Marten H Hofker

Marten H Hofker

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Marten H Hofker

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NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.

Biochim Biophys Acta Mol Cell Res 2017 Oct 16;1864(10):1785-1798. Epub 2017 Jul 16.

Section of Molecular Genetics, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01674889173019
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http://dx.doi.org/10.1016/j.bbamcr.2017.07.005DOI Listing
October 2017

Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation.

Sci Rep 2017 10 2;7(1):12550. Epub 2017 Oct 2.

Departments of Molecular Genetics, Molecular Cell Biology and Electron Microscopy, School of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht; Universiteitssingel 50, ER 6229 ER, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-13058-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624963PMC
October 2017

Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer.

PLoS One 2016 27;11(10):e0165385. Epub 2016 Oct 27.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165385PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082896PMC
June 2017

Cathepsin D regulates lipid metabolism in murine steatohepatitis.

Sci Rep 2017 06 14;7(1):3494. Epub 2017 Jun 14.

Departments of Molecular Genetics, Human Biology and Surgery, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-03796-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471235PMC
June 2017

Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity.

Mediators Inflamm 2016 6;2016:2042107. Epub 2016 Jun 6.

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands; Top Institute Food and Nutrition, 6709 AN Wageningen, Netherlands.

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http://dx.doi.org/10.1155/2016/2042107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913062PMC
May 2017

Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis.

Biomark Med 2015 19;9(12):1301-9. Epub 2015 Nov 19.

Departments of Molecular Genetics, Molecular Cell Biology & Population Genetics, Nutrition & Toxicology Research (NUTRIM) Institutes of Maastricht, University of Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.2217/bmm.15.71DOI Listing
September 2016

Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease.

BMC Med 2016 07 22;14(1):107. Epub 2016 Jul 22.

Departments of Molecular Genetics, Pathology, and Internal Medicine, Division of Gastroenterology and Hepatology, School of Nutrition and Translational Research in Metabolism (NUTRIM) and School of Oncology and Developmental Biology (GROW), Maastricht University and Maastricht University Medical Center (MUMC), PO Box 616, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1186/s12916-016-0652-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957359PMC
July 2016

Cholesterol-induced hepatic inflammation does not underlie the predisposition to insulin resistance in dyslipidemic female LDL receptor knockout mice.

J Diabetes Res 2015 28;2015:956854. Epub 2015 Feb 28.

Molecular Genetics Section, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.

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http://dx.doi.org/10.1155/2015/956854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359820PMC
December 2015

GWAS as a Driver of Gene Discovery in Cardiometabolic Diseases.

Trends Endocrinol Metab 2015 Dec 18;26(12):722-732. Epub 2015 Nov 18.

Molecular Genetics Section, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2015.10.004DOI Listing
December 2015

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.

Circ Res 2015 Oct 10;117(9):817-24. Epub 2015 Sep 10.

From the Department of Pediatrics (J.F., E.B., M.H.H.), Department of Genetics (J.F., M.J.B., M.C.C., E.F.T., A.M., J.A.M.D., J.M., L.F., C.W., A.Z.), and Department of Gastroenterology and Hepatology (F.I., R.K.W.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Top Institute Food and Nutrition, Wageningen, The Netherlands (E.F.T., J.A.M.D., A.Z.); Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland (J.M.); Broad Institute of MIT and Harvard, Cambridge, MA (T.W.P., R.J.X., D.G.); and Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease (R.J.X.) and Center for Computational and Integrative Biology (R.J.X.), Massachusetts General Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596485PMC
October 2015

Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development in Ldlr(-/-) mice.

FEBS J 2015 Jun 20;282(12):2327-38. Epub 2015 Apr 20.

Departments of Molecular Genetics and Pathology, School of Nutrition and Translational Research in Metabolism (NUTRIM) and School for Cardiovascular Diseases, University of Maastricht, The Netherlands.

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http://dx.doi.org/10.1111/febs.13279DOI Listing
June 2015

The immunity-diet-microbiota axis in the development of metabolic syndrome.

Curr Opin Lipidol 2015 Apr;26(2):73-81

aDepartment of Pediatrics, Molecular Genetics, University of Groningen, University Medical Center Groningen, Groningen bDepartment of Molecular Genetics, Maastricht University, Maastricht cDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1097/MOL.0000000000000154DOI Listing
April 2015

High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice.

Aging (Albany NY) 2015 Apr;7(4):256-68

University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Section Medical Biology, Groningen, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429090PMC
http://dx.doi.org/10.18632/aging.100738DOI Listing
April 2015

Mendelian randomization of blood lipids for coronary heart disease.

Eur Heart J 2015 Mar 27;36(9):539-50. Epub 2014 Jan 27.

Genetic Epidemiology Group, Institute of Cardiovacular Science, Faculty of Population Healh Sciences, University College London, 1-19 Torrington Place, London WC1E 6BT, UK Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

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https://eurheartj.oxfordjournals.org/content/ehj/36/9/539.fu
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http://eurheartj.oxfordjournals.org/cgi/doi/10.1093/eurheart
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http://dx.doi.org/10.1093/eurheartj/eht571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344957PMC
March 2015

Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice.

J Hepatol 2015 Feb 2;62(2):430-6. Epub 2014 Oct 2.

Department of Molecular Genetics, ELMI Unit (CRISP) and Pathology, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular Research (CARIM), Institutes of Maastricht, University of Maastricht, Maastricht, The Netherlands; Department of Molecular Cell Biology, ELMI Unit (CRISP) and Pathology, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular Research (CARIM), Institutes of Maastricht, University of Maastricht, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.09.027DOI Listing
February 2015

A cell-type-specific role for murine Commd1 in liver inflammation.

Biochim Biophys Acta 2014 Nov 27;1842(11):2257-65. Epub 2014 Jul 27.

University of Groningen, University Medical Center Groningen, Department of Pediatrics, Molecular Genetics Section, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188638PMC
November 2014

Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison?

Biochim Biophys Acta 2014 Nov 14;1842(11):2329-2343. Epub 2014 Aug 14.

University of Groningen, University Medical Center Groningen, Department of Pediatrics, Molecular Genetics Section, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439140025
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http://dx.doi.org/10.1016/j.bbadis.2014.08.004DOI Listing
November 2014

The genome revolution and its role in understanding complex diseases.

Biochim Biophys Acta 2014 Oct 13;1842(10):1889-1895. Epub 2014 May 13.

University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbadis.2014.05.002DOI Listing
October 2014

Pleiotropic effects of lipid genes on plasma glucose, HbA1c, and HOMA-IR levels.

Diabetes 2014 Sep 10;63(9):3149-58. Epub 2014 Apr 10.

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db13-18
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http://dx.doi.org/10.2337/db13-1800DOI Listing
September 2014

Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice.

PLoS One 2013 2;8(12):e78792. Epub 2013 Dec 2.

Departments of Molecular Genetics, Electron Microscopy and Internal Medicine, Nutrition and Toxicology Research (NUTRIM) Institute of Maastricht and Maastricht University Medical Centre (MUMC), Maastricht University, Maastricht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078792PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846469PMC
August 2014

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.

Authors:
Michael V Holmes Caroline E Dale Luisa Zuccolo Richard J Silverwood Yiran Guo Zheng Ye David Prieto-Merino Abbas Dehghan Stella Trompet Andrew Wong Alana Cavadino Dagmar Drogan Sandosh Padmanabhan Shanshan Li Ajay Yesupriya Maarten Leusink Johan Sundstrom Jaroslav A Hubacek Hynek Pikhart Daniel I Swerdlow Andrie G Panayiotou Svetlana A Borinskaya Chris Finan Sonia Shah Karoline B Kuchenbaecker Tina Shah Jorgen Engmann Lasse Folkersen Per Eriksson Fulvio Ricceri Olle Melander Carlotta Sacerdote Dale M Gamble Sruti Rayaprolu Owen A Ross Stela McLachlan Olga Vikhireva Ivonne Sluijs Robert A Scott Vera Adamkova Leon Flicker Frank M van Bockxmeer Christine Power Pedro Marques-Vidal Tom Meade Michael G Marmot Jose M Ferro Sofia Paulos-Pinheiro Steve E Humphries Philippa J Talmud Irene Mateo Leach Niek Verweij Allan Linneberg Tea Skaaby Pieter A Doevendans Maarten J Cramer Pim van der Harst Olaf H Klungel Nicole F Dowling Anna F Dominiczak Meena Kumari Andrew N Nicolaides Cornelia Weikert Heiner Boeing Shah Ebrahim Tom R Gaunt Jackie F Price Lars Lannfelt Anne Peasey Ruzena Kubinova Andrzej Pajak Sofia Malyutina Mikhail I Voevoda Abdonas Tamosiunas Anke H Maitland-van der Zee Paul E Norman Graeme J Hankey Manuela M Bergmann Albert Hofman Oscar H Franco Jackie Cooper Jutta Palmen Wilko Spiering Pim A de Jong Diana Kuh Rebecca Hardy Andre G Uitterlinden M Arfan Ikram Ian Ford Elina Hyppönen Osvaldo P Almeida Nicholas J Wareham Kay-Tee Khaw Anders Hamsten Lise Lotte N Husemoen Anne Tjønneland Janne S Tolstrup Eric Rimm Joline W J Beulens W M Monique Verschuren N Charlotte Onland-Moret Marten H Hofker S Goya Wannamethee Peter H Whincup Richard Morris Astrid M Vicente Hugh Watkins Martin Farrall J Wouter Jukema James Meschia L Adrienne Cupples Stephen J Sharp Myriam Fornage Charles Kooperberg Andrea Z LaCroix James Y Dai Matthew B Lanktree David S Siscovick Eric Jorgenson Bonnie Spring Josef Coresh Yun R Li Sarah G Buxbaum Pamela J Schreiner R Curtis Ellison Michael Y Tsai Sanjay R Patel Susan Redline Andrew D Johnson Ron C Hoogeveen Hakon Hakonarson Jerome I Rotter Eric Boerwinkle Paul I W de Bakker Mika Kivimaki Folkert W Asselbergs Naveed Sattar Debbie A Lawlor John Whittaker George Davey Smith Kenneth Mukamal Bruce M Psaty James G Wilson Leslie A Lange Ajna Hamidovic Aroon D Hingorani Børge G Nordestgaard Martin Bobak David A Leon Claudia Langenberg Tom M Palmer Alex P Reiner Brendan J Keating Frank Dudbridge Juan P Casas

BMJ 2014 Jul 10;349:g4164. Epub 2014 Jul 10.

Genetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091648PMC
http://dx.doi.org/10.1136/bmj.g4164DOI Listing
July 2014

Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations.

Hum Mol Genet 2014 May 17;23(9):2498-510. Epub 2013 Dec 17.

Gillings School of Global Public Health.

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http://hmg.oxfordjournals.org/content/23/9/2498.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddt626
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http://dx.doi.org/10.1093/hmg/ddt626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988452PMC
May 2014

Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance?

Atherosclerosis 2014 Mar 7;233(1):130-8. Epub 2014 Jan 7.

University of Groningen, University Medical Center Groningen, Department of Molecular Genetics, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2013.12.013DOI Listing
March 2014

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

Authors:
Vinicius Tragante Michael R Barnes Santhi K Ganesh Matthew B Lanktree Wei Guo Nora Franceschini Erin N Smith Toby Johnson Michael V Holmes Sandosh Padmanabhan Konrad J Karczewski Berta Almoguera John Barnard Jens Baumert Yen-Pei Christy Chang Clara C Elbers Martin Farrall Mary E Fischer Tom R Gaunt Johannes M I H Gho Christian Gieger Anuj Goel Yan Gong Aaron Isaacs Marcus E Kleber Irene Mateo Leach Caitrin W McDonough Matthijs F L Meijs Olle Melander Christopher P Nelson Ilja M Nolte Nathan Pankratz Tom S Price Jonathan Shaffer Sonia Shah Maciej Tomaszewski Peter J van der Most Erik P A Van Iperen Judith M Vonk Kate Witkowska Caroline O L Wong Li Zhang Amber L Beitelshees Gerald S Berenson Deepak L Bhatt Morris Brown Amber Burt Rhonda M Cooper-DeHoff John M Connell Karen J Cruickshanks Sean P Curtis George Davey-Smith Christian Delles Ron T Gansevoort Xiuqing Guo Shen Haiqing Claire E Hastie Marten H Hofker G Kees Hovingh Daniel S Kim Susan A Kirkland Barbara E Klein Ronald Klein Yun R Li Steffi Maiwald Christopher Newton-Cheh Eoin T O'Brien N Charlotte Onland-Moret Walter Palmas Afshin Parsa Brenda W Penninx Mary Pettinger Ramachandran S Vasan Jane E Ranchalis Paul M Ridker Lynda M Rose Peter Sever Daichi Shimbo Laura Steele Ronald P Stolk Barbara Thorand Mieke D Trip Cornelia M van Duijn W Monique Verschuren Cisca Wijmenga Sharon Wyatt J Hunter Young Aeilko H Zwinderman Connie R Bezzina Eric Boerwinkle Juan P Casas Mark J Caulfield Aravinda Chakravarti Daniel I Chasman Karina W Davidson Pieter A Doevendans Anna F Dominiczak Garret A FitzGerald John G Gums Myriam Fornage Hakon Hakonarson Indrani Halder Hans L Hillege Thomas Illig Gail P Jarvik Julie A Johnson John J P Kastelein Wolfgang Koenig Meena Kumari Winfried März Sarah S Murray Jeffery R O'Connell Albertine J Oldehinkel James S Pankow Daniel J Rader Susan Redline Muredach P Reilly Eric E Schadt Kandice Kottke-Marchant Harold Snieder Michael Snyder Alice V Stanton Martin D Tobin André G Uitterlinden Pim van der Harst Yvonne T van der Schouw Nilesh J Samani Hugh Watkins Andrew D Johnson Alex P Reiner Xiaofeng Zhu Paul I W de Bakker Daniel Levy Folkert W Asselbergs Patricia B Munroe Brendan J Keating

Am J Hum Genet 2014 Mar 20;94(3):349-60. Epub 2014 Feb 20.

Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2013.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951943PMC
March 2014

Tuning NF-κB activity: a touch of COMMD proteins.

Biochim Biophys Acta 2013 Dec 29;1832(12):2315-21. Epub 2013 Sep 29.

University of Groningen, University Medical Center Groningen, Molecular Genetics, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S09254439130029
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http://dx.doi.org/10.1016/j.bbadis.2013.09.014DOI Listing
December 2013

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study.

Authors:
Michael V Holmes Tabassome Simon Holly J Exeter Lasse Folkersen Folkert W Asselbergs Montse Guardiola Jackie A Cooper Jutta Palmen Jaroslav A Hubacek Kathryn F Carruthers Benjamin D Horne Kimberly D Brunisholz Jessica L Mega Erik P A van Iperen Mingyao Li Maarten Leusink Stella Trompet Jeffrey J W Verschuren G Kees Hovingh Abbas Dehghan Christopher P Nelson Salma Kotti Nicolas Danchin Markus Scholz Christiane L Haase Dietrich Rothenbacher Daniel I Swerdlow Karoline B Kuchenbaecker Eleonora Staines-Urias Anuj Goel Ferdinand van 't Hooft Karl Gertow Ulf de Faire Andrie G Panayiotou Elena Tremoli Damiano Baldassarre Fabrizio Veglia Lesca M Holdt Frank Beutner Ron T Gansevoort Gerjan J Navis Irene Mateo Leach Lutz P Breitling Hermann Brenner Joachim Thiery Dhayana Dallmeier Anders Franco-Cereceda Jolanda M A Boer Jeffrey W Stephens Marten H Hofker Alain Tedgui Albert Hofman André G Uitterlinden Vera Adamkova Jan Pitha N Charlotte Onland-Moret Maarten J Cramer Hendrik M Nathoe Wilko Spiering Olaf H Klungel Meena Kumari Peter H Whincup David A Morrow Peter S Braund Alistair S Hall Anders G Olsson Pieter A Doevendans Mieke D Trip Martin D Tobin Anders Hamsten Hugh Watkins Wolfgang Koenig Andrew N Nicolaides Daniel Teupser Ian N M Day John F Carlquist Tom R Gaunt Ian Ford Naveed Sattar Sotirios Tsimikas Gregory G Schwartz Debbie A Lawlor Richard W Morris Manjinder S Sandhu Rudolf Poledne Anke H Maitland-van der Zee Kay-Tee Khaw Brendan J Keating Pim van der Harst Jackie F Price Shamir R Mehta Salim Yusuf Jaqueline C M Witteman Oscar H Franco J Wouter Jukema Peter de Knijff Anne Tybjaerg-Hansen Daniel J Rader Martin Farrall Nilesh J Samani Mika Kivimaki Keith A A Fox Steve E Humphries Jeffrey L Anderson S Matthijs Boekholdt Tom M Palmer Per Eriksson Guillaume Paré Aroon D Hingorani Marc S Sabatine Ziad Mallat Juan P Casas Philippa J Talmud

J Am Coll Cardiol 2013 Nov 31;62(21):1966-1976. Epub 2013 Jul 31.

Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jacc.2013.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826105PMC
November 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

Authors:
Santhi K Ganesh Vinicius Tragante Wei Guo Yiran Guo Matthew B Lanktree Erin N Smith Toby Johnson Berta Almoguera Castillo John Barnard Jens Baumert Yen-Pei Christy Chang Clara C Elbers Martin Farrall Mary E Fischer Nora Franceschini Tom R Gaunt Johannes M I H Gho Christian Gieger Yan Gong Aaron Isaacs Marcus E Kleber Irene Mateo Leach Caitrin W McDonough Matthijs F L Meijs Olle Mellander Cliona M Molony Ilja M Nolte Sandosh Padmanabhan Tom S Price Ramakrishnan Rajagopalan Jonathan Shaffer Sonia Shah Haiqing Shen Nicole Soranzo Peter J van der Most Erik P A Van Iperen Jessica Van Setten Jessic A Van Setten Judith M Vonk Li Zhang Amber L Beitelshees Gerald S Berenson Deepak L Bhatt Jolanda M A Boer Eric Boerwinkle Ben Burkley Amber Burt Aravinda Chakravarti Wei Chen Rhonda M Cooper-Dehoff Sean P Curtis Albert Dreisbach David Duggan Georg B Ehret Richard R Fabsitz Myriam Fornage Ervin Fox Clement E Furlong Ron T Gansevoort Marten H Hofker G Kees Hovingh Susan A Kirkland Kandice Kottke-Marchant Abdullah Kutlar Andrea Z Lacroix Taimour Y Langaee Yun R Li Honghuang Lin Kiang Liu Steffi Maiwald Rainer Malik Gurunathan Murugesan Christopher Newton-Cheh Jeffery R O'Connell N Charlotte Onland-Moret Willem H Ouwehand Walter Palmas Brenda W Penninx Carl J Pepine Mary Pettinger Joseph F Polak Vasan S Ramachandran Jane Ranchalis Susan Redline Paul M Ridker Lynda M Rose Hubert Scharnag Nicholas J Schork Daichi Shimbo Alan R Shuldiner Sathanur R Srinivasan Ronald P Stolk Herman A Taylor Barbara Thorand Mieke D Trip Cornelia M van Duijn W Monique Verschuren Cisca Wijmenga Bernhard R Winkelmann Sharon Wyatt J Hunter Young Bernhard O Boehm Mark J Caulfield Daniel I Chasman Karina W Davidson Pieter A Doevendans Garret A Fitzgerald John G Gums Hakon Hakonarson Hans L Hillege Thomas Illig Gail P Jarvik Julie A Johnson John J P Kastelein Wolfgang Koenig Winfried März Braxton D Mitchell Sarah S Murray Albertine J Oldehinkel Daniel J Rader Muredach P Reilly Alex P Reiner Eric E Schadt Roy L Silverstein Harold Snieder Alice V Stanton André G Uitterlinden Pim van der Harst Yvonne T van der Schouw Nilesh J Samani Andrew D Johnson Patricia B Munroe Paul I W de Bakker Xiaofeng Zhu Daniel Levy Brendan J Keating Folkert W Asselbergs

Hum Mol Genet 2013 Apr 8;22(8):1663-78. Epub 2013 Jan 8.

Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI, USA.

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http://hmg.oxfordjournals.org/content/22/8/1663.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/dds555
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http://dx.doi.org/10.1093/hmg/dds555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657476PMC
April 2013

Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model.

Hepatology 2013 Feb 10;57(2):566-76. Epub 2013 Jan 10.

Molecular Genetics, Medical Biology Section, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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http://doi.wiley.com/10.1002/hep.26046
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http://dx.doi.org/10.1002/hep.26046DOI Listing
February 2013

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

Authors:
Folkert W Asselbergs Yiran Guo Erik P A van Iperen Suthesh Sivapalaratnam Vinicius Tragante Matthew B Lanktree Leslie A Lange Berta Almoguera Yolande E Appelman John Barnard Jens Baumert Amber L Beitelshees Tushar R Bhangale Yii-Der Ida Chen Tom R Gaunt Yan Gong Jemma C Hopewell Toby Johnson Marcus E Kleber Taimour Y Langaee Mingyao Li Yun R Li Kiang Liu Caitrin W McDonough Matthijs F L Meijs Rita P S Middelberg Kiran Musunuru Christopher P Nelson Jeffery R O'Connell Sandosh Padmanabhan James S Pankow Nathan Pankratz Suzanne Rafelt Ramakrishnan Rajagopalan Simon P R Romaine Nicholas J Schork Jonathan Shaffer Haiqing Shen Erin N Smith Sam E Tischfield Peter J van der Most Jana V van Vliet-Ostaptchouk Niek Verweij Kelly A Volcik Li Zhang Kent R Bailey Kristian M Bailey Florianne Bauer Jolanda M A Boer Peter S Braund Amber Burt Paul R Burton Sarah G Buxbaum Wei Chen Rhonda M Cooper-Dehoff L Adrienne Cupples Jonas S deJong Christian Delles David Duggan Myriam Fornage Clement E Furlong Nicole Glazer John G Gums Claire Hastie Michael V Holmes Thomas Illig Susan A Kirkland Mika Kivimaki Ronald Klein Barbara E Klein Charles Kooperberg Kandice Kottke-Marchant Meena Kumari Andrea Z LaCroix Laya Mallela Gurunathan Murugesan Jose Ordovas Willem H Ouwehand Wendy S Post Richa Saxena Hubert Scharnagl Pamela J Schreiner Tina Shah Denis C Shields Daichi Shimbo Sathanur R Srinivasan Ronald P Stolk Daniel I Swerdlow Herman A Taylor Eric J Topol Elina Toskala Joost L van Pelt Jessica van Setten Salim Yusuf John C Whittaker A H Zwinderman Sonia S Anand Anthony J Balmforth Gerald S Berenson Connie R Bezzina Bernhard O Boehm Eric Boerwinkle Juan P Casas Mark J Caulfield Robert Clarke John M Connell Karen J Cruickshanks Karina W Davidson Ian N M Day Paul I W de Bakker Pieter A Doevendans Anna F Dominiczak Alistair S Hall Catharina A Hartman Christian Hengstenberg Hans L Hillege Marten H Hofker Steve E Humphries Gail P Jarvik Julie A Johnson Bernhard M Kaess Sekar Kathiresan Wolfgang Koenig Debbie A Lawlor Winfried März Olle Melander Braxton D Mitchell Grant W Montgomery Patricia B Munroe Sarah S Murray Stephen J Newhouse N Charlotte Onland-Moret Neil Poulter Bruce Psaty Susan Redline Stephen S Rich Jerome I Rotter Heribert Schunkert Peter Sever Alan R Shuldiner Roy L Silverstein Alice Stanton Barbara Thorand Mieke D Trip Michael Y Tsai Pim van der Harst Ellen van der Schoot Yvonne T van der Schouw W M Monique Verschuren Hugh Watkins Arthur A M Wilde Bruce H R Wolffenbuttel John B Whitfield G Kees Hovingh Christie M Ballantyne Cisca Wijmenga Muredach P Reilly Nicholas G Martin James G Wilson Daniel J Rader Nilesh J Samani Alex P Reiner Robert A Hegele John J P Kastelein Aroon D Hingorani Philippa J Talmud Hakon Hakonarson Clara C Elbers Brendan J Keating Fotios Drenos

Am J Hum Genet 2012 Nov 11;91(5):823-38. Epub 2012 Oct 11.

Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.ajhg.2012.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487124PMC
November 2012

Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells.

PLoS One 2012 28;7(3):e34378. Epub 2012 Mar 28.

Department of Molecular Genetics, Electron Microscopy Unit of Molecular Cell Biology, and Pathology, Nutrition and Toxicology Research (NUTRIM) Institute of Maastricht, University of Maastricht, Maastricht, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314620PMC
August 2012

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.

Authors:
Benjamin F Voight Gina M Peloso Marju Orho-Melander Ruth Frikke-Schmidt Maja Barbalic Majken K Jensen George Hindy Hilma Hólm Eric L Ding Toby Johnson Heribert Schunkert Nilesh J Samani Robert Clarke Jemma C Hopewell John F Thompson Mingyao Li Gudmar Thorleifsson Christopher Newton-Cheh Kiran Musunuru James P Pirruccello Danish Saleheen Li Chen Alexandre F R Stewart Arne Schillert Unnur Thorsteinsdottir Gudmundur Thorgeirsson Sonia Anand James C Engert Thomas Morgan John Spertus Monika Stoll Klaus Berger Nicola Martinelli Domenico Girelli Pascal P McKeown Christopher C Patterson Stephen E Epstein Joseph Devaney Mary-Susan Burnett Vincent Mooser Samuli Ripatti Ida Surakka Markku S Nieminen Juha Sinisalo Marja-Liisa Lokki Markus Perola Aki Havulinna Ulf de Faire Bruna Gigante Erik Ingelsson Tanja Zeller Philipp Wild Paul I W de Bakker Olaf H Klungel Anke-Hilse Maitland-van der Zee Bas J M Peters Anthonius de Boer Diederick E Grobbee Pieter W Kamphuisen Vera H M Deneer Clara C Elbers N Charlotte Onland-Moret Marten H Hofker Cisca Wijmenga W M Monique Verschuren Jolanda M A Boer Yvonne T van der Schouw Asif Rasheed Philippe Frossard Serkalem Demissie Cristen Willer Ron Do Jose M Ordovas Gonçalo R Abecasis Michael Boehnke Karen L Mohlke Mark J Daly Candace Guiducci Noël P Burtt Aarti Surti Elena Gonzalez Shaun Purcell Stacey Gabriel Jaume Marrugat John Peden Jeanette Erdmann Patrick Diemert Christina Willenborg Inke R König Marcus Fischer Christian Hengstenberg Andreas Ziegler Ian Buysschaert Diether Lambrechts Frans Van de Werf Keith A Fox Nour Eddine El Mokhtari Diana Rubin Jürgen Schrezenmeir Stefan Schreiber Arne Schäfer John Danesh Stefan Blankenberg Robert Roberts Ruth McPherson Hugh Watkins Alistair S Hall Kim Overvad Eric Rimm Eric Boerwinkle Anne Tybjaerg-Hansen L Adrienne Cupples Muredach P Reilly Olle Melander Pier M Mannucci Diego Ardissino David Siscovick Roberto Elosua Kari Stefansson Christopher J O'Donnell Veikko Salomaa Daniel J Rader Leena Peltonen Stephen M Schwartz David Altshuler Sekar Kathiresan

Lancet 2012 Aug 17;380(9841):572-80. Epub 2012 May 17.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/S0140-6736(12)60312-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419820PMC
August 2012

LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease.

PLoS One 2012 25;7(1):e30668. Epub 2012 Jan 25.

Department of Molecular Genetics, Pathology, Physiology and Clinical Genetics of Nutrition and Toxicology Research (NUTRIM) Institute of Maastricht, University of Maastricht, Maastricht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030668PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266276PMC
June 2012

Bone marrow transplantation as an established approach for understanding the role of macrophages in atherosclerosis and the metabolic syndrome.

Curr Opin Lipidol 2012 Apr;23(2):111-21

Molecular Genetics, Medical Biology Section, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1097/MOL.0b013e3283508c4fDOI Listing
April 2012

Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis.

J Hepatol 2012 Mar 10;56(3):647-55. Epub 2011 Sep 10.

Department of Internal Medicine, Laboratory of Metabolism and Vascular Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2011.07.028DOI Listing
March 2012

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.

Authors:
Richa Saxena Clara C Elbers Yiran Guo Inga Peter Tom R Gaunt Jessica L Mega Matthew B Lanktree Archana Tare Berta Almoguera Castillo Yun R Li Toby Johnson Marcel Bruinenberg Diane Gilbert-Diamond Ramakrishnan Rajagopalan Benjamin F Voight Ashok Balasubramanyam John Barnard Florianne Bauer Jens Baumert Tushar Bhangale Bernhard O Böhm Peter S Braund Paul R Burton Hareesh R Chandrupatla Robert Clarke Rhonda M Cooper-DeHoff Errol D Crook George Davey-Smith Ian N Day Anthonius de Boer Mark C H de Groot Fotios Drenos Jane Ferguson Caroline S Fox Clement E Furlong Quince Gibson Christian Gieger Lisa A Gilhuijs-Pederson Joseph T Glessner Anuj Goel Yan Gong Struan F A Grant Diederick E Grobbee Claire Hastie Steve E Humphries Cecilia E Kim Mika Kivimaki Marcus Kleber Christa Meisinger Meena Kumari Taimour Y Langaee Debbie A Lawlor Mingyao Li Maximilian T Lobmeyer Anke-Hilse Maitland-van der Zee Matthijs F L Meijs Cliona M Molony David A Morrow Gurunathan Murugesan Solomon K Musani Christopher P Nelson Stephen J Newhouse Jeffery R O'Connell Sandosh Padmanabhan Jutta Palmen Sanjey R Patel Carl J Pepine Mary Pettinger Thomas S Price Suzanne Rafelt Jane Ranchalis Asif Rasheed Elisabeth Rosenthal Ingo Ruczinski Sonia Shah Haiqing Shen Günther Silbernagel Erin N Smith Annemieke W M Spijkerman Alice Stanton Michael W Steffes Barbara Thorand Mieke Trip Pim van der Harst Daphne L van der A Erik P A van Iperen Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Bruce H R Wolffenbuttel Taylor Young M Hadi Zafarmand Joseph M Zmuda Michael Boehnke David Altshuler Mark McCarthy W H Linda Kao James S Pankow Thomas P Cappola Peter Sever Neil Poulter Mark Caulfield Anna Dominiczak Denis C Shields Deepak L Bhatt Deepak Bhatt Li Zhang Sean P Curtis John Danesh Juan P Casas Yvonne T van der Schouw N Charlotte Onland-Moret Pieter A Doevendans Gerald W Dorn Martin Farrall Garret A FitzGerald Anders Hamsten Robert Hegele Aroon D Hingorani Marten H Hofker Gordon S Huggins Thomas Illig Gail P Jarvik Julie A Johnson Olaf H Klungel William C Knowler Wolfgang Koenig Winfried März James B Meigs Olle Melander Patricia B Munroe Braxton D Mitchell Susan J Bielinski Daniel J Rader Muredach P Reilly Stephen S Rich Jerome I Rotter Danish Saleheen Nilesh J Samani Eric E Schadt Alan R Shuldiner Roy Silverstein Kandice Kottke-Marchant Philippa J Talmud Hugh Watkins Folkert W Asselbergs Folkert Asselbergs Paul I W de Bakker Jeanne McCaffery Cisca Wijmenga Marc S Sabatine James G Wilson Alex Reiner Donald W Bowden Hakon Hakonarson David S Siscovick Brendan J Keating

Am J Hum Genet 2012 Mar 9;90(3):410-25. Epub 2012 Feb 9.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, USA.

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http://dx.doi.org/10.1016/j.ajhg.2011.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309185PMC
March 2012

NASH and atherosclerosis are two aspects of a shared disease: central role for macrophages.

Atherosclerosis 2012 Feb 3;220(2):287-93. Epub 2011 Sep 3.

Dept. of Molecular Genetics, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2011.08.041DOI Listing
February 2012

Introduction: Strategies for developing genetically modified mice.

Authors:
Marten H Hofker

Methods Mol Biol 2011 ;693:1-10

Department of Pathology & Medical Biology, Medical Biology Section, Molecular Genetics, University Medical Center Groningen, University of Gronignen, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/978-1-60761-974-1_1DOI Listing
March 2011

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.

Authors:
Matthew B Lanktree Yiran Guo Muhammed Murtaza Joseph T Glessner Swneke D Bailey N Charlotte Onland-Moret Guillaume Lettre Halit Ongen Ramakrishnan Rajagopalan Toby Johnson Haiqing Shen Christopher P Nelson Norman Klopp Jens Baumert Sandosh Padmanabhan Nathan Pankratz James S Pankow Sonia Shah Kira Taylor John Barnard Bas J Peters Cliona M Maloney Maximilian T Lobmeyer Alice Stanton M Hadi Zafarmand Simon P R Romaine Amar Mehta Erik P A van Iperen Yan Gong Tom S Price Erin N Smith Cecilia E Kim Yun R Li Folkert W Asselbergs Larry D Atwood Kristian M Bailey Deepak Bhatt Florianne Bauer Elijah R Behr Tushar Bhangale Jolanda M A Boer Bernhard O Boehm Jonathan P Bradfield Morris Brown Peter S Braund Paul R Burton Cara Carty Hareesh R Chandrupatla Wei Chen John Connell Chrysoula Dalgeorgou Anthonius de Boer Fotios Drenos Clara C Elbers James C Fang Caroline S Fox Edward C Frackelton Barry Fuchs Clement E Furlong Quince Gibson Christian Gieger Anuj Goel Diederik E Grobbee Claire Hastie Philip J Howard Guan-Hua Huang W Craig Johnson Qing Li Marcus E Kleber Barbara E K Klein Ronald Klein Charles Kooperberg Bonnie Ky Andrea Lacroix Paul Lanken Mark Lathrop Mingyao Li Vanessa Marshall Olle Melander Frank D Mentch Nuala J Meyer Keri L Monda Alexandre Montpetit Gurunathan Murugesan Karen Nakayama Dave Nondahl Abiodun Onipinla Suzanne Rafelt Stephen J Newhouse F George Otieno Sanjey R Patel Mary E Putt Santiago Rodriguez Radwan N Safa Douglas B Sawyer Pamela J Schreiner Claire Simpson Suthesh Sivapalaratnam Sathanur R Srinivasan Christine Suver Gary Swergold Nancy K Sweitzer Kelly A Thomas Barbara Thorand Nicholas J Timpson Sam Tischfield Martin Tobin Maciej Tomaszewski Maciej Tomaszweski W M Monique Verschuren Chris Wallace Bernhard Winkelmann Haitao Zhang Dongling Zheng Li Zhang Joseph M Zmuda Robert Clarke Anthony J Balmforth John Danesh Ian N Day Nicholas J Schork Paul I W de Bakker Christian Delles David Duggan Aroon D Hingorani Joel N Hirschhorn Marten H Hofker Steve E Humphries Mika Kivimaki Debbie A Lawlor Kandice Kottke-Marchant Jessica L Mega Braxton D Mitchell David A Morrow Jutta Palmen Susan Redline Denis C Shields Alan R Shuldiner Patrick M Sleiman George Davey Smith Martin Farrall Yalda Jamshidi David C Christiani Juan P Casas Alistair S Hall Pieter A Doevendans Jason D Christie Gerald S Berenson Sarah S Murray Thomas Illig Gerald W Dorn Thomas P Cappola Eric Boerwinkle Peter Sever Daniel J Rader Muredach P Reilly Mark Caulfield Philippa J Talmud Eric Topol James C Engert Kai Wang Anna Dominiczak Anders Hamsten Sean P Curtis Roy L Silverstein Leslie A Lange Marc S Sabatine Mieke Trip Danish Saleheen John F Peden Karen J Cruickshanks Winfried März Jeffrey R O'Connell Olaf H Klungel Cisca Wijmenga Anke Hilse Maitland-van der Zee Eric E Schadt Julie A Johnson Gail P Jarvik George J Papanicolaou Struan F A Grant Patricia B Munroe Kari E North Nilesh J Samani Wolfgang Koenig Tom R Gaunt Sonia S Anand Yvonne T van der Schouw Nicole Soranzo Garret A Fitzgerald Alex Reiner Robert A Hegele Hakon Hakonarson Brendan J Keating

Am J Hum Genet 2011 Jan 30;88(1):6-18. Epub 2010 Dec 30.

Department of Medicine and Biochemistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada.

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http://dx.doi.org/10.1016/j.ajhg.2010.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014369PMC
January 2011

Bone marrow transplantation in mice as a tool for studying the role of hematopoietic cells in metabolic and cardiovascular diseases.

Atherosclerosis 2010 Dec 1;213(2):335-44. Epub 2010 Jun 1.

Molecular Genetics, Medical Biology Section, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2010.05.030DOI Listing
December 2010

Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study.

BMC Med Genomics 2010 Aug 5;3:34. Epub 2010 Aug 5.

Department of Pathology and Medical Biology, Medical Biology Section, Molecular Genetics, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands.

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http://dx.doi.org/10.1186/1755-8794-3-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925326PMC
August 2010

Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice.

Gastroenterology 2010 Jun 2;138(7):2477-86, 2486.e1-3. Epub 2010 Mar 2.

Department of Molecular Genetics, Pathology and Physiology, Nutrition and Toxicology Research and Cardiovascular Research Institutes of Maastricht, University of Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2010.02.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114629PMC
June 2010

COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.

J Clin Invest 2010 Jun 10;120(6):2119-30. Epub 2010 May 10.

Complex Genetics Section, Division of Biomedical Genetics, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.1172/JCI40583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877941PMC
June 2010

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice.

FEBS Lett 2010 Mar 29;584(5):1001-5. Epub 2010 Jan 29.

Department of Molecular Genetics, Institutes of Maastricht University Maastricht, Maastricht, The Netherlands.

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http://doi.wiley.com/10.1016/j.febslet.2010.01.046
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http://dx.doi.org/10.1016/j.febslet.2010.01.046DOI Listing
March 2010

[Genetic background of diabetes mellitus type 2].

Ned Tijdschr Geneeskd 2009 ;153:A959

Universitair Medisch Centrum Groningen en Universiteit van Groningen, Afd. Genetica, Groningen, The Netherlands.

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February 2010

P55 tumour necrosis factor receptor in bone marrow-derived cells promotes atherosclerosis development in low-density lipoprotein receptor knock-out mice.

Cardiovasc Res 2008 Nov 15;80(2):309-18. Epub 2008 Jul 15.

Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, UNS 50/11, 6229ER Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvn193DOI Listing
November 2008

Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice.

Arterioscler Thromb Vasc Biol 2008 Nov 28;28(11):2023-9. Epub 2008 Aug 28.

Department of Biochemistry, CARIM and NUTRIM, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.107.156992DOI Listing
November 2008

Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology.

J Biol Chem 2008 Aug 28;283(31):21640-8. Epub 2008 May 28.

Departments of Molecular Genetics and Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, Maastricht, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M710584200DOI Listing
August 2008

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis.

Hepatology 2008 Aug;48(2):474-86

Department of Molecular Genetics, Physiology and Electron Microscopy Unit, Nutrition and Toxicology Research and Cardiovascular Research, Institutes of Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/hep.22363DOI Listing
August 2008

Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice.

Circulation 2008 Aug 4;118(8):828-36. Epub 2008 Aug 4.

Department of Genetics and Cell Biology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.743690DOI Listing
August 2008

Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: association study in 2000 Dutch Caucasians.

Mol Genet Metab 2008 Jul 28;94(3):352-5. Epub 2008 Apr 28.

University of Maastricht, Cardiovascular Research Institute Maastricht (CARIM), Department of Internal Medicine, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.ymgme.2008.03.011DOI Listing
July 2008

HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort.

Eur J Hum Genet 2008 May 30;16(5):652-6. Epub 2008 Jan 30.

Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/sj.ejhg.5202008DOI Listing
May 2008

The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides.

J Lipid Res 2007 Oct 3;48(10):2182-92. Epub 2007 Jul 3.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1194/jlr.M700009-JLR200DOI Listing
October 2007

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.

Nat Genet 2007 Aug 1;39(8):977-83. Epub 2007 Jul 1.

deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng2062DOI Listing
August 2007

Intra- and interindividual variation in gene expression in human adipose tissue.

Pflugers Arch 2007 Mar 24;453(6):851-61. Epub 2006 Oct 24.

Bioactives group, RIKILT- Institute of Food Safety, Wageningen, Wageningen, The Netherlands.

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http://dx.doi.org/10.1007/s00424-006-0164-4DOI Listing
March 2007

Lipopolysaccharide-induced gene expression in murine macrophages is enhanced by prior exposure to oxLDL.

J Lipid Res 2006 Oct 13;47(10):2259-67. Epub 2006 Jul 13.

Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1194/jlr.M600181-JLR200DOI Listing
October 2006

Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates.

J Hepatol 2006 Apr 20;44(4):732-41. Epub 2005 Dec 20.

Department of Molecular Genetics, University Maastricht, UNS40/11 P.O. Box 16, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2005.10.033DOI Listing
April 2006

The role of phospholipases in lipid modification and atherosclerosis.

Cardiovasc Toxicol 2005 ;5(2):161-82

Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands.

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October 2005

Nuclear factor kappa B signaling in macrophage function and atherogenesis.

Curr Opin Lipidol 2005 Oct;16(5):536-42

Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands.

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October 2005

Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice.

Clin Chem Lab Med 2005 ;43(5):470-9

Department of Molecular Genetics, Universiteit Maastricht, The Netherlands.

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http://dx.doi.org/10.1515/CCLM.2005.085DOI Listing
August 2005