Publications by authors named "Markus Metzler"

92Publications

Horn of plenty: Value of the international registry for pediatric chronic myeloid leukemia.

World J Clin Oncol 2020 Jun;11(6):308-319

Inserm CIC 1402, University Hospital Poitiers, Poitiers F-86000, France.

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http://dx.doi.org/10.5306/wjco.v11.i6.308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450816PMC
June 2020

Vaccination With Live Attenuated Vaccines in Four Children With Chronic Myeloid Leukemia While on Imatinib Treatment.

Front Immunol 2020 17;11:628. Epub 2020 Apr 17.

Medical Faculty, Pediatric Hemato-Oncology, Technical University Dresden, Dresden, Germany.

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http://dx.doi.org/10.3389/fimmu.2020.00628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181227PMC
April 2020

Model-Based Simulation of Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia.

Front Physiol 2020 18;11:217. Epub 2020 Mar 18.

Department of Mathematics, Institute of Mathematical Optimization, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

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http://dx.doi.org/10.3389/fphys.2020.00217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093595PMC
March 2020

Distribution and Cytokine Profile of Peripheral B Cell Subsets Is Perturbed in Pediatric IBD and Partially Restored During a Successful IFX Therapy.

Inflamm Bowel Dis 2020 Mar 18. Epub 2020 Mar 18.

Pediatric Gastroenterology and Hepatology, Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1093/ibd/izaa054DOI Listing
March 2020

Blood counts in adult and elderly individuals: defining the norms over eight decades of life.

Br J Haematol 2020 May 6;189(4):777-789. Epub 2020 Feb 6.

Department of Medicine 5 - Haematology and Oncology, University Hospital Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1111/bjh.16430DOI Listing
May 2020

Reference Interval Estimation from Mixed Distributions using Truncation Points and the Kolmogorov-Smirnov Distance (kosmic).

Sci Rep 2020 02 3;10(1):1704. Epub 2020 Feb 3.

Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1038/s41598-020-58749-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997422PMC
February 2020

Molecular Composition of Genomic Rearrangements in Prostate Cancer.

Dis Markers 2019 12;2019:5085373. Epub 2019 Dec 12.

Department of Pediatrics, University Hospital Erlangen, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1155/2019/5085373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930771PMC
May 2020

Data mining of reference intervals for coagulation screening tests in adult patients.

Clin Chim Acta 2019 Dec 9;499:108-114. Epub 2019 Sep 9.

Department of Transfusion Medicine and Haemostaseology, University Hospital of Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1016/j.cca.2019.09.006DOI Listing
December 2019

The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns.

Blood 2019 10;134(16):1355-1358

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1182/blood.2019002215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005361PMC
October 2019

The German National Registry of Primary Immunodeficiencies (2012-2017).

Authors:
Sabine M El-Helou Anika-Kerstin Biegner Sebastian Bode Stephan R Ehl Maximilian Heeg Maria E Maccari Henrike Ritterbusch Carsten Speckmann Stephan Rusch Raphael Scheible Klaus Warnatz Faranaz Atschekzei Renata Beider Diana Ernst Stev Gerschmann Alexandra Jablonka Gudrun Mielke Reinhold E Schmidt Gesine Schürmann Georgios Sogkas Ulrich H Baumann Christian Klemann Dorothee Viemann Horst von Bernuth Renate Krüger Leif G Hanitsch Carmen M Scheibenbogen Kirsten Wittke Michael H Albert Anna Eichinger Fabian Hauck Christoph Klein Anita Rack-Hoch Franz M Sollinger Anne Avila Michael Borte Stephan Borte Maria Fasshauer Anja Hauenherm Nils Kellner Anna H Müller Anett Ülzen Peter Bader Shahrzad Bakhtiar Jae-Yun Lee Ursula Heß Ralf Schubert Sandra Wölke Stefan Zielen Sujal Ghosh Hans-Juergen Laws Jennifer Neubert Prasad T Oommen Manfred Hönig Ansgar Schulz Sandra Steinmann Klaus Schwarz Gregor Dückers Beate Lamers Vanessa Langemeyer Tim Niehues Sonu Shai Dagmar Graf Carmen Müglich Marc T Schmalzing Eva C Schwaneck Hans-Peter Tony Johannes Dirks Gabriele Haase Johannes G Liese Henner Morbach Dirk Foell Antje Hellige Helmut Wittkowski Katja Masjosthusmann Michael Mohr Linda Geberzahn Christian M Hedrich Christiane Müller Angela Rösen-Wolff Joachim Roesler Antje Zimmermann Uta Behrends Nikolaus Rieber Uwe Schauer Rupert Handgretinger Ursula Holzer Jörg Henes Lothar Kanz Christoph Boesecke Jürgen K Rockstroh Carolynne Schwarze-Zander Jan-Christian Wasmuth Dagmar Dilloo Brigitte Hülsmann Stefan Schönberger Stefan Schreiber Rainald Zeuner Tobias Ankermann Philipp von Bismarck Hans-Iko Huppertz Petra Kaiser-Labusch Johann Greil Donate Jakoby Andreas E Kulozik Markus Metzler Nora Naumann-Bartsch Bettina Sobik Norbert Graf Sabine Heine Robin Kobbe Kai Lehmberg Ingo Müller Friedrich Herrmann Gerd Horneff Ariane Klein Joachim Peitz Nadine Schmidt Stefan Bielack Ute Groß-Wieltsch Carl F Classen Jessica Klasen Peter Deutz Dirk Kamitz Lisa Lassay Klaus Tenbrock Norbert Wagner Benedikt Bernbeck Bastian Brummel Eusebia Lara-Villacanas Esther Münstermann Dominik T Schneider Nadine Tietsch Marco Westkemper Michael Weiß Christof Kramm Ingrid Kühnle Silke Kullmann Hermann Girschick Christof Specker Elisabeth Vinnemeier-Laubenthal Henriette Haenicke Claudia Schulz Lothar Schweigerer Thomas G Müller Martina Stiefel Bernd H Belohradsky Veronika Soetedjo Gerhard Kindle Bodo Grimbacher

Front Immunol 2019 19;10:1272. Epub 2019 Jul 19.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.01272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659583PMC
July 2019

Large amplicon droplet digital PCR for DNA-based monitoring of pediatric chronic myeloid leukaemia.

J Cell Mol Med 2019 08 14;23(8):4955-4961. Epub 2019 Jun 14.

Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1111/jcmm.14321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653534PMC
August 2019

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 06 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
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http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
June 2019

Computed Tomography-Guided Wire-Marking for Thoracoscopic Resection of Small Lung Nodules in Children.

J Laparoendosc Adv Surg Tech A 2019 May 4;29(5):688-693. Epub 2019 Apr 4.

1 Department of Paediatric Surgery, University Medical Center Erlangen, Friedrich-Alexander-University of Erlangen-Nuremberg (FAU), Erlangen, Germany.

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http://dx.doi.org/10.1089/lap.2018.0184DOI Listing
May 2019

A mathematical model of white blood cell dynamics during maintenance therapy of childhood acute lymphoblastic leukemia.

Math Med Biol 2019 12;36(4):471-488

Institute of Mathematical Optimization, Faculty of Mathematics, Otto-von-Guericke University Magdeburg, Germany.

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https://academic.oup.com/imammb/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/imammb/dqy017DOI Listing
December 2019

Generic formulations of imatinib for treatment of Philadelphia chromosome-positive leukemia in pediatric patients.

Pediatr Blood Cancer 2018 12 30;65(12):e27431. Epub 2018 Aug 30.

Department of General Pediatrics, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Universitäts-Kinderklinik, Kiel, Germany.

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http://dx.doi.org/10.1002/pbc.27431DOI Listing
December 2018

Adrenal crisis in a 14-year-old boy 12 years after hematopoietic stem cell transplantation.

Endocrinol Diabetes Metab Case Rep 2018 6;2018. Epub 2018 Jun 6.

Divisions of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine, University Hospital of Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1530/EDM-18-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993059PMC
June 2018

A Comparison of GFR Estimation Formulae in Pediatric Oncology.

Klin Padiatr 2018 Apr 9;230(3):142-150. Epub 2018 Apr 9.

Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1055/a-0587-5753DOI Listing
April 2018

Pharmacology and pharmacokinetics of imatinib in pediatric patients.

Expert Rev Clin Pharmacol 2018 Mar 6;11(3):219-231. Epub 2017 Nov 6.

b I. Medical Clinic , University Hospital 'Carl Gustav Carus' , Dresden , Germany.

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https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1
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http://dx.doi.org/10.1080/17512433.2018.1398644DOI Listing
March 2018

Evaluation of an Interactive Visualization Tool for the Interpretation of Pediatric Laboratory Test Results.

Stud Health Technol Inform 2017 ;243:207-211

Medical Informatics, Univ. of Erlangen-Nürnberg, Erlangen, Germany.

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April 2018

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

Authors:
Rhea van den Bruck Patrick P Weil Thomas Ziegenhals Philipp Schreiner Stefan Juranek Daniel Gödde Silvia Vogel Frauke Schuster Valerie Orth Johannes Dörner Daniel Pembaur Meike Röper Stefan Störkel Hubert Zirngibl Stefan Wirth Andreas C W Jenke Jan Postberg Nikolas Boy Jana Heringer Gisela Haege Esther M Glahn Georg F Hoffmann Sven F Garbade Peter Burgard Stefan Kölker Cho-Ming Chao Faady Yahya Alena Moiseenko Amit Shrestha Negah Ahmadvand Jennifer Quantius Jochen Wilhelm Elie El-Agha Klaus-Peter Zimmer Saverio Bellusci Christian Staufner Stefan Kölker Holger Prokisch Georg F Hoffmann Stephan Seeliger Matthias Müller Andreas Hippe Henrik Steinkraus Roland Wauer Burkhard Lachmann Sigrun R Hofmann Christian M Hedrich Jakob Zierk Farhad Arzideh Rainer Haeckel Wolfgang Rascher Manfred Rauh Markus Metzler Sebastian Thieme Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Michelle P Ashton Malte von Bonin Matthias Kuhn Christian M Hedrich Ezio Bonifacio Reinhard Berner Sebastian Brenner Johanna Hammersen Cristina Has Nora Naumann-Bartsch Daniel Stachel Dimitra Kiritsi Stephan Söder Mathilde Tardieu Markus Metzler Leena Bruckner-Tuderman Holm Schneider F Bohne D Langer R Cencic T Eggermann U Zechner J Pelletier F Zepp T Enklaar D Prawitt Martin Pech Markus Weckmann Femke-Anouska Heinsen Andre Franke Christine Happle Anna-Maria Dittrich Gesine Hansen Oliver Fuchs Erika von Mutius Brian G Oliver Matthias V Kopp Claudia Paret Alexandra Russo Johanna Theruvath Bettina Keller Khalifa El Malki Nadine Lehmann Arthur Wingerter Marie A Neu Gerhold-Ay Aslihan Wolfgang Wagner Clemens Sommer Torsten Pietsch Larissa Seidmann Jörg Faber Felix Schreiner Merle Ackermann Michael Michalik Eva Rother Andras Bilkei-Gorzo Ildiko Racz Laura Bindila Beat Lutz Jörg Dötsch Andreas Zimmer Joachim Woelfle Hendrik S Fischer Tim L Ullrich Christoph Bührer Christoph Czernik Gerd Schmalisch Robert Stein Sigrun R Hofmann Judith Hagenbuchner Ursula Kiechl-Kohlendorfer Petra Obexer Michael J Ausserlechner Niki T Loges Adrien Tobias Frommer Julia Wallmeier Heymut Omran Soner Öner-Sieben Martina Gimpfl Jan Rozman Martin Irmler Johannes Beckers Martin Hrabe De Angelis Adelbert Roscher Eckhard Wolf Regina Ensenauer Karolina Nemes Michael Frühwald Martin Hasselblatt Reiner Siebert Uwe Kordes Marcel Kool Haicui Wang Holly Hardy Osama Refai Katy E S Barwick Holly H Zimmerman Joachim Weis Emma L Baple Andrew H Crosby Sebahattin Cirak C Hellmuth O Uhl M Standl J Heinrich E Thiering B Koletzko Lena Blümel Kornelius Kerl Daniel Picard Michael C Frühwald Max C Liebau Guido Reifenberger Arndt Borkhardt Martin Hasselblatt Marc Remke D Tews M Wabitsch P Fischer-Posovszky Mike-Andrew Westhoff Lisa Nonnenmacher Julia Langhans Lukas Schneele Nancy Trenkler Klaus-Michael Debatin

Mol Cell Pediatr 2017 May;4(Suppl 1)

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

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http://dx.doi.org/10.1186/s40348-017-0071-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435609PMC
May 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas.

Am J Surg Pathol 2017 Feb;41(2):195-203

*Institute of Pathology ¶Department of Paediatrics, University Hospital, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen †Division of Theoretical Bioinformatics (B080) #Division Molecular Genome Analysis **Genomics & Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg §Institute of Pathology, St. Vincent's Hospital, Karlsruhe ∥Institute of Pathology, Klinikum Augsburg, Augsburg ‡‡Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany ‡Department of Pathology, Faculty of Medicine in Plzen and Charles University Hospital, Biomedical Center ††Department of Pathology, Faculty of Medicine, Charles University, Plzen, Czech Republic.

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http://dx.doi.org/10.1097/PAS.0000000000000752DOI Listing
February 2017

Sclerosing epithelioid fibrosarcoma of the kidney: clinicopathologic and molecular study of a rare neoplasm at a novel location.

Ann Diagn Pathol 2015 Aug 6;19(4):221-5. Epub 2015 May 6.

Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2015.04.005DOI Listing
August 2015

Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence.

Clin Chem 2015 Jul 12;61(7):964-73. Epub 2015 May 12.

Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany;

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http://clinchem.aaccjnls.org/content/clinchem/61/7/964.full.
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http://dx.doi.org/10.1373/clinchem.2015.239731DOI Listing
July 2015

Response monitoring of infant acute myeloid leukemia treatment by quantification of the tumor specific MLL-FNBP1 fusion gene.

Leuk Lymphoma 2015 Mar 17;56(3):793-6. Epub 2014 Jul 17.

Department of Pediatrics, University Hospital Erlangen , Erlangen , Germany.

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http://dx.doi.org/10.3109/10428194.2014.928933DOI Listing
March 2015

Sustained complete molecular remission after imatinib discontinuation in children with chronic myeloid leukemia.

Pediatr Blood Cancer 2014 Nov 9;61(11):2080-2. Epub 2014 May 9.

Department of Pediatric Hematology and Oncology, University Hospital Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/pbc.25090DOI Listing
November 2014

Insights into the infiltrative behavior of adamantinomatous craniopharyngioma in a new xenotransplant mouse model.

Brain Pathol 2015 Jan 19;25(1):1-10. Epub 2014 May 19.

Department of Neuropathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://doi.wiley.com/10.1111/bpa.12148
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http://dx.doi.org/10.1111/bpa.12148DOI Listing
January 2015

DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia.

Br J Haematol 2014 Jul 27;166(2):250-3. Epub 2014 Mar 27.

Division of Paediatric Oncology/Haematology, Department of Paediatrics, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/bjh.12850DOI Listing
July 2014

Clustering of genomic breakpoints at the MLL locus in therapy-related acute leukemia with t(4;11)(q21;q23).

Genes Chromosomes Cancer 2014 Mar 5;53(3):248-54. Epub 2013 Dec 5.

Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy; Laboratorio di Neuro-Oncoematologia, Fondazione Santa Lucia, Rome, Italy.

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http://dx.doi.org/10.1002/gcc.22135DOI Listing
March 2014

Indirect determination of pediatric blood count reference intervals.

Clin Chem Lab Med 2013 Apr;51(4):863-72

Department of Pediatrics, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1515/cclm-2012-0684DOI Listing
April 2013

Identification of the genomic BCR-ABL1 fusion sequence from blood specimen stored on filter paper.

Leuk Res 2013 Jan 3;37(1):117-9. Epub 2012 Nov 3.

University Hospital Erlangen, Department of Paediatrics, Erlangen, Germany.

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http://dx.doi.org/10.1016/j.leukres.2012.10.007DOI Listing
January 2013

Novel MLL2 mutation in Kabuki syndrome with hypogammaglobulinemia and severe chronic thrombopenia.

J Pediatr Hematol Oncol 2013 Oct;35(7):e314-6

Department of Pediatrics, University of Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1097/MPH.0b013e3182707fa8DOI Listing
October 2013

Genomic BCR-ABL1 breakpoints in pediatric chronic myeloid leukemia.

Genes Chromosomes Cancer 2012 Nov 9;51(11):1045-53. Epub 2012 Aug 9.

Department of Pediatrics, University Hospital Erlangen, Germany.

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http://dx.doi.org/10.1002/gcc.21989DOI Listing
November 2012

Malignant epithelioid peripheral nerve sheath tumor with prominent reticular/microcystic pattern in a child: a low-grade neoplasm with 18-years follow-up.

Appl Immunohistochem Mol Morphol 2014 Sep;22(8):627-33

*Institute of Pathology, Universitätsklinikum Erlangen †University Children's Hospital ‡Department of Radiology §Department of Surgery, Erlangen, Germany.

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https://insights.ovid.com/crossref?an=00129039-201409000-000
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http://dx.doi.org/10.1097/PAI.0b013e318224751fDOI Listing
September 2014

The turnover of synovial T cells is higher than in T cells in the peripheral blood in persistent oligoarticular juvenile idiopathic arthritis.

Rheumatol Int 2010 Sep 30;30(11):1529-32. Epub 2010 Mar 30.

Department of Pediatrics, Innsbruck Medical School, Anichstrasse 35, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s00296-010-1465-7DOI Listing
September 2010

Low prevalence of Gs alpha mutations in śomatotroph adenomas of children and adolescents.

Cancer Genet Cytogenet 2006 Apr;166(2):146-51

Department of Pediatrics, University of Erlangen-Nuremberg, Loschgestr. 15, 91054 Erlangen, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S016546080500662
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http://dx.doi.org/10.1016/j.cancergencyto.2005.11.001DOI Listing
April 2006

The invertor knock-in conditional chromosomal translocation mimic.

Nat Methods 2005 Jan;2(1):27-30

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1038/nmeth727DOI Listing
January 2005

Protracted postnatal natural histories in childhood leukemia.

Genes Chromosomes Cancer 2004 Apr;39(4):335-40

LRF Centre, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1002/gcc.20003DOI Listing
April 2004

An unusual manifestation of Wegener's granulomatosis in a 4-year-old girl.

Pediatr Neurol 2002 Jul;27(1):71-4

Department of Pediatrics, Friedrich-Alexander University, Erlangen, Germany.

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http://dx.doi.org/10.1016/s0887-8994(02)00392-2DOI Listing
July 2002

Adrenomedullin, calcitonin gene-related peptide and their receptors: evidence for a decreased placental mRNA content in preeclampsia and HELLP syndrome.

Eur J Obstet Gynecol Reprod Biol 2002 Feb;101(1):47-53

Department of Pediatrics, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1016/s0301-2115(01)00519-xDOI Listing
February 2002