Publications by authors named "Markus Trunzer"

7Publications

Evaluation of relative MS response factors of drug metabolites for semi-quantitative assessment of chemical liabilities in drug discovery.

Authors:
Joachim Blanz Gareth Williams Jerôme Dayer Thierry Délémonté Werner Gertsch Philippe Ramstein Reiner Aichholz Markus Trunzer David Pearson

J Mass Spectrom 2017 04;52(4):210-217

DMPK, Novartis Institutes for Biomedical Research, Postfach, Basel, CH-4002, Switzerland.

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April 2017

An integrated approach for identification and target validation of antifungal compounds active against Erg11p.

Authors:
Dominic Hoepfner Shantanu Karkare Stephen B Helliwell Martin Pfeifer Markus Trunzer Sophie De Bonnechose Alfred Zimmerlin Jianshi Tao Daryl Richie Andreas Hofmann Stefan Reinker Mathias Frederiksen N Rao Movva Jeffrey A Porter Neil S Ryder Christian N Parker

Antimicrob Agents Chemother 2012 Aug 21;56(8):4233-40. Epub 2012 May 21.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland.

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August 2012

CYP3A time-dependent inhibition risk assessment validated with 400 reference drugs.

Authors:
Alfred Zimmerlin Markus Trunzer Bernard Faller

Drug Metab Dispos 2011 Jun 7;39(6):1039-46. Epub 2011 Mar 7.

Discovery ADME, Novartis Institutes for BioMedical Research, WSJ-350.3.12, P.O. Box, CH-4002 Basel, Switzerland.

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June 2011

Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation.

Authors:
Markus Trunzer Bernard Faller Alfred Zimmerlin

J Med Chem 2009 Jan;52(2):329-35

Novartis Institutes for BioMedical Research, Metabolism and Pharmacokinetics, Postfach, CH-4002, Basel, Switzerland.

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January 2009

Cytostar-T plates--a valid alternative for microplate scintillation counting of low radioactivity in combination with high-performance liquid chromatography in drug metabolism studies?

Authors:
Michael Kiffe Robert Nufer Markus Trunzer Daniel Graf

J Chromatogr A 2007 Jul 19;1157(1-2):65-72. Epub 2007 Apr 19.

Novartis Pharma AG, Metabolism and pharmacokinetics (MAP), WSJ-360.2.02, CH-4002 Basel, Switzerland.

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July 2007

Two-dimensional liquid chromatography/mass spectrometry set-up for structural elucidation of metabolites in complex biological matrices.

Authors:
Michael Kiffe Daniel Graf Markus Trunzer

Rapid Commun Mass Spectrom 2007 ;21(6):961-70

Novartis Institutes for BioMedical Research, Metabolism and Pharmacokinetics, CH-4002 Basel, Switzerland.

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May 2007

Comparison of a two-dimensional liquid chromatography/mass spectrometry approach with a chip-based nanoelectrospray device for structural elucidation of metabolites in a human ADME study using a quadrupole time-of-flight mass spectrometer.

Authors:
Markus Trunzer Daniel Graf Michael Kiffe

Rapid Commun Mass Spectrom 2007 ;21(6):937-44

Novartis Pharma AG, Drug Metabolism and Pharmacokinetics, CH-4002 Basel, Switzerland.

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May 2007