Madden Dana DiNino Mark Leonard Martin Clynes

Biotechnol Bioeng 2012 Jun 4;109(6):1368-70. Epub 2012 Jan 4.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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June 2012

Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer.

Authors:
Niall Barron Joanne Keenan Patrick Gammell Vanesa G Martinez Alex Freeman John R Masters Martin Clynes

Prostate 2012 Aug 7;72(11):1193-9. Epub 2011 Dec 7.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland.

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August 2012

Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines.

Authors:
Padraig Doolan Niall Barron Paula Kinsella Colin Clarke Paula Meleady Finbarr O'Sullivan Mark Melville Mark Leonard Martin Clynes

Biotechnol J 2012 Apr 18;7(4):516-26. Epub 2012 Jan 18.

National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland.

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April 2012

A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis.

Authors:
Emer P Reeves David A Bergin Sean Fitzgerald Elaine Hayes Joanne Keenan Michael Henry Paula Meleady Isabel Vega-Carrascal Michelle A Murray Teck Boon Low Cormac McCarthy Emmet O'Brien Martin Clynes Cedric Gunaratnam Noel G McElvaney

J Cyst Fibros 2012 Mar 28;11(2):100-7. Epub 2011 Oct 28.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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March 2012

Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer.

Authors:
Paul Dowling Colin Clarke Kim Hennessy Beatriz Torralbo-Lopez Jo Ballot John Crown Ingrid Kiernan Kenneth J O'Byrne M John Kennedy Vincent Lynch Martin Clynes

Int J Cancer 2012 Aug 19;131(4):911-23. Epub 2011 Nov 19.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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August 2012

Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity.

Authors:
Colin Clarke Padraig Doolan Niall Barron Paula Meleady Finbarr O'Sullivan Patrick Gammell Mark Melville Mark Leonard Martin Clynes

J Biotechnol 2011 Sep 27;155(3):350-9. Epub 2011 Jul 27.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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September 2011

Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype.

Authors:
Paula Meleady Padraig Doolan Michael Henry Niall Barron Joanne Keenan Finbar O'Sullivan Colin Clarke Patrick Gammell Mark W Melville Mark Leonard Martin Clynes

BMC Biotechnol 2011 Jul 24;11:78. Epub 2011 Jul 24.

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

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July 2011