Publications by authors named "Marsha A McLaughlin"

21Publications

Effects of Rho Kinase Inhibitors on Intraocular Pressure and Aqueous Humor Dynamics in Nonhuman Primates and Rabbits.

J Ocul Pharmacol Ther 2016 Jul-Aug;32(6):355-64. Epub 2016 Jun 6.

5 Department of Ophthalmology, Novartis Institutes for Biomedical Research (NIBR) , Cambridge, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jop.2015.0116DOI Listing
October 2017

In vivo optimization of 2,3-diaminopyrazine Rho Kinase inhibitors for the treatment of glaucoma.

Bioorg Med Chem Lett 2014 Apr 19;24(8):1875-9. Epub 2014 Mar 19.

Alcon Laboratories Inc, A Division of Novartis, 6201 South Freeway, Fort Worth, TX 76134, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2014.03.017DOI Listing
April 2014

Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension.

Exp Eye Res 2010 Dec 22;91(6):860-5. Epub 2010 Sep 22.

Department of Ophthalmology, University of Nebraska Medical Center, 985840 Nebraska Medical Center, Omaha, NE 68198-5840, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2010.09.011DOI Listing
December 2010

Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity.

Bioorg Med Chem 2009 Jan 6;17(2):576-84. Epub 2008 Dec 6.

Medicinal Chemistry, Ophthalmic Products Research, Alcon Research Ltd., 6201 South Freeway, Mail code: R2-39, Fort Worth, TX 76134, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2008.11.070DOI Listing
January 2009

Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.

Bioorg Med Chem Lett 2007 Jun 25;17(11):2998-3002. Epub 2007 Mar 25.

Alcon Research, Ltd, Research Chemistry, 6201 South Freeway, Fort Worth, TX 76134, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.03.073DOI Listing
June 2007

AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist.

J Ocul Pharmacol Ther 2007 Feb;23(1):1-13

Ophthalmology Discovery Research, Alcon Research, Ltd., Fort Worth, TX 76134, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jop.2006.0093DOI Listing
February 2007

Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog.

J Ocul Pharmacol Ther 2006 Oct;22(5):291-309

Ophthalmology Discovery Research, Alcon Research, Ltd., Fort Worth, TX 76137, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jop.2006.22.291DOI Listing
October 2006

Effects of a prostaglandin DP receptor agonist, AL-6598, on aqueous humor dynamics in a nonhuman primate model of glaucoma.

J Ocul Pharmacol Ther 2006 Apr;22(2):86-92

Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE 68198-5840, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jop.2006.22.86DOI Listing
April 2006

1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.

J Med Chem 2006 Jan;49(1):318-28

Ophthalmology Discovery Research, Alcon Research, Ltd., 6201 South Freeway, Fort Worth, Texas 76134, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm050663xDOI Listing
January 2006

Effects of travoprost on aqueous humor dynamics in monkeys.

J Glaucoma 2005 Feb;14(1):70-3

Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5840, USA.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/glaucomajournal/2005/02000/Effe
Web Search
http://dx.doi.org/10.1097/01.ijg.0000146361.15163.eaDOI Listing
February 2005

Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.

J Med Chem 2004 Nov;47(24):6034-41

Department of Medicinal Chemistry, Box 980540, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm040082sDOI Listing
November 2004

Effects of brinzolamide on aqueous humor dynamics in monkeys and rabbits.

J Ocul Pharmacol Ther 2003 Oct;19(5):397-404

Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE 68198-5145, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/108076803322472962DOI Listing
October 2003

A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.

J Med Chem 2003 Sep;46(19):4188-95

Medicinal Chemistry Department, Ophthalmic Products Research, Alcon Research, Ltd., 6201 South Freeway, Fort Worth, Texas 76134, USA.

View Article

Download full-text PDF

Source
https://www.erowid.org/archive/rhodium/pdf/45-trimethylenoxy
Web Search
http://pubs.acs.org/doi/abs/10.1021/jm030205t
Publisher Site
http://dx.doi.org/10.1021/jm030205tDOI Listing
September 2003

3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents.

Bioorg Med Chem 2002 Jun;10(6):2031-49

Department of Medicinal Chemistry, Alcon Research, Ltd., Pharmaceutical Products Research, 6201 South Freeway, Fort Worth, TX 76134, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0968-0896(02)00016-0DOI Listing
June 2002