Markus Seifert

Markus Seifert

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Markus Seifert

Publications by authors named "Markus Seifert"

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Dopamine Is a Siderophore-Like Iron Chelator That Promotes Serovar Typhimurium Virulence in Mice.

MBio 2019 02 5;10(1). Epub 2019 Feb 5.

Department of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria

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http://dx.doi.org/10.1128/mBio.02624-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428752PMC
February 2019

Dopamine promotes cellular iron accumulation and oxidative stress responses in macrophages.

Biochem Pharmacol 2018 02 5;148:193-201. Epub 2017 Dec 5.

Department of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, A-6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.12.001DOI Listing
February 2018

Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo.

Haematologica 2011 Dec 22;96(12):1761-9. Epub 2011 Aug 22.

Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.3324/haematol.2011.048926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232257PMC
December 2011

Reciprocal responses of fibroblasts and melanocytes to α-MSH depending on MC1R polymorphisms.

Dermatoendocrinol 2011 Oct 1;3(4):259-65. Epub 2011 Oct 1.

Department of Dermatology, Venerology and Allergology; University Hospital of Saarland; Homburg, Germany.

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http://dx.doi.org/10.4161/derm.3.4.17454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256344PMC
October 2011

Impact of iron treatment on immune effector function and cellular iron status of circulating monocytes in dialysis patients.

Nephrol Dial Transplant 2011 Mar 8;26(3):977-87. Epub 2010 Sep 8.

Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria.

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https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/
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http://dx.doi.org/10.1093/ndt/gfq483DOI Listing
March 2011

Peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) signaling pathways in melanoma cells: promising new therapeutic targets?

J Steroid Biochem Mol Biol 2010 Jul 7;121(1-2):383-6. Epub 2010 Mar 7.

Department of Dermatology, University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2010.03.003DOI Listing
July 2010

1,25-dihydroxyvitamin D3 modulates effects of ionizing radiation (IR) on human keratinocytes: in vitro analysis of cell viability/proliferation, DNA-damage and -repair.

J Steroid Biochem Mol Biol 2010 Jul 7;121(1-2):324-7. Epub 2010 Mar 7.

Department of Dermatology, The Saarland University Hospital, Kirrberger Str., 66421 Homburg/Saar, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S096007601000096
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http://dx.doi.org/10.1016/j.jsbmb.2010.03.007DOI Listing
July 2010

Iron absorption and distribution in TNF(DeltaARE/+) mice, a model of chronic inflammation.

J Trace Elem Med Biol 2010 Jan 17;24(1):58-66. Epub 2009 Nov 17.

Science Centre Weihenstephan, Technical University Munich, 85350 Freising, Germany.

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http://dx.doi.org/10.1016/j.jtemb.2009.10.002DOI Listing
January 2010

Robust optimization of scoring functions for a target class.

J Comput Aided Mol Des 2009 Sep 27;23(9):633-44. Epub 2009 May 27.

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http://dx.doi.org/10.1007/s10822-009-9276-1DOI Listing
September 2009

Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells.

Anticancer Res 2009 Sep;29(9):3647-58

Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany.

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September 2009

Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitro.

Anticancer Res 2009 Sep;29(9):3659-67

Universitäts-Hautklinik, Universitätsklinikum des Saarlandes, Homburg, Germany.

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September 2009

Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.

Bioorg Med Chem Lett 2009 Jun 23;19(12):3305-9. Epub 2009 Apr 23.

Department of Molecular Biology, Max Planck Institute of Biochemistry, and Center for Integrated Protein Science Munich, Am Klopferspitz 18, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.bmcl.2009.04.083DOI Listing
June 2009

Targeted scoring functions for virtual screening.

Drug Discov Today 2009 Jun 5;14(11-12):562-9. Epub 2009 Apr 5.

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http://dx.doi.org/10.1016/j.drudis.2009.03.013DOI Listing
June 2009

Characterization of the vitamin D endocrine system in human sebocytes in vitro.

J Steroid Biochem Mol Biol 2009 Jan 5;113(1-2):9-16. Epub 2008 Nov 5.

Department of Dermatology, The Saarland University Hospital, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2008.10.010DOI Listing
January 2009

Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease.

Gastroenterology 2008 Aug 15;135(2):680-8. Epub 2008 Apr 15.

General Hospital Oberndorf, Department of Internal Medicine, Oberndorf, Austria.

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http://dx.doi.org/10.1053/j.gastro.2008.04.007DOI Listing
August 2008

Proteasome inhibition by peptide-semicarbazones.

Bioorg Med Chem 2008 Apr 15;16(8):4579-88. Epub 2008 Feb 15.

4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany.

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http://dx.doi.org/10.1016/j.bmc.2008.02.042DOI Listing
April 2008

Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases.

Am J Clin Dermatol 2008 ;9(1):15-31

Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany.

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http://dx.doi.org/10.2165/00128071-200809010-00002DOI Listing
March 2008

Optimizing the signal-to-noise ratio of scoring functions for protein--ligand docking.

J Chem Inf Model 2008 Mar 23;48(3):602-12. Epub 2008 Feb 23.

4SC AG, Am Klopferspitz 19a, D-82152 Planegg-Martinsried, Germany.

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http://dx.doi.org/10.1021/ci700345nDOI Listing
March 2008

Autocrine formation of hepcidin induces iron retention in human monocytes.

Blood 2008 Feb 11;111(4):2392-9. Epub 2007 Dec 11.

Department of General Internal Medicine, Medical University, Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1182/blood-2007-05-090019DOI Listing
February 2008

The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.

J Invest Dermatol 2008 Jan 5;128(1):203-13. Epub 2007 Jul 5.

Department of Dermatology, The Saarland University Hospital, Homburg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1533605
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http://dx.doi.org/10.1038/sj.jid.5700941DOI Listing
January 2008

Essential factors for successful virtual screening.

Mini Rev Med Chem 2008 Jan;8(1):63-72

4SC AG, Am Klopferspitz 19A, D-82152 Planegg-Martinsried, Germany.

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http://dx.doi.org/10.2174/138955708783331540DOI Listing
January 2008

A novel class of potent NF-kappaB signaling inhibitors.

Bioorg Med Chem Lett 2007 Nov 15;17(21):5858-62. Epub 2007 Aug 15.

4SC AG, Am Klopferspitz 19a, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.bmcl.2007.08.022DOI Listing
November 2007

Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain.

Oncol Rep 2007 May;17(5):1207-11

Department of Human Genetics, Saarland University Hospital, Homburg, Saar, Germany.

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May 2007

Virtual high-throughput screening of molecular databases.

Curr Opin Drug Discov Devel 2007 May;10(3):298-307

4SC AG, Am Klopferspitz 19A, D-82152 Planegg-Martinsried, Germany.

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May 2007

In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells.

Cancer Biol Ther 2007 Jan;6(1):48-55

Department of Dermatology , The Saarland University Hospital, Homburg Germany.

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http://dx.doi.org/10.4161/cbt.6.1.3493DOI Listing
January 2007

The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer.

J Mol Histol 2006 Sep 2;37(5-7):301-7. Epub 2006 Nov 2.

Department of Dermatology, The Saarland University Hospital, Building 18, Kirrberger Strasse, 66421 Homburg, Germany.

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http://dx.doi.org/10.1007/s10735-006-9062-5DOI Listing
September 2006

Expression analysis of CYP27B1 in tumor biopsies and cell cultures.

Anticancer Res 2006 Jul-Aug;26(4A):2683-6

Department of Human Genetics, The Saarland University Hospital, 66421 Homburg/Saar, Germany.

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August 2006

Cutaneous photosynthesis of vitamin D: an evolutionary highly-conserved endocrine system that protects against environmental hazards including UV-radiation and microbial infections.

Anticancer Res 2006 Jul-Aug;26(4A):2743-8

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.

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August 2006

ProPose: steered virtual screening by simultaneous protein-ligand docking and ligand-ligand alignment.

J Chem Inf Model 2005 Mar-Apr;45(2):449-60

4SC AG, Am Klopferspitz 19a, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1021/ci0496393DOI Listing
June 2006

Assessing the discriminatory power of scoring functions for virtual screening.

J Chem Inf Model 2006 May-Jun;46(3):1456-65

4SC AG, Am Klopferspitz 19a, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1021/ci060027nDOI Listing
June 2006

Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease.

Blood 2006 May 24;107(10):4142-8. Epub 2006 Jan 24.

Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-08-33
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http://dx.doi.org/10.1182/blood-2005-08-3364DOI Listing
May 2006

Human endogenous retrovirus HERV-K(HML-2) Rec expression and transcriptional activities in normal and rheumatoid arthritis synovia.

J Rheumatol 2006 Jan;33(1):16-23

Department of Human Genetics and Department of Dermatology, Saarland University, University Hospital, Homburg/Saar, Germany.

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January 2006

Pathways for the regulation of body iron homeostasis in response to experimental iron overload.

J Hepatol 2005 Oct;43(4):711-9

Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Anichstr. 35, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.jhep.2005.03.030DOI Listing
October 2005

No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM).

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):163-6

Department of Dermatology, The Saarland University Hospital, Kirrberger Str., 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.096DOI Listing
May 2004

Differential biological effects of 1,25-dihydroxyVitamin D3 on melanoma cell lines in vitro.

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):375-9

Department of Dermatology, The Saarland University Hospital, Homburg, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.002DOI Listing
May 2004

Towards a complete picture of splice variants of the gene for 25-hydroxyvitamin D31alpha-hydroxylase in brain and skin cancer.

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):527-32

Institut für Humangenetik, Theoretische Medizin, Bldg. 60, Universität des Saarlandes, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.062DOI Listing
May 2004

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

Virology 2004 Apr;322(1):190-8

Department of Human Genetics, Medical Faculty, University of Saarland, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.virol.2004.01.023DOI Listing
April 2004

Backbone dynamics of green fluorescent protein and the effect of histidine 148 substitution.

Biochemistry 2003 Mar;42(9):2500-12

Max-Planck-Institute for Biochemistry, 82152 Martinsried, Germany, and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1021/bi026481bDOI Listing
March 2003

Purification, crystallization, NMR spectroscopy and biochemical analyses of alpha-phycoerythrocyanin peptides.

Eur J Biochem 2002 Oct;269(20):5046-55

Max-Planck-Institut für Biochemie, Martinsried, Germany.

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http://dx.doi.org/10.1046/j.1432-1033.2002.03221.xDOI Listing
October 2002

Slow exchange in the chromophore of a green fluorescent protein variant.

J Am Chem Soc 2002 Jul;124(27):7932-42

Max-Planck-Institute for Biochemistry, 82152 Martinsried, Munich, Germany.

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http://dx.doi.org/10.1021/ja0257725DOI Listing
July 2002

Phosphorylation and flexibility of cyclic-AMP-dependent protein kinase (PKA) using (31)P NMR spectroscopy.

Biochemistry 2002 May;41(19):5968-77

Abteilung Strukturforschung, Max-Planck-Institut für Biochemie, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1021/bi025509gDOI Listing
May 2002