Martin Biel

Martin Biel

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Martin Biel

Publications by authors named "Martin Biel"

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HCN3 ion channels: roles in sensory neuronal excitability and pain.

J Physiol 2019 Sep 27;597(17):4661-4675. Epub 2019 Jul 27.

Wolfson Centre for Age-Related Research, King's College London, Guy's Campus, London, UK.

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http://dx.doi.org/10.1113/JP278211DOI Listing
September 2019

The protein interaction networks of mucolipins and two-pore channels.

Biochim Biophys Acta Mol Cell Res 2019 Jul 2;1866(7):1111-1123. Epub 2018 Nov 2.

Department of Pharmacology and Toxicology, Faculty of Medicine, University of Munich (LMU) Nussbaumstrasse 26, 80336 Munich. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183049
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http://dx.doi.org/10.1016/j.bbamcr.2018.10.020DOI Listing
July 2019

In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy.

Methods Mol Biol 2019 ;1834:383-390

Department of Pharmacy-Center for Drug Research, Center for Integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Munich, Germany.

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http://link.springer.com/10.1007/978-1-4939-8669-9_24
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http://dx.doi.org/10.1007/978-1-4939-8669-9_24DOI Listing
April 2019

Optimized Subretinal Injection Technique for Gene Therapy Approaches.

Methods Mol Biol 2019 ;1834:405-412

Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls Universität Tübingen, Tübingen, Germany.

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http://link.springer.com/10.1007/978-1-4939-8669-9_26
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http://dx.doi.org/10.1007/978-1-4939-8669-9_26DOI Listing
April 2019

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress.

Cell Death Differ 2018 12 17;25(12):2071-2085. Epub 2018 Apr 17.

Lab for Retinal Cell Biology, Department of Ophthalmology, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1038/s41418-018-0094-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261999PMC
December 2018

Design and Development of AAV-based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa.

Methods Mol Biol 2018 ;1715:33-46

Department of Pharmacy, Center for Drug Research, Center for Integrated Protein Science Munich CiPSM, Ludwig-Maximilian-University, Munich, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7522-8_3DOI Listing
July 2018

Optogenetic Control of Neural Circuits in the Mongolian Gerbil.

Front Cell Neurosci 2018 24;12:111. Epub 2018 Apr 24.

Division of Neurobiology, Department Biology II, Biocenter, Ludwig Maximilian University of Munich, Munich, Germany.

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http://dx.doi.org/10.3389/fncel.2018.00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928259PMC
April 2018

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.

Int J Mol Sci 2018 Mar 7;19(3). Epub 2018 Mar 7.

Center for Integrated Protein Science Munich (CIPSM), Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstr, 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.3390/ijms19030749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877610PMC
March 2018

Endolysosomal Cation Channels and Cancer-A Link with Great Potential.

Pharmaceuticals (Basel) 2018 Jan 5;11(1). Epub 2018 Jan 5.

Munich Center for Integrated Protein Science CIPSM, 81377 München, Germany.

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http://dx.doi.org/10.3390/ph11010004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874700PMC
January 2018

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.

Front Immunol 2017 5;8:1930. Epub 2018 Jan 5.

Center for Integrated Protein Science Munich CiPSM and Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.01930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760536PMC
January 2018

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.

Mol Ther 2017 Dec 31;25(12):2648-2660. Epub 2017 Aug 31.

University Eye Hospital, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany; STZ eyetrial at the Center for Ophthalmology, University of Tübingen, Tübingen, Germany; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768589PMC
December 2017

From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.

Cell Calcium 2017 11 23;67:148-155. Epub 2017 Apr 23.

Munich Center for Integrated Protein Science CIPSM, Center for Drug Research, Ludwig-Maximilians-Universität, München, Germany; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2017.04.003DOI Listing
November 2017

Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons.

Pain 2017 Oct;158(10):2012-2024

aInstitut für Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, GermanybInstitut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, GermanycCenter for Integrated Protein Science Munich CiPSM at the Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, München, Germany.

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http://dx.doi.org/10.1097/j.pain.0000000000001005DOI Listing
October 2017

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.

Proc Natl Acad Sci U S A 2017 10 18;114(41):E8595-E8602. Epub 2017 Sep 18.

Department of Pharmacy, Center for Drug Research and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, 81377 Munich, Germany;

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http://dx.doi.org/10.1073/pnas.1705739114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642689PMC
October 2017

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.

Nat Protoc 2017 Aug 20;12(8):1639-1658. Epub 2017 Jul 20.

Department of Pharmacy - Center for Drug Research and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, München, Germany.

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http://dx.doi.org/10.1038/nprot.2017.036DOI Listing
August 2017

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae.

Invest Ophthalmol Vis Sci 2017 08;58(10):4155-4160

University Eye Hospital, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1167/iovs.17-22402DOI Listing
August 2017

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.

Sci Rep 2017 08 30;7(1):10038. Epub 2017 Aug 30.

Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University, Albertstrasse 25, 79104, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41598-017-10607-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577145PMC
August 2017

Small Molecules for Early Endosome-Specific Patch Clamping.

Cell Chem Biol 2017 Jul;24(7):907-916.e4

Department of Pharmacy, Center for Drug Research and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.05.025DOI Listing
July 2017

AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects.

Front Neurosci 2017 24;11:292. Epub 2017 May 24.

Department of Pharmacy, Center for Drug Research, Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität MünchenMunich, Germany.

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http://dx.doi.org/10.3389/fnins.2017.00292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442229PMC
May 2017

Recombinant tandem of pore-domains in a Weakly Inward rectifying K channel 2 (TWIK2) forms active lysosomal channels.

Sci Rep 2017 04 5;7(1):649. Epub 2017 Apr 5.

Université Côte d'Azur, Inserm, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, 660 Route des Lucioles, 06560, Valbonne, France.

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http://dx.doi.org/10.1038/s41598-017-00640-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428834PMC
April 2017

Gene therapy for achromatopsia.

J Gene Med 2017 Mar;19(3)

Center for Integrated Protein Science Munich CiPSM and Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.1002/jgm.2944DOI Listing
March 2017

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.

Cancer Res 2017 03 20;77(6):1427-1438. Epub 2017 Jan 20.

Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0852DOI Listing
March 2017

Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation.

Mol Ther 2017 03 28;25(3):634-653. Epub 2017 Jan 28.

Unit of Retinal Degeneration and Regeneration, Department of Ophthalmology, University of Lausanne, Hôpital ophtalmique Jules-Gonin, Fondation asile des aveugles, 1004 Lausanne, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016164549
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http://dx.doi.org/10.1016/j.ymthe.2016.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363218PMC
March 2017

Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.

Front Pharmacol 2017 7;8:45. Epub 2017 Feb 7.

Center for Integrated Protein Science Munich, Ludwig Maximilian University of MunichMunich, Germany; Department of Pharmacy - Center for Drug Research, Ludwig Maximilian University of MunichMunich, Germany.

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http://dx.doi.org/10.3389/fphar.2017.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293812PMC
February 2017

Quantifying macromolecular interactions in living cells using FRET two-hybrid assays.

Nat Protoc 2016 Dec 10;11(12):2470-2498. Epub 2016 Nov 10.

Center for Integrated Protein Science CIPS-M and Zentrum für Pharmaforschung, Department Pharmazie; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.

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http://dx.doi.org/10.1038/nprot.2016.128DOI Listing
December 2016

AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments.

Front Neurosci 2016 28;10:356. Epub 2016 Jul 28.

Department of Pharmacy - Center for Integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität MünchenMunich, Germany; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität MünchenMunich, Germany.

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http://dx.doi.org/10.3389/fnins.2016.00356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963399PMC
August 2016

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.

PLoS One 2016 25;11(1):e0147728. Epub 2016 Jan 25.

Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls University of Tübingen, Schleichstr. 4/3, D-72076, Tübingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147728PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725747PMC
July 2016

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.

Hum Mol Genet 2016 06 30;25(12):2367-2377. Epub 2016 Mar 30.

Munich Center for Integrated Protein Science CIPS , 81377 München, Germany,

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http://dx.doi.org/10.1093/hmg/ddw103DOI Listing
June 2016

Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response.

Invest Ophthalmol Vis Sci 2016 05;57(6):2501-8

Department of Ophthalmology University Lausanne, Hôpital Ophtalmique Jules Gonin, Lausanne, Switzerland.

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http://dx.doi.org/10.1167/iovs.16-19150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868103PMC
May 2016

Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia.

Hum Mol Genet 2016 Mar 5;25(6):1165-75. Epub 2016 Jan 5.

Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy - Center for Drug Research,

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http://dx.doi.org/10.1093/hmg/ddv639DOI Listing
March 2016

Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.

Nat Protoc 2016 Jan 10;11(1):61-86. Epub 2015 Dec 10.

Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München, and DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.

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http://www.nature.com/articles/nprot.2015.139
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http://dx.doi.org/10.1038/nprot.2015.139DOI Listing
January 2016

Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.

Hum Mol Genet 2015 Oct 17;24(19):5486-99. Epub 2015 Jul 17.

Cell Death Mechanisms Group, Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Roentgenweg 11, Tuebingen 72076, Germany,

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http://dx.doi.org/10.1093/hmg/ddv275DOI Listing
October 2015

Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications.

Eur J Pharm Biopharm 2015 Sep 20;95(Pt B):343-52. Epub 2015 Jan 20.

Center for Integrated Protein Science Munich CiPSM, Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2015.01.009DOI Listing
September 2015

Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia.

Hum Mol Genet 2015 Jul 8;24(13):3699-707. Epub 2015 Apr 8.

Deparment of Ophthalmology, University of Florida, Gainesville, FL 32610, USA, School of Ophthalmology and Optometry, The Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China, Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China,

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http://hmg.oxfordjournals.org/content/early/2015/04/22/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddv114
Publisher Site
http://dx.doi.org/10.1093/hmg/ddv114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459390PMC
July 2015

Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice.

Sci Rep 2015 Jun 1;5:10731. Epub 2015 Jun 1.

Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls University, Schleichstr. 4/3, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1038/srep10731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377071PMC
June 2015

Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments.

Anesthesiology 2015 May;122(5):1047-59

From the Department of Anesthesiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany (C.M., S.K., M. Buerge, M.K., T.E., C.K., E.K., R.H., G.R.); Department Pharmazie-Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Munich, Germany (M. Biel, V.H.); and Department of Anesthesiology, Weill Cornell Medical College, New York, New York (S.-W.Y., P.A.G.).

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http://dx.doi.org/10.1097/ALN.0000000000000635DOI Listing
May 2015

TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.

Cell Rep 2015 Apr 2;11(2):283-94. Epub 2015 Apr 2.

Center for Integrated Protein Science Munich CiPS(M) at the Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.020DOI Listing
April 2015

Investigation of the immunogenicity of different types of aggregates of a murine monoclonal antibody in mice.

Pharm Res 2015 Feb 15;32(2):430-44. Epub 2014 Aug 15.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, D-81377, Munich, Germany.

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http://dx.doi.org/10.1007/s11095-014-1472-6DOI Listing
February 2015

Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition.

Nat Neurosci 2014 Dec 26;17(12):1728-35. Epub 2014 Oct 26.

Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://www.nature.com/articles/nn.3852
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http://dx.doi.org/10.1038/nn.3852DOI Listing
December 2014

Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors.

Hum Mol Genet 2014 Nov 24;23(22):5989-97. Epub 2014 Jun 24.

Munich Center for Integrated Protein Science CIPSM and Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, München, Germany,

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http://dx.doi.org/10.1093/hmg/ddu323DOI Listing
November 2014

Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.

Traffic 2014 Nov 2;15(11):1247-65. Epub 2014 Sep 2.

Department of Biological Science and Center for Applied Biotechnology Studies, California State University, Fullerton, CA, 92831, USA; Mental Health Research Institute, Melbourne Brain Centre, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1111/tra.12205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205267PMC
November 2014

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.

Nat Commun 2014 Aug 14;5:4681. Epub 2014 Aug 14.

1] Department of Pharmacy-Center for Drug Research and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Munchen 81377, Germany [2].

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http://dx.doi.org/10.1038/ncomms5681DOI Listing
August 2014

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

Adv Exp Med Biol 2014 ;801:733-9

Center for Integrated Protein Science Munich (CIPSM), Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany,

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http://dx.doi.org/10.1007/978-1-4614-3209-8_92DOI Listing
July 2014

Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb.

Nat Commun 2014 May 28;5:3915. Epub 2014 May 28.

1] German Center for Neurodegeneratione Diseases (DZNE), Department for Translational Brain Research, Feodor-Lynen-Strasse 23, Munich 81377, Germany [2] Munich Cluster of Systems Neurology (SyNergy), Ludwig Maximilian University, Feodor-Lynen-Strasse 23, Munich 81377, Germany.

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http://dx.doi.org/10.1038/ncomms4915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050256PMC
May 2014

HCN channels: new roles in sinoatrial node function.

Curr Opin Pharmacol 2014 Apr 20;15:83-90. Epub 2014 Jan 20.

Center for Integrated Protein Science CIPS-M and Zentrum für Pharmaforschung - Department Pharmazie, Ludwig Maximilians University, Munich, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2013.12.005DOI Listing
April 2014

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.

Mol Biol Cell 2014 Mar 22;25(6):948-64. Epub 2014 Jan 22.

Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians University, 81377 München, Germany Department of Pharmacy, Ludwig-Maximilians University, 81377 München, Germany Institute for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University, 79104 Freiburg, Germany Institute for Anatomy, University of Duisburg-Essen, 45141 Essen, Germany.

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http://www.molbiolcell.org/doi/10.1091/mbc.e13-09-0523
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http://dx.doi.org/10.1091/mbc.E13-09-0523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952862PMC
March 2014

Auditory event-related signals in mouse ERG recordings.

Doc Ophthalmol 2014 Feb 13;128(1):25-32. Epub 2013 Nov 13.

Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls University, Schleichstr. 4/3, 72076, Tübingen, Germany,

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http://link.springer.com/10.1007/s10633-013-9417-7
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http://dx.doi.org/10.1007/s10633-013-9417-7DOI Listing
February 2014

A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network.

Sci Rep 2014 Feb 3;4:3931. Epub 2014 Feb 3.

1] German Center for Neurodegenerative Diseases (DZNE), Munich, Schillerstraße 44, 80336 Munich, Germany [2] Munich Cluster of Systems Neurology (SyNergy), Ludwig Maximilian University Munich, Schillerstraße 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1038/srep03931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909899PMC
February 2014

Detection of cGMP in the degenerating retina.

Methods Mol Biol 2013 ;1020:235-45

Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität, Munich, Germany.

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http://dx.doi.org/10.1007/978-1-62703-459-3_16DOI Listing
December 2013

Sick sinus syndrome in HCN1-deficient mice.

Circulation 2013 Dec 11;128(24):2585-94. Epub 2013 Nov 11.

Center for Integrated Protein Science CIPS-M and Zentrum für Pharmaforschung, Department Pharmazie (S.F., S.C.K., S.I.H.H., E.B., F.A., R.B., V.H., C.P., M.B., C.A.W.-S.) and Medizinische Klinik und Poliklinik I, Klinikum Großhadern (C.K., P.L., T.Z.), Ludwig Maximilians University, Munich, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany (C.K., P.L., T.Z., M.B., C.A.W.-S.); Max-Planck-Institut für Psychiatrie München, Germany (C.T.W.); and School of Physics & Astronomy, University of Manchester, UK (H.Z.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.003712DOI Listing
December 2013

Gene replacement therapy for retinal CNG channelopathies.

Mol Genet Genomics 2013 Oct 17;288(10):459-67. Epub 2013 Jul 17.

Center for Integrated Protein Science Munich, CIPSM and Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstr 5-13, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00438-013-0766-4DOI Listing
October 2013

cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function.

J Neurosci 2013 Sep;33(37):14939-48

Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, Center for Integrated Protein Science Munich and Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, 80539 Munich, Germany, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, and Department of Basic Sciences and Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania 19027.

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http://dx.doi.org/10.1523/JNEUROSCI.0909-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771030PMC
September 2013

Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction.

Cell Mol Life Sci 2013 May 27;70(10):1831-47. Epub 2012 Dec 27.

Center for Integrated Protein Science Munich CiPSM and Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstr 7, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00018-012-1230-zDOI Listing
May 2013

Optimized technique for subretinal injections in mice.

Methods Mol Biol 2013 ;935:343-9

Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1007/978-1-62703-080-9_24DOI Listing
April 2013

Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).

J Biol Chem 2013 Mar 4;288(11):7580-9. Epub 2013 Feb 4.

Center for Integrated Protein Science CIPS-M and Zentrum für Pharmaforschung, Department Pharmazie, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M112.434803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597799PMC
March 2013

Odorant-evoked electrical responses in Grueneberg ganglion neurons rely on cGMP-associated signaling proteins.

Neurosci Lett 2013 Feb 4;539:38-42. Epub 2013 Feb 4.

Institute of Physiology, University of Hohenheim, Stuttgart, Germany.

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http://dx.doi.org/10.1016/j.neulet.2013.01.032DOI Listing
February 2013

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

Hum Mol Genet 2012 Oct 16;21(20):4486-96. Epub 2012 Jul 16.

Center for Integrated Protein Science Munich, Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1093/hmg/dds290DOI Listing
October 2012

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.

Angew Chem Int Ed Engl 2012 Oct 4;51(44):11162-5. Epub 2012 Oct 4.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.1002/anie.201203769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533783PMC
October 2012

Role of TRPML and two-pore channels in endolysosomal cation homeostasis.

J Pharmacol Exp Ther 2012 Aug 19;342(2):236-44. Epub 2012 Apr 19.

Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, 81377 Germany.

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http://dx.doi.org/10.1124/jpet.112.192880DOI Listing
August 2012

Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP.

J Biol Chem 2012 Aug 19;287(32):26506-12. Epub 2012 Jun 19.

Center for Integrated Protein Science (CIPSM) and Zentrum für Pharmaforschung, Department Pharmazie, Ludwig-Maximilians-Universität München, 80539 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M112.357129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410992PMC
August 2012

Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency.

J Biol Chem 2012 May 9;287(22):18018-29. Epub 2012 Apr 9.

Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1074/jbc.M112.342220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365688PMC
May 2012

Chemo- and thermosensory responsiveness of Grueneberg ganglion neurons relies on cyclic guanosine monophosphate signaling elements.

Neurosignals 2011 31;19(4):198-209. Epub 2011 Aug 31.

Institute of Physiology, University of Hohenheim, Stuttgart, Germany.

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http://dx.doi.org/10.1159/000329333DOI Listing
April 2012

CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration.

Invest Ophthalmol Vis Sci 2012 Mar 1;53(3):1117-29. Epub 2012 Mar 1.

Department of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1167/iovs.11-8168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339899PMC
March 2012

Exploring HCN channels as novel drug targets.

Nat Rev Drug Discov 2011 Nov 18;10(12):903-14. Epub 2011 Nov 18.

Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstr. 7, 81377 Munich, Germany.

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http://dx.doi.org/10.1038/nrd3576DOI Listing
November 2011

The role of HCN channels in ventricular repolarization.

Trends Cardiovasc Med 2011 Nov;21(8):216-20

Center for Integrated Protein Science CIPS-M and Zentrum für Pharmaforschung-Department Pharmazie, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.1016/j.tcm.2012.05.013DOI Listing
November 2011

HCN3 contributes to the ventricular action potential waveform in the murine heart.

Circ Res 2011 Oct 8;109(9):1015-23. Epub 2011 Sep 8.

Center for Integrated Protein Science CIPS-M, Department Pharmazie, Ludwig-Maximilians-Universität München, München, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.111.246173DOI Listing
October 2011

CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity.

J Neurosci 2011 Aug;31(31):11184-92

Pharmazentrum Frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.6159-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6623383PMC
August 2011

The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel.

PLoS One 2011 Feb 14;6(2):e17078. Epub 2011 Feb 14.

Munich Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universität München, München, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017078PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038938PMC
February 2011

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.

J Neurosci 2011 Jan;31(1):133-41

Munich Center for Integrated Protein Science, Ludwig-Maximilians-Universität München, D-81377 München, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.4735-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622767PMC
January 2011

Planar patch clamp approach to characterize ionic currents from intact lysosomes.

Sci Signal 2010 Dec 7;3(151):pl3. Epub 2010 Dec 7.

Center for Integrated Protein Science CIPS-M and Zentrum für Pharmaforschung-Department Pharmazie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5 -13, D-81377 München, Germany.

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http://dx.doi.org/10.1126/scisignal.3151pl3DOI Listing
December 2010