Markus Seifert

Markus Seifert

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Markus Seifert

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Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Authors:
Shane J F Cronin Corey Seehus Adelheid Weidinger Sebastien Talbot Sonja Reissig Markus Seifert Yann Pierson Eileen McNeill Maria Serena Longhi Bruna Lenfers Turnes Taras Kreslavsky Melanie Kogler David Hoffmann Melita Ticevic Débora da Luz Scheffer Luigi Tortola Domagoj Cikes Alexander Jais Manu Rangachari Shuan Rao Magdalena Paolino Maria Novatchkova Martin Aichinger Lee Barrett Alban Latremoliere Gerald Wirnsberger Guenther Lametschwandtner Meinrad Busslinger Stephen Zicha Alexandra Latini Simon C Robson Ari Waisman Nick Andrews Michael Costigan Keith M Channon Guenter Weiss Andrey V Kozlov Mark Tebbe Kai Johnsson Clifford J Woolf Josef M Penninger

Nature 2019 Aug;572(7769):E18

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/s41586-019-1459-xDOI Listing
August 2019

Enhanced labile plasma iron in hematopoietic stem cell transplanted patients promotes outgrowth.

Authors:
Verena Petzer Martin Wermke Piotr Tymoszuk Dominik Wolf Markus Seifert Rıdvan Ovaçin Sylvia Berger Dorothea Orth-Höller Lorin Loacker Günter Weiss Hubertus Haas Uwe Platzbecker Igor Theurl

Blood Adv 2019 Jun;3(11):1695-1700

Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1182/bloodadvances.2019000043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560355PMC
June 2019

Classical and intermediate monocytes scavenge non-transferrin-bound iron and damaged erythrocytes.

Authors:
David Haschka Verena Petzer Florian Kocher Christoph Tschurtschenthaler Benedikt Schaefer Markus Seifert Sieghart Sopper Thomas Sonnweber Clemens Feistritzer Tara L Arvedson Heinz Zoller Reinhard Stauder Igor Theurl Guenter Weiss Piotr Tymoszuk

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Internal Medicine II.

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https://insight.jci.org/articles/view/98867
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http://dx.doi.org/10.1172/jci.insight.98867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538345PMC
April 2019

Dopamine Is a Siderophore-Like Iron Chelator That Promotes Serovar Typhimurium Virulence in Mice.

Authors:
Stefanie Dichtl Egon Demetz David Haschka Piotr Tymoszuk Verena Petzer Manfred Nairz Markus Seifert Alexander Hoffmann Natascha Brigo Reinhard Würzner Igor Theurl Joyce E Karlinsey Ferric C Fang Günter Weiss

MBio 2019 02 5;10(1). Epub 2019 Feb 5.

Department of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria

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http://dx.doi.org/10.1128/mBio.02624-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428752PMC
February 2019

Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome.

Authors:
David Haschka Chiara Volani Ambra Stefani Piotr Tymoszuk Thomas Mitterling Evi Holzknecht Anna Heidbreder Stefan Coassin Zuzana Sumbalova Markus Seifert Stefanie Dichtl Igor Theurl Erich Gnaiger Florian Kronenberg Birgit Frauscher Birgit Högl Guenter Weiss

Mov Disord 2019 01 11;34(1):114-123. Epub 2018 Oct 11.

Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1002/mds.27482DOI Listing
January 2019

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Authors:
Shane J F Cronin Corey Seehus Adelheid Weidinger Sebastien Talbot Sonja Reissig Markus Seifert Yann Pierson Eileen McNeill Maria Serena Longhi Bruna Lenfers Turnes Taras Kreslavsky Melanie Kogler David Hoffmann Melita Ticevic Débora da Luz Scheffer Luigi Tortola Domagoj Cikes Alexander Jais Manu Rangachari Shuan Rao Magdalena Paolino Maria Novatchkova Martin Aichinger Lee Barrett Alban Latremoliere Gerald Wirnsberger Guenther Lametschwandtner Meinrad Busslinger Stephen Zicha Alexandra Latini Simon C Robson Ari Waisman Nick Andrews Michael Costigan Keith M Channon Guenter Weiss Andrey V Kozlov Mark Tebbe Kai Johnsson Clifford J Woolf Josef M Penninger

Nature 2018 11 7;563(7732):564-568. Epub 2018 Nov 7.

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.

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http://www.nature.com/articles/s41586-018-0701-2
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http://dx.doi.org/10.1038/s41586-018-0701-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438708PMC
November 2018

Correction for Wu et al., "Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages via Modulation of NF-κB Signaling".

Authors:
Aimin Wu Piotr Tymoszuk David Haschka Simon Heeke Stefanie Dichtl Verena Petzer Markus Seifert Richard Hilbe Sieghart Sopper Heribert Talasz Dirk Bumann Cornelia Lass-Flörl Igor Theurl Keying Zhang Guenter Weiss

Infect Immun 2018 03 20;86(3). Epub 2018 Feb 20.

Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1128/IAI.00881-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820951PMC
March 2018

Dopamine promotes cellular iron accumulation and oxidative stress responses in macrophages.

Authors:
Stefanie Dichtl David Haschka Manfred Nairz Markus Seifert Chiara Volani Oliver Lutz Günter Weiss

Biochem Pharmacol 2018 02 5;148:193-201. Epub 2017 Dec 5.

Department of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, A-6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.12.001DOI Listing
February 2018

Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages via Modulation of NF-κB Signaling.

Authors:
Aimin Wu Piotr Tymoszuk David Haschka Simon Heeke Stefanie Dichtl Verena Petzer Markus Seifert Richard Hilbe Sieghart Sopper Heribert Talasz Dirk Bumann Cornelia Lass-Flörl Igor Theurl Keying Zhang Guenter Weiss

Infect Immun 2017 12 17;85(12). Epub 2017 Nov 17.

Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria

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http://dx.doi.org/10.1128/IAI.00418-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695101PMC
December 2017

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.

Authors:
Malte Asshoff Verena Petzer Matthew R Warr David Haschka Piotr Tymoszuk Egon Demetz Markus Seifert Wilfried Posch Manfred Nairz Pat Maciejewski Peter Fowles Christopher J Burns Gregg Smith Kay-Uwe Wagner Guenter Weiss J Andrew Whitney Igor Theurl

Blood 2017 03 10;129(13):1823-1830. Epub 2017 Feb 10.

Department of Internal Medicine VI (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1182/blood-2016-09-740092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693322PMC
March 2017

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.

Authors:
Igor Theurl Ingo Hilgendorf Manfred Nairz Piotr Tymoszuk David Haschka Malte Asshoff Shun He Louisa M S Gerhardt Tobias A W Holderried Markus Seifert Sieghart Sopper Ashley M Fenn Atsushi Anzai Sara Rattik Cameron McAlpine Milan Theurl Peter Wieghofer Yoshiko Iwamoto Georg F Weber Nina K Harder Benjamin G Chousterman Tara L Arvedson Mary McKee Fudi Wang Oliver M D Lutz Emanuele Rezoagli Jodie L Babitt Lorenzo Berra Marco Prinz Matthias Nahrendorf Guenter Weiss Ralph Weissleder Herbert Y Lin Filip K Swirski

Nat Med 2016 08 18;22(8):945-51. Epub 2016 Jul 18.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.4146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957133PMC
August 2016

The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients.

Authors:
Juliana Casimiro de Almeida Randall Lou-Meda Marion Olbert Markus Seifert Günter Weiss Erwin T Wiegerinck Dorine W Swinkels Noel W Solomons Klaus Schümann

PLoS One 2015 7;10(10):e0140062. Epub 2015 Oct 7.

Molecular Nutrition Unit, ZIEL, Research Center for Nutrition and Food Science, Technische Universität München, Freising, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140062PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596869PMC
June 2016

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB.

Authors:
Thomas Sonnweber David Nachbaur Andrea Schroll Manfred Nairz Markus Seifert Egon Demetz David Haschka Anna-Maria Mitterstiller Axel Kleinsasser Martin Burtscher Susanne Trübsbach Anthony T Murphy Victor Wroblewski Derrick R Witcher Katarzyna Mleczko-Sanecka Chiara Vecchi Martina U Muckenthaler Antonello Pietrangelo Igor Theurl Günter Weiss

Gut 2014 Dec 5;63(12):1951-9. Epub 2014 Mar 5.

Department of Internal Medicine VI, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1136/gutjnl-2013-305317DOI Listing
December 2014

Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients.

Authors:
John B Porter Patrick B Walter Lynne D Neumayr Patricia Evans Sukhvinder Bansal Maciej Garbowski Marcela G Weyhmiller Paul R Harmatz John C Wood Jeffery L Miller Colleen Byrnes Guenter Weiss Markus Seifert Regine Grosse Dagmar Grabowski Angelica Schmidt Roland Fischer Peter Nielsen Charlotte Niemeyer Elliott Vichinsky

Br J Haematol 2014 Dec 11;167(5):692-6. Epub 2014 Sep 11.

Department of Haematology, University College London, London, UK.

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http://dx.doi.org/10.1111/bjh.13081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577015PMC
December 2014

The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.

Authors:
Egon Demetz Andrea Schroll Kristina Auer Christiane Heim Josef R Patsch Philipp Eller Markus Theurl Igor Theurl Milan Theurl Markus Seifert Daniela Lener Ursula Stanzl David Haschka Malte Asshoff Stefanie Dichtl Manfred Nairz Eva Huber Martin Stadlinger Alexander R Moschen Xiaorong Li Petra Pallweber Hubert Scharnagl Tatjana Stojakovic Winfried März Marcus E Kleber Katia Garlaschelli Patrizia Uboldi Alberico L Catapano Frans Stellaard Mats Rudling Keiji Kuba Yumiko Imai Makoto Arita John D Schuetz Peter P Pramstaller Uwe J F Tietge Michael Trauner Giuseppe D Norata Thierry Claudel Andrew A Hicks Guenter Weiss Ivan Tancevski

Cell Metab 2014 Nov;20(5):787-798

Department of Internal Medicine VI, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232508PMC
November 2014

Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats.

Authors:
Milan Theurl Manfred Nairz Andrea Schroll Thomas Sonnweber Malte Asshoff David Haschka Markus Seifert Wolfgang Willenbacher Doris Wilflingseder Wilfried Posch Anthony T Murphy Derrick R Witcher Igor Theurl Günter Weiss

Haematologica 2014 Sep 3;99(9):1516-24. Epub 2014 Jun 3.

Department of Internal Medicine VI, Innsbruck Medical University, Innsbruck, Austria

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http://dx.doi.org/10.3324/haematol.2013.099481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562542PMC
September 2014

Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis.

Authors:
Rosa Bellmann-Weiler Andrea Schroll Sabine Engl Manfred Nairz Heribert Talasz Markus Seifert Guenter Weiss

Immunobiology 2013 Jul 21;218(7):969-78. Epub 2012 Nov 21.

Department of Internal Medicine VI, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Austria.

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http://ac.els-cdn.com/S0171298512005359/1-s2.0-S017129851200
Web Search
http://link.springer.com/content/pdf/10.1007/s00430-015-0394
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S017129851200535
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http://dx.doi.org/10.1016/j.imbio.2012.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657155PMC
July 2013

Candidate gene sequencing of SLC11A2 and TMPRSS6 in a family with severe anaemia: common SNPs, rare haplotypes, no causative mutation.

Authors:
Anita Kloss-Brandstätter Gertraud Erhart Claudia Lamina Bernhard Meister Margot Haun Stefan Coassin Markus Seifert Andreas Klein-Franke Bernhard Paulweber Lyudmyla Kedenko Barbara Kollerits Dorine W Swinkels Sita H Vermeulen Tessel E Galesloot Florian Kronenberg Günter Weiss

PLoS One 2012 11;7(4):e35015. Epub 2012 Apr 11.

Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035015PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324414PMC
August 2012

Effects of erythropoietin on frataxin levels and mitochondrial function in Friedreich ataxia--a dose-response trial.

Authors:
Wolfgang Nachbauer Sascha Hering Markus Seifert Hannes Steinkellner Brigitte Sturm Barbara Scheiber-Mojdehkar Markus Reindl Alexander Strasak Werner Poewe Guenter Weiss Sylvia Boesch

Cerebellum 2011 Dec;10(4):763-9

Department of Neurology, Medical University Innsbruck, Anichstrasse 35, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s12311-011-0287-9DOI Listing
December 2011

Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo.

Authors:
Igor Theurl Andrea Schroll Manfred Nairz Markus Seifert Milan Theurl Thomas Sonnweber Hasan Kulaksiz Guenter Weiss

Haematologica 2011 Dec 22;96(12):1761-9. Epub 2011 Aug 22.

Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.3324/haematol.2011.048926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232257PMC
December 2011

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats.

Authors:
Igor Theurl Andrea Schroll Thomas Sonnweber Manfred Nairz Milan Theurl Wolfgang Willenbacher Kathrin Eller Dominik Wolf Markus Seifert Chia Chi Sun Jodie L Babitt Charles C Hong Tracey Menhall Patrick Gearing Herbert Y Lin Guenter Weiss

Blood 2011 Nov 5;118(18):4977-84. Epub 2011 Jul 5.

Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1182/blood-2011-03-345066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208302PMC
November 2011

Reciprocal responses of fibroblasts and melanocytes to α-MSH depending on MC1R polymorphisms.

Authors:
Hedwig Stanisz Markus Seifert Wolfgang Tilgen Thomas Vogt Knuth Rass

Dermatoendocrinol 2011 Oct 1;3(4):259-65. Epub 2011 Oct 1.

Department of Dermatology, Venerology and Allergology; University Hospital of Saarland; Homburg, Germany.

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http://dx.doi.org/10.4161/derm.3.4.17454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256344PMC
October 2011

Discovery and hit-to-lead optimization of novel allosteric glucokinase activators.

Authors:
Martin Lang Markus H-J Seifert Kristina K Wolf Andrea Aschenbrenner Roland Baumgartner Tanja Wieber Viola Trentinaglia Marcus Blisse Nobumitsu Tajima Tokuyuki Yamashita Daniel Vitt Hitoshi Noda

Bioorg Med Chem Lett 2011 Sep 18;21(18):5417-22. Epub 2011 Jul 18.

4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X1100937
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http://dx.doi.org/10.1016/j.bmcl.2011.06.128DOI Listing
September 2011

Impact of iron treatment on immune effector function and cellular iron status of circulating monocytes in dialysis patients.

Authors:
Thomas Sonnweber Igor Theurl Markus Seifert Andrea Schroll Susanne Eder Gert Mayer Günter Weiss

Nephrol Dial Transplant 2011 Mar 8;26(3):977-87. Epub 2010 Sep 8.

Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria.

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https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/
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http://dx.doi.org/10.1093/ndt/gfq483DOI Listing
March 2011

Peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) signaling pathways in melanoma cells: promising new therapeutic targets?

Authors:
Pit Sertznig Markus Seifert Wolfgang Tilgen Jörg Reichrath

J Steroid Biochem Mol Biol 2010 Jul 7;121(1-2):383-6. Epub 2010 Mar 7.

Department of Dermatology, University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2010.03.003DOI Listing
July 2010

1,25-dihydroxyvitamin D3 modulates effects of ionizing radiation (IR) on human keratinocytes: in vitro analysis of cell viability/proliferation, DNA-damage and -repair.

Authors:
Lea Trémezaygues Markus Seifert Thomas Vogt Wolfgang Tilgen Jörg Reichrath

J Steroid Biochem Mol Biol 2010 Jul 7;121(1-2):324-7. Epub 2010 Mar 7.

Department of Dermatology, The Saarland University Hospital, Kirrberger Str., 66421 Homburg/Saar, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S096007601000096
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http://dx.doi.org/10.1016/j.jsbmb.2010.03.007DOI Listing
July 2010

Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia.

Authors:
Igor Theurl Armin Finkenstedt Andrea Schroll Manfred Nairz Thomas Sonnweber Rosa Bellmann-Weiler Milan Theurl Markus Seifert Victor J Wroblewski Anthony T Murphy Derrick Witcher Heinz Zoller Günter Weiss

Br J Haematol 2010 Feb 15;148(3):449-55. Epub 2009 Oct 15.

Deparment of Medicine I, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07961.xDOI Listing
February 2010

Iron absorption and distribution in TNF(DeltaARE/+) mice, a model of chronic inflammation.

Authors:
Klaus Schümann Nadia Herbach Christina Kerling Markus Seifert Carine Fillebeen Isabella Prysch Jens Reich Günter Weiss Kostas Pantopoulos

J Trace Elem Med Biol 2010 Jan 17;24(1):58-66. Epub 2009 Nov 17.

Science Centre Weihenstephan, Technical University Munich, 85350 Freising, Germany.

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http://dx.doi.org/10.1016/j.jtemb.2009.10.002DOI Listing
January 2010

Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.

Authors:
Manfred Nairz Igor Theurl Andrea Schroll Milan Theurl Gernot Fritsche Ewald Lindner Markus Seifert Marie-Laure V Crouch Klaus Hantke Shizuo Akira Ferric C Fang Günter Weiss

Blood 2009 Oct 21;114(17):3642-51. Epub 2009 Aug 21.

Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-05-22
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http://dx.doi.org/10.1182/blood-2009-05-223354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766679PMC
October 2009

Robust optimization of scoring functions for a target class.

Authors:
Markus H J Seifert

J Comput Aided Mol Des 2009 Sep 27;23(9):633-44. Epub 2009 May 27.

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http://dx.doi.org/10.1007/s10822-009-9276-1DOI Listing
September 2009

Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells.

Authors:
Pit Sertznig Tom Dunlop Markus Seifert Wolfgang Tilgen Jörg Reichrath

Anticancer Res 2009 Sep;29(9):3647-58

Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany.

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September 2009

Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitro.

Authors:
Markus Seifert Wolfgang Tilgen Jörg Reichrath

Anticancer Res 2009 Sep;29(9):3659-67

Universitäts-Hautklinik, Universitätsklinikum des Saarlandes, Homburg, Germany.

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September 2009

Activation of vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling pathways through 1,25(OH)(2)D(3) in melanoma cell lines and other skin-derived cell lines.

Authors:
Pit Sertznig Markus Seifert Wolfgang Tilgen Jörg Reichrath

Dermatoendocrinol 2009 Jul;1(4):232-8

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835881PMC
http://dx.doi.org/10.4161/derm.1.4.9629DOI Listing
July 2009

1,25-dihydroxyvitamin D(3) protects human keratinocytes against UV-B-induced damage: In vitro analysis of cell viability/proliferation, DNA-damage and -repair.

Authors:
Lea Trémezaygues Markus Seifert Wolfgang Tilgen Jörg Reichrath

Dermatoendocrinol 2009 Jul;1(4):239-45

Department of Dermatology; The Saarland University Hospital; Homburg/Saar, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835882PMC
http://dx.doi.org/10.4161/derm.1.4.9705DOI Listing
July 2009

Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.

Authors:
Bianca Sperl Markus H J Seifert Thorsten Berg

Bioorg Med Chem Lett 2009 Jun 23;19(12):3305-9. Epub 2009 Apr 23.

Department of Molecular Biology, Max Planck Institute of Biochemistry, and Center for Integrated Protein Science Munich, Am Klopferspitz 18, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.bmcl.2009.04.083DOI Listing
June 2009

Targeted scoring functions for virtual screening.

Authors:
Markus H J Seifert

Drug Discov Today 2009 Jun 5;14(11-12):562-9. Epub 2009 Apr 5.

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http://dx.doi.org/10.1016/j.drudis.2009.03.013DOI Listing
June 2009

Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications.

Authors:
Igor Theurl Elmar Aigner Milan Theurl Manfred Nairz Markus Seifert Andrea Schroll Thomas Sonnweber Lukas Eberwein Derrick R Witcher Anthony T Murphy Victor J Wroblewski Eva Wurz Christian Datz Guenter Weiss

Blood 2009 May 17;113(21):5277-86. Epub 2009 Mar 17.

Department of Internal Medicine I, Medical University of Innsbruck, Austria.

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http://dx.doi.org/10.1182/blood-2008-12-195651DOI Listing
May 2009

Characterization of the vitamin D endocrine system in human sebocytes in vitro.

Authors:
Christina Krämer Holger Seltmann Markus Seifert Wolfgang Tilgen Christos C Zouboulis Jörg Reichrath

J Steroid Biochem Mol Biol 2009 Jan 5;113(1-2):9-16. Epub 2008 Nov 5.

Department of Dermatology, The Saarland University Hospital, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2008.10.010DOI Listing
January 2009

Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease.

Authors:
Elmar Aigner Igor Theurl Heike Haufe Markus Seifert Florian Hohla Ludwig Scharinger Felix Stickel Frederic Mourlane Günter Weiss Christian Datz

Gastroenterology 2008 Aug 15;135(2):680-8. Epub 2008 Apr 15.

General Hospital Oberndorf, Department of Internal Medicine, Oberndorf, Austria.

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http://dx.doi.org/10.1053/j.gastro.2008.04.007DOI Listing
August 2008

Proteasome inhibition by peptide-semicarbazones.

Authors:
Johann Leban Marcus Blisse Babett Krauss Sandra Rath Roland Baumgartner Markus H J Seifert

Bioorg Med Chem 2008 Apr 15;16(8):4579-88. Epub 2008 Feb 15.

4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany.

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http://dx.doi.org/10.1016/j.bmc.2008.02.042DOI Listing
April 2008

Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases.

Authors:
Pit Sertznig Markus Seifert Wolfgang Tilgen Jörg Reichrath

Am J Clin Dermatol 2008 ;9(1):15-31

Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany.

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http://dx.doi.org/10.2165/00128071-200809010-00002DOI Listing
March 2008

Optimizing the signal-to-noise ratio of scoring functions for protein--ligand docking.

Authors:
Markus H J Seifert

J Chem Inf Model 2008 Mar 23;48(3):602-12. Epub 2008 Feb 23.

4SC AG, Am Klopferspitz 19a, D-82152 Planegg-Martinsried, Germany.

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http://dx.doi.org/10.1021/ci700345nDOI Listing
March 2008

Autocrine formation of hepcidin induces iron retention in human monocytes.

Authors:
Igor Theurl Milan Theurl Markus Seifert Sabine Mair Manfred Nairz Holger Rumpold Heinz Zoller Rosa Bellmann-Weiler Harald Niederegger Heribert Talasz Günter Weiss

Blood 2008 Feb 11;111(4):2392-9. Epub 2007 Dec 11.

Department of General Internal Medicine, Medical University, Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1182/blood-2007-05-090019DOI Listing
February 2008

The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.

Authors:
Markus Seifert Stefan J Scherer Wilfried Edelmann Markus Böhm Viktor Meineke Markus Löbrich Wolfgang Tilgen Jörg Reichrath

J Invest Dermatol 2008 Jan 5;128(1):203-13. Epub 2007 Jul 5.

Department of Dermatology, The Saarland University Hospital, Homburg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1533605
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http://dx.doi.org/10.1038/sj.jid.5700941DOI Listing
January 2008

Essential factors for successful virtual screening.

Authors:
Markus H J Seifert Martin Lang

Mini Rev Med Chem 2008 Jan;8(1):63-72

4SC AG, Am Klopferspitz 19A, D-82152 Planegg-Martinsried, Germany.

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http://dx.doi.org/10.2174/138955708783331540DOI Listing
January 2008

A novel class of potent NF-kappaB signaling inhibitors.

Authors:
Johann Leban Marcel Baierl Jan Mies Viola Trentinaglia Sandra Rath Kerstin Kronthaler Kristina Wolf Astrid Gotschlich Markus H J Seifert

Bioorg Med Chem Lett 2007 Nov 15;17(21):5858-62. Epub 2007 Aug 15.

4SC AG, Am Klopferspitz 19a, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.bmcl.2007.08.022DOI Listing
November 2007

Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain.

Authors:
Markus Seifert Christina Ampofo Yasmin Mehraein Jörg Reichrath Cornelius Welter

Oncol Rep 2007 May;17(5):1207-11

Department of Human Genetics, Saarland University Hospital, Homburg, Saar, Germany.

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May 2007

Virtual high-throughput screening of molecular databases.

Authors:
Markus H J Seifert Jürgen Kraus Bernd Kramer

Curr Opin Drug Discov Devel 2007 May;10(3):298-307

4SC AG, Am Klopferspitz 19A, D-82152 Planegg-Martinsried, Germany.

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May 2007

In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells.

Authors:
Jörg Reichrath Martin Rech Maryam Moeini Eckart Meese Wolfgang Tilgen Markus Seifert

Cancer Biol Ther 2007 Jan;6(1):48-55

Department of Dermatology , The Saarland University Hospital, Homburg Germany.

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http://dx.doi.org/10.4161/cbt.6.1.3493DOI Listing
January 2007

The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer.

Authors:
Markus Seifert Jörg Reichrath

J Mol Histol 2006 Sep 2;37(5-7):301-7. Epub 2006 Nov 2.

Department of Dermatology, The Saarland University Hospital, Building 18, Kirrberger Strasse, 66421 Homburg, Germany.

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http://dx.doi.org/10.1007/s10735-006-9062-5DOI Listing
September 2006

Expression analysis of CYP27B1 in tumor biopsies and cell cultures.

Authors:
Jens Radermacher Britta Diesel Markus Seifert Wolfgang Tilgen Jörg Reichrath Ulrike Fischer Eckart Meese

Anticancer Res 2006 Jul-Aug;26(4A):2683-6

Department of Human Genetics, The Saarland University Hospital, 66421 Homburg/Saar, Germany.

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August 2006

Cutaneous photosynthesis of vitamin D: an evolutionary highly-conserved endocrine system that protects against environmental hazards including UV-radiation and microbial infections.

Authors:
Lea Tremezaygues Michael Sticherling Claudia Pföhler Michael Friedrich Viktor Meineke Markus Seifert Wolfgang Tilgen Jörg Reichrath

Anticancer Res 2006 Jul-Aug;26(4A):2743-8

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.

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August 2006

ProPose: steered virtual screening by simultaneous protein-ligand docking and ligand-ligand alignment.

Authors:
Markus H J Seifert

J Chem Inf Model 2005 Mar-Apr;45(2):449-60

4SC AG, Am Klopferspitz 19a, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1021/ci0496393DOI Listing
June 2006

Assessing the discriminatory power of scoring functions for virtual screening.

Authors:
Markus H J Seifert

J Chem Inf Model 2006 May-Jun;46(3):1456-65

4SC AG, Am Klopferspitz 19a, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1021/ci060027nDOI Listing
June 2006

Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease.

Authors:
Igor Theurl Verena Mattle Markus Seifert Mariagabriella Mariani Christian Marth Günter Weiss

Blood 2006 May 24;107(10):4142-8. Epub 2006 Jan 24.

Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-08-33
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http://dx.doi.org/10.1182/blood-2005-08-3364DOI Listing
May 2006

Human endogenous retrovirus HERV-K(HML-2) Rec expression and transcriptional activities in normal and rheumatoid arthritis synovia.

Authors:
Sandra Ehlhardt Markus Seifert Johannes Schneider Andreas Ojak Klaus D Zang Yasmin Mehraein

J Rheumatol 2006 Jan;33(1):16-23

Department of Human Genetics and Department of Dermatology, Saarland University, University Hospital, Homburg/Saar, Germany.

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January 2006

Pathways for the regulation of body iron homeostasis in response to experimental iron overload.

Authors:
Igor Theurl Susanne Ludwiczek Philipp Eller Markus Seifert Erika Artner Peter Brunner Günter Weiss

J Hepatol 2005 Oct;43(4):711-9

Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Anichstr. 35, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.jhep.2005.03.030DOI Listing
October 2005

Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol.

Authors:
Britta Diesel Jens Radermacher Matthias Bureik Rita Bernhardt Markus Seifert Jörg Reichrath Ulrike Fischer Eckart Meese

Clin Cancer Res 2005 Aug;11(15):5370-80

Institut für Humangenetik, Theoretische Medizin, Universität des Saarlandes, Saarbrücken, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1968DOI Listing
August 2005

ProPose: a docking engine based on a fully configurable protein-ligand interaction model.

Authors:
Markus H J Seifert Frank Schmitt Thomas Herz Bernd Kramer

J Mol Model 2004 Dec 8;10(5-6):342-57. Epub 2004 Oct 8.

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http://dx.doi.org/10.1007/s00894-004-0201-1DOI Listing
December 2004

No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM).

Authors:
Jörg Reichrath Leyla Rafi Martin Rech Viktor Meineke Wolfgang Tilgen Markus Seifert

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):163-6

Department of Dermatology, The Saarland University Hospital, Kirrberger Str., 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.096DOI Listing
May 2004

Differential biological effects of 1,25-dihydroxyVitamin D3 on melanoma cell lines in vitro.

Authors:
Markus Seifert Martin Rech Viktor Meineke Wolfgang Tilgen Jörg Reichrath

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):375-9

Department of Dermatology, The Saarland University Hospital, Homburg, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.002DOI Listing
May 2004

Towards a complete picture of splice variants of the gene for 25-hydroxyvitamin D31alpha-hydroxylase in brain and skin cancer.

Authors:
Britta Diesel Markus Seifert Jens Radermacher Ulrike Fischer Wolfgang Tilgen Jörg Reichrath Eckart Meese

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):527-32

Institut für Humangenetik, Theoretische Medizin, Bldg. 60, Universität des Saarlandes, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.062DOI Listing
May 2004

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

Authors:
Jens Mayer Sandra Ehlhardt Markus Seifert Marlies Sauter Nikolaus Müller-Lantzsch Yasmin Mehraein Klaus-Dieter Zang Eckart Meese

Virology 2004 Apr;322(1):190-8

Department of Human Genetics, Medical Faculty, University of Saarland, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.virol.2004.01.023DOI Listing
April 2004

Vitamin D-induced apoptosis and melanoma: does calpain represent the major execution protease rather than caspases?

Authors:
Jörg Reichrath Martin Rech Markus Seifert

J Pathol 2003 Oct;201(2):335-6

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http://dx.doi.org/10.1002/path.1445DOI Listing
October 2003

Expansion of the genetic code enables design of a novel "gold" class of green fluorescent proteins.

Authors:
Jae Hyun Bae Marina Rubini Gregor Jung Georg Wiegand Markus H J Seifert M Kamran Azim Jeong Sun Kim Andreas Zumbusch Tad A Holak Luis Moroder Robert Huber Nediljko Budisa

J Mol Biol 2003 May;328(5):1071-81

Max-Planck-Institut für Biochemie, Am Klopferspitz 18A, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/s0022-2836(03)00364-4DOI Listing
May 2003

Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin.

Authors:
Jörg Reichrath Cornelius Welter Tanja Mitschele Ulf Classen Viktor Meineke Wolfgang Tilgen Markus Seifert

J Pathol 2003 Apr;199(4):509-16

Department of Dermatology, University of Saarland, Homburg, Germany.

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http://dx.doi.org/10.1002/path.1308DOI Listing
April 2003

Backbone dynamics of green fluorescent protein and the effect of histidine 148 substitution.

Authors:
Markus H J Seifert Julia Georgescu Dorota Ksiazek Pawel Smialowski Till Rehm Boris Steipe Tad A Holak

Biochemistry 2003 Mar;42(9):2500-12

Max-Planck-Institute for Biochemistry, 82152 Martinsried, Germany, and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1021/bi026481bDOI Listing
March 2003

Purification, crystallization, NMR spectroscopy and biochemical analyses of alpha-phycoerythrocyanin peptides.

Authors:
Georg Wiegand Axel Parbel Markus H J Seifert Tad A Holak Wolfgang Reuter

Eur J Biochem 2002 Oct;269(20):5046-55

Max-Planck-Institut für Biochemie, Martinsried, Germany.

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http://dx.doi.org/10.1046/j.1432-1033.2002.03221.xDOI Listing
October 2002

Slow exchange in the chromophore of a green fluorescent protein variant.

Authors:
Markus H J Seifert Dorota Ksiazek M Kamran Azim Pawel Smialowski Nediljko Budisa Tad A Holak

J Am Chem Soc 2002 Jul;124(27):7932-42

Max-Planck-Institute for Biochemistry, 82152 Martinsried, Munich, Germany.

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http://dx.doi.org/10.1021/ja0257725DOI Listing
July 2002

Phosphorylation and flexibility of cyclic-AMP-dependent protein kinase (PKA) using (31)P NMR spectroscopy.

Authors:
Markus H J Seifert Christine B Breitenlechner Dirk Bossemeyer Robert Huber Tad A Holak Richard A Engh

Biochemistry 2002 May;41(19):5968-77

Abteilung Strukturforschung, Max-Planck-Institut für Biochemie, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1021/bi025509gDOI Listing
May 2002