Publications by authors named "Markus Zollinger"

15Publications

A Study of the Effect of Cyclosporine on Fevipiprant Pharmacokinetics and its Absolute Bioavailability Using an Intravenous Microdose Approach.

Authors:
H Markus Weiss Ken-Ichi Umehara Veit J Erpenbeck Meredith Cain Janardhana Vemula Walid Elbast Markus Zollinger

Drug Metab Dispos 2020 10 1;48(10):917-924. Epub 2020 Aug 1.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

View Article and Find Full Text PDF
October 2020

Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors.

Authors:
Ken-Ichi Umehara Markus Zollinger Elizabeth Kigondu Marc Witschi Claire Juif Felix Huth Hilmar Schiller Kelly Chibale Gian Camenisch

Xenobiotica 2016 Oct 18;46(10):862-7. Epub 2016 Feb 18.

a Department of Drug Metabolism and Pharmacokinetics , Integrated Drug Disposition Section, Novartis Institutes for BioMedical Research , Basel , Switzerland .

View Article and Find Full Text PDF
October 2016

Absorption, distribution, metabolism, and excretion (ADME) of ¹⁴C-sonidegib (LDE225) in healthy volunteers.

Authors:
Markus Zollinger Frédéric Lozac'h Eunju Hurh Corinne Emotte Hounayda Bauly Piet Swart

Cancer Chemother Pharmacol 2014 Jul 10;74(1):63-75. Epub 2014 May 10.

Drug Metabolism and Pharmacokinetics (DMPK), Novartis Institutes for BioMedical Research, Fabrikstrasse 14, 4002, Basel, Switzerland,

View Article and Find Full Text PDF
July 2014

Metabolism of patupilone in patients with advanced solid tumor malignancies.

Authors:
Kevin R Kelly Markus Zollinger Frédéric Lozac'h Eugene Tan Alain Mita Felix Waldmeier Patrick Urban Suraj Anand Yanfeng Wang Piet Swart Chris Takimoto Monica Mita

Invest New Drugs 2013 Jun 18;31(3):605-15. Epub 2012 Jul 18.

Institute For Drug Development, Cancer Therapy and Research Center at the University of Texas Health Science Center, San Antonio, TX, USA.

View Article and Find Full Text PDF
June 2013

CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis.

Authors:
Yi Jin Markus Zollinger Hubert Borell Alfred Zimmerlin Christopher J Patten

Drug Metab Dispos 2011 Feb 2;39(2):191-8. Epub 2010 Nov 2.

Novartis Institutes for BioMedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland.

View Article and Find Full Text PDF
February 2011

Absorption and disposition of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in healthy volunteers: a case of xenobiotic biotransformation following endogenous metabolic pathways.

Authors:
Markus Zollinger Hans-Peter Gschwind Yi Jin Claudia Sayer Frédéric Zécri Stefan Hartmann

Drug Metab Dispos 2011 Feb 2;39(2):199-207. Epub 2010 Nov 2.

Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, Basel, Switzerland.

View Article and Find Full Text PDF
February 2011

The macrolide everolimus forms an unusual metabolite in animals and humans: identification of a phosphocholine ester.

Authors:
Markus Zollinger Claudia Sayer Robert Dannecker Walter Schuler Richard Sedrani

Drug Metab Dispos 2008 Aug 30;36(8):1457-60. Epub 2008 Apr 30.

Novartis Pharma AG, WKL-135.2.21 P.O. Box, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF
August 2008

Pimecrolimus: skin disposition after topical administration in minipigs in vivo and in human skin in vitro.

Authors:
Hans-Peter Gschwind Felix Waldmeier Markus Zollinger Alain Schweitzer Maximilian Grassberger

Eur J Pharm Sci 2008 Jan 22;33(1):9-19. Epub 2007 Sep 22.

Novartis Pharma AG, Exploratory Development/DMPK, WKL-135.2.25, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF
January 2008

A microplate solid scintillation counter as a radioactivity detector for high performance liquid chromatography in drug metabolism: validation and applications.

Authors:
Gerard J Bruin Felix Waldmeier K Olaf Boernsen Ulrike Pfaar Gerhard Gross Markus Zollinger

J Chromatogr A 2006 Nov 12;1133(1-2):184-94. Epub 2006 Sep 12.

Novartis Pharma AG, Drug Metabolism and Pharmacokinetics, WSJ-103.4.26, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF
November 2006

Pimecrolimus: absorption, distribution, metabolism, and excretion in healthy volunteers after a single oral dose and supplementary investigations in vitro.

Authors:
Markus Zollinger Felix Waldmeier Stefan Hartmann Gerhard Zenke Alfred G Zimmerlin Ulrike Glaenzel Jean-Pierre Baldeck Alain Schweitzer Stephane Berthier Thomas Moenius Maximilian A Grassberger

Drug Metab Dispos 2006 May 7;34(5):765-74. Epub 2006 Feb 7.

Novartis Pharma AG, WKL-135.2.21, P.O. box, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF
May 2006

Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.

Authors:
Rainer Albert Klaus Hinterding Volker Brinkmann Danilo Guerini Constanze Müller-Hartwieg Helmut Knecht Corinne Simeon Markus Streiff Trixie Wagner Karl Welzenbach Frédéric Zécri Markus Zollinger Nigel Cooke Eric Francotte

J Med Chem 2005 Aug;48(16):5373-7

Novartis Institutes for BioMedical Research, Lichtstrasse 35, WSJ-507.3.02, CH-4056 Basel, Switzerland.

View Article and Find Full Text PDF
August 2005

Metabolism and disposition of imatinib mesylate in healthy volunteers.

Authors:
Hans-Peter Gschwind Ulrike Pfaar Felix Waldmeier Markus Zollinger Claudia Sayer Peter Zbinden Michael Hayes Rolf Pokorny Michael Seiberling Monique Ben-Am Bin Peng Gerhard Gross

Drug Metab Dispos 2005 Oct 8;33(10):1503-12. Epub 2005 Jul 8.

Exploratory Development/DMPK, Novartis Pharma AG, WKL-135.2.25, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF
October 2005

A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.

Authors:
Rene Hersperger Karl-Heinz Buchheit Salvatore Cammisuli Albert Enz Olivier Lohse Monique Ponelle Walter Schuler Alain Schweitzer Christoph Walker Hartmut Zehender Gerhard Zenke Alfred G Zimmerlin Markus Zollinger Lazzaro Mazzoni John R Fozard

J Med Chem 2004 Sep;47(20):4950-7

Novartis Institutes for BioMedical Research and Novartis Pharma Development, CH-4002 Basle, Switzerland.

View Article and Find Full Text PDF
September 2004

The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

Authors:
Volker Brinkmann Michael D Davis Christopher E Heise Rainer Albert Sylvain Cottens Robert Hof Christian Bruns Eva Prieschl Thomas Baumruker Peter Hiestand Carolyn A Foster Markus Zollinger Kevin R Lynch

J Biol Chem 2002 Jun 19;277(24):21453-7. Epub 2002 Apr 19.

Department of Transplantation, Novartis Pharma AG, Lichtstrasse 35, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF
June 2002

Effect of Climbing Fibre Deprivation on the K+-evoked Release of Endogenous Adenosine from Rat Cerebellar Slices.

Authors:
Kim Quang Do Franz X. Vollenweider Markus Zollinger Michel Cuénod

Eur J Neurosci 1991 ;3(2):201-208

Brain Research Institute, University of Zürich, August Forel-Strasse 1, CH-8029 Zürich, Switzerland.

View Article and Find Full Text PDF
January 1991