Markus H Heim

Markus H Heim

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Markus H Heim

Publications by authors named "Markus H Heim"

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Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma.

Cell Mol Gastroenterol Hepatol 2019 Aug 22. Epub 2019 Aug 22.

Experimental Immunology, Department of Biomedicine, University of Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.08.004DOI Listing
August 2019

The IFN-λ Pony Express.

Nat Immunol 2019 05;20(5):522-524

Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1038/s41590-019-0362-9DOI Listing
May 2019

Diagnostic Targeted Sequencing Panel for Hepatocellular Carcinoma Genomic Screening.

J Mol Diagn 2018 11 22;20(6):836-848. Epub 2018 Aug 22.

Institute of Pathology, University Hospital Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2018.07.003DOI Listing
November 2018

Growth of Epithelial Organoids in a Defined Hydrogel.

Adv Mater 2018 Oct 10;30(43):e1801621. Epub 2018 Sep 10.

Institute of Molecular Health Sciences, ETH Zürich, Otto-Stern-Weg 7, 8093, Zürich, Switzerland.

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http://doi.wiley.com/10.1002/adma.201801621
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http://dx.doi.org/10.1002/adma.201801621DOI Listing
October 2018

New insights into HDV-induced innate immunity: MDA5 senses HDV replication.

J Hepatol 2018 07 12;69(1):5-7. Epub 2018 Apr 12.

Department of Biomedicine, University Hospital Basel, University of Basel, Basel CH-4031, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.03.030DOI Listing
July 2018

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies.

Cell Rep 2018 07;24(5):1363-1376

Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland; Clinic of Gastroenterology and Hepatology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088153PMC
July 2018

Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver.

Gastroenterology 2018 05 19;154(6):1778-1790. Epub 2018 Mar 19.

Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland; Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.01.034DOI Listing
May 2018

mTORC2 Promotes Tumorigenesis via Lipid Synthesis.

Cancer Cell 2017 Dec;32(6):807-823.e12

Biozentrum, University of Basel, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.011DOI Listing
December 2017

A systematic review and meta-analysis of HCV clearance.

Liver Int 2017 10 30;37(10):1431-1445. Epub 2017 Mar 30.

Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1111/liv.13401DOI Listing
October 2017

SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)-induced gene expression .

J Biol Chem 2017 10 12;292(43):17928-17938. Epub 2017 Sep 12.

From the Department of Biomedicine, University of Basel, 4031 Basel, Switzerland and

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http://dx.doi.org/10.1074/jbc.M117.788877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663890PMC
October 2017

Transcriptional response to hepatitis C virus infection and interferon-alpha treatment in the human liver.

EMBO Mol Med 2017 06;9(6):816-834

Laboratory of Developmental Genomics, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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http://dx.doi.org/10.15252/emmm.201607006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452008PMC
June 2017

Host - hepatitis C viral interactions: The role of genetics.

J Hepatol 2016 10;65(1 Suppl):S22-S32

Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.07.037DOI Listing
October 2016

Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation.

Lab Invest 2016 09 18;96(9):972-80. Epub 2016 Jul 18.

Hepatology Laboratory, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland.

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http://www.nature.com/articles/labinvest201675
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http://dx.doi.org/10.1038/labinvest.2016.75DOI Listing
September 2016

Gene expression analysis of biopsy samples reveals critical limitations of transcriptome-based molecular classifications of hepatocellular carcinoma.

J Pathol Clin Res 2016 Apr 5;2(2):80-92. Epub 2016 Feb 5.

Department of BiomedicineUniversity of BaselBaselSwitzerland; Division of Hepatology and GastroenterologyUniversity Hospital of BaselBaselSwitzerland.

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http://doi.wiley.com/10.1002/cjp2.37
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http://dx.doi.org/10.1002/cjp2.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907058PMC
April 2016

An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B.

Liver Int 2015 Jul 21;35(7):1824-32. Epub 2015 Jan 21.

Department of Gastroenterology and Hepatology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/liv.12768DOI Listing
July 2015

Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model.

Lab Invest 2015 Mar 24;95(3):351-62. Epub 2014 Nov 24.

1] Department of Biomedicine, University Basel, Basel, Switzerland [2] Division of Gastroenterology and Hepatology, Kantonsspital St. Gallen, St. Gallen, Switzerland.

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http://dx.doi.org/10.1038/labinvest.2014.141DOI Listing
March 2015

Innate and adaptive immune responses in HCV infections.

J Hepatol 2014 Nov 3;61(1 Suppl):S14-25. Epub 2014 Nov 3.

Department of Medicine, Clinic for Gastroenterology, Hepatology, Endocrinology, Infectious Diseases, University Hospital Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.06.035DOI Listing
November 2014

Glucose-induced glucagon-like Peptide 1 secretion is deficient in patients with non-alcoholic fatty liver disease.

PLoS One 2014 29;9(1):e87488. Epub 2014 Jan 29.

Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland ; Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087488PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906180PMC
October 2014

Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.

PLoS Genet 2014 Jul 31;10(7):e1004508. Epub 2014 Jul 31.

Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

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http://dx.doi.org/10.1371/journal.pgen.1004508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117451PMC
July 2014

Nodular regenerative hyperplasia in a patient with generalized essential telangiectasia: endotheliopathy as a causal factor.

Hepatology 2014 Jun 28;59(6):2419-21. Epub 2014 Apr 28.

Department of Biomedicine, University Hospital Basel, University Basel, Basel, Switzerland.

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http://dx.doi.org/10.1002/hep.26942DOI Listing
June 2014

Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-α.

J Immunol 2014 Jun 12;192(12):6037-44. Epub 2014 May 12.

Division of Gastroenterology and Hepatology, Vaud University Hospital Center, University of Lausanne, CH-1011 Lausanne, Switzerland;

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http://dx.doi.org/10.4049/jimmunol.1302296DOI Listing
June 2014

IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies.

J Exp Med 2014 May 21;211(5):857-68. Epub 2014 Apr 21.

Department of Biomedicine; and 2 Division of Gastroenterology and Hepatology, University Hospital Basel; University of Basel, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1084/jem.20131557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010915PMC
May 2014

Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia.

Liver Int 2014 Apr 21;34(4):594-603. Epub 2013 Jul 21.

Department of Biomedicine, University Hospital Basel, University Basel, Basel, Switzerland.

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http://dx.doi.org/10.1111/liv.12261DOI Listing
April 2014

SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules.

Eur J Cancer 2014 Mar 3;50(4):731-8. Epub 2013 Dec 3.

Institute of Pathology, University Hospital of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2013.11.018DOI Listing
March 2014

Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease.

Hepatology 2014 Feb 18;59(2):423-33. Epub 2013 Dec 18.

From the Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/hep.26671DOI Listing
February 2014

Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha.

Hepatology 2013 Oct 5;58(4):1225-35. Epub 2013 Sep 5.

Inserm, U1110, Institut de Virologie, Strasbourg, France; Université de Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1002/hep.26404DOI Listing
October 2013

25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end.

Authors:
Markus H Heim

Nat Rev Immunol 2013 07 7;13(7):535-42. Epub 2013 Jun 7.

Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1038/nri3463DOI Listing
July 2013

Constitutive Notch2 signaling induces hepatic tumors in mice.

Hepatology 2013 Apr 14;57(4):1607-19. Epub 2013 Mar 14.

Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1002/hep.26165DOI Listing
April 2013

Innate immunity and HCV.

Authors:
Markus H Heim

J Hepatol 2013 Mar 11;58(3):564-74. Epub 2012 Oct 11.

Division of Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.jhep.2012.10.005DOI Listing
March 2013

Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress.

J Virol 2012 Oct 1;86(20):11043-56. Epub 2012 Aug 1.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1128/JVI.07101-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457181PMC
October 2012

Interferon-γ-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C.

Gastroenterology 2012 Sep 4;143(3):777-786.e6. Epub 2012 Jun 4.

Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland; Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085120081
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http://dx.doi.org/10.1053/j.gastro.2012.05.044DOI Listing
September 2012

Interferon signaling in the liver during hepatitis C virus infection.

Cytokine 2012 Sep 28;59(3):460-6. Epub 2012 Jun 28.

Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.cyto.2012.06.015DOI Listing
September 2012

Interferons and hepatitis C virus.

Authors:
Markus H Heim

Swiss Med Wkly 2012 9;142:w13586. Epub 2012 May 9.

University Hospital Basel, Switzerland.

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http://dx.doi.org/10.4414/smw.2012.13586DOI Listing
August 2012

MicroRNAs 103 and 107 regulate insulin sensitivity.

Nature 2011 Jun 8;474(7353):649-53. Epub 2011 Jun 8.

Institute for Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli Strasse 16, CH-8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/nature10112DOI Listing
June 2011

Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo.

Hepatology 2011 Apr;53(4):1154-63

Department of Biomedicine, University Basel, Basel, Switzerland.

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http://dx.doi.org/10.1002/hep.24189DOI Listing
April 2011

Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair.

Hepatology 2010 Mar;51(3):741-51

Department of Biomedicine, Hepatology Laboratory, University Hospital Basel, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1002/hep.23388DOI Listing
March 2010

HCV innate immune responses.

Authors:
Markus H Heim

Viruses 2009 12 30;1(3):1073-88. Epub 2009 Nov 30.

Clinic for Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.3390/v1031073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185522PMC
December 2009

Insulin resistance in chronic hepatitis C: mechanisms and clinical relevance.

Swiss Med Wkly 2009 Nov;139(47-48):678-84

Department of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/smw-12765DOI Listing
November 2009

Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice.

Hepatology 2009 Sep;50(3):871-9

Department of Biomedicine, Institute of Physiology, University of Basel, Switzerland.

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http://dx.doi.org/10.1002/hep.23048DOI Listing
September 2009

Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy.

Nat Med 2009 Jan 4;15(1):31-3. Epub 2009 Jan 4.

Department of Biomedicine, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1038/nm.1902DOI Listing
January 2009

Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C.

J Hepatol 2008 Sep 30;49(3):429-40. Epub 2008 Apr 30.

Department of Biomedicine, Division of Gastroenterology and Hepatology, University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.jhep.2008.04.007DOI Listing
September 2008

Interferon signaling and treatment outcome in chronic hepatitis C.

Proc Natl Acad Sci U S A 2008 May 8;105(19):7034-9. Epub 2008 May 8.

Department of Biomedicine, University of Basel, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1073/pnas.0707882105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2383932PMC
May 2008

Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A.

Hepatology 2007 Aug;46(2):558-65

Department of Research, University Hospital Basel, Basel, Switzerland.

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http://doi.wiley.com/10.1002/hep.21611
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http://dx.doi.org/10.1002/hep.21611DOI Listing
August 2007

Inhibition of alpha interferon signaling by hepatitis B virus.

J Virol 2007 Jan 25;81(1):159-65. Epub 2006 Oct 25.

Department of Research, University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1128/JVI.01292-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797249PMC
January 2007

S-Adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro.

Hepatology 2006 Apr;43(4):796-806

Department of Research and Division of Gastroenterology and Hepatology, University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1002/hep.21116DOI Listing
April 2006

Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice.

Hepatology 2005 Mar;41(3):487-96

Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.

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http://dx.doi.org/10.1002/hep.20571DOI Listing
March 2005

IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis.

J Immunol 2004 Mar;172(6):3775-83

Institut National de la Santé et de la Recherche Médicale, Unité 45, Faculté de Médecine RTH Laennec, Lyon, France.

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http://dx.doi.org/10.4049/jimmunol.172.6.3775DOI Listing
March 2004

Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A.

Gastroenterology 2004 Jan;126(1):263-77

Department of Research, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1053/j.gastro.2003.10.076DOI Listing
January 2004