Martha H Stipanuk

Martha H Stipanuk

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Martha H Stipanuk

Martha H Stipanuk

Publications by authors named "Martha H Stipanuk"

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Identification of Taurine-Responsive Genes in Murine Liver Using the Cdo1-Null Mouse Model.

Adv Exp Med Biol 2017;975 Pt 1:475-495

Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.

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http://dx.doi.org/10.1007/978-94-024-1079-2_38DOI Listing
October 2018

GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells.

Amino Acids 2016 12 10;48(12):2831-2842. Epub 2016 Sep 10.

Division of Nutritional Sciences, Cornell University, Savage Hall, Rm. 227, Ithaca, NY, 14853, USA.

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http://dx.doi.org/10.1007/s00726-016-2318-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107328PMC
December 2016

Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase.

J Mol Biol 2016 10 29;428(20):3999-4012. Epub 2016 Jul 29.

Department of Biochemistry and Biophysics, 2011 Ag & Life Sciences Building, Oregon State University, Corvallis, OR 97331, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048534PMC
http://dx.doi.org/10.1016/j.jmb.2016.07.012DOI Listing
October 2016

Amino acids in healthy aging skeletal muscle.

Front Biosci (Elite Ed) 2016 Jan 1;8:326-50. Epub 2016 Jan 1.

109 Savage Hall, Cornell University, Ithaca, NY 14853, Tel: 607-255-7007, Fax: 607-2550130,

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January 2016

Insights into Taurine Synthesis and Function Based on Studies with Cysteine Dioxygenase (CDO1) Knockout Mice.

Adv Exp Med Biol 2015 ;803:29-39

Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA,

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http://dx.doi.org/10.1007/978-3-319-15126-7_3DOI Listing
August 2015

Total 4EBP1 Is Elevated in Liver of Rats in Response to Low Sulfur Amino Acid Intake.

J Amino Acids 2013 8;2013:864757. Epub 2013 Sep 8.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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https://www.hindawi.com/archive/2013/864757/
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http://dx.doi.org/10.1155/2013/864757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782060PMC
October 2013

Cysteine dioxygenase structures from pH4 to 9: consistent cys-persulfenate formation at intermediate pH and a Cys-bound enzyme at higher pH.

J Mol Biol 2013 Sep 7;425(17):3121-36. Epub 2013 Jun 7.

Department of Biochemistry and Biophysics, 2011 Ag and Life Sciences Building, Oregon State University, Corvallis, OR 97331, USA.

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http://dx.doi.org/10.1016/j.jmb.2013.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744157PMC
September 2013

Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase.

Am J Physiol Endocrinol Metab 2012 May 13;302(10):E1292-9. Epub 2012 Mar 13.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1152/ajpendo.00589.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361984PMC
May 2012

Protein intake and muscle strength in older persons: does inflammation matter?

J Am Geriatr Soc 2012 Mar 27;60(3):480-4. Epub 2012 Jan 27.

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1111/j.1532-5415.2011.03833.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390191PMC
March 2012

Thiol dioxygenases: unique families of cupin proteins.

Amino Acids 2011 Jun 1;41(1):91-102. Epub 2010 Mar 1.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1007/s00726-010-0518-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136866PMC
June 2011

Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium.

Amino Acids 2011 Jun 2;41(1):159-71. Epub 2010 Apr 2.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1007/s00726-010-0571-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119335PMC
June 2011

Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur.

J Inherit Metab Dis 2011 Feb 17;34(1):17-32. Epub 2010 Feb 17.

Division of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA.

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http://dx.doi.org/10.1007/s10545-009-9006-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901774PMC
February 2011

Macroautophagy and its role in nutrient homeostasis.

Nutr Rev 2009 Dec;67(12):677-89

Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2009.00252.xDOI Listing
December 2009

A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase.

Biochemistry 2008 Nov 11;47(44):11390-2. Epub 2008 Oct 11.

Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1021/bi801546nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684787PMC
November 2008

Measurement of Cysteine Dioxygenase Activity and Protein Abundance.

Curr Protoc Toxicol 2008 Nov;38:6.15.1-6.15.25

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853.

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http://dx.doi.org/10.1002/0471140856.tx0615s38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757781PMC
November 2008

HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway.

Physiol Genomics 2008 Apr 19;33(2):218-29. Epub 2008 Feb 19.

Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00263.2007DOI Listing
April 2008

Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.

J Biol Chem 2007 Aug 20;282(35):25189-98. Epub 2007 Jun 20.

Department of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1074/jbc.M703089200DOI Listing
August 2007

The keto acid of methionine is a safe and efficacious substitute for dietary L-methionine: the answer from chick bioassays.

J Nutr 2007 Aug;137(8):1844-5

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1093/jn/137.8.1844DOI Listing
August 2007

Enzymes of the taurine biosynthetic pathway are expressed in rat mammary gland.

J Nutr 2007 Aug;137(8):1887-94

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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https://academic.oup.com/jn/article/137/8/1887/4664927
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099301PMC
http://dx.doi.org/10.1093/jn/137.8.1887DOI Listing
August 2007

Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells.

Am J Physiol Endocrinol Metab 2007 Jul 27;293(1):E62-9. Epub 2007 Feb 27.

Department of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://www.physiology.org/doi/10.1152/ajpendo.00053.2007
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http://dx.doi.org/10.1152/ajpendo.00053.2007DOI Listing
July 2007

Cysteamine dioxygenase: evidence for the physiological conversion of cysteamine to hypotaurine in rat and mouse tissues.

Adv Exp Med Biol 2006 ;583:25-36

Cornell University, Division of Nutritional Sciences, Ithaca, New York 148453, USA.

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http://dx.doi.org/10.1007/978-0-387-33504-9_3DOI Listing
March 2007

In vivo regulation of cysteine dioxygenase via the ubiquitin-26S proteasome system.

Adv Exp Med Biol 2006 ;583:37-47

Cornell University, Division of Nutritional Sciences, Ithaca, 14853 New York, USA.

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http://dx.doi.org/10.1007/978-0-387-33504-9_4DOI Listing
March 2007

Leucine and protein synthesis: mTOR and beyond.

Nutr Rev 2007 Mar;65(3):122-9

Division of Nutritional Sciences, 227 Savage Hall, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2007.tb00289.xDOI Listing
March 2007

Copper deficiency does not lead to taurine deficiency in rats.

J Nutr 2006 Oct;136(10):2502-5

Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, CA 95616, USA.

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https://academic.oup.com/jn/article/136/10/2502/4746687
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http://dx.doi.org/10.1093/jn/136.10.2502DOI Listing
October 2006

Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria.

J Bacteriol 2006 Aug;188(15):5561-9

Division of Nutritional Sciences, 227 Savage Hall, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1128/JB.00291-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540046PMC
August 2006

Crystal structure of mammalian cysteine dioxygenase. A novel mononuclear iron center for cysteine thiol oxidation.

J Biol Chem 2006 Jul 11;281(27):18723-33. Epub 2006 Apr 11.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853-8001, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M601555200
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http://dx.doi.org/10.1074/jbc.M601555200DOI Listing
July 2006

Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism.

J Nutr 2006 06;136(6 Suppl):1652S-1659S

Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.

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http://dx.doi.org/10.1093/jn/136.6.1652SDOI Listing
June 2006

Expression, purification, and kinetic characterization of recombinant rat cysteine dioxygenase, a non-heme metalloenzyme necessary for regulation of cellular cysteine levels.

Protein Expr Purif 2006 May 18;47(1):74-81. Epub 2005 Nov 18.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853-6301, USA.

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http://dx.doi.org/10.1016/j.pep.2005.10.025DOI Listing
May 2006

Preparation, crystallization and X-ray diffraction analysis to 1.5 A resolution of rat cysteine dioxygenase, a mononuclear iron enzyme responsible for cysteine thiol oxidation.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Nov 25;61(Pt 11):1013-6. Epub 2005 Oct 25.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853-8001, USA.

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http://scripts.iucr.org/cgi-bin/paper?S1744309105033737
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http://dx.doi.org/10.1107/S1744309105033737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978133PMC
November 2005

Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine.

Annu Rev Nutr 2004 ;24:539-77

Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.nutr.24.012
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http://dx.doi.org/10.1146/annurev.nutr.24.012003.132418DOI Listing
November 2004

New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant.

Nutr Rev 2004 Sep;62(9):348-53

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2004.tb00060.xDOI Listing
September 2004

The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver.

Am J Physiol Endocrinol Metab 2004 Mar 25;286(3):E439-48. Epub 2003 Nov 25.

Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853-6301, USA.

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http://www.physiology.org/doi/10.1152/ajpendo.00336.2003
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http://dx.doi.org/10.1152/ajpendo.00336.2003DOI Listing
March 2004

Regulation of cysteine dioxygenase and gamma-glutamylcysteine synthetase is associated with hepatic cysteine level.

J Nutr Biochem 2004 Feb;15(2):112-22

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1016/j.jnutbio.2003.10.005DOI Listing
February 2004

Role of the liver in regulation of body cysteine and taurine levels: a brief review.

Neurochem Res 2004 Jan;29(1):105-10

227 Savage Hall, Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1023/b:nere.0000010438.40376.c9DOI Listing
January 2004

Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats.

J Nutr 2003 Sep;133(9):2697-702

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1093/jn/133.9.2697DOI Listing
September 2003