Publications by authors named "Markus Walles"

28Publications

Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans.

Xenobiotica 2021 Jan 12:1-14. Epub 2021 Jan 12.

Pharmacokinetics Sciences, Novartis Institutes for BioMedical Research, East Hanover, NJ, USA.

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January 2021

New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides.

Chem Res Toxicol 2020 Jul 29;33(7):1551-1560. Epub 2020 Jun 29.

PK Sciences, Novartis Institutes for Biomedical Research, Novartis Campus, 4052 Basel, Switzerland.

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July 2020

Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS).

Drug Metab Lett 2019 ;13(1):53-63

Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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January 2020

F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers.

Xenobiotica 2019 Aug 29;49(8):953-960. Epub 2018 Nov 29.

a Pharmacokinetic Sciences , Novartis Institutes for BioMedical Research , Novartis Pharma AG , Basel , Switzerland.

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August 2019

Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route.

Drug Metab Dispos 2018 11 15;46(11):1670-1683. Epub 2018 Aug 15.

Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)

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November 2018

Functional assessment of rat pulmonary flavin-containing monooxygenase activity.

Xenobiotica 2019 May 15;49(5):503-512. Epub 2018 May 15.

a Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research , Basel , Switzerland.

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May 2019

Evaluation of cAMS for C microtracer ADME studies: opportunities to change the current drug development paradigm.

Bioanalysis 2018 Mar 16;10(5):321-339. Epub 2018 Feb 16.

Novartis Pharma AG, Novartis Institutes for Biomedical Research, PK Sciences, Fabrikstrasse 14, CH-4002 Basel, Switzerland.

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March 2018

Immunoprecipitation middle-up LC-MS for in vivo drug-to-antibody ratio determination for antibody-drug conjugates.

Bioanalysis 2017 Oct 26;9(20):1535-1549. Epub 2017 Oct 26.

Safety/ADME Bioanalysis, Pre-Clinical Bioanalysis Mass Spectrometry Sciences, PK Sciences, Novartis, One Health Plaza, East Hanover, NJ 07936, USA.

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October 2017

The flexibility of a generic LC-MS/MS method for the quantitative analysis of therapeutic proteins based on human immunoglobulin G and related constructs in animal studies.

J Pharm Biomed Anal 2016 Nov 31;131:214-222. Epub 2016 Aug 31.

Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Fabrikstrasse 14 - Novartis Campus, 4056, Basel, Switzerland. Electronic address:

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November 2016

New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats.

Drug Metab Dispos 2016 07 27;44(7):897-910. Epub 2016 Apr 27.

Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.).

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July 2016

The use of generic surrogate peptides for the quantitative analysis of human immunoglobulin G1 in pre-clinical species with high-resolution mass spectrometry.

Anal Bioanal Chem 2016 Feb 12;408(6):1687-99. Epub 2016 Jan 12.

Drug Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, Fabrikstrasse 14 - Novartis Campus, 4056, Basel, Switzerland.

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February 2016

Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.

Drug Metab Dispos 2016 May 15;44(5):617-23. Epub 2015 Dec 15.

Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., La Jolla, California (E.K.); Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, South San Francisco, California (A.V.K.); Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, Novartis Pharma, Basel, Switzerland (M.W.); Drug Metabolism, Pharmacokinetics, and Bioanalysis Department, AbbVie, Worcester, Massachusetts (E.T.); Disposition, Safety and Animal Research, Sanofi, Vitry sur Seine, France (A.D.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (R.A.I.); Departments of Drug Disposition, Development, and Commercialization, Eli Lilly and Co., Indianapolis, Indiana (A.D.-M.); Drug Metabolism and Pharmacokinetics, Celgene Corp., Summit, New Jersey (P.S.); Drug Metabolism and Pharmacokinetics, Bayer Pharma AG, Wuppertal, Germany (Mi.B.); Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., Boston, Massachusetts (J.J.Y.); Bioanalytical Science and Toxicokinetics, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline R&D, Ware, United Kingdom (Ma.B.); Preclinical Pharmacokinetics and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Biologics Discovery Drug Metabolism and Pharmacokinetics and Bioanalytics Department, Merck Research Laboratories, Palo Alto, California (E.E.); Biologics Clinical Pharmacology, Janssen R&D, Spring House, Pennsylvania, (W.W.); Amgen Pharmacokinetics and Drug Metabolism, Thousand Oaks, California (D.A.R.); Seattle Genetics Inc., Seattle, Washington (N.V.C); and Department of Pharmaceutical Sciences, Roche Innovation Center, New York City, New York (D.J.M.).

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May 2016

Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.

Drug Metab Dispos 2015 Jan 22;43(1):126-39. Epub 2014 Oct 22.

Drug Metabolism and Pharmacokinetics (N.M., P.S., G.C., O.K., H.S., M.W., K.L.), Pre-clinical Safety (K.K.B., B.B., F.P., A.W.), and Clinical Sciences and Innovation Translational Medicine (J.A.-C.), Novartis Institutes for BioMedical Research, Novartis Pharma, Basel, Switzerland; and Department of Plastic, Reconstructive, Aesthetic and Hand Surgery (B.L., R.W., D.J.S.), and Department of Dermatology (P.I.), University Hospital Basel, Basel, Switzerland

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January 2015

Aldehyde oxidase activity in fresh human skin.

Drug Metab Dispos 2014 Dec 23;42(12):2049-57. Epub 2014 Sep 23.

Drug Metabolism and Pharmacokinetics (N.M., P.S., M.W., G.C., H.S., O.K., K.L.) and Pre-clinical Safety (K.K.B., B.B., F.P., A.W.), Novartis Institutes for BioMedical Research, Novartis Pharma, Basel, Switzerland; and Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland (B.L., R.W., D.J.S.)

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December 2014

Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite.

Xenobiotica 2015 Feb 2;45(2):107-23. Epub 2014 Sep 2.

Department of Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research , Basel , Switzerland .

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February 2015

A unique automation platform for measuring low level radioactivity in metabolite identification studies.

PLoS One 2012 18;7(6):e39070. Epub 2012 Jun 18.

DMPK/Isotope Laboratories, Novartis Pharma AG, Basel, Switzerland.

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December 2012