Martha Hale

Martha Hale

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Martha Hale

Martha Hale

Publications by authors named "Martha Hale"

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Role of critical elements in botulinum neurotoxin complex in toxin routing across intestinal and bronchial barriers.

PLoS One 2018 5;13(7):e0199524. Epub 2018 Jul 5.

Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199524PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033393PMC
December 2018

Rational design of peptide derivatives for inhibition of MyD88-mediated toll-like receptor signaling in human peripheral blood mononuclear cells and epithelial cells exposed to Francisella tularensis.

Chem Biol Drug Des 2017 Dec 17;90(6):1190-1205. Epub 2017 Jul 17.

Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/cbdd.13039DOI Listing
December 2017

Medical applications of clostridia and clostridial toxins.

J Toxicol 2012 18;2012:678963. Epub 2012 Oct 18.

Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.

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http://dx.doi.org/10.1155/2012/678963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483836PMC
November 2012

Evaluation of a ricin vaccine candidate (RVEc) for human toxicity using an in vitro vascular leak assay.

Toxicon 2011 Jul 17;58(1):68-75. Epub 2011 May 17.

Center for Aerobiological Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.toxicon.2011.05.005DOI Listing
July 2011

Endocytosis and toxicity of clostridial binary toxins depend on a clathrin-independent pathway regulated by Rho-GDI.

Cell Microbiol 2011 Jan 19;13(1):154-70. Epub 2010 Oct 19.

Institut Pasteur, Bactéries anaérobies et Toxines, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1111/j.1462-5822.2010.01527.xDOI Listing
January 2011

Basic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity.

J Biol Chem 2011 Jan 20;286(3):1802-11. Epub 2010 Oct 20.

Department Cell Biology and Biochemistry, Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.

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http://dx.doi.org/10.1074/jbc.M110.146464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023475PMC
January 2011

Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies.

J Biomol Screen 2010 Jan 4;15(1):42-51. Epub 2009 Dec 4.

US Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702, USA.

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http://jbx.sagepub.com/cgi/doi/10.1177/1087057109354779
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http://dx.doi.org/10.1177/1087057109354779DOI Listing
January 2010

Translocation of ricin across polarized human bronchial epithelial cells.

Toxicon 2009 Aug 15;54(2):184-91. Epub 2009 Apr 15.

Brooke Army Medical Center, Department of Clinical Investigation, Fort Sam Houston, TX 78234, USA.

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http://dx.doi.org/10.1016/j.toxicon.2009.04.003DOI Listing
August 2009

Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity.

BMC Biotechnol 2009 Jun 30;9:60. Epub 2009 Jun 30.

Groupe de biotechnologie des anticorps, Département de biologie des agents transmissibles, Centre de Recherche du Service de Santé des Armées, La Tronche, France.

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http://dx.doi.org/10.1186/1472-6750-9-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716335PMC
June 2009

Evidence that membrane rafts are not required for the action of Clostridium perfringens enterotoxin.

Infect Immun 2008 Dec 22;76(12):5677-85. Epub 2008 Sep 22.

Department of Microbiology and Molecular Genetics, Molecular Virology and Microbiology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1128/IAI.00854-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583595PMC
December 2008

Development of antiricin single domain antibodies toward detection and therapeutic reagents.

Anal Chem 2008 Dec;80(24):9604-11

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375, USA.

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http://dx.doi.org/10.1021/ac8019398DOI Listing
December 2008

Protective effects of anti-ricin A-chain RNA aptamer against ricin toxicity.

World J Gastroenterol 2008 Nov;14(41):6360-5

Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, New York 10987, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766118PMC
http://dx.doi.org/10.3748/wjg.14.6360DOI Listing
November 2008

Identification of the RNA N-glycosidase activity of ricin in castor bean extracts by an electrochemiluminescence-based assay.

Anal Biochem 2008 Jul 15;378(1):87-9. Epub 2008 Mar 15.

U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.ab.2008.03.019DOI Listing
July 2008

Intralaboratory validation of cell-free translation assay for detecting ricin toxin biological activity.

J AOAC Int 2007 Sep-Oct;90(5):1316-25

U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702-5011, USA.

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November 2007

Monoclonal antibodies to ricin: in vitro inhibition of toxicity and utility as diagnostic reagents.

Hybridoma (Larchmt) 2005 Oct;24(5):236-43

Toxinology & Aerobiology Division, Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702-5011, USA.

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http://www.liebertpub.com/doi/10.1089/hyb.2005.24.236
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http://dx.doi.org/10.1089/hyb.2005.24.236DOI Listing
October 2005

Characterization of botulinum progenitor toxins by mass spectrometry.

Appl Environ Microbiol 2005 Aug;71(8):4478-86

Dept. of Cell Biology and Biochemistry, Toxinology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Frederick, MD 21702-5011, USA.

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http://dx.doi.org/10.1128/AEM.71.8.4478-4486.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183299PMC
August 2005

Quantitative profiling of the detergent-resistant membrane proteome of iota-b toxin induced vero cells.

J Proteome Res 2005 Mar-Apr;4(2):523-31

Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., National Cancer Institute at Frederick, P.O. Box B, Frederick, Maryland 21702-1201, USA.

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http://pubs.acs.org/doi/abs/10.1021/pr049790s
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http://dx.doi.org/10.1021/pr049790sDOI Listing
July 2005

High-performance liquid chromatography-mass selective detection assay for adenine released from a synthetic RNA substrate by ricin A chain.

Anal Biochem 2004 Jul;330(1):119-22

Toxinology and Aerobiology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011, USA.

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http://dx.doi.org/10.1016/j.ab.2004.03.046DOI Listing
July 2004

Proteomic analysis of detergent-resistant membrane rafts.

Electrophoresis 2004 May;25(9):1307-18

Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, National Cancer Institute, MD, USA.

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http://dx.doi.org/10.1002/elps.200405891DOI Listing
May 2004

Detergent-resistant membrane microdomains facilitate Ib oligomer formation and biological activity of Clostridium perfringens iota-toxin.

Infect Immun 2004 Apr;72(4):2186-93

Toxinology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC375178PMC
http://dx.doi.org/10.1128/iai.72.4.2186-2193.2004DOI Listing
April 2004

Impact of inhalation exposure modality and particle size on the respiratory deposition of ricin in BALB/c mice.

Inhal Toxicol 2003 May;15(6):619-38

Division of Toxinology and Aerobiology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.

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http://dx.doi.org/10.1080/08958370390205092 DOI Listing
May 2003

Clostridium perfringens iota toxin: characterization of the cell-associated iota b complex.

Biochem J 2002 Nov;367(Pt 3):801-8

Toxinology Division, Department of Immunology and Molecular Biology, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702-5011, USA.

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http://dx.doi.org/10.1042/BJ20020566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222948PMC
November 2002

Clostridium botulinum C2 toxin: binding studies with fluorescence-activated cytometry.

Toxicon 2002 Aug;40(8):1135-140

Department of Immunology and Molecular Biology, US Army Medical Research Institute of Infectious Diseases, Frederick MD 21702-5011, USA.

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August 2002

Pirfenidone blocks the in vitro and in vivo effects of staphylococcal enterotoxin B.

Infect Immun 2002 Jun;70(6):2989-94

Toxinology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127993PMC
http://dx.doi.org/10.1128/iai.70.6.2989-2994.2002DOI Listing
June 2002