Marlene A Jacobson

Marlene A Jacobson

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Marlene A Jacobson

Marlene A Jacobson

Publications by authors named "Marlene A Jacobson"

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35Publications

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Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells.

Bioorg Med Chem Lett 2020 Jan 11;30(2):126806. Epub 2019 Nov 11.

Moulder Center for Drug Discovery Research, Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.126806DOI Listing
January 2020

mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells.

Dis Model Mech 2019 10 16;12(10). Epub 2019 Oct 16.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA

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http://dx.doi.org/10.1242/dmm.038596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826018PMC
October 2019

High-Throughput Ca Flux Assay To Monitor Cyclic Nucleotide-Gated Channel Activity and Characterize Achromatopsia Mutant Channel Function.

ACS Chem Neurosci 2019 08 24;10(8):3662-3670. Epub 2019 Jul 24.

Department of Biology, College of Science and Technology , Temple University , Philadelphia , Pennsylvania 19122 , United States.

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http://dx.doi.org/10.1021/acschemneuro.9b00231DOI Listing
August 2019

Patient-Derived Phenotypic High-Throughput Assay to Identify Small Molecules Restoring Lysosomal Function in Tay-Sachs Disease.

SLAS Discov 2019 03 7;24(3):295-303. Epub 2019 Jan 7.

1 Moulder Center for Drug Discovery Research and Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/2472555218814538DOI Listing
March 2019

Identification of Novel Inhibitors of DLK Palmitoylation and Signaling by High Content Screening.

Sci Rep 2019 03 6;9(1):3632. Epub 2019 Mar 6.

Shriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1038/s41598-019-39968-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403299PMC
March 2019

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.

ACS Med Chem Lett 2016 Mar 10;7(3):312-7. Epub 2016 Jan 10.

Departments of Medicinal Chemistry, In Vitro Sciences, Psychiatry Research, Central Pharmacology, Drug Metabolism, Process and Analytical Chemistry, and Structural Chemistry, Merck Research Laboratories , P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789683PMC
March 2016

Dynamic mass redistribution analysis of endogenous β-adrenergic receptor signaling in neonatal rat cardiac fibroblasts.

Pharmacol Res Perspect 2014 Feb;2(1)

Center for Translational Medicine (R.L.C., L.A.G., J.E.Y., A.A.R., M.W., J.I., W.J.K. and D.G.T.) and Department of Pharmacology (W.J.K. and D.G.T.), Temple University School of Medicine, and Moulder Center for Drug Discovery Research and Temple University School of Pharmacy (M.A.J.), Philadelphia, PA 19140, USA.

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http://doi.wiley.com/10.1002/prp2.24
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http://dx.doi.org/10.1002/prp2.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968527PMC
February 2014

Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.

Bioorg Med Chem Lett 2009 Mar 9;19(5):1488-91. Epub 2009 Jan 9.

Department of Medicinal Chemistry, Technology Enabled Synthesis Group, Merck & Co., Inc., WP-14-1, PO Box 4 Sumneytown Pike, West Point, PA 19486, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0900012
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http://dx.doi.org/10.1016/j.bmcl.2008.12.115DOI Listing
March 2009

Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.

Bioorg Med Chem Lett 2009 Mar 10;19(5):1492-5. Epub 2009 Jan 10.

Department of Medicinal Chemistry, Technology Enabled Synthesis Group, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.01.015DOI Listing
March 2009

Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice.

Physiol Behav 2008 Dec 27;95(5):668-76. Epub 2008 Sep 27.

Department of Physiology and Pharmacology, Karolinska Institutet, S - 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.physbeh.2008.09.018DOI Listing
December 2008

Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.

Circulation 2007 Mar 12;115(12):1581-90. Epub 2007 Mar 12.

Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Hoppe-Seyler-Str 3, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.669697DOI Listing
March 2007

Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor.

J Pharmacol Exp Ther 2006 Dec 19;319(3):1200-10. Epub 2006 Sep 19.

Department of Pharmacology and Toxicology and the Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

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http://dx.doi.org/10.1124/jpet.106.111351DOI Listing
December 2006

Activation of murine lung mast cells by the adenosine A3 receptor.

J Immunol 2003 Jul;171(1):338-45

Department of Biochemistry and Molecular Biology, University of Texas-Houston Medical School, Houston, TX 77030, USA.

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http://dx.doi.org/10.4049/jimmunol.171.1.338DOI Listing
July 2003

Behavioral characterization of mice lacking the A3 adenosine receptor: sensitivity to hypoxic neurodegeneration.

Cell Mol Neurobiol 2003 Jun;23(3):431-47

Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145360PMC
http://dx.doi.org/10.1023/a:1023601007518DOI Listing
June 2003

A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure.

Am J Physiol Renal Physiol 2003 Feb 15;284(2):F267-73. Epub 2002 Oct 15.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1152/ajprenal.00271.2002DOI Listing
February 2003

Targeted deletion of adenosine A(3) receptors augments adenosine-induced coronary flow in isolated mouse heart.

Am J Physiol Heart Circ Physiol 2002 Jun;282(6):H2183-9

Department of Pharmacology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA.

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http://dx.doi.org/10.1152/ajpheart.00964.2001DOI Listing
June 2002